EA015846B1 - 2-[5-бром-4-(4-циклопропилнафталин-1-ил)-4н-[1,2,4]триазол-3-илсульфанил]уксусная кислота и ее метиловый эфир - Google Patents

2-[5-бром-4-(4-циклопропилнафталин-1-ил)-4н-[1,2,4]триазол-3-илсульфанил]уксусная кислота и ее метиловый эфир Download PDF

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Publication number
EA015846B1
EA015846B1 EA200901186A EA200901186A EA015846B1 EA 015846 B1 EA015846 B1 EA 015846B1 EA 200901186 A EA200901186 A EA 200901186A EA 200901186 A EA200901186 A EA 200901186A EA 015846 B1 EA015846 B1 EA 015846B1
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EA
Eurasian Patent Office
Prior art keywords
triazol
ylsulfanyl
bromo
compounds
mmol
Prior art date
Application number
EA200901186A
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English (en)
Russian (ru)
Other versions
EA200901186A1 (ru
Inventor
Жан-Люк Жирарде
Юнг-Хио Кох
Марта Де Ла Роза
Эсмир Гуник
Чжи Хун
Стенли Лэнг
Хонг Воо Ким
Original Assignee
Ардеа Байосайенсиз, Инк.
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Application filed by Ардеа Байосайенсиз, Инк. filed Critical Ардеа Байосайенсиз, Инк.
Publication of EA200901186A1 publication Critical patent/EA200901186A1/ru
Publication of EA015846B1 publication Critical patent/EA015846B1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D249/12—Oxygen or sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D249/14—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
EA200901186A 2004-08-25 2005-08-25 2-[5-бром-4-(4-циклопропилнафталин-1-ил)-4н-[1,2,4]триазол-3-илсульфанил]уксусная кислота и ее метиловый эфир EA015846B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US60422004P 2004-08-25 2004-08-25
US60421904P 2004-08-25 2004-08-25
US68635105P 2005-05-31 2005-05-31

Publications (2)

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EA200901186A1 EA200901186A1 (ru) 2010-04-30
EA015846B1 true EA015846B1 (ru) 2011-12-30

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EA200901186A EA015846B1 (ru) 2004-08-25 2005-08-25 2-[5-бром-4-(4-циклопропилнафталин-1-ил)-4н-[1,2,4]триазол-3-илсульфанил]уксусная кислота и ее метиловый эфир
EA200700488A EA014737B1 (ru) 2004-08-25 2005-08-25 S-ТРИАЗОЛИЛ-α-МЕРКАПТОАЦЕТАНИЛИДЫ В КАЧЕСТВЕ ИНГИБИТОРА ОБРАТНОЙ ТРАНСКРИПТАЗЫ ВИЧ

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EA200700488A EA014737B1 (ru) 2004-08-25 2005-08-25 S-ТРИАЗОЛИЛ-α-МЕРКАПТОАЦЕТАНИЛИДЫ В КАЧЕСТВЕ ИНГИБИТОРА ОБРАТНОЙ ТРАНСКРИПТАЗЫ ВИЧ

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US (8) US7947721B2 (zh)
EP (5) EP2433633A1 (zh)
JP (2) JP4952943B2 (zh)
KR (1) KR101241716B1 (zh)
CN (2) CN101083987B (zh)
AT (2) ATE540677T1 (zh)
AU (2) AU2005280130C9 (zh)
BR (2) BRPI0520870B8 (zh)
CA (1) CA2578068C (zh)
CY (2) CY1112221T1 (zh)
DK (1) DK2135608T3 (zh)
EA (2) EA015846B1 (zh)
EC (1) ECSP077322A (zh)
ES (2) ES2380604T3 (zh)
FR (1) FR16C0031I2 (zh)
HK (1) HK1133582A1 (zh)
HR (1) HRP20130075T1 (zh)
HU (1) HUS1600034I1 (zh)
IL (3) IL181523A (zh)
IN (1) IN2014CN03762A (zh)
LT (1) LTC2135608I2 (zh)
LU (1) LU93169I2 (zh)
ME (1) ME01512B (zh)
MX (1) MX2007002236A (zh)
NL (1) NL300825I2 (zh)
NZ (2) NZ553534A (zh)
PL (1) PL2135608T3 (zh)
PT (1) PT2135608E (zh)
RS (1) RS52632B (zh)
SG (2) SG185992A1 (zh)
SI (1) SI2135608T1 (zh)
WO (1) WO2006026356A2 (zh)

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RU2666549C2 (ru) * 2012-07-03 2018-09-18 Ардеа Биосайнсиз, Инк. Получение 2-(5-бром-4-(4-циклопропилнафталин-1-ил)-4h-1,2,4-триазол-3-илтио)уксусной кислоты

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