SI2616454T1 - Estri heksanojskih kislin, kot vmesne spojine za pripravo atorvastatina - Google Patents
Estri heksanojskih kislin, kot vmesne spojine za pripravo atorvastatinaInfo
- Publication number
- SI2616454T1 SI2616454T1 SI201130537T SI201130537T SI2616454T1 SI 2616454 T1 SI2616454 T1 SI 2616454T1 SI 201130537 T SI201130537 T SI 201130537T SI 201130537 T SI201130537 T SI 201130537T SI 2616454 T1 SI2616454 T1 SI 2616454T1
- Authority
- SI
- Slovenia
- Prior art keywords
- atorvastatin
- intermediates
- esters
- preparation
- hexanoic acids
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
- C07D319/06—1,3-Dioxanes; Hydrogenated 1,3-dioxanes not condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/36—Oxygen or sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
- C07D319/08—1,3-Dioxanes; Hydrogenated 1,3-dioxanes condensed with carbocyclic rings or ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pyrrole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP10177138 | 2010-09-16 | ||
PCT/EP2011/065706 WO2012034958A1 (en) | 2010-09-16 | 2011-09-12 | Esters of hexanoic acids as intermediates for the preparation of atorvastatin |
EP11754425.4A EP2616454B1 (en) | 2010-09-16 | 2011-09-12 | Esters of hexanoic acids as intermediates for the preparation of atorvastatin |
Publications (1)
Publication Number | Publication Date |
---|---|
SI2616454T1 true SI2616454T1 (sl) | 2015-08-31 |
Family
ID=43304877
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SI201130537T SI2616454T1 (sl) | 2010-09-16 | 2011-09-12 | Estri heksanojskih kislin, kot vmesne spojine za pripravo atorvastatina |
Country Status (6)
Country | Link |
---|---|
US (1) | US20130178636A1 (sl) |
EP (1) | EP2616454B1 (sl) |
CN (1) | CN103108870A (sl) |
MX (1) | MX2013002809A (sl) |
SI (1) | SI2616454T1 (sl) |
WO (1) | WO2012034958A1 (sl) |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5003080A (en) * | 1988-02-22 | 1991-03-26 | Warner-Lambert Company | Process for trans-6-(2-(substituted-pyrrol-1-yl)alkyl)pryan-2-one inhibitors of cholesterol synthesis |
US5245047A (en) | 1988-02-22 | 1993-09-14 | Warner-Lambert Company | Process for trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis |
US5329018A (en) * | 1992-06-10 | 1994-07-12 | Chisso Corporation | Optically active 1-5-disubstituted-2,4-o-isopropylidene-2,4-dihydroxypentane and a process for producing the same |
NL1015744C2 (nl) | 2000-07-19 | 2002-01-22 | Dsm Nv | Werkwijze voor de bereiding van 2-(6-gesubstitueerde-1,3-dioxan-4-yl) azijnzuurderivaten. |
US6476235B2 (en) | 2001-01-09 | 2002-11-05 | Warner-Lambert Company | Process for the synthesis of 5-(4-fluorophenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid phenylamide |
CN101880227A (zh) * | 2001-07-06 | 2010-11-10 | 西巴特殊化学品控股有限公司 | 一种用于制备适合于制备他汀类衍生物的中间体化合物的方法及其中间体 |
SI1620423T1 (sl) * | 2003-05-02 | 2008-06-30 | Dsm Ip Assets Bv | Postopek za pripravo (4-hidroksi-6-okso-tetrahidro-piran-2-il)-aceetonitrila in njihovih derivatov |
WO2008075165A1 (en) * | 2006-12-19 | 2008-06-26 | Pfizer Products Inc. | Novel process for the synthesis of [r-(r*, r*)]-2-(4-fluorophenyl)-beta, delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-heptanoic acid or a pharmaceutically acceptable salt thereof |
WO2008129562A2 (en) | 2007-04-20 | 2008-10-30 | Morepen Laboratories Limited | An improved process for the preparation of stable amorphous atorvastatin hemi calcium and their salts thereof |
ES2523304T3 (es) * | 2007-08-03 | 2014-11-24 | Pfizer Products Inc. | Procedimiento de preparación de compuestos quirales |
US20090081801A1 (en) | 2007-08-15 | 2009-03-26 | Vinod Kumar Kansal | Process for synthesis of pyrrole derivative, an intermediate for atorvastatin |
KR100850850B1 (ko) * | 2008-01-25 | 2008-08-06 | 주식회사종근당 | 아토르바스타틴의 제조방법 및 이에 사용되는 중간체 |
HUE025861T2 (en) * | 2010-09-09 | 2016-05-30 | Dsm Sinochem Pharm Nl Bv | Salts of 7-amino-3,5-dihydroxy-heptanoic acid esters |
-
2011
- 2011-09-12 CN CN2011800448968A patent/CN103108870A/zh active Pending
- 2011-09-12 SI SI201130537T patent/SI2616454T1/sl unknown
- 2011-09-12 WO PCT/EP2011/065706 patent/WO2012034958A1/en active Application Filing
- 2011-09-12 MX MX2013002809A patent/MX2013002809A/es active IP Right Grant
- 2011-09-12 EP EP11754425.4A patent/EP2616454B1/en not_active Not-in-force
- 2011-09-12 US US13/822,740 patent/US20130178636A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
MX2013002809A (es) | 2013-04-29 |
CN103108870A (zh) | 2013-05-15 |
EP2616454A1 (en) | 2013-07-24 |
EP2616454B1 (en) | 2015-04-15 |
US20130178636A1 (en) | 2013-07-11 |
WO2012034958A1 (en) | 2012-03-22 |
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