CY1105881T1 - Διαδικασια για την παρασκευη παραγωγων 2-(6-υποκατεστημενου-1,3-διοξανο-4υλ)οξικου οξεως - Google Patents

Διαδικασια για την παρασκευη παραγωγων 2-(6-υποκατεστημενου-1,3-διοξανο-4υλ)οξικου οξεως

Info

Publication number
CY1105881T1
CY1105881T1 CY20061101848T CY061101848T CY1105881T1 CY 1105881 T1 CY1105881 T1 CY 1105881T1 CY 20061101848 T CY20061101848 T CY 20061101848T CY 061101848 T CY061101848 T CY 061101848T CY 1105881 T1 CY1105881 T1 CY 1105881T1
Authority
CY
Cyprus
Prior art keywords
substituted
formula
preparation
acetic acid
group
Prior art date
Application number
CY20061101848T
Other languages
English (en)
Inventor
Jacob Hermanus Mattheus Hero Kooistra
Hubertus Josephus Marie Zeegers
Daniel Mink
Joannes Maria Cornelis Antonius Mulders
Original Assignee
Astrazeneca Uk Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Uk Limited filed Critical Astrazeneca Uk Limited
Publication of CY1105881T1 publication Critical patent/CY1105881T1/el

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
    • C07D319/06—1,3-Dioxanes; Hydrogenated 1,3-dioxanes not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/30—Oxygen atoms, e.g. delta-lactones
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Catalysts (AREA)

Abstract

Η εφεύρεση αναφέρεται στην παρασκευή παραγώγων 2-(6-υποκατεστημένου-1,3-διοξανο-4-υλ)οξικού οξέος του τύπου (1), όπου το Χ συμβολίζει μία ομάδα αναχώρησης, και τα R1, R2, και R3, το καθένα ανεξάρτητα, συμβολίζουν μία αλκυλ ομάδα με 1-3 άτομα άνθρακα από ενώσεις 4-υδροξυ-6-Χ-υποκατεστημένης-μεθυλ-τετραϋδροπυραν-2-όνης, όπου το Χ είναι όπως ορίζεται παραπάνω, με τη βοήθεια ενός μέσου ακεταλίωσης, υπό την παρουσία ενός καταλύτη οξέος. Η εφεύρεση επίσης αναφέρεται στις νέες ενώσεις του τύπου (1) όπως επίσης σε άλατα και οξέα που παρασκευάζονται από αυτές, με την ομάδα ΟR3 του τύπου (1) να αντικαθίσταται από μία ΟΥ ομάδα, όπου τα Χ, R1 και R2 έχουν τις έννοιες που ορίστηκαν παραπάνω και όπου το Υ συμβολίζει ένα αλκαλικό (γαίας) μέταλλο ή μία υποκατεστημένη ή μη υποκατεστημένη ομάδα αμμωνίου ή συμβολίζει υδρογόνο, και στις νέες ενώσεις του τύπου (2). Τα προϊόντα στα οποία αφορούν είναι, μετά από τη μετατροπή σε t-βουτυλ εστέρα από 2-(6-υδροξυμεθυλ-1,3-διοξανο-4-υλ)οξικό οξύ, σημαντικά ως ενδιάμεσα προϊόντα για την παρασκευή στατινών.
CY20061101848T 2000-07-19 2006-12-21 Διαδικασια για την παρασκευη παραγωγων 2-(6-υποκατεστημενου-1,3-διοξανο-4υλ)οξικου οξεως CY1105881T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
NL1015744A NL1015744C2 (nl) 2000-07-19 2000-07-19 Werkwijze voor de bereiding van 2-(6-gesubstitueerde-1,3-dioxan-4-yl) azijnzuurderivaten.
PCT/NL2001/000535 WO2002006266A1 (en) 2000-07-19 2001-07-12 Process for the preparation of 2-(6-substituted-1,3-dioxane-4-yl)acetic acid derivatives

Publications (1)

Publication Number Publication Date
CY1105881T1 true CY1105881T1 (el) 2011-02-02

Family

ID=19771761

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20061101848T CY1105881T1 (el) 2000-07-19 2006-12-21 Διαδικασια για την παρασκευη παραγωγων 2-(6-υποκατεστημενου-1,3-διοξανο-4υλ)οξικου οξεως

Country Status (30)

Country Link
US (4) US6870059B2 (el)
EP (2) EP1700854B1 (el)
JP (2) JP5006499B2 (el)
KR (3) KR20080078925A (el)
CN (3) CN101081842B (el)
AT (1) ATE340790T1 (el)
AU (2) AU7583001A (el)
BR (1) BR0112535A (el)
CA (1) CA2415963C (el)
CY (1) CY1105881T1 (el)
CZ (1) CZ302718B6 (el)
DE (1) DE60123444T2 (el)
DK (1) DK1317440T3 (el)
EE (1) EE200300024A (el)
ES (2) ES2272506T3 (el)
HK (1) HK1097260A1 (el)
HU (1) HUP0303166A3 (el)
IL (3) IL153980A0 (el)
IS (2) IS2386B (el)
MX (1) MXPA03000498A (el)
NL (1) NL1015744C2 (el)
NO (1) NO328935B1 (el)
NZ (1) NZ523703A (el)
PL (1) PL207115B1 (el)
PT (1) PT1317440E (el)
RU (1) RU2266903C2 (el)
SK (2) SK287755B6 (el)
UA (1) UA77944C2 (el)
WO (1) WO2002006266A1 (el)
ZA (1) ZA200300478B (el)

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Also Published As

Publication number Publication date
AU2001275830B2 (en) 2006-07-20
NO20030025L (no) 2003-01-03
DK1317440T3 (da) 2007-01-08
US20110251406A1 (en) 2011-10-13
KR20080078925A (ko) 2008-08-28
ES2387313T3 (es) 2012-09-20
EE200300024A (et) 2004-10-15
SK287756B6 (sk) 2011-08-04
CN101081842A (zh) 2007-12-05
US7642363B2 (en) 2010-01-05
CZ302718B6 (cs) 2011-09-21
IS8690A (is) 2007-11-15
PT1317440E (pt) 2007-01-31
MXPA03000498A (es) 2003-06-24
US6870059B2 (en) 2005-03-22
WO2002006266A1 (en) 2002-01-24
BR0112535A (pt) 2003-07-01
DE60123444T2 (de) 2007-08-23
US20030158426A1 (en) 2003-08-21
CN1443183A (zh) 2003-09-17
ES2272506T3 (es) 2007-05-01
KR20030040224A (ko) 2003-05-22
US20050148785A1 (en) 2005-07-07
EP1317440B1 (en) 2006-09-27
IS6680A (is) 2003-01-15
HUP0303166A2 (hu) 2003-12-29
PL207115B1 (pl) 2010-11-30
CZ2003163A3 (cs) 2003-05-14
NO20030025D0 (no) 2003-01-03
HK1097260A1 (en) 2007-06-22
ZA200300478B (en) 2004-01-26
IS2386B (is) 2008-07-15
NZ523703A (en) 2004-08-27
SK352003A3 (en) 2003-05-02
UA77944C2 (en) 2007-02-15
PL359332A1 (en) 2004-08-23
CN101081842B (zh) 2012-01-04
IL153980A (en) 2006-10-05
NO328935B1 (no) 2010-06-21
EP1317440A1 (en) 2003-06-11
RU2266903C2 (ru) 2005-12-27
JP5006499B2 (ja) 2012-08-22
EP1700854A1 (en) 2006-09-13
IL153980A0 (en) 2003-07-31
CN1680363A (zh) 2005-10-12
US20100136339A1 (en) 2010-06-03
US7989643B2 (en) 2011-08-02
CN100378091C (zh) 2008-04-02
IL177824A0 (en) 2006-12-31
SK287755B6 (sk) 2011-08-04
NL1015744C2 (nl) 2002-01-22
KR20070121063A (ko) 2007-12-26
CA2415963A1 (en) 2002-01-24
AU7583001A (en) 2002-01-30
DE60123444D1 (de) 2006-11-09
ATE340790T1 (de) 2006-10-15
HUP0303166A3 (en) 2005-11-28
JP2004504315A (ja) 2004-02-12
CA2415963C (en) 2008-02-26
KR100865016B1 (ko) 2008-10-23
EP1700854B1 (en) 2012-05-23
JP2012111757A (ja) 2012-06-14

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