ATE508128T1 - Cyclopropaheterocyclen als nicht-nukleosidische hemmer der reversen transkriptase - Google Patents
Cyclopropaheterocyclen als nicht-nukleosidische hemmer der reversen transkriptaseInfo
- Publication number
- ATE508128T1 ATE508128T1 AT02748329T AT02748329T ATE508128T1 AT E508128 T1 ATE508128 T1 AT E508128T1 AT 02748329 T AT02748329 T AT 02748329T AT 02748329 T AT02748329 T AT 02748329T AT E508128 T1 ATE508128 T1 AT E508128T1
- Authority
- AT
- Austria
- Prior art keywords
- cyclopropaheterocycles
- reverse transcriptase
- nucleosidic inhibitors
- nucleosidic
- inhibitors
- Prior art date
Links
- 102100034343 Integrase Human genes 0.000 title 1
- 108010092799 RNA-directed DNA polymerase Proteins 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4433—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with oxygen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4436—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C245/00—Compounds containing chains of at least two nitrogen atoms with at least one nitrogen-to-nitrogen multiple bond
- C07C245/12—Diazo compounds, i.e. compounds having the free valencies of >N2 groups attached to the same carbon atom
- C07C245/14—Diazo compounds, i.e. compounds having the free valencies of >N2 groups attached to the same carbon atom having diazo groups bound to acyclic carbon atoms of a carbon skeleton
- C07C245/18—Diazo compounds, i.e. compounds having the free valencies of >N2 groups attached to the same carbon atom having diazo groups bound to acyclic carbon atoms of a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C43/00—Ethers; Compounds having groups, groups or groups
- C07C43/02—Ethers
- C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
- C07C43/23—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing hydroxy or O-metal groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Virology (AREA)
- Engineering & Computer Science (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- AIDS & HIV (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Furan Compounds (AREA)
- Pyrane Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0100733A SE0100733D0 (sv) | 2001-03-05 | 2001-03-05 | Non-nucleoside reverse transcriptase inhibitors |
| PCT/EP2002/002328 WO2002070516A2 (en) | 2001-03-05 | 2002-03-04 | Cyclopropaheterocycles as non-nucleoside reverse transcriptase inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE508128T1 true ATE508128T1 (de) | 2011-05-15 |
Family
ID=20283208
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT02748329T ATE508128T1 (de) | 2001-03-05 | 2002-03-04 | Cyclopropaheterocyclen als nicht-nukleosidische hemmer der reversen transkriptase |
Country Status (21)
| Country | Link |
|---|---|
| US (3) | US6716850B2 (de) |
| EP (1) | EP1373261B1 (de) |
| JP (2) | JP4463478B2 (de) |
| KR (1) | KR100884494B1 (de) |
| CN (2) | CN1264839C (de) |
| AR (1) | AR035941A1 (de) |
| AT (1) | ATE508128T1 (de) |
| AU (1) | AU2002308231B2 (de) |
| BR (1) | BR0207886A (de) |
| CA (1) | CA2438524C (de) |
| DE (1) | DE60239924D1 (de) |
| DK (1) | DK1373261T3 (de) |
| ES (1) | ES2364926T3 (de) |
| IL (2) | IL157543A0 (de) |
| MX (1) | MXPA03008040A (de) |
| MY (1) | MY137083A (de) |
| PL (1) | PL207392B1 (de) |
| RU (1) | RU2281284C2 (de) |
| SE (1) | SE0100733D0 (de) |
| TW (1) | TWI228990B (de) |
| WO (1) | WO2002070516A2 (de) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE413174T1 (de) * | 2002-09-05 | 2008-11-15 | Medivir Ab | Nicht-nucleoside revers-transcriptase inhibitoren |
| WO2005037845A1 (en) * | 2003-10-17 | 2005-04-28 | Rigel Pharmaceuticals, Inc. | Benzothiazole and thiazole[5,5-b] pyridine compositions and their use as ubiquitin ligase inhibitors |
| AU2004312284B2 (en) * | 2004-01-08 | 2010-08-05 | Medivir Ab | Non-nucleotide reverse transcriptase inhibitors |
| SE0400021D0 (sv) * | 2004-01-08 | 2004-01-08 | Medivir Ab | Non-nucleoside reverse transcriptase inhibitors |
| GB0608876D0 (en) | 2006-05-05 | 2006-06-14 | Medivir Ab | Combination therapy |
| ATE552245T1 (de) | 2006-05-15 | 2012-04-15 | Merck Sharp & Dohme | Antidiabetische bicyclische verbindungen |
| US9670231B2 (en) | 2013-06-28 | 2017-06-06 | Beigene, Ltd. | Fused tricyclic amide compounds as multiple kinase inhibitors |
| JP6380861B2 (ja) | 2013-06-28 | 2018-08-29 | ベイジーン リミテッド | Ｒａｆキナ−ゼおよび／またはＲａｆキナ−ゼの二量体阻害剤としての縮合三環式ウレア系化合物 |
| WO2015089842A1 (en) * | 2013-12-20 | 2015-06-25 | Merck Sharp & Dohme Corp. | Novel tricyclic calcium sensing receptor antagonists for the treatment of osteoporosis |
| TWI849043B (zh) | 2019-01-25 | 2024-07-21 | 英屬開曼群島商百濟神州有限公司 | B-raf激酶二聚體抑制劑之穩定固體分散體、製備方法及其用途 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA973885A (en) * | 1969-08-22 | 1975-09-02 | Universal Oil Products Company | Vinylation of aromatic compounds |
| US3803175A (en) | 1969-08-22 | 1974-04-09 | Universal Oil Prod Co | Preparation of coumarin compounds |
| US4931221A (en) * | 1988-12-30 | 1990-06-05 | Ppg Industries, Inc. | Photochromic spiropyran compounds |
| IL102548A (en) | 1991-08-02 | 1998-08-16 | Medivir Ab | Thiourea derivatives for use in the preparation of medicaments for the inhibition of hiv and the treatment of aids and some such novel compounds |
| CA2115426C (en) * | 1991-08-14 | 2001-09-11 | Stanford Salvatore Pelosi Jr. | Novel cyclic ureas useful as antiarrhythmic and antifibrillatory agents |
| WO1993004061A1 (en) * | 1991-08-14 | 1993-03-04 | Procter & Gamble Pharmaceuticals | Novel 4-oxocyclic ureas useful as antiarrhythmic and antifibrillatory agents |
| DE69414708T2 (de) * | 1993-08-24 | 1999-04-15 | Medivir Ab, Huddinge | Verbindungen und methoden zur inhibition von hiv und verwandten viren |
| DE69916425T2 (de) * | 1998-01-16 | 2005-05-19 | Medivir Ab | Antivirale mittel |
| US5998411A (en) | 1998-03-17 | 1999-12-07 | Hughes Institute | Heterocyclic nonnucleoside inhibitors of reverse transcriptase |
| WO1999051613A1 (en) | 1998-04-03 | 1999-10-14 | Medivir Ab | Prodrugs of phosphorous-containing pharmaceuticals |
| US6136335A (en) | 1998-12-31 | 2000-10-24 | Hughes Institute | Phenethyl-5-bromopyridylthiourea (PBT) and dihydroalkoxybenzyloxopyrimidine (DABO) derivatives exhibiting spermicidal activity |
| US7186736B1 (en) | 1999-03-20 | 2007-03-06 | Parker Hughes Institute | NNI for treatment of multi-drug resistant HIV |
| US6469034B1 (en) | 1999-06-23 | 2002-10-22 | Parker Hughes Institute | Cyclohexenyl-ethyl-thiourea compounds for inhibiting HIV reverse transcriptase |
| US6124324A (en) | 1999-06-23 | 2000-09-26 | Hughes Institute | Thiophene-ethyl thiourea compounds and use |
| US6207688B1 (en) | 1999-06-23 | 2001-03-27 | Parker Hughes Institute | Phenethyl-thiourea compounds and use |
-
2001
- 2001-03-05 SE SE0100733A patent/SE0100733D0/xx unknown
-
2002
- 2002-02-25 TW TW091103297A patent/TWI228990B/zh not_active IP Right Cessation
- 2002-03-01 MY MYPI20020739A patent/MY137083A/en unknown
- 2002-03-04 IL IL15754302A patent/IL157543A0/xx unknown
- 2002-03-04 EP EP02748329A patent/EP1373261B1/de not_active Expired - Lifetime
- 2002-03-04 ES ES02748329T patent/ES2364926T3/es not_active Expired - Lifetime
- 2002-03-04 WO PCT/EP2002/002328 patent/WO2002070516A2/en not_active Ceased
- 2002-03-04 DE DE60239924T patent/DE60239924D1/de not_active Expired - Lifetime
- 2002-03-04 CN CNB02806027XA patent/CN1264839C/zh not_active Expired - Fee Related
- 2002-03-04 BR BR0207886-4A patent/BR0207886A/pt not_active IP Right Cessation
- 2002-03-04 PL PL364414A patent/PL207392B1/pl not_active IP Right Cessation
- 2002-03-04 JP JP2002569836A patent/JP4463478B2/ja not_active Expired - Fee Related
- 2002-03-04 KR KR1020037011616A patent/KR100884494B1/ko not_active Expired - Fee Related
- 2002-03-04 AU AU2002308231A patent/AU2002308231B2/en not_active Ceased
- 2002-03-04 MX MXPA03008040A patent/MXPA03008040A/es active IP Right Grant
- 2002-03-04 AT AT02748329T patent/ATE508128T1/de not_active IP Right Cessation
- 2002-03-04 CA CA2438524A patent/CA2438524C/en not_active Expired - Fee Related
- 2002-03-04 CN CN200610082490XA patent/CN101081843B/zh not_active Expired - Fee Related
- 2002-03-04 DK DK02748329.6T patent/DK1373261T3/da active
- 2002-03-04 RU RU2003129513/04A patent/RU2281284C2/ru not_active IP Right Cessation
- 2002-03-05 AR ARP020100797A patent/AR035941A1/es unknown
- 2002-03-05 US US10/092,752 patent/US6716850B2/en not_active Expired - Fee Related
-
2003
- 2003-02-28 US US10/377,057 patent/US6894177B2/en not_active Expired - Fee Related
- 2003-08-21 IL IL157543A patent/IL157543A/en not_active IP Right Cessation
-
2005
- 2005-03-02 US US11/071,675 patent/US7405310B2/en not_active Expired - Fee Related
-
2009
- 2009-02-10 JP JP2009028717A patent/JP2009102436A/ja active Pending
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |