EE200300024A - Meetod 2-(6-asendatud-1,3-dioksaan-4-üül)etaanhappe derivaadi valmistamiseks, lähteühend ning lõppsaadused - Google Patents
Meetod 2-(6-asendatud-1,3-dioksaan-4-üül)etaanhappe derivaadi valmistamiseks, lähteühend ning lõppsaadusedInfo
- Publication number
- EE200300024A EE200300024A EEP200300024A EEP200300024A EE200300024A EE 200300024 A EE200300024 A EE 200300024A EE P200300024 A EEP200300024 A EE P200300024A EE P200300024 A EEP200300024 A EE P200300024A EE 200300024 A EE200300024 A EE 200300024A
- Authority
- EE
- Estonia
- Prior art keywords
- substituted
- preparation
- acetic acid
- formula
- group
- Prior art date
Links
- -1 2- (6-substituted-1,3-dioxan-4-yl) -acetic acid Chemical class 0.000 title abstract 2
- 239000007795 chemical reaction product Substances 0.000 title 1
- 239000007858 starting material Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- XYICPZVNNCLGCU-UHFFFAOYSA-N 2-[6-(hydroxymethyl)-1,3-dioxan-4-yl]acetic acid Chemical compound OCC1CC(CC(O)=O)OCO1 XYICPZVNNCLGCU-UHFFFAOYSA-N 0.000 abstract 1
- 229940121710 HMGCoA reductase inhibitor Drugs 0.000 abstract 1
- 238000006359 acetalization reaction Methods 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 239000003377 acid catalyst Substances 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- QGZKDVFQNNGYKY-UHFFFAOYSA-O ammonium group Chemical group [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 1
- 239000002471 hydroxymethylglutaryl coenzyme A reductase inhibitor Substances 0.000 abstract 1
- 239000002184 metal Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/30—Oxygen atoms, e.g. delta-lactones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
- C07D319/06—1,3-Dioxanes; Hydrogenated 1,3-dioxanes not condensed with other rings
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
- Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Catalysts (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
NL1015744A NL1015744C2 (nl) | 2000-07-19 | 2000-07-19 | Werkwijze voor de bereiding van 2-(6-gesubstitueerde-1,3-dioxan-4-yl) azijnzuurderivaten. |
PCT/NL2001/000535 WO2002006266A1 (en) | 2000-07-19 | 2001-07-12 | Process for the preparation of 2-(6-substituted-1,3-dioxane-4-yl)acetic acid derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
EE200300024A true EE200300024A (et) | 2004-10-15 |
Family
ID=19771761
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EEP200300024A EE200300024A (et) | 2000-07-19 | 2001-07-12 | Meetod 2-(6-asendatud-1,3-dioksaan-4-üül)etaanhappe derivaadi valmistamiseks, lähteühend ning lõppsaadused |
Country Status (29)
Country | Link |
---|---|
US (4) | US6870059B2 (cs) |
EP (2) | EP1317440B1 (cs) |
JP (2) | JP5006499B2 (cs) |
KR (3) | KR20080078925A (cs) |
CN (3) | CN101081842B (cs) |
AT (1) | ATE340790T1 (cs) |
AU (2) | AU2001275830B2 (cs) |
BR (1) | BR0112535A (cs) |
CA (1) | CA2415963C (cs) |
CY (1) | CY1105881T1 (cs) |
CZ (1) | CZ302718B6 (cs) |
DE (1) | DE60123444T2 (cs) |
DK (1) | DK1317440T3 (cs) |
EE (1) | EE200300024A (cs) |
ES (2) | ES2387313T3 (cs) |
HU (1) | HUP0303166A3 (cs) |
IL (3) | IL153980A0 (cs) |
IS (2) | IS2386B (cs) |
MX (1) | MXPA03000498A (cs) |
NL (1) | NL1015744C2 (cs) |
NO (1) | NO328935B1 (cs) |
NZ (1) | NZ523703A (cs) |
PL (1) | PL207115B1 (cs) |
PT (1) | PT1317440E (cs) |
RU (1) | RU2266903C2 (cs) |
SK (2) | SK287755B6 (cs) |
UA (1) | UA77944C2 (cs) |
WO (1) | WO2002006266A1 (cs) |
ZA (1) | ZA200300478B (cs) |
Families Citing this family (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0011120D0 (en) | 2000-05-09 | 2000-06-28 | Avecia Ltd | Process |
NL1015744C2 (nl) | 2000-07-19 | 2002-01-22 | Dsm Nv | Werkwijze voor de bereiding van 2-(6-gesubstitueerde-1,3-dioxan-4-yl) azijnzuurderivaten. |
JP4359141B2 (ja) | 2001-07-13 | 2009-11-04 | アストラゼネカ・ユーケイ・リミテッド | アミノピリミジン化合物の製造 |
EP1323717A1 (en) * | 2001-12-27 | 2003-07-02 | Dsm N.V. | Process for the preparation of 2-(6-Substituted-1,3-Dioxane-4-yL) acetic acid derivatives |
EP1375493A1 (en) * | 2002-06-17 | 2004-01-02 | Dsm N.V. | Process for the preparation of an dioxane acetic acid ester |
GB0218781D0 (en) * | 2002-08-13 | 2002-09-18 | Astrazeneca Ab | Chemical process |
EP1625223A4 (en) * | 2002-09-20 | 2009-11-11 | Verenium Corp | CHEMOENZYMATIC PROCEDURES FOR SYNTHESIS OF STATINES AND STATIN INTERCONNECTIONS |
US9740817B1 (en) | 2002-10-18 | 2017-08-22 | Dennis Sunga Fernandez | Apparatus for biological sensing and alerting of pharmaco-genomic mutation |
WO2004054986A2 (en) | 2002-12-16 | 2004-07-01 | Astrazeneca Uk Limited | Process for the preparation of pyrimidine compounds |
SI1620423T1 (sl) * | 2003-05-02 | 2008-06-30 | Dsm Ip Assets Bv | Postopek za pripravo (4-hidroksi-6-okso-tetrahidro-piran-2-il)-aceetonitrila in njihovih derivatov |
GB0312896D0 (en) | 2003-06-05 | 2003-07-09 | Astrazeneca Ab | Chemical process |
US8346482B2 (en) | 2003-08-22 | 2013-01-01 | Fernandez Dennis S | Integrated biosensor and simulation system for diagnosis and therapy |
UY28501A1 (es) * | 2003-09-10 | 2005-04-29 | Astrazeneca Uk Ltd | Compuestos químicos |
GB0321827D0 (en) * | 2003-09-18 | 2003-10-15 | Astrazeneca Uk Ltd | Chemical compounds |
GB0324791D0 (en) | 2003-10-24 | 2003-11-26 | Astrazeneca Ab | Chemical process |
DE10352659B4 (de) * | 2003-11-11 | 2007-09-13 | Ratiopharm Gmbh | Verfahren zur Herstellung von Statinen und Tetrahydropyranonderivate zur Verwendung in dem Verfahren |
GB0428328D0 (en) | 2004-12-24 | 2005-02-02 | Astrazeneca Uk Ltd | Chemical process |
GB0514078D0 (en) * | 2005-07-08 | 2005-08-17 | Astrazeneca Uk Ltd | Chemical process |
US7264743B2 (en) * | 2006-01-23 | 2007-09-04 | Lam Research Corporation | Fin structure formation |
TW200831469A (en) * | 2006-12-01 | 2008-08-01 | Astrazeneca Uk Ltd | Chemical process |
ES2398802T3 (es) * | 2009-04-15 | 2013-03-21 | Pharmathen S.A. | Procedimiento mejorado para la preparación de fluvastatina y sales de la misma |
GB2482525A (en) * | 2010-08-05 | 2012-02-08 | Phoenix Chemicals Ltd | A process for the production of acyloxymethyldioxanylacetic derivatives |
HUE025861T2 (en) | 2010-09-09 | 2016-05-30 | Dsm Sinochem Pharm Nl Bv | Salts of 7-amino-3,5-dihydroxy-heptanoic acid esters |
EP2616454B1 (en) | 2010-09-16 | 2015-04-15 | DSM Sinochem Pharmaceuticals Netherlands B.V. | Esters of hexanoic acids as intermediates for the preparation of atorvastatin |
MX2013008285A (es) | 2011-01-18 | 2013-09-13 | Dsm Sinochem Pharm Bv | Procedimiento para la preparacion de diolsulfonas. |
CN103313983B (zh) | 2011-01-18 | 2016-06-29 | 中化帝斯曼制药有限公司荷兰公司 | 在碱存在下制备他汀类化合物的方法 |
US8865900B2 (en) | 2011-01-18 | 2014-10-21 | Dsm Sinochem Pharmaceuticals Netherlands B.V. | Methyltetrazole sulfides and sulfones |
US8987478B2 (en) | 2011-12-09 | 2015-03-24 | Dsm Sinochem Pharmaceuticals Netherlands B.V. | Process for the preparation of a statin precursor |
WO2013083719A1 (en) * | 2011-12-09 | 2013-06-13 | Dsm Sinochem Pharmaceuticals Netherlands B.V. | Process for the preparation of a thioprecursor for statins |
JP6065862B2 (ja) * | 2013-04-10 | 2017-01-25 | 信越化学工業株式会社 | パターン形成方法、レジスト組成物、高分子化合物及び単量体 |
WO2014203045A1 (en) | 2013-06-20 | 2014-12-24 | Lupin Limited | A novel, green and cost effective process for synthesis of tert-butyl (3r,5s)-6-oxo-3,5-dihydroxy-3,5-o-isopropylidene-hexanoate |
CN105624127B (zh) * | 2014-10-28 | 2019-07-26 | 上海弈柯莱生物医药科技有限公司 | 一种葡萄糖脱氢酶及其在合成他汀类药物中间体中的应用 |
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DE3929913A1 (de) * | 1989-09-08 | 1991-04-04 | Hoechst Ag | 4-hydroxytetrahydropyran-2-one sowie die entsprechenden dihydroxycarbonsaeurederivate, salze und ester, verfahren zu ihrer herstellung, ihre verwendung als arzneimittel, pharmazeutische praeparate sowie vorprodukte |
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US5292891A (en) * | 1991-02-21 | 1994-03-08 | Chisso Corporation | Optically active 2,2-dimethyl-1,3-dioxin-4-ones and method for preparing same and method for preparing optically active compound for synthesis of physiologically active substance and optically active intermediate compound |
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GB9523924D0 (en) | 1995-11-23 | 1996-01-24 | Zeneca Ltd | Production of optically active 2-substituted tetrahydropyran-4-ones |
FR2741620B1 (fr) * | 1995-11-28 | 1997-12-26 | Oreal | Procede de preparation de composes a groupement beta-hydroxy -delta-lactone analogues de la (+) compactine et de la (+) mevinoline |
US6278001B1 (en) | 1995-11-28 | 2001-08-21 | L'oréal | Method for preparing (+) compactin and (+) mevinolin analog compounds having a β-hydroxy-δ-lactone grouping |
DE69910562T2 (de) | 1998-04-30 | 2004-06-17 | Kaneka Corp. | Verfahren zur herstellung von derivaten der 6-cyanomethyl-1,3-dioxan-4-essigsäure |
US6472544B1 (en) * | 1998-08-05 | 2002-10-29 | Kaneka Corporation | Process for the preparation of optically active 2-[6-hydroxymethyl)-1,3-dioxan-4yl]acetic acid derivatives |
EP1533308B1 (en) | 1998-12-10 | 2014-01-15 | Kaneka Corporation | A process for producing a simvastatin precursor |
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HU227840B1 (en) | 1999-05-06 | 2012-05-02 | Egis Gyogyszergyar Nyilvanosan M Kod Ruszvunytarsasag | Intermediates of atorvastatin synthesis and process for producing them |
ATE264290T1 (de) * | 1999-06-04 | 2004-04-15 | Kaneka Corp | Verfahren zur herstellung von 5-hydroxy-3-oxo- pentansäure-derivaten |
WO2001072706A1 (en) * | 2000-03-28 | 2001-10-04 | Biocon India Limited | Synthesis of [r-(r*,r*)]-2-(4-fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-heptanoic acid hemi calcium salt (atorvastatin) |
GB0011120D0 (en) * | 2000-05-09 | 2000-06-28 | Avecia Ltd | Process |
DE60124907D1 (de) * | 2000-06-05 | 2007-01-11 | Kaneka Corp | VERFAHREN FÜR DIE HERSTELLUNG VON OPTISCH AKTIVEN 2-i6-(HYDROXYMETHYL)-1,3-DIOXAN-4-YLöESSIGSÄURE-DERIVATEN (19.12.01) |
NL1015744C2 (nl) | 2000-07-19 | 2002-01-22 | Dsm Nv | Werkwijze voor de bereiding van 2-(6-gesubstitueerde-1,3-dioxan-4-yl) azijnzuurderivaten. |
JP4359141B2 (ja) | 2001-07-13 | 2009-11-04 | アストラゼネカ・ユーケイ・リミテッド | アミノピリミジン化合物の製造 |
EP1323717A1 (en) | 2001-12-27 | 2003-07-02 | Dsm N.V. | Process for the preparation of 2-(6-Substituted-1,3-Dioxane-4-yL) acetic acid derivatives |
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KR100511533B1 (ko) | 2002-04-09 | 2005-08-31 | 임광민 | 키랄 중간체, 그의 제조방법 및 그를 이용한 HMG-CoA환원저해제의 제조방법 |
EP1375493A1 (en) | 2002-06-17 | 2004-01-02 | Dsm N.V. | Process for the preparation of an dioxane acetic acid ester |
GB0218781D0 (en) * | 2002-08-13 | 2002-09-18 | Astrazeneca Ab | Chemical process |
WO2004054986A2 (en) * | 2002-12-16 | 2004-07-01 | Astrazeneca Uk Limited | Process for the preparation of pyrimidine compounds |
WO2004103977A2 (en) | 2003-05-21 | 2004-12-02 | Ciba Specialty Chemicals Holding Inc. | Process for the preparation of pyrimidine derivatives |
GB0312896D0 (en) * | 2003-06-05 | 2003-07-09 | Astrazeneca Ab | Chemical process |
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UY28501A1 (es) * | 2003-09-10 | 2005-04-29 | Astrazeneca Uk Ltd | Compuestos químicos |
GB0321827D0 (en) | 2003-09-18 | 2003-10-15 | Astrazeneca Uk Ltd | Chemical compounds |
GB0324791D0 (en) | 2003-10-24 | 2003-11-26 | Astrazeneca Ab | Chemical process |
KR20090010126A (ko) | 2003-12-24 | 2009-01-28 | 테바 파마슈티컬 인더스트리즈 리미티드 | 높은 syn형 대 anti형 비율을 지닌 스타틴의 제조 방법 |
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GB0428328D0 (en) | 2004-12-24 | 2005-02-02 | Astrazeneca Uk Ltd | Chemical process |
GB0514078D0 (en) | 2005-07-08 | 2005-08-17 | Astrazeneca Uk Ltd | Chemical process |
TW200831469A (en) * | 2006-12-01 | 2008-08-01 | Astrazeneca Uk Ltd | Chemical process |
-
2000
- 2000-07-19 NL NL1015744A patent/NL1015744C2/nl not_active IP Right Cessation
-
2001
- 2001-07-12 EE EEP200300024A patent/EE200300024A/xx unknown
- 2001-07-12 SK SK35-2003A patent/SK287755B6/sk not_active IP Right Cessation
- 2001-07-12 MX MXPA03000498A patent/MXPA03000498A/es active IP Right Grant
- 2001-07-12 DE DE60123444T patent/DE60123444T2/de not_active Expired - Lifetime
- 2001-07-12 ES ES06010837T patent/ES2387313T3/es not_active Expired - Lifetime
- 2001-07-12 PT PT01953373T patent/PT1317440E/pt unknown
- 2001-07-12 NZ NZ523703A patent/NZ523703A/en not_active IP Right Cessation
- 2001-07-12 AU AU2001275830A patent/AU2001275830B2/en not_active Ceased
- 2001-07-12 BR BR0112535-4A patent/BR0112535A/pt not_active IP Right Cessation
- 2001-07-12 HU HU0303166A patent/HUP0303166A3/hu unknown
- 2001-07-12 EP EP01953373A patent/EP1317440B1/en not_active Expired - Lifetime
- 2001-07-12 CN CN2007101118797A patent/CN101081842B/zh not_active Expired - Lifetime
- 2001-07-12 IL IL15398001A patent/IL153980A0/xx active IP Right Grant
- 2001-07-12 KR KR1020087019878A patent/KR20080078925A/ko not_active Ceased
- 2001-07-12 KR KR1020077027471A patent/KR20070121063A/ko not_active Ceased
- 2001-07-12 PL PL359332A patent/PL207115B1/pl not_active IP Right Cessation
- 2001-07-12 AT AT01953373T patent/ATE340790T1/de active
- 2001-07-12 SK SK123-2010A patent/SK287756B6/sk not_active IP Right Cessation
- 2001-07-12 RU RU2003104825/04A patent/RU2266903C2/ru not_active IP Right Cessation
- 2001-07-12 CZ CZ20030163A patent/CZ302718B6/cs not_active IP Right Cessation
- 2001-07-12 CA CA002415963A patent/CA2415963C/en not_active Expired - Fee Related
- 2001-07-12 DK DK01953373T patent/DK1317440T3/da active
- 2001-07-12 EP EP06010837A patent/EP1700854B1/en not_active Expired - Lifetime
- 2001-07-12 CN CN01812999A patent/CN1443183A/zh not_active Withdrawn
- 2001-07-12 CN CNB2005100657442A patent/CN100378091C/zh not_active Expired - Lifetime
- 2001-07-12 AU AU7583001A patent/AU7583001A/xx active Pending
- 2001-07-12 US US10/333,351 patent/US6870059B2/en not_active Expired - Lifetime
- 2001-07-12 JP JP2002512170A patent/JP5006499B2/ja not_active Expired - Lifetime
- 2001-07-12 KR KR1020027017684A patent/KR100865016B1/ko not_active Expired - Fee Related
- 2001-07-12 ES ES01953373T patent/ES2272506T3/es not_active Expired - Lifetime
- 2001-07-12 WO PCT/NL2001/000535 patent/WO2002006266A1/en active Application Filing
- 2001-12-07 UA UA2003010456A patent/UA77944C2/uk unknown
-
2003
- 2003-01-03 NO NO20030025A patent/NO328935B1/no not_active IP Right Cessation
- 2003-01-15 IS IS6680A patent/IS2386B/is unknown
- 2003-01-16 IL IL153980A patent/IL153980A/en not_active IP Right Cessation
- 2003-01-17 ZA ZA200300478A patent/ZA200300478B/en unknown
-
2005
- 2005-02-07 US US11/053,090 patent/US7642363B2/en not_active Expired - Lifetime
-
2006
- 2006-08-31 IL IL177824A patent/IL177824A0/en not_active IP Right Cessation
- 2006-12-21 CY CY20061101848T patent/CY1105881T1/el unknown
-
2007
- 2007-11-15 IS IS8690A patent/IS8690A/is unknown
-
2009
- 2009-11-24 US US12/625,156 patent/US7989643B2/en not_active Expired - Fee Related
-
2011
- 2011-06-22 US US13/166,607 patent/US20110251406A1/en not_active Abandoned
- 2011-12-06 JP JP2011267056A patent/JP2012111757A/ja active Pending
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