GB2460350B - Intermediates for the preparation of bile acids - Google Patents

Intermediates for the preparation of bile acids

Info

Publication number
GB2460350B
GB2460350B GB0912493A GB0912493A GB2460350B GB 2460350 B GB2460350 B GB 2460350B GB 0912493 A GB0912493 A GB 0912493A GB 0912493 A GB0912493 A GB 0912493A GB 2460350 B GB2460350 B GB 2460350B
Authority
GB
United Kingdom
Prior art keywords
intermediates
preparation
bile acids
bile
acids
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
GB0912493A
Other versions
GB2460350A (en
GB0912493D0 (en
Inventor
Achampeta Rathan Prasad
Roy Archibald Swaringen Jr
John Gregory Reid
Robert M Moriarty
Akhila Kumar Sahoo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kythera Biopharmaceuticals LLC
Original Assignee
Kythera Biopharmaceuticals LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kythera Biopharmaceuticals LLC filed Critical Kythera Biopharmaceuticals LLC
Priority to GB0912493A priority Critical patent/GB2460350B/en
Priority claimed from GB0807615A external-priority patent/GB2452358C/en
Publication of GB0912493D0 publication Critical patent/GB0912493D0/en
Publication of GB2460350A publication Critical patent/GB2460350A/en
Application granted granted Critical
Publication of GB2460350B publication Critical patent/GB2460350B/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0011—Androstane derivatives substituted in position 17 by a keto group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0018—Androstane derivatives substituted in position 17 beta, not substituted in position 17 alfa
    • C07J1/0022—Androstane derivatives substituted in position 17 beta, not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J13/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J13/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17
    • C07J13/007—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17 with double bond in position 17 (20)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
GB0912493A 2008-04-25 2008-04-25 Intermediates for the preparation of bile acids Expired - Fee Related GB2460350B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB0912493A GB2460350B (en) 2008-04-25 2008-04-25 Intermediates for the preparation of bile acids

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0807615A GB2452358C (en) 2008-04-25 2008-04-25 Preparation of bile acids.
GB0912493A GB2460350B (en) 2008-04-25 2008-04-25 Intermediates for the preparation of bile acids

Publications (3)

Publication Number Publication Date
GB0912493D0 GB0912493D0 (en) 2009-08-26
GB2460350A GB2460350A (en) 2009-12-02
GB2460350B true GB2460350B (en) 2011-04-06

Family

ID=41058157

Family Applications (1)

Application Number Title Priority Date Filing Date
GB0912493A Expired - Fee Related GB2460350B (en) 2008-04-25 2008-04-25 Intermediates for the preparation of bile acids

Country Status (1)

Country Link
GB (1) GB2460350B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115611961B (en) * 2022-10-18 2024-02-13 湖南科瑞生物制药股份有限公司 Cholic acid intermediate A2 and preparation method thereof

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993003732A1 (en) * 1991-08-13 1993-03-04 Cocensys, Inc. Gaba receptor modulators
WO1994027608A1 (en) * 1993-05-24 1994-12-08 Cocensys, Inc. Methods and compositions for inducing sleep
WO1998005337A1 (en) * 1996-08-01 1998-02-12 Cocensys, Inc. Use of gaba and nmda receptor ligands for the treatment of migraine headache
US20050042539A1 (en) * 2003-08-23 2005-02-24 Korea Advanced Institute Of Science And Technology Novel monomers containing an oxepan-2-one group, photoresist compositions comprising polymers prepared from the monomers, methods for preparing the compositions, and methods for forming photoresist patterns using the compositions

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993003732A1 (en) * 1991-08-13 1993-03-04 Cocensys, Inc. Gaba receptor modulators
WO1994027608A1 (en) * 1993-05-24 1994-12-08 Cocensys, Inc. Methods and compositions for inducing sleep
WO1998005337A1 (en) * 1996-08-01 1998-02-12 Cocensys, Inc. Use of gaba and nmda receptor ligands for the treatment of migraine headache
US20050042539A1 (en) * 2003-08-23 2005-02-24 Korea Advanced Institute Of Science And Technology Novel monomers containing an oxepan-2-one group, photoresist compositions comprising polymers prepared from the monomers, methods for preparing the compositions, and methods for forming photoresist patterns using the compositions

Non-Patent Citations (13)

* Cited by examiner, † Cited by third party
Title
Canadian Journal of Biochemistry 1979, Vol.57(3), Child et al., pp.216-25. *
Canadian Journal of Chemistry 1968, Vol.46(9), Ziegler et al., pp.1574-7 *
Canadian Journal of Chemistry, 1979, Vol.57(24), Kakushima et al., pp.3354-6. *
Chemical & Pharmaceutical Bulletin, 1982, Vol.30(7), Yoshizawa et al., pp.2474-86 *
Collection of Czechoslovak Chemical Communications, 1985, Vol.50(5), Mickova et al.,pp.1239-43. *
Journal of Lipid Research 1976, Vol.17(4), Szczepanik et al., pp.314-34. *
Journal of Medicinal Chemistry (2007), Vol.50(24), Katona et al., pp.6048-6058. *
Journal of Organic Chemistry, 1995, Vol.60(8), Arnone et al., pp.2314-15. *
Journal of the American Chemical Society, 1981, Vol.103(5), Batcho et al., pp.1293-5. *
Journal of the Chemical Society, Perkin Transactions 1 (1982), Vol. (8), Barton et al., pp.1947-52. *
Journal of the Chemical Society: Chemical Communications, 1971, Vol.18, Mukawa, pp.1060-1061. *
Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy, 2000, Vol.56A(1), Dias et al., pp.53-77. *
Tetrahedron: Asymmetry, 2001, Vol.12(20), Iuliano et al., pp.2811-2825. *

Also Published As

Publication number Publication date
GB2460350A (en) 2009-12-02
GB0912493D0 (en) 2009-08-26

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