BRPI0514630A - alfa-mercaptoacetanilidas e s-triazolila como inibidores de transcriptase reversa de hiv - Google Patents
alfa-mercaptoacetanilidas e s-triazolila como inibidores de transcriptase reversa de hivInfo
- Publication number
- BRPI0514630A BRPI0514630A BRPI0514630-5A BRPI0514630A BRPI0514630A BR PI0514630 A BRPI0514630 A BR PI0514630A BR PI0514630 A BRPI0514630 A BR PI0514630A BR PI0514630 A BRPI0514630 A BR PI0514630A
- Authority
- BR
- Brazil
- Prior art keywords
- triazolyl
- reverse transcriptase
- alpha
- hiv reverse
- mercaptoacetanilides
- Prior art date
Links
- 108010078851 HIV Reverse Transcriptase Proteins 0.000 title abstract 3
- -1 s-triazolyl Chemical group 0.000 title abstract 3
- 239000003419 rna directed dna polymerase inhibitor Substances 0.000 title abstract 2
- DLVKRCGYGJZXFK-UHFFFAOYSA-N n-phenyl-2-sulfanylacetamide Chemical class SCC(=O)NC1=CC=CC=C1 DLVKRCGYGJZXFK-UHFFFAOYSA-N 0.000 title 1
- 208000031886 HIV Infections Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D249/12—Oxygen or sulfur atoms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4196—1,2,4-Triazoles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D249/14—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Virology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Road Signs Or Road Markings (AREA)
- Pens And Brushes (AREA)
- Diaphragms For Electromechanical Transducers (AREA)
Abstract
ALFA-MERGAPTOACETANìLIDAS DE S-TRIAZOLILA COMO INIBIDORES DE TRANSCRIPTASE REVERSA DE HIV Uma série de a-mercaptoacetanílidas de s-triazolila tendo a estrutura geral (1) é fornecida, onde Q é CO~ 2~H, CONR~ 2~, SO~ 3~H, ou SO~ 2~NR~ 2~.Os compostos inibem diversas variantes da transcriptase reversa de HIV, e são úteis no tratamento de infecções de HIV.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
BRPI0520870A BRPI0520870B8 (pt) | 2004-08-25 | 2005-08-25 | compostos intermediários para a preparação de alfa-mercaptoacetanilidas de s-triazolila |
Applications Claiming Priority (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US60422004P | 2004-08-25 | 2004-08-25 | |
US60421904P | 2004-08-25 | 2004-08-25 | |
US60/604,220 | 2004-08-25 | ||
US60/604,219 | 2004-08-25 | ||
US68635105P | 2005-05-31 | 2005-05-31 | |
US60/686,351 | 2005-05-31 | ||
PCT/US2005/030259 WO2006026356A2 (en) | 2004-08-25 | 2005-08-25 | S-TRIAZOLYL α-MERCAPTOACETANILDES AS INHIBITORS OF HIV REVERSE TRANSCRIPTASE |
Publications (3)
Publication Number | Publication Date |
---|---|
BRPI0514630A true BRPI0514630A (pt) | 2008-06-17 |
BRPI0514630B1 BRPI0514630B1 (pt) | 2020-09-15 |
BRPI0514630B8 BRPI0514630B8 (pt) | 2021-05-25 |
Family
ID=36000576
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0514630A BRPI0514630B8 (pt) | 2004-08-25 | 2005-08-25 | compostos de alfa-mercaptoacetanilidas de s-triazolila e composições farmacêuticas |
BRPI0520870A BRPI0520870B8 (pt) | 2004-08-25 | 2005-08-25 | compostos intermediários para a preparação de alfa-mercaptoacetanilidas de s-triazolila |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0520870A BRPI0520870B8 (pt) | 2004-08-25 | 2005-08-25 | compostos intermediários para a preparação de alfa-mercaptoacetanilidas de s-triazolila |
Country Status (32)
Country | Link |
---|---|
US (8) | US7947721B2 (pt) |
EP (5) | EP2135608B8 (pt) |
JP (2) | JP4952943B2 (pt) |
KR (1) | KR101241716B1 (pt) |
CN (2) | CN101083987B (pt) |
AT (2) | ATE540677T1 (pt) |
AU (2) | AU2005280130C9 (pt) |
BR (2) | BRPI0514630B8 (pt) |
CA (1) | CA2578068C (pt) |
CY (2) | CY1112221T1 (pt) |
DK (1) | DK2135608T3 (pt) |
EA (2) | EA015846B1 (pt) |
EC (1) | ECSP077322A (pt) |
ES (2) | ES2380604T3 (pt) |
FR (1) | FR16C0031I2 (pt) |
HK (1) | HK1133582A1 (pt) |
HR (1) | HRP20130075T1 (pt) |
HU (1) | HUS1600034I1 (pt) |
IL (3) | IL181523A (pt) |
IN (1) | IN2014CN03762A (pt) |
LT (1) | LTC2135608I2 (pt) |
LU (1) | LU93169I2 (pt) |
ME (1) | ME01512B (pt) |
MX (1) | MX2007002236A (pt) |
NL (1) | NL300825I2 (pt) |
NZ (2) | NZ581376A (pt) |
PL (1) | PL2135608T3 (pt) |
PT (1) | PT2135608E (pt) |
RS (1) | RS52632B (pt) |
SG (2) | SG155246A1 (pt) |
SI (1) | SI2135608T1 (pt) |
WO (1) | WO2006026356A2 (pt) |
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