UA34419C2 - Ліофілізований препарат для ін'єкцій та спосіб інгібування росту пухлин - Google Patents

Ліофілізований препарат для ін'єкцій та спосіб інгібування росту пухлин

Info

Publication number
UA34419C2
UA34419C2 UA5010680A UA5010680A UA34419C2 UA 34419 C2 UA34419 C2 UA 34419C2 UA 5010680 A UA5010680 A UA 5010680A UA 5010680 A UA5010680 A UA 5010680A UA 34419 C2 UA34419 C2 UA 34419C2
Authority
UA
Ukraine
Prior art keywords
growth inhibition
injectable preparation
tumour growth
lyophilised
lyophilised injectable
Prior art date
Application number
UA5010680A
Other languages
English (en)
Russian (ru)
Inventor
Гаетано Гатті
Гаэтано Гатти
Дієго ОЛДАНІ
Диего Олдани
Карло КОНФАЛОНІЄРІ
Карло Конфалониери
Лучіано Гамбіні
Лучиано Гамбини
Original Assignee
Фармація Енд Апджон С.П.А.
Фармация Энл Апджон С.П.А.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Фармація Енд Апджон С.П.А., Фармация Энл Апджон С.П.А. filed Critical Фармація Енд Апджон С.П.А.
Publication of UA34419C2 publication Critical patent/UA34419C2/uk

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Molecular Biology (AREA)
  • Dermatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Даний винахід стосується стабільних, швидкорозчинних, ліофілізованих, придатних для ін’єкцій препаратів, що містять глікозид антрацикліну або його фармацевтично прийнятну сіль як активного лікарського засобу, а також застосування вказаних препаратів для лікування пухлин.
UA5010680A 1984-10-22 1985-10-18 Ліофілізований препарат для ін'єкцій та спосіб інгібування росту пухлин UA34419C2 (uk)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB848426672A GB8426672D0 (en) 1984-10-22 1984-10-22 Pharmaceutical compositions

Publications (1)

Publication Number Publication Date
UA34419C2 true UA34419C2 (uk) 2001-03-15

Family

ID=10568553

Family Applications (2)

Application Number Title Priority Date Filing Date
UA5010680A UA34419C2 (uk) 1984-10-22 1985-10-18 Ліофілізований препарат для ін'єкцій та спосіб інгібування росту пухлин
UA3964940A UA19169A (uk) 1984-10-22 1985-10-18 Спосіб одержаhhя порошку ліофілізоваhого аhтрацикліh глікозиду

Family Applications After (1)

Application Number Title Priority Date Filing Date
UA3964940A UA19169A (uk) 1984-10-22 1985-10-18 Спосіб одержаhhя порошку ліофілізоваhого аhтрацикліh глікозиду

Country Status (35)

Country Link
US (4) US4675311A (uk)
JP (1) JPH0611700B2 (uk)
KR (1) KR920005813B1 (uk)
CN (1) CN85107562B (uk)
AT (1) AT401345B (uk)
AU (1) AU572003B2 (uk)
BE (1) BE903484A (uk)
BG (1) BG60934B2 (uk)
CA (1) CA1248453A (uk)
CH (1) CH667594A5 (uk)
CS (1) CS270421B2 (uk)
DE (1) DE3536896C2 (uk)
DK (1) DK165620C (uk)
ES (1) ES8605374A1 (uk)
FI (2) FI853913A (uk)
FR (1) FR2571966B1 (uk)
GB (2) GB8426672D0 (uk)
GR (1) GR852549B (uk)
HK (1) HK94390A (uk)
HU (1) HU197988B (uk)
IE (1) IE56992B1 (uk)
IL (1) IL76732A (uk)
IT (1) IT1186779B (uk)
MY (1) MY103956A (uk)
NL (1) NL191308C (uk)
NO (1) NO170616C (uk)
NZ (1) NZ213885A (uk)
PH (1) PH23982A (uk)
PT (1) PT81347B (uk)
RU (2) RU1836088C (uk)
SE (1) SE467520B (uk)
SG (1) SG80290G (uk)
UA (2) UA34419C2 (uk)
YU (1) YU46160B (uk)
ZA (1) ZA858033B (uk)

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US5124318A (en) * 1985-08-02 1992-06-23 Farmitalia Carlo Erba S.R.L. Injectable ready-to-use solutions containing an antitumor anthracycline glycoside
US5124317A (en) * 1985-08-02 1992-06-23 Farmitalia Carlo Erba S.P.A. Injectable ready-to-use solutions containing an antitumor anthracycline glycoside
US5977082A (en) * 1985-08-02 1999-11-02 Pharmacia & Upjohn Company Injectable ready-to-use solutions containing an antitumor anthracycline glycoside
GB2200047B (en) * 1986-12-05 1990-11-21 Erba Carlo Spa Injectable ready-to-use solutions containing an antitumor anthracycline glycoside
JP2603480B2 (ja) * 1987-08-05 1997-04-23 住友製薬株式会社 安定化されたアンスラサイクリン系製剤
DE3801178A1 (de) * 1988-01-18 1989-07-27 Hoechst Ag Stabilisierte trockenzubereitung zytostatisch wirksamer anthracyclin-antibiotika und verfahren zu ihrer herstellung
US6300362B1 (en) 1990-07-25 2001-10-09 Novartis Ag (Formerly Sandoz Ltd.) Stabilized pharmaceutical compositions comprising acid donors
US6471943B1 (en) 1996-12-30 2002-10-29 Battelle Pulmonary Therapeutics, Inc. Formulation and method for treating neoplasms by inhalation
US5942508A (en) * 1997-02-04 1999-08-24 Senju Pharmaceutical Co., Ltd. Method for solubilizing pyridonecarboxylic acid solubilizer thereof and aqueous solution containing solubilized pyridonecarboxylic acid
CA2476494C (en) 2002-02-22 2010-04-27 Schering Corporation Pharmaceutical formulations of antineoplastic agents, in particular temozolomide, processes of making and using the same
DK1474995T3 (da) * 2003-05-06 2013-02-18 Gumlink As Fremgangsmåde til fremstilling af tyggegummigranulater, et gummisammensætningsekstruder- og granuleringssystem og et tyggegummiprodukt
US7485707B2 (en) * 2003-07-02 2009-02-03 Solux Corporation Thermally stable crystalline epirubicin hydrochloride and method of making the same
US20090099346A1 (en) * 2003-07-02 2009-04-16 Victor Matvienko Thermally stable crystalline epirubicin hydrochloride
SI2263694T1 (sl) * 2003-09-25 2013-09-30 Astellas Pharma Inc. Antitumorsko sredstvo, ki obsega inhibitor histon-deacetilaze FK228 in inhibitor topoizomeraze II doksorubicin
US7388083B2 (en) * 2005-03-07 2008-06-17 Solux Corporation Epimerization of 4′-C bond and modification of 14-CH3-(CO)-fragment in anthracyclin antibiotics
CA2606390A1 (en) * 2005-05-11 2006-11-16 Sicor, Inc. Stable lyophilized anthracycline glycosides
EP1921919B1 (en) 2005-07-14 2012-04-04 Lithera, Inc. Sustained release enhanced lipolytic formulation for regional adipose tissue treatment
EP1976858B1 (en) * 2005-12-13 2016-01-06 Solux Corporation Method for preparing 4-demethyldaunorubicin
US8802830B2 (en) * 2005-12-20 2014-08-12 Solux Corporation Synthesis of epirubicin from 13-dihydrodaunorubicine
US8148338B2 (en) * 2006-02-22 2012-04-03 Supratek Pharma Inc. Doxorubicin formulations for anti-cancer use
US7470672B2 (en) * 2006-07-31 2008-12-30 Savvipharm Inc. Compositions and methods of reducing tissue levels of drugs when given as orotate derivatives
CA2687291A1 (en) * 2007-05-16 2008-11-20 Ktb Tumorforschungsgesellschaft Mbh Low-viscous anthracycline formulation
MX2010001263A (es) * 2007-09-04 2010-10-04 Meiji Seika Kaisha Inyeccion, solucion de inyeccion y preparacion de equipo de inyeccion.
BRPI0818860A2 (pt) * 2007-10-26 2015-04-22 Pfizer Prod Inc Idarubicina para o tratamento de linfoma em um cão
US8357785B2 (en) * 2008-01-08 2013-01-22 Solux Corporation Method of aralkylation of 4′-hydroxyl group of anthracylins
US9132084B2 (en) 2009-05-27 2015-09-15 Neothetics, Inc. Methods for administration and formulations for the treatment of regional adipose tissue
SG2014014351A (en) * 2010-01-15 2014-07-30 Lithera Inc Lyophilized cake formulations
EP2646012A4 (en) 2010-11-24 2014-12-10 Neothetics Inc MONOTHERAPEUTIC FORMULATIONS OF SELECTIVE, LIPOPHILIC AND PROLONGED BETA AGONISTS AND METHODS OF COSMETIC TREATMENT OF SILHOUETTE ADPOSITY AND REINFORCEMENT
DE102011103751A1 (de) 2011-05-31 2012-12-06 Heraeus Precious Metals Gmbh & Co. Kg Kristallisierung von Epirubicinhydrochlorid
DE102011111991A1 (de) * 2011-08-30 2013-02-28 Lead Discovery Center Gmbh Neue Cyclosporin-Derivate
US20150342975A1 (en) 2012-12-13 2015-12-03 Cytrx Corporation Anthracycline formulations
WO2014197569A1 (en) 2013-06-05 2014-12-11 Cytrx Corporation Cytotoxic agents for the treatment of cancer

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YU33730B (en) * 1967-04-18 1978-02-28 Farmaceutici Italia Process for preparing a novel antibiotic substance and salts thereof
US4039663A (en) * 1975-03-19 1977-08-02 Societa' Farmaceutici Italia S.P.A. Daunomycins, process for their uses and intermediates
GB1506200A (en) * 1975-04-30 1978-04-05 Farmaceutici Italia Glycosides
GB1567456A (en) * 1976-11-16 1980-05-14 Farmaceutici Italia Daunomycin derivatives
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US4325947A (en) * 1981-05-12 1982-04-20 Farmitalia Carlo Erba S.P.A. 4-Demethoxy-4'-deoxydoxorubicin
IT1210476B (it) * 1981-05-28 1989-09-14 Erba Farmitalia Antracicline.
US4438105A (en) * 1982-04-19 1984-03-20 Farmaitalia Carlo Erba S.P.A 4'-Iododerivatives of anthracycline glycosides
DE3317702A1 (de) * 1982-05-24 1983-11-24 Farmitalia Carlo Erba S.p.A., 20159 Milano Anthracyclinglykoside, verfahren zu deren herstellung und arzneimittel, welche diese enthalten
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JPS5982395A (ja) * 1982-11-02 1984-05-12 Microbial Chem Res Found アントラサイクリン化合物、その製造法およびその用途
GR79729B (uk) * 1982-12-20 1984-10-31 Univ Ohio State Res Found
JPS6092212A (ja) * 1983-10-26 1985-05-23 Kyowa Hakko Kogyo Co Ltd ドキソルビシン塩の製剤
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Also Published As

Publication number Publication date
CN85107562B (zh) 1988-06-01
ATA303285A (de) 1996-01-15
FI853913A0 (fi) 1985-10-08
BG60934B2 (bg) 1996-06-28
ES547578A0 (es) 1986-03-16
YU164485A (en) 1987-10-31
KR920005813B1 (ko) 1992-07-20
IE56992B1 (en) 1992-02-26
DE3536896C2 (de) 1996-11-14
FI854035L (fi) 1986-04-23
GB2165751A (en) 1986-04-23
US4675311A (en) 1987-06-23
NZ213885A (en) 1988-05-30
DK481585D0 (da) 1985-10-21
GB8426672D0 (en) 1984-11-28
MY103956A (en) 1993-10-30
SE8504945D0 (sv) 1985-10-21
US5091373A (en) 1992-02-25
NL191308B (nl) 1994-12-16
JPH0611700B2 (ja) 1994-02-16
CN85107562A (zh) 1986-07-23
SE8504945L (sv) 1986-04-23
SG80290G (en) 1990-11-23
PT81347A (en) 1985-11-01
UA19169A (uk) 1997-12-25
NL8502869A (nl) 1986-05-16
HUT40759A (en) 1987-02-27
CS756585A2 (en) 1989-11-14
GB8525709D0 (en) 1985-11-20
FR2571966A1 (fr) 1986-04-25
IL76732A0 (en) 1986-02-28
IE852593L (en) 1986-04-22
NO170616C (no) 1992-11-11
FI86252B (fi) 1992-04-30
DK165620C (da) 1993-06-01
DE3536896A1 (de) 1986-04-24
BE903484A (fr) 1986-04-21
FI854035A0 (fi) 1985-10-16
NL191308C (nl) 1995-05-16
RU1836088C (ru) 1993-08-23
FI86252C (fi) 1992-08-10
DK165620B (da) 1992-12-28
FI853913A (fi) 1986-04-23
GR852549B (uk) 1986-02-24
YU46160B (sh) 1993-05-28
AT401345B (de) 1996-08-26
HK94390A (en) 1990-11-23
DK481585A (da) 1986-04-23
IL76732A (en) 1989-07-31
FR2571966B1 (fr) 1988-04-15
PT81347B (pt) 1987-11-11
PH23982A (en) 1990-02-09
JPS61246129A (ja) 1986-11-01
CH667594A5 (de) 1988-10-31
CA1248453A (en) 1989-01-10
IT8522507A0 (it) 1985-10-16
AU4880585A (en) 1986-05-01
US4840938A (en) 1989-06-20
SE467520B (sv) 1992-08-03
ZA858033B (en) 1986-06-25
RU2101018C1 (ru) 1998-01-10
NO854194L (no) 1986-04-23
KR860003014A (ko) 1986-05-19
ES8605374A1 (es) 1986-03-16
HU197988B (en) 1989-07-28
IT1186779B (it) 1987-12-16
GB2165751B (en) 1988-08-17
NO170616B (no) 1992-08-03
CS270421B2 (en) 1990-06-13
US5091372A (en) 1992-02-25
AU572003B2 (en) 1988-04-28

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