IS2386B - Aðferð til að framleiða 2-(6-útskiptar-1,3-díoxan-4-ýl)ediksýruafleiður - Google Patents

Aðferð til að framleiða 2-(6-útskiptar-1,3-díoxan-4-ýl)ediksýruafleiður

Info

Publication number
IS2386B
IS2386B IS6680A IS6680A IS2386B IS 2386 B IS2386 B IS 2386B IS 6680 A IS6680 A IS 6680A IS 6680 A IS6680 A IS 6680A IS 2386 B IS2386 B IS 2386B
Authority
IS
Iceland
Prior art keywords
substituted
formula
acetic acid
group
stands
Prior art date
Application number
IS6680A
Other languages
English (en)
Other versions
IS6680A (is
Inventor
Hermanus Mattheus Hero Kooistra Jacob
Josephus Marie Zeegers Hubertus
Mink Daniel
Maria Cornelis Antonius Mulders Joannes
Original Assignee
Astrazeneca Uk Limited.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Uk Limited. filed Critical Astrazeneca Uk Limited.
Publication of IS6680A publication Critical patent/IS6680A/is
Publication of IS2386B publication Critical patent/IS2386B/is

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/30—Oxygen atoms, e.g. delta-lactones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
    • C07D319/06—1,3-Dioxanes; Hydrogenated 1,3-dioxanes not condensed with other rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Catalysts (AREA)
IS6680A 2000-07-19 2003-01-15 Aðferð til að framleiða 2-(6-útskiptar-1,3-díoxan-4-ýl)ediksýruafleiður IS2386B (is)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
NL1015744A NL1015744C2 (nl) 2000-07-19 2000-07-19 Werkwijze voor de bereiding van 2-(6-gesubstitueerde-1,3-dioxan-4-yl) azijnzuurderivaten.
PCT/NL2001/000535 WO2002006266A1 (en) 2000-07-19 2001-07-12 Process for the preparation of 2-(6-substituted-1,3-dioxane-4-yl)acetic acid derivatives

Publications (2)

Publication Number Publication Date
IS6680A IS6680A (is) 2003-01-15
IS2386B true IS2386B (is) 2008-07-15

Family

ID=19771761

Family Applications (2)

Application Number Title Priority Date Filing Date
IS6680A IS2386B (is) 2000-07-19 2003-01-15 Aðferð til að framleiða 2-(6-útskiptar-1,3-díoxan-4-ýl)ediksýruafleiður
IS8690A IS8690A (is) 2000-07-19 2007-11-15 Aðferð til að framleiða 2- (6-útskiptar-1,3-díoxan-4-ýl)ediksýruafleiður

Family Applications After (1)

Application Number Title Priority Date Filing Date
IS8690A IS8690A (is) 2000-07-19 2007-11-15 Aðferð til að framleiða 2- (6-útskiptar-1,3-díoxan-4-ýl)ediksýruafleiður

Country Status (30)

Country Link
US (4) US6870059B2 (is)
EP (2) EP1317440B1 (is)
JP (2) JP5006499B2 (is)
KR (3) KR20080078925A (is)
CN (3) CN101081842B (is)
AT (1) ATE340790T1 (is)
AU (2) AU7583001A (is)
BR (1) BR0112535A (is)
CA (1) CA2415963C (is)
CY (1) CY1105881T1 (is)
CZ (1) CZ302718B6 (is)
DE (1) DE60123444T2 (is)
DK (1) DK1317440T3 (is)
EE (1) EE200300024A (is)
ES (2) ES2387313T3 (is)
HK (1) HK1097260A1 (is)
HU (1) HUP0303166A3 (is)
IL (3) IL153980A0 (is)
IS (2) IS2386B (is)
MX (1) MXPA03000498A (is)
NL (1) NL1015744C2 (is)
NO (1) NO328935B1 (is)
NZ (1) NZ523703A (is)
PL (1) PL207115B1 (is)
PT (1) PT1317440E (is)
RU (1) RU2266903C2 (is)
SK (2) SK287755B6 (is)
UA (1) UA77944C2 (is)
WO (1) WO2002006266A1 (is)
ZA (1) ZA200300478B (is)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0011120D0 (en) 2000-05-09 2000-06-28 Avecia Ltd Process
NL1015744C2 (nl) * 2000-07-19 2002-01-22 Dsm Nv Werkwijze voor de bereiding van 2-(6-gesubstitueerde-1,3-dioxan-4-yl) azijnzuurderivaten.
EP1417180B1 (en) 2001-07-13 2006-12-27 AstraZeneca UK Limited Preparation of aminopyrimidine compounds
EP1323717A1 (en) * 2001-12-27 2003-07-02 Dsm N.V. Process for the preparation of 2-(6-Substituted-1,3-Dioxane-4-yL) acetic acid derivatives
EP1375493A1 (en) * 2002-06-17 2004-01-02 Dsm N.V. Process for the preparation of an dioxane acetic acid ester
GB0218781D0 (en) * 2002-08-13 2002-09-18 Astrazeneca Ab Chemical process
EP1625223A4 (en) * 2002-09-20 2009-11-11 Verenium Corp CHEMOENZYMATIC PROCEDURES FOR SYNTHESIS OF STATINES AND STATIN INTERCONNECTIONS
US9740817B1 (en) 2002-10-18 2017-08-22 Dennis Sunga Fernandez Apparatus for biological sensing and alerting of pharmaco-genomic mutation
AU2003288443B2 (en) 2002-12-16 2007-10-25 Astrazeneka Uk Limited Process for the preparation of pyrimidine compounds
DE602004011921T2 (de) * 2003-05-02 2009-02-19 Dsm Ip Assets B.V. Verfahren zur herstellung von (4-hydroxy-6-oxo-tetrahydropyran-2-yl) acetonitril und dessen derivaten
GB0312896D0 (en) * 2003-06-05 2003-07-09 Astrazeneca Ab Chemical process
US8346482B2 (en) 2003-08-22 2013-01-01 Fernandez Dennis S Integrated biosensor and simulation system for diagnosis and therapy
UY28501A1 (es) * 2003-09-10 2005-04-29 Astrazeneca Uk Ltd Compuestos químicos
GB0321827D0 (en) * 2003-09-18 2003-10-15 Astrazeneca Uk Ltd Chemical compounds
GB0324791D0 (en) * 2003-10-24 2003-11-26 Astrazeneca Ab Chemical process
DE10352659B4 (de) * 2003-11-11 2007-09-13 Ratiopharm Gmbh Verfahren zur Herstellung von Statinen und Tetrahydropyranonderivate zur Verwendung in dem Verfahren
GB0428328D0 (en) 2004-12-24 2005-02-02 Astrazeneca Uk Ltd Chemical process
GB0514078D0 (en) * 2005-07-08 2005-08-17 Astrazeneca Uk Ltd Chemical process
US7264743B2 (en) * 2006-01-23 2007-09-04 Lam Research Corporation Fin structure formation
TW200831469A (en) * 2006-12-01 2008-08-01 Astrazeneca Uk Ltd Chemical process
US20120035374A1 (en) * 2009-04-15 2012-02-09 Pharmathen S.A. Process for the preparation of fluvastatin and salts thereof
GB2482525A (en) * 2010-08-05 2012-02-08 Phoenix Chemicals Ltd A process for the production of acyloxymethyldioxanylacetic derivatives
WO2012032035A1 (en) 2010-09-09 2012-03-15 Dsm Sinochem Pharmaceuticals Netherlands B.V. Salts of 7-amino-3,5-dihydroxyheptanoic acid esters
SI2616454T1 (sl) 2010-09-16 2015-08-31 Dsm Sinochem Pharmaceuticals Netherlands B.V. Estri heksanojskih kislin, kot vmesne spojine za pripravo atorvastatina
CN103313983B (zh) 2011-01-18 2016-06-29 中化帝斯曼制药有限公司荷兰公司 在碱存在下制备他汀类化合物的方法
US8865900B2 (en) 2011-01-18 2014-10-21 Dsm Sinochem Pharmaceuticals Netherlands B.V. Methyltetrazole sulfides and sulfones
US9150562B2 (en) 2011-01-18 2015-10-06 Dsm Sinochem Pharmaceuticals Netherlands B.V. Process for the preparation of diol sulfones
HUE032936T2 (en) * 2011-12-09 2017-11-28 Dsm Sinochem Pharm Nl Bv A method for producing thioprecursors of statins
WO2013083718A1 (en) 2011-12-09 2013-06-13 Dsm Sinochem Pharmaceuticals Netherlands B.V. Process for the preparation of a statin precursor
JP6065862B2 (ja) * 2013-04-10 2017-01-25 信越化学工業株式会社 パターン形成方法、レジスト組成物、高分子化合物及び単量体
WO2014203045A1 (en) 2013-06-20 2014-12-24 Lupin Limited A novel, green and cost effective process for synthesis of tert-butyl (3r,5s)-6-oxo-3,5-dihydroxy-3,5-o-isopropylidene-hexanoate
CN105624127B (zh) * 2014-10-28 2019-07-26 上海弈柯莱生物医药科技有限公司 一种葡萄糖脱氢酶及其在合成他汀类药物中间体中的应用

Family Cites Families (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US544390A (en) * 1895-08-13 Chimney-cowl
GB885516A (en) 1958-01-16 1961-12-28 Arthur Henry Clarkson Higher fatty acid esters of dextran
US3325466A (en) * 1961-01-11 1967-06-13 American Cyanamid Co Tertiary butyl group as a carboxyl protecting group in the synthesis of peptides
US3992432A (en) 1967-04-05 1976-11-16 Continental Oil Company Phase transfer catalysis of heterogeneous reactions by quaternary salts
DE3929913A1 (de) * 1989-09-08 1991-04-04 Hoechst Ag 4-hydroxytetrahydropyran-2-one sowie die entsprechenden dihydroxycarbonsaeurederivate, salze und ester, verfahren zu ihrer herstellung, ihre verwendung als arzneimittel, pharmazeutische praeparate sowie vorprodukte
GB9005966D0 (en) 1990-03-16 1990-05-09 May & Baker Ltd New compositions of matter
CA2048716A1 (en) * 1990-08-17 1992-02-18 William B. Mattingly, Iii Absorbent articles with integral release system and methods of making same
US5292891A (en) * 1991-02-21 1994-03-08 Chisso Corporation Optically active 2,2-dimethyl-1,3-dioxin-4-ones and method for preparing same and method for preparing optically active compound for synthesis of physiologically active substance and optically active intermediate compound
JP3097143B2 (ja) * 1991-02-21 2000-10-10 チッソ株式会社 生理活性物質合成用光学活性化合物の製造法および光学活性中間体化合物
CA2118796A1 (en) * 1991-09-20 1993-04-01 John Crosby Pyranones
WO1993008823A1 (en) * 1991-11-06 1993-05-13 Tanabe Seiyaku Co., Ltd. Guanidinyl and related cell adhesion modulation compounds
US5278313A (en) * 1992-03-27 1994-01-11 E. R. Squibb & Sons, Inc. Process for the preparation of 1,3-dioxane derivatives useful in the preparation of HMG-COA reductase inhibitors
US5449793A (en) * 1993-06-04 1995-09-12 Chisso Corporation Process for producing an optically active 1,5-disubstituted-2,4-O-isopropylidene-2,4-dihydroxypentane
US5795749A (en) 1995-04-05 1998-08-18 The Scripps Research Institution Use of 2-deoxyribose-5-phosphate aldolase to prepare 2-deoxyfucose, analogues and derivatives
GB9523924D0 (en) 1995-11-23 1996-01-24 Zeneca Ltd Production of optically active 2-substituted tetrahydropyran-4-ones
US6278001B1 (en) 1995-11-28 2001-08-21 L'oréal Method for preparing (+) compactin and (+) mevinolin analog compounds having a β-hydroxy-δ-lactone grouping
FR2741620B1 (fr) * 1995-11-28 1997-12-26 Oreal Procede de preparation de composes a groupement beta-hydroxy -delta-lactone analogues de la (+) compactine et de la (+) mevinoline
EP1077212B1 (en) 1998-04-30 2003-08-20 Kaneka Corporation Process for producing 6-cyanomethyl-1,3-dioxane-4-acetic acid derivatives
CA2305564C (en) * 1998-08-05 2008-06-17 Kaneka Corporation Process for the preparation of optically active 2-[6-(hydroxymethyl)-1,3-dioxan-4-yl]acetic acid derivatives
KR100672269B1 (ko) 1998-12-10 2007-01-23 카네카 코포레이션 심바스타틴의 제조 방법
GB9903472D0 (en) 1999-02-17 1999-04-07 Zeneca Ltd Chemical process
HU227840B1 (en) 1999-05-06 2012-05-02 Egis Gyogyszergyar Nyilvanosan M Kod Ruszvunytarsasag Intermediates of atorvastatin synthesis and process for producing them
HUP0103788A3 (en) * 1999-06-04 2003-05-28 Kaneka Corp Processes for the preparation of 5-hydroxy-3-oxopentanoic acid derivatives
AU2000254249A1 (en) * 2000-03-28 2001-10-08 Biocon India Limited Synthesis of (r-(r*,r*))-2-(4-fluorophenyl)-beta,delta-dihydroxy-5-(1-
GB0011120D0 (en) 2000-05-09 2000-06-28 Avecia Ltd Process
AU6269201A (en) * 2000-06-05 2001-12-17 Kaneka Corporation Process for preparing optically active 2-(6-(hydroxy-methyl)-1,3-dioxan-4-yl)acetic acid derivatives
NL1015744C2 (nl) 2000-07-19 2002-01-22 Dsm Nv Werkwijze voor de bereiding van 2-(6-gesubstitueerde-1,3-dioxan-4-yl) azijnzuurderivaten.
EP1417180B1 (en) 2001-07-13 2006-12-27 AstraZeneca UK Limited Preparation of aminopyrimidine compounds
EP1323717A1 (en) 2001-12-27 2003-07-02 Dsm N.V. Process for the preparation of 2-(6-Substituted-1,3-Dioxane-4-yL) acetic acid derivatives
DE60233899D1 (de) 2002-02-25 2009-11-12 Biocon Ltd Neue boronatester
KR100511533B1 (ko) 2002-04-09 2005-08-31 임광민 키랄 중간체, 그의 제조방법 및 그를 이용한 HMG-CoA환원저해제의 제조방법
EP1375493A1 (en) 2002-06-17 2004-01-02 Dsm N.V. Process for the preparation of an dioxane acetic acid ester
GB0218781D0 (en) 2002-08-13 2002-09-18 Astrazeneca Ab Chemical process
AU2003288443B2 (en) 2002-12-16 2007-10-25 Astrazeneka Uk Limited Process for the preparation of pyrimidine compounds
WO2004103977A2 (en) 2003-05-21 2004-12-02 Ciba Specialty Chemicals Holding Inc. Process for the preparation of pyrimidine derivatives
GB0312896D0 (en) 2003-06-05 2003-07-09 Astrazeneca Ab Chemical process
WO2004113314A1 (en) 2003-06-23 2004-12-29 Biocon Limited Novel boronate esters
UY28501A1 (es) 2003-09-10 2005-04-29 Astrazeneca Uk Ltd Compuestos químicos
GB0321827D0 (en) 2003-09-18 2003-10-15 Astrazeneca Uk Ltd Chemical compounds
GB0324791D0 (en) 2003-10-24 2003-11-26 Astrazeneca Ab Chemical process
EP1697338A2 (en) 2003-12-24 2006-09-06 Teva Pharmaceutical Industries Ltd. Process for preparation of statins with high syn to anti ratio
JP4266879B2 (ja) 2004-05-12 2009-05-20 大阪瓦斯株式会社 ガス化炉及び複合リサイクル装置
US7161004B2 (en) 2004-06-21 2007-01-09 Dr. Reddy's Laboratories Limited Processes to produce intermediates for rosuvastatin
GB0428328D0 (en) 2004-12-24 2005-02-02 Astrazeneca Uk Ltd Chemical process
GB0514078D0 (en) 2005-07-08 2005-08-17 Astrazeneca Uk Ltd Chemical process
TW200831469A (en) 2006-12-01 2008-08-01 Astrazeneca Uk Ltd Chemical process

Also Published As

Publication number Publication date
DE60123444D1 (de) 2006-11-09
IL153980A0 (en) 2003-07-31
US20110251406A1 (en) 2011-10-13
NO20030025D0 (no) 2003-01-03
US7642363B2 (en) 2010-01-05
SK352003A3 (en) 2003-05-02
US6870059B2 (en) 2005-03-22
US20030158426A1 (en) 2003-08-21
IS8690A (is) 2007-11-15
IL153980A (en) 2006-10-05
ES2272506T3 (es) 2007-05-01
RU2266903C2 (ru) 2005-12-27
KR20080078925A (ko) 2008-08-28
ZA200300478B (en) 2004-01-26
CN1443183A (zh) 2003-09-17
CZ302718B6 (cs) 2011-09-21
US20050148785A1 (en) 2005-07-07
JP2004504315A (ja) 2004-02-12
ES2387313T3 (es) 2012-09-20
KR20030040224A (ko) 2003-05-22
MXPA03000498A (es) 2003-06-24
CZ2003163A3 (cs) 2003-05-14
JP2012111757A (ja) 2012-06-14
EE200300024A (et) 2004-10-15
DK1317440T3 (da) 2007-01-08
CN101081842B (zh) 2012-01-04
CN101081842A (zh) 2007-12-05
CY1105881T1 (el) 2011-02-02
AU7583001A (en) 2002-01-30
EP1317440B1 (en) 2006-09-27
AU2001275830B2 (en) 2006-07-20
KR100865016B1 (ko) 2008-10-23
CN1680363A (zh) 2005-10-12
UA77944C2 (en) 2007-02-15
IS6680A (is) 2003-01-15
EP1700854B1 (en) 2012-05-23
KR20070121063A (ko) 2007-12-26
US7989643B2 (en) 2011-08-02
NO20030025L (no) 2003-01-03
WO2002006266A1 (en) 2002-01-24
CA2415963C (en) 2008-02-26
SK287755B6 (sk) 2011-08-04
CA2415963A1 (en) 2002-01-24
HUP0303166A2 (hu) 2003-12-29
NO328935B1 (no) 2010-06-21
PL359332A1 (en) 2004-08-23
NL1015744C2 (nl) 2002-01-22
PT1317440E (pt) 2007-01-31
US20100136339A1 (en) 2010-06-03
SK287756B6 (sk) 2011-08-04
JP5006499B2 (ja) 2012-08-22
EP1700854A1 (en) 2006-09-13
HUP0303166A3 (en) 2005-11-28
EP1317440A1 (en) 2003-06-11
DE60123444T2 (de) 2007-08-23
ATE340790T1 (de) 2006-10-15
PL207115B1 (pl) 2010-11-30
IL177824A0 (en) 2006-12-31
BR0112535A (pt) 2003-07-01
CN100378091C (zh) 2008-04-02
HK1097260A1 (en) 2007-06-22
NZ523703A (en) 2004-08-27

Similar Documents

Publication Publication Date Title
IS8690A (is) Aðferð til að framleiða 2- (6-útskiptar-1,3-díoxan-4-ýl)ediksýruafleiður
RU2003104825A (ru) Способ получения производных 2-(6-замещенной-1, 3-диоксан-4-ил) укусной кислоты
IS7617A (is) Aðferð til að framleiða díoxanediksýruestera
ATE286870T1 (de) Verfahren zur herstellung von estern
FI881959A (fi) Karboksyylihappoestereiden pelkistys
GB0015771D0 (en) Cyclic ketones and their use in the synthesis of amino acids
EP0402063A3 (en) Alpha-(omega-cyanoalkanoyl)-gamma-butyrolactone and method for producing the same
PL326563A1 (en) Method of obtaining derivatives of methoxyiminophenyglyoxalic acid
ATE520679T1 (de) Verfahren zur herstellung von (dioxolenon-4- yl)methylester-derivate
Takei et al. Reaction of α-bromo-α, β-unsaturated esters and butenolides with malonamic esters
FI20030026A (fi) Menetelmä substituoitujen imidatsolijohdannaisten valmistamiseksi ja menetelmässä käytettäviä välituotteita
BR0013025A (pt) Processo para preparar ácidos via ésteres alfa-cloroepóxi
FR2788517B1 (fr) Procede de preparation d'azoiminoethers et d'esters d'acides azocarboxyliques, et nouveaux esters mixtes d'acides azocarboxyliques
DE69906009D1 (de) Verfahren zur Herstellung von 2-Alkyliden-4-Bromacetessigsäureestern
SE8302158D0 (sv) Verfahren zur herstellung von 1-alkyl-5-aroyl-pyrrol-2-essigseure-derivaten
KR970010737A (ko) 2-(4-아세틸아미노벤조일아미노)벤즈아미드 유도체, 그 제조방법 및 그를 함유하는 진통제
KR910018345A (ko) 치환 및 비치환 n-히드록시-2-아미노부탄 이산 유도체 및 퀴놀린 유도체의 제조방법