ATE540677T1 - S-triazolyl alpha mercaptoacetanilide als hemmer der reversen transkriptase von hiv - Google Patents

S-triazolyl alpha mercaptoacetanilide als hemmer der reversen transkriptase von hiv

Info

Publication number
ATE540677T1
ATE540677T1 AT05790722T AT05790722T ATE540677T1 AT E540677 T1 ATE540677 T1 AT E540677T1 AT 05790722 T AT05790722 T AT 05790722T AT 05790722 T AT05790722 T AT 05790722T AT E540677 T1 ATE540677 T1 AT E540677T1
Authority
AT
Austria
Prior art keywords
hiv
reverse transcriptase
mercaptoacetanilide
inhibitor
triazolyl
Prior art date
Application number
AT05790722T
Other languages
English (en)
Inventor
Jean-Luc Girardet
Yung-Hyo Koh
La Rosa Martha De
Esmir Gunic
Zhi Hong
Stanley Lang
Hong Kim
Original Assignee
Ardea Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ardea Biosciences Inc filed Critical Ardea Biosciences Inc
Application granted granted Critical
Publication of ATE540677T1 publication Critical patent/ATE540677T1/de

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D249/12—Oxygen or sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D249/14—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
AT05790722T 2004-08-25 2005-08-25 S-triazolyl alpha mercaptoacetanilide als hemmer der reversen transkriptase von hiv ATE540677T1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US60421904P 2004-08-25 2004-08-25
US60422004P 2004-08-25 2004-08-25
US68635105P 2005-05-31 2005-05-31
PCT/US2005/030259 WO2006026356A2 (en) 2004-08-25 2005-08-25 S-TRIAZOLYL α-MERCAPTOACETANILDES AS INHIBITORS OF HIV REVERSE TRANSCRIPTASE

Publications (1)

Publication Number Publication Date
ATE540677T1 true ATE540677T1 (de) 2012-01-15

Family

ID=36000576

Family Applications (2)

Application Number Title Priority Date Filing Date
AT09170772T ATE528001T1 (de) 2004-08-25 2005-08-25 S-triazolyl-alpha-mercaptoacetanilide als inhibitoren von hiv-umkehrtranskriptase
AT05790722T ATE540677T1 (de) 2004-08-25 2005-08-25 S-triazolyl alpha mercaptoacetanilide als hemmer der reversen transkriptase von hiv

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AT09170772T ATE528001T1 (de) 2004-08-25 2005-08-25 S-triazolyl-alpha-mercaptoacetanilide als inhibitoren von hiv-umkehrtranskriptase

Country Status (32)

Country Link
US (8) US7947721B2 (de)
EP (5) EP2135608B8 (de)
JP (2) JP4952943B2 (de)
KR (1) KR101241716B1 (de)
CN (2) CN101083987B (de)
AT (2) ATE528001T1 (de)
AU (2) AU2005280130C9 (de)
BR (2) BRPI0520870B8 (de)
CA (1) CA2578068C (de)
CY (2) CY1112221T1 (de)
DK (1) DK2135608T3 (de)
EA (2) EA014737B1 (de)
EC (1) ECSP077322A (de)
ES (2) ES2374773T3 (de)
FR (1) FR16C0031I2 (de)
HK (1) HK1133582A1 (de)
HR (1) HRP20130075T1 (de)
HU (1) HUS1600034I1 (de)
IL (3) IL181523A (de)
IN (1) IN2014CN03762A (de)
LT (1) LTC2135608I2 (de)
LU (1) LU93169I2 (de)
ME (1) ME01512B (de)
MX (1) MX2007002236A (de)
NL (1) NL300825I2 (de)
NZ (2) NZ581376A (de)
PL (1) PL2135608T3 (de)
PT (1) PT2135608E (de)
RS (1) RS52632B (de)
SG (2) SG185992A1 (de)
SI (1) SI2135608T1 (de)
WO (1) WO2006026356A2 (de)

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EP2402011A1 (de) 2012-01-04
US20110190491A1 (en) 2011-08-04
PL2135608T3 (pl) 2012-07-31
US8481581B2 (en) 2013-07-09
US8946273B2 (en) 2015-02-03
CY2016028I1 (el) 2016-12-14
AU2005280130C9 (en) 2010-03-04
SG155246A1 (en) 2009-09-30
BRPI0514630B1 (pt) 2020-09-15
MX2007002236A (es) 2007-07-09
AU2009217458A1 (en) 2009-10-15
HUS1600034I1 (hu) 2016-09-28
US20120283301A1 (en) 2012-11-08
DK2135608T3 (da) 2012-01-23
WO2006026356A3 (en) 2006-08-10
PT2135608E (pt) 2012-01-13
US20100267724A2 (en) 2010-10-21
WO2006026356A2 (en) 2006-03-09
HRP20130075T1 (hr) 2013-02-28
AU2009217458B2 (en) 2009-11-19
CN101083987A (zh) 2007-12-05
LU93169I2 (fr) 2016-10-10
IL181523A (en) 2013-12-31
CA2578068C (en) 2011-08-09
ECSP077322A (es) 2007-04-26
ES2374773T3 (es) 2012-02-21
JP2012077088A (ja) 2012-04-19
IN2014CN03762A (de) 2015-09-25
SI2135608T1 (sl) 2012-03-30
US7947721B2 (en) 2011-05-24
NZ553534A (en) 2010-10-29
IL201546A (en) 2013-10-31
CY1112221T1 (el) 2015-12-09
RS52632B (en) 2013-06-28
NL300825I2 (de) 2017-01-24
FR16C0031I2 (fr) 2017-03-31
US20110313157A1 (en) 2011-12-22
BRPI0514630B8 (pt) 2021-05-25
JP4952943B2 (ja) 2012-06-13
US8252828B2 (en) 2012-08-28
AU2005280130C1 (en) 2010-02-18
KR101241716B1 (ko) 2013-03-08
NZ581376A (en) 2011-05-27
EP1789039A4 (de) 2009-08-05
FR16C0031I1 (de) 2016-09-23
CY2016028I2 (el) 2016-12-14
EP2433633A1 (de) 2012-03-28
BRPI0520870B8 (pt) 2021-05-25
IL219131A0 (en) 2012-06-28
US20150094284A1 (en) 2015-04-02
JP2008510828A (ja) 2008-04-10
EP2135608A1 (de) 2009-12-23
US20100069645A1 (en) 2010-03-18
KR20070054694A (ko) 2007-05-29
BRPI0514630A (pt) 2008-06-17
EP1789039A2 (de) 2007-05-30
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BRPI0520870B1 (pt) 2020-11-10
US20100081827A1 (en) 2010-04-01
EA014737B1 (ru) 2011-02-28
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HK1133582A1 (en) 2010-04-01
ATE528001T1 (de) 2011-10-15
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CN101083987B (zh) 2011-01-26
EP1789039B1 (de) 2012-01-11
US20180002296A1 (en) 2018-01-04
EP2609917A1 (de) 2013-07-03
CA2578068A1 (en) 2006-03-09
AU2005280130A1 (en) 2006-03-09
EA200700488A1 (ru) 2007-08-31
EA015846B1 (ru) 2011-12-30
AU2009217458A8 (en) 2009-10-29
EP2402011B1 (de) 2012-11-14
EA200901186A1 (ru) 2010-04-30
CN101817793B (zh) 2014-01-08
ME01512B (me) 2014-04-20
LTC2135608I2 (lt) 2017-07-25
ES2380604T3 (es) 2012-05-16
EP2135608B1 (de) 2011-10-12
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US20080176850A1 (en) 2008-07-24

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