DK1317440T3 - Fremgangsmåde til fremstilling af 2- (6-substitueret 1,3-dioxan-4yl) eddikesyrederivater - Google Patents

Fremgangsmåde til fremstilling af 2- (6-substitueret 1,3-dioxan-4yl) eddikesyrederivater

Info

Publication number
DK1317440T3
DK1317440T3 DK01953373T DK01953373T DK1317440T3 DK 1317440 T3 DK1317440 T3 DK 1317440T3 DK 01953373 T DK01953373 T DK 01953373T DK 01953373 T DK01953373 T DK 01953373T DK 1317440 T3 DK1317440 T3 DK 1317440T3
Authority
DK
Denmark
Prior art keywords
substituted
formula
dioxane
preparation
acetic acid
Prior art date
Application number
DK01953373T
Other languages
English (en)
Inventor
Daniel Mink
Jacob Hermanus Matthe Kooistra
Hubertus Josephus Mari Zeegers
Joannes Maria Cornelis Mulders
Original Assignee
Astrazeneca Uk Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Uk Ltd filed Critical Astrazeneca Uk Ltd
Application granted granted Critical
Publication of DK1317440T3 publication Critical patent/DK1317440T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/30—Oxygen atoms, e.g. delta-lactones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
    • C07D319/06—1,3-Dioxanes; Hydrogenated 1,3-dioxanes not condensed with other rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Catalysts (AREA)
DK01953373T 2000-07-19 2001-07-12 Fremgangsmåde til fremstilling af 2- (6-substitueret 1,3-dioxan-4yl) eddikesyrederivater DK1317440T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
NL1015744A NL1015744C2 (nl) 2000-07-19 2000-07-19 Werkwijze voor de bereiding van 2-(6-gesubstitueerde-1,3-dioxan-4-yl) azijnzuurderivaten.

Publications (1)

Publication Number Publication Date
DK1317440T3 true DK1317440T3 (da) 2007-01-08

Family

ID=19771761

Family Applications (1)

Application Number Title Priority Date Filing Date
DK01953373T DK1317440T3 (da) 2000-07-19 2001-07-12 Fremgangsmåde til fremstilling af 2- (6-substitueret 1,3-dioxan-4yl) eddikesyrederivater

Country Status (30)

Country Link
US (4) US6870059B2 (da)
EP (2) EP1700854B1 (da)
JP (2) JP5006499B2 (da)
KR (3) KR20070121063A (da)
CN (3) CN100378091C (da)
AT (1) ATE340790T1 (da)
AU (2) AU7583001A (da)
BR (1) BR0112535A (da)
CA (1) CA2415963C (da)
CY (1) CY1105881T1 (da)
CZ (1) CZ302718B6 (da)
DE (1) DE60123444T2 (da)
DK (1) DK1317440T3 (da)
EE (1) EE200300024A (da)
ES (2) ES2272506T3 (da)
HK (1) HK1097260A1 (da)
HU (1) HUP0303166A3 (da)
IL (3) IL153980A0 (da)
IS (2) IS2386B (da)
MX (1) MXPA03000498A (da)
NL (1) NL1015744C2 (da)
NO (1) NO328935B1 (da)
NZ (1) NZ523703A (da)
PL (1) PL207115B1 (da)
PT (1) PT1317440E (da)
RU (1) RU2266903C2 (da)
SK (2) SK287756B6 (da)
UA (1) UA77944C2 (da)
WO (1) WO2002006266A1 (da)
ZA (1) ZA200300478B (da)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0011120D0 (en) * 2000-05-09 2000-06-28 Avecia Ltd Process
NL1015744C2 (nl) 2000-07-19 2002-01-22 Dsm Nv Werkwijze voor de bereiding van 2-(6-gesubstitueerde-1,3-dioxan-4-yl) azijnzuurderivaten.
ATE349431T1 (de) 2001-07-13 2007-01-15 Astrazeneca Uk Ltd Herstellung von aminopyrimidinverbindungen
EP1323717A1 (en) 2001-12-27 2003-07-02 Dsm N.V. Process for the preparation of 2-(6-Substituted-1,3-Dioxane-4-yL) acetic acid derivatives
EP1375493A1 (en) * 2002-06-17 2004-01-02 Dsm N.V. Process for the preparation of an dioxane acetic acid ester
GB0218781D0 (en) 2002-08-13 2002-09-18 Astrazeneca Ab Chemical process
US7414119B2 (en) 2002-09-20 2008-08-19 Verenium Corporation Aldolases, nucleic acids encoding them and methods for making and using them
US9740817B1 (en) 2002-10-18 2017-08-22 Dennis Sunga Fernandez Apparatus for biological sensing and alerting of pharmaco-genomic mutation
WO2004054986A2 (en) * 2002-12-16 2004-07-01 Astrazeneca Uk Limited Process for the preparation of pyrimidine compounds
SI1620423T1 (sl) 2003-05-02 2008-06-30 Dsm Ip Assets Bv Postopek za pripravo (4-hidroksi-6-okso-tetrahidro-piran-2-il)-aceetonitrila in njihovih derivatov
GB0312896D0 (en) 2003-06-05 2003-07-09 Astrazeneca Ab Chemical process
US8346482B2 (en) * 2003-08-22 2013-01-01 Fernandez Dennis S Integrated biosensor and simulation system for diagnosis and therapy
UY28501A1 (es) * 2003-09-10 2005-04-29 Astrazeneca Uk Ltd Compuestos químicos
GB0321827D0 (en) * 2003-09-18 2003-10-15 Astrazeneca Uk Ltd Chemical compounds
GB0324791D0 (en) * 2003-10-24 2003-11-26 Astrazeneca Ab Chemical process
DE10352659B4 (de) * 2003-11-11 2007-09-13 Ratiopharm Gmbh Verfahren zur Herstellung von Statinen und Tetrahydropyranonderivate zur Verwendung in dem Verfahren
GB0428328D0 (en) * 2004-12-24 2005-02-02 Astrazeneca Uk Ltd Chemical process
GB0514078D0 (en) * 2005-07-08 2005-08-17 Astrazeneca Uk Ltd Chemical process
US7264743B2 (en) * 2006-01-23 2007-09-04 Lam Research Corporation Fin structure formation
TW200831469A (en) * 2006-12-01 2008-08-01 Astrazeneca Uk Ltd Chemical process
WO2010118757A1 (en) * 2009-04-15 2010-10-21 Pharmathen S.A. Improved process for the preparation of fluvastatin and salts thereof
GB2482525A (en) * 2010-08-05 2012-02-08 Phoenix Chemicals Ltd A process for the production of acyloxymethyldioxanylacetic derivatives
WO2012032035A1 (en) 2010-09-09 2012-03-15 Dsm Sinochem Pharmaceuticals Netherlands B.V. Salts of 7-amino-3,5-dihydroxyheptanoic acid esters
EP2616454B1 (en) 2010-09-16 2015-04-15 DSM Sinochem Pharmaceuticals Netherlands B.V. Esters of hexanoic acids as intermediates for the preparation of atorvastatin
EP2665723B1 (en) 2011-01-18 2015-07-22 DSM Sinochem Pharmaceuticals Netherlands B.V. Process for the preparation of statins in the presence of base
ES2601479T3 (es) 2011-01-18 2017-02-15 Dsm Sinochem Pharmaceuticals Netherlands B.V. Proceso para la preparación de diolsulfonas
EP2665721B1 (en) 2011-01-18 2015-07-08 DSM Sinochem Pharmaceuticals Netherlands B.V. Methyltetrazole sulfides and sulfones
EP2788341B1 (en) 2011-12-09 2017-04-05 DSM Sinochem Pharmaceuticals Netherlands B.V. Process for the preparation of a thioprecursor for statins
WO2013083718A1 (en) 2011-12-09 2013-06-13 Dsm Sinochem Pharmaceuticals Netherlands B.V. Process for the preparation of a statin precursor
JP6065862B2 (ja) * 2013-04-10 2017-01-25 信越化学工業株式会社 パターン形成方法、レジスト組成物、高分子化合物及び単量体
WO2014203045A1 (en) 2013-06-20 2014-12-24 Lupin Limited A novel, green and cost effective process for synthesis of tert-butyl (3r,5s)-6-oxo-3,5-dihydroxy-3,5-o-isopropylidene-hexanoate
CN105624127B (zh) * 2014-10-28 2019-07-26 上海弈柯莱生物医药科技有限公司 一种葡萄糖脱氢酶及其在合成他汀类药物中间体中的应用

Family Cites Families (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US544390A (en) * 1895-08-13 Chimney-cowl
GB885516A (en) 1958-01-16 1961-12-28 Arthur Henry Clarkson Higher fatty acid esters of dextran
US3325466A (en) * 1961-01-11 1967-06-13 American Cyanamid Co Tertiary butyl group as a carboxyl protecting group in the synthesis of peptides
US3992432A (en) * 1967-04-05 1976-11-16 Continental Oil Company Phase transfer catalysis of heterogeneous reactions by quaternary salts
DE3929913A1 (de) * 1989-09-08 1991-04-04 Hoechst Ag 4-hydroxytetrahydropyran-2-one sowie die entsprechenden dihydroxycarbonsaeurederivate, salze und ester, verfahren zu ihrer herstellung, ihre verwendung als arzneimittel, pharmazeutische praeparate sowie vorprodukte
GB9005966D0 (en) 1990-03-16 1990-05-09 May & Baker Ltd New compositions of matter
CA2048716A1 (en) * 1990-08-17 1992-02-18 William B. Mattingly, Iii Absorbent articles with integral release system and methods of making same
JP3097143B2 (ja) * 1991-02-21 2000-10-10 チッソ株式会社 生理活性物質合成用光学活性化合物の製造法および光学活性中間体化合物
US5292891A (en) * 1991-02-21 1994-03-08 Chisso Corporation Optically active 2,2-dimethyl-1,3-dioxin-4-ones and method for preparing same and method for preparing optically active compound for synthesis of physiologically active substance and optically active intermediate compound
EP0604483A1 (en) 1991-09-20 1994-07-06 Zeneca Limited Process for the preparation of enantiomerically pure 4-hydroxytetrahydro-2-pyranone derivatives
WO1993008823A1 (en) * 1991-11-06 1993-05-13 Tanabe Seiyaku Co., Ltd. Guanidinyl and related cell adhesion modulation compounds
US5278313A (en) * 1992-03-27 1994-01-11 E. R. Squibb & Sons, Inc. Process for the preparation of 1,3-dioxane derivatives useful in the preparation of HMG-COA reductase inhibitors
US5449793A (en) * 1993-06-04 1995-09-12 Chisso Corporation Process for producing an optically active 1,5-disubstituted-2,4-O-isopropylidene-2,4-dihydroxypentane
US5795749A (en) 1995-04-05 1998-08-18 The Scripps Research Institution Use of 2-deoxyribose-5-phosphate aldolase to prepare 2-deoxyfucose, analogues and derivatives
GB9523924D0 (en) 1995-11-23 1996-01-24 Zeneca Ltd Production of optically active 2-substituted tetrahydropyran-4-ones
FR2741620B1 (fr) * 1995-11-28 1997-12-26 Oreal Procede de preparation de composes a groupement beta-hydroxy -delta-lactone analogues de la (+) compactine et de la (+) mevinoline
US6278001B1 (en) 1995-11-28 2001-08-21 L'oréal Method for preparing (+) compactin and (+) mevinolin analog compounds having a β-hydroxy-δ-lactone grouping
CA2329893A1 (en) 1998-04-30 1999-11-11 Kaneka Corporation Process for producing 6-cyanomethyl-1,3-dioxane-4-acetic acid derivatives
EP1619191B1 (en) * 1998-08-05 2010-10-27 Kaneka Corporation Process for producing optically active 2-[6-(hydroxymethyl)-1,3-dioxan-4-yl] acetic acid derivatives
JP4440476B2 (ja) 1998-12-10 2010-03-24 株式会社カネカ シンバスタチンの製造方法
GB9903472D0 (en) 1999-02-17 1999-04-07 Zeneca Ltd Chemical process
HU227840B1 (en) 1999-05-06 2012-05-02 Egis Gyogyszergyar Nyilvanosan M Kod Ruszvunytarsasag Intermediates of atorvastatin synthesis and process for producing them
KR20010072175A (ko) * 1999-06-04 2001-07-31 후루타 타케시 5-히드록시-3-옥소펜탄산 유도체 제조방법
AU2000254249A1 (en) * 2000-03-28 2001-10-08 Biocon India Limited Synthesis of (r-(r*,r*))-2-(4-fluorophenyl)-beta,delta-dihydroxy-5-(1-
GB0011120D0 (en) * 2000-05-09 2000-06-28 Avecia Ltd Process
EP1288213B1 (en) * 2000-06-05 2006-11-29 Kaneka Corporation Process for preparing optically active 2- 6-(hydroxy-methyl)-1,3-dioxan-4-yl|acetic acid derivatives
NL1015744C2 (nl) * 2000-07-19 2002-01-22 Dsm Nv Werkwijze voor de bereiding van 2-(6-gesubstitueerde-1,3-dioxan-4-yl) azijnzuurderivaten.
ATE349431T1 (de) 2001-07-13 2007-01-15 Astrazeneca Uk Ltd Herstellung von aminopyrimidinverbindungen
EP1323717A1 (en) * 2001-12-27 2003-07-02 Dsm N.V. Process for the preparation of 2-(6-Substituted-1,3-Dioxane-4-yL) acetic acid derivatives
DK1478650T3 (da) 2002-02-25 2010-01-25 Biocon Ltd Nye boronatestere
KR100511533B1 (ko) 2002-04-09 2005-08-31 임광민 키랄 중간체, 그의 제조방법 및 그를 이용한 HMG-CoA환원저해제의 제조방법
EP1375493A1 (en) * 2002-06-17 2004-01-02 Dsm N.V. Process for the preparation of an dioxane acetic acid ester
GB0218781D0 (en) * 2002-08-13 2002-09-18 Astrazeneca Ab Chemical process
WO2004054986A2 (en) 2002-12-16 2004-07-01 Astrazeneca Uk Limited Process for the preparation of pyrimidine compounds
WO2004103977A2 (en) 2003-05-21 2004-12-02 Ciba Specialty Chemicals Holding Inc. Process for the preparation of pyrimidine derivatives
GB0312896D0 (en) * 2003-06-05 2003-07-09 Astrazeneca Ab Chemical process
WO2004113314A1 (en) 2003-06-23 2004-12-29 Biocon Limited Novel boronate esters
UY28501A1 (es) * 2003-09-10 2005-04-29 Astrazeneca Uk Ltd Compuestos químicos
GB0321827D0 (en) * 2003-09-18 2003-10-15 Astrazeneca Uk Ltd Chemical compounds
GB0324791D0 (en) 2003-10-24 2003-11-26 Astrazeneca Ab Chemical process
EP1697338A2 (en) 2003-12-24 2006-09-06 Teva Pharmaceutical Industries Ltd. Process for preparation of statins with high syn to anti ratio
JP4266879B2 (ja) 2004-05-12 2009-05-20 大阪瓦斯株式会社 ガス化炉及び複合リサイクル装置
US7161004B2 (en) 2004-06-21 2007-01-09 Dr. Reddy's Laboratories Limited Processes to produce intermediates for rosuvastatin
GB0428328D0 (en) 2004-12-24 2005-02-02 Astrazeneca Uk Ltd Chemical process
GB0514078D0 (en) 2005-07-08 2005-08-17 Astrazeneca Uk Ltd Chemical process
TW200831469A (en) * 2006-12-01 2008-08-01 Astrazeneca Uk Ltd Chemical process

Also Published As

Publication number Publication date
DE60123444D1 (de) 2006-11-09
JP5006499B2 (ja) 2012-08-22
PT1317440E (pt) 2007-01-31
CZ302718B6 (cs) 2011-09-21
AU2001275830B2 (en) 2006-07-20
EP1317440B1 (en) 2006-09-27
CA2415963C (en) 2008-02-26
EE200300024A (et) 2004-10-15
NO20030025L (no) 2003-01-03
US6870059B2 (en) 2005-03-22
IS6680A (is) 2003-01-15
CN101081842A (zh) 2007-12-05
RU2266903C2 (ru) 2005-12-27
KR20070121063A (ko) 2007-12-26
KR20080078925A (ko) 2008-08-28
NO328935B1 (no) 2010-06-21
UA77944C2 (en) 2007-02-15
CN1680363A (zh) 2005-10-12
CN1443183A (zh) 2003-09-17
IS8690A (is) 2007-11-15
PL359332A1 (en) 2004-08-23
SK352003A3 (en) 2003-05-02
WO2002006266A1 (en) 2002-01-24
JP2012111757A (ja) 2012-06-14
CY1105881T1 (el) 2011-02-02
BR0112535A (pt) 2003-07-01
HUP0303166A2 (hu) 2003-12-29
AU7583001A (en) 2002-01-30
HK1097260A1 (en) 2007-06-22
IL177824A0 (en) 2006-12-31
HUP0303166A3 (en) 2005-11-28
US20050148785A1 (en) 2005-07-07
US20110251406A1 (en) 2011-10-13
SK287756B6 (sk) 2011-08-04
MXPA03000498A (es) 2003-06-24
NL1015744C2 (nl) 2002-01-22
EP1700854A1 (en) 2006-09-13
EP1700854B1 (en) 2012-05-23
NZ523703A (en) 2004-08-27
KR100865016B1 (ko) 2008-10-23
IL153980A (en) 2006-10-05
US7642363B2 (en) 2010-01-05
US20030158426A1 (en) 2003-08-21
IS2386B (is) 2008-07-15
US7989643B2 (en) 2011-08-02
CN101081842B (zh) 2012-01-04
PL207115B1 (pl) 2010-11-30
CN100378091C (zh) 2008-04-02
DE60123444T2 (de) 2007-08-23
KR20030040224A (ko) 2003-05-22
ATE340790T1 (de) 2006-10-15
IL153980A0 (en) 2003-07-31
CA2415963A1 (en) 2002-01-24
EP1317440A1 (en) 2003-06-11
NO20030025D0 (no) 2003-01-03
US20100136339A1 (en) 2010-06-03
ZA200300478B (en) 2004-01-26
ES2272506T3 (es) 2007-05-01
CZ2003163A3 (cs) 2003-05-14
ES2387313T3 (es) 2012-09-20
JP2004504315A (ja) 2004-02-12
SK287755B6 (sk) 2011-08-04

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