LU93169I2 - Lésinurad , ou un sel pharmaceutiquement acceptable de celui-ci - Google Patents
Lésinurad , ou un sel pharmaceutiquement acceptable de celui-ci Download PDFInfo
- Publication number
- LU93169I2 LU93169I2 LU93169C LU93169C LU93169I2 LU 93169 I2 LU93169 I2 LU 93169I2 LU 93169 C LU93169 C LU 93169C LU 93169 C LU93169 C LU 93169C LU 93169 I2 LU93169 I2 LU 93169I2
- Authority
- LU
- Luxembourg
- Prior art keywords
- lésinurad
- pharmaceutically acceptable
- acceptable salt
- hiv
- mercaptoacetanilides
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D249/12—Oxygen or sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4196—1,2,4-Triazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D249/14—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- AIDS & HIV (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Road Signs Or Road Markings (AREA)
- Pens And Brushes (AREA)
- Diaphragms For Electromechanical Transducers (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US60422004P | 2004-08-25 | 2004-08-25 | |
US60421904P | 2004-08-25 | 2004-08-25 | |
US68635105P | 2005-05-31 | 2005-05-31 | |
EP05790722A EP1789039B1 (fr) | 2004-08-25 | 2005-08-25 | S-triazolyl alpha-mercaptoacetanildes tenant lieu d'inhibiteurs de la transcriptase inverse vih |
Publications (1)
Publication Number | Publication Date |
---|---|
LU93169I2 true LU93169I2 (fr) | 2016-10-10 |
Family
ID=36000576
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
LU93169C LU93169I2 (fr) | 2004-08-25 | 2016-08-10 | Lésinurad , ou un sel pharmaceutiquement acceptable de celui-ci |
Country Status (32)
Country | Link |
---|---|
US (8) | US7947721B2 (fr) |
EP (5) | EP2433633A1 (fr) |
JP (2) | JP4952943B2 (fr) |
KR (1) | KR101241716B1 (fr) |
CN (2) | CN101083987B (fr) |
AT (2) | ATE540677T1 (fr) |
AU (2) | AU2005280130C9 (fr) |
BR (2) | BRPI0514630B8 (fr) |
CA (1) | CA2578068C (fr) |
CY (2) | CY1112221T1 (fr) |
DK (1) | DK2135608T3 (fr) |
EA (2) | EA015846B1 (fr) |
EC (1) | ECSP077322A (fr) |
ES (2) | ES2380604T3 (fr) |
FR (1) | FR16C0031I2 (fr) |
HK (1) | HK1133582A1 (fr) |
HR (1) | HRP20130075T1 (fr) |
HU (1) | HUS1600034I1 (fr) |
IL (3) | IL181523A (fr) |
IN (1) | IN2014CN03762A (fr) |
LT (1) | LTC2135608I2 (fr) |
LU (1) | LU93169I2 (fr) |
ME (1) | ME01512B (fr) |
MX (1) | MX2007002236A (fr) |
NL (1) | NL300825I2 (fr) |
NZ (2) | NZ581376A (fr) |
PL (1) | PL2135608T3 (fr) |
PT (1) | PT2135608E (fr) |
RS (1) | RS52632B (fr) |
SG (2) | SG155246A1 (fr) |
SI (1) | SI2135608T1 (fr) |
WO (1) | WO2006026356A2 (fr) |
Families Citing this family (51)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EA015846B1 (ru) * | 2004-08-25 | 2011-12-30 | Ардеа Байосайенсиз, Инк. | 2-[5-бром-4-(4-циклопропилнафталин-1-ил)-4н-[1,2,4]триазол-3-илсульфанил]уксусная кислота и ее метиловый эфир |
WO2007050087A1 (fr) | 2004-08-25 | 2007-05-03 | Ardea Biosciences, Inc. | Acides N[S(4-aryltriazol-3-yl)α-mercaptoacétyl]-p-aminobenzoïques EN TANT QU'INHIBITEURS DE TRANSCRIPTASE INVERSE DE VIH |
KR101542629B1 (ko) | 2007-05-30 | 2015-08-06 | 에프. 호프만-라 로슈 아게 | 비-뉴클레오사이드 역전사효소 억제제 |
WO2009030996A1 (fr) * | 2007-09-05 | 2009-03-12 | Coley Pharmaceutical Group, Inc. | Composés triazole utilisés comme agonistes du récepteur de type toll (tlr) |
NZ601774A (en) * | 2007-11-27 | 2013-07-26 | Ardea Biosciences Inc | Substituted diazole and triazole compounds and compositions and methods of use |
US8173690B2 (en) * | 2008-09-04 | 2012-05-08 | Ardea Biosciences, Inc. | Compounds, compositions and methods of using same for modulating uric acid levels |
AU2009289647C1 (en) * | 2008-09-04 | 2013-03-21 | Ardea Biosciences, Inc. | Compounds, compositions and methods of using same for modulating uric acid levels |
US8242154B2 (en) | 2008-09-04 | 2012-08-14 | Ardea Biosciences, Inc. | Compounds, compositions and methods of using same for modulating uric acid levels |
AR073964A1 (es) * | 2008-10-24 | 2010-12-15 | Ardea Biosciences Inc | Composiciones que comprenden acido 4-(2-(5-bromo-4-(1-ciclopropilnaftalen -4-il) -4h- 1,2,4-triazol-3-il tio ) acetamido)-3-clorobenzoico y sus sales farmaceuticamente aceptables y metodos de preparacion y uso delos mismos |
WO2010048592A1 (fr) * | 2008-10-24 | 2010-04-29 | Ardea Biosciences, Inc. | Compositions comprenant l'acide 4-(2-(5-bromo-4-(1- cyclopropylnaphtalén-4-yl)-4h-1,2,4-triazol-3-ylthio)acétamido-3- chlorobenzoïque et ses sels de qualité pharmaceutique |
EP2432468A2 (fr) | 2009-05-20 | 2012-03-28 | Ardea Biosciences, Inc. | Procédés pour moduler des taux d'acide urique |
CN102040546B (zh) * | 2009-10-10 | 2014-10-15 | 台州市华南医化有限公司 | 一种4-环丙基-1-异硫氰基萘的制备方法及中间体4-环丙基-1-萘甲醛肟/卤化物 |
NZ600984A (en) * | 2010-01-08 | 2013-10-25 | Ardea Biosciences Inc | Polymorphic, crystalline and mesophase forms of sodium 2-(5-bromo-4-(4-cyclopropylnaphthalen-1-yl)-4h-1,2,4-triazol-3-ylthio)acetate, and uses thereof |
WO2011126852A2 (fr) | 2010-03-30 | 2011-10-13 | Ardea Biosciences, Inc. | Traitement de la goutte |
CA2802407C (fr) | 2010-06-15 | 2018-01-23 | Ardea Biosciences, Inc. | Traitement de la goutte et de l'hyperuricemie |
US9212135B2 (en) | 2010-06-16 | 2015-12-15 | Ardea Biosciences, Inc. | Phenylthioacetate compounds, compositions and methods of use |
AR081930A1 (es) | 2010-06-16 | 2012-10-31 | Ardea Biosciences Inc | Compuestos de tioacetato |
CN101899013B (zh) * | 2010-07-12 | 2012-07-25 | 山东大学 | 2-(2-取代芳基-2h-1,2,4-三唑-3-巯基)乙酰胺衍生物及其制备方法与应用 |
CN103249417A (zh) * | 2010-10-15 | 2013-08-14 | 阿迪亚生命科学公司 | 用于治疗高尿酸血症及相关疾病的方法 |
DK2658846T3 (en) | 2010-12-30 | 2017-02-13 | Ardea Biosciences Inc | POLYMORPHE FORMS OF 2- (5-BROMO-4- (4-CYCLOPROPYLNAPHTHALEN-1-YL) -4H-1,2,4-TRIAZOL-3-YLTHIO) ACETIC ACID AND APPLICATIONS THEREOF |
KR101988066B1 (ko) | 2011-11-03 | 2019-09-27 | 아디아 바이오사이언스즈 인크. | 3,4-이치환된 피리딘 화합물, 이의 사용 방법 및 이를 포함하는 조성물 |
AR091651A1 (es) * | 2012-07-03 | 2015-02-18 | Ardea Biosciences Inc | Elaboracion de acido 2-(5-bromo-4-(4-ciclopropilnaftalen-1-il)-4h-1,2,4-triazol-3-iltio)acetico |
CN105263913B (zh) * | 2013-06-14 | 2017-12-15 | 广东东阳光药业有限公司 | 硫代1,2,4‑三唑衍生物及其制备方法 |
CN103524440B (zh) * | 2013-10-15 | 2015-09-09 | 苏州鹏旭医药科技有限公司 | 痛风治疗药Lesinurad的制备方法及Lesinurad中间体 |
EP3071554B1 (fr) * | 2013-11-22 | 2018-10-03 | Crystal Pharmatech Co., Ltd. | Formes cristallines de lésinurad |
CN104557748A (zh) * | 2014-01-25 | 2015-04-29 | 广东东阳光药业有限公司 | 硫代-1,2,4-三唑衍生物的新的固体形态 |
CN105315218A (zh) * | 2014-07-17 | 2016-02-10 | 天津药物研究院 | 一种制备lesinurad中间体1-萘基三唑硫酮的方法 |
CN104341363B (zh) * | 2014-10-27 | 2016-08-17 | 张远强 | 一种硝基取代的三氮唑磺酰丙二酸类化合物、其制备方法及用途 |
CN104370842B (zh) * | 2014-10-27 | 2016-07-13 | 张远强 | 苯基取代的三氮唑磺酰丙二酸类化合物、其制备方法及用途 |
CN104327000B (zh) * | 2014-10-27 | 2016-08-17 | 张远强 | 苯基取代的三氮唑亚磺酰丙二酸类化合物、其制备方法及用途 |
CN104326993B (zh) * | 2014-10-27 | 2016-08-17 | 张远强 | 一种硝基取代三氮唑亚磺酰丙二酸类化合物、其制备方法及用途 |
CN104341361B (zh) * | 2014-10-27 | 2017-01-11 | 张远强 | 一种腈基取代三氮唑亚磺酰丙二酸类化合物、其制备方法及用途 |
CN104370841B (zh) * | 2014-10-27 | 2016-07-13 | 张远强 | 三氮唑亚磺酰丙二酸类化合物、其制备方法及用途 |
CN104326998B (zh) * | 2014-10-27 | 2016-08-17 | 张远强 | 苯基取代的三氮唑丙二酸类化合物、其制备方法及用途 |
CN104341362B (zh) * | 2014-10-27 | 2016-07-13 | 张远强 | 三氮唑磺酰丙二酸类化合物、其制备方法及用途 |
CN104311498B (zh) * | 2014-10-27 | 2016-04-06 | 张远强 | 烷氧基取代的三氮唑磺酰丙二酸类化合物、其制备方法及用途 |
EP3112334A1 (fr) | 2015-06-29 | 2017-01-04 | DPx Fine Chemicals Austria GmbH & CoKG | Procédé de fabrication de 1-cyclopropyl-naphthalènes |
CN104987311A (zh) * | 2015-06-30 | 2015-10-21 | 安徽万邦医药科技有限公司 | 一种[4-(4-环丙基萘-1-基)-5-硝基- 4h-[1,2,4]三唑-3-基硫烷基]-乙酸乙酯的制备方法及其中间体(5-硝基-4h-[1,2,4]三唑-3-基硫基)-乙酸乙酯 |
CN105017168A (zh) * | 2015-07-01 | 2015-11-04 | 安徽万邦医药科技有限公司 | 一种[5-溴-4-(4-环丙基萘-1-基)-4h-[1,2,4]三唑-3-基硫烷基]-乙酸甲酯的新制备方法 |
CN105153056A (zh) * | 2015-07-01 | 2015-12-16 | 安徽万邦医药科技有限公司 | 一种[5-溴-4-(4-环丙基萘-1-基)-4h-[1,2,4]三唑-3-基硫烷基]-乙酸甲酯的新制备方法 |
WO2017036884A1 (fr) | 2015-08-28 | 2017-03-09 | Sandoz Ag | Co-cristal de lésinurad, forme libre/ester éthylique de lésinurad |
CN105566237B (zh) * | 2016-03-01 | 2018-05-18 | 山东大学 | 一种治疗痛风的三唑巯乙酸类化合物的制备方法 |
EP3473617B1 (fr) * | 2016-06-17 | 2022-09-07 | Medshine Discovery Inc. | Composé halogéné et ses isomères chiraux axial |
EP3281941B1 (fr) | 2016-08-11 | 2019-07-24 | Zentiva K.S. | Procédé de préparation d'acide 2-(5-bromo-4-(1-cyclopropylnaphtalén-4-yl)-4h-1,2,4-triazol-3-ythio) acétique |
EP3372592A1 (fr) | 2017-03-07 | 2018-09-12 | Zentiva, k.s. | Formes solides de sels d'amines de lesinurad |
US10351537B2 (en) * | 2017-03-10 | 2019-07-16 | Apotex Inc. | Processes for the preparation of lesinurad and intermediates thereof |
EP3315494A1 (fr) | 2017-04-19 | 2018-05-02 | Química Sintética, S.A. | Forme amorphe de lésinurad et ses procédés de préparation |
CN108947919B (zh) | 2017-05-17 | 2023-05-02 | 上海奥博生物医药股份有限公司 | 一种抗痛风药Lesinurad的新型制备方法及其关键中间体 |
WO2019001325A1 (fr) * | 2017-06-28 | 2019-01-03 | 苏州科睿思制药有限公司 | Forme cristalline xv de lésinurad et son procédé de préparation |
EP3498697A1 (fr) | 2017-12-12 | 2019-06-19 | Química Sintética, S.A. | Nouveaux sels et polymorphes de lesinurad |
WO2022249788A1 (fr) | 2021-05-28 | 2022-12-01 | 住友化学株式会社 | Procédé de production de bromure de cycloalkyle |
Family Cites Families (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2009A (en) * | 1841-03-18 | Improvement in machines for boring war-rockets | ||
US2006A (en) * | 1841-03-16 | Clamp for crimping leather | ||
US226186A (en) | 1880-04-06 | Car-coupling | ||
US2008A (en) * | 1841-03-18 | Gas-lamp eok conducting gas pkom ah elevated buhner to one below it | ||
JPS5641637B2 (fr) | 1973-11-26 | 1981-09-29 | ||
US6832996B2 (en) * | 1995-06-07 | 2004-12-21 | Arthrocare Corporation | Electrosurgical systems and methods for treating tissue |
JPH07215940A (ja) | 1994-01-27 | 1995-08-15 | Torii Yakuhin Kk | 抗ウイルス活性を有する化合物 |
US6245817B1 (en) * | 1997-02-14 | 2001-06-12 | Bayer Corporation | NPY5 receptor antagonists and methods for using same |
WO1998035957A1 (fr) | 1997-02-14 | 1998-08-20 | Bayer Corporation | Derives amides actifs comme antagonistes selectifs du recepteur du neuropeptide y |
JPH10243033A (ja) * | 1997-02-28 | 1998-09-11 | Oki Electric Ind Co Ltd | 復調装置 |
ES2361146T3 (es) * | 1998-03-27 | 2011-06-14 | Janssen Pharmaceutica Nv | Derivados de la piramidina inhibitatoria de vih. |
CN1178941C (zh) | 1998-11-12 | 2004-12-08 | 纽罗克里恩生物科学有限公司 | Crf受体拮抗剂以及与其有关的方法 |
WO2000037471A1 (fr) * | 1998-12-23 | 2000-06-29 | Neurogen Corporation | 2-amino-9-alkylpurines: ligands pour recepteurs cerebraux gaba |
CA2353961A1 (fr) * | 1998-12-25 | 2000-07-06 | Shionogi & Co., Ltd. | Composes heterocycliques aromatiques possedant des activites inhibitrices de l'integrase du vih |
US6593077B2 (en) * | 1999-03-22 | 2003-07-15 | Special Materials Research And Technology, Inc. | Method of making thin films dielectrics using a process for room temperature wet chemical growth of SiO based oxides on a substrate |
MXPA03007883A (es) | 2001-03-02 | 2003-12-04 | Smithkline Beecham Corp | Benzofenonas como inhibidores de transcriptasa inversa. |
JO3429B1 (ar) | 2001-08-13 | 2019-10-20 | Janssen Pharmaceutica Nv | مشتقات برميدينات مثبطة فيروس الايدز |
EP1505968A1 (fr) | 2002-05-13 | 2005-02-16 | Eli Lilly And Company | Composes multicycliques que l'on utilise comme antagonistes de l'hormone de concentration de melanine dans le traitement de l'obesite et du diabete |
CN1697650B (zh) | 2002-08-23 | 2010-11-10 | 阿迪亚生命科学公司 | 非核苷类逆转录酶抑制剂 |
US7642277B2 (en) * | 2002-12-04 | 2010-01-05 | Boehringer Ingelheim International Gmbh | Non-nucleoside reverse transcriptase inhibitors |
CL2004000192A1 (es) | 2003-02-07 | 2005-03-18 | Janssen Pharmaceutica Nv | Uso de compuestos derivados de 2-aminopirimidina para preparar un medicamento para la prevencion de una infeccion por vih relaciones sexuales o un contacto intimo en la pareja. |
DE602004031641D1 (de) | 2003-09-25 | 2011-04-14 | Janssen Pharmaceutica Nv | Die replikation von hiv hemmende purinderivate |
US20080031901A1 (en) * | 2004-09-24 | 2008-02-07 | Abbott Laboratories | Sustained release monoeximic formulations of opioid and nonopioid analgesics |
US7517998B2 (en) | 2004-06-01 | 2009-04-14 | Boehringer Ingelheim International Gmbh | Non nucleoside reverse transcriptase inhibitors |
WO2007050087A1 (fr) | 2004-08-25 | 2007-05-03 | Ardea Biosciences, Inc. | Acides N[S(4-aryltriazol-3-yl)α-mercaptoacétyl]-p-aminobenzoïques EN TANT QU'INHIBITEURS DE TRANSCRIPTASE INVERSE DE VIH |
EA015846B1 (ru) | 2004-08-25 | 2011-12-30 | Ардеа Байосайенсиз, Инк. | 2-[5-бром-4-(4-циклопропилнафталин-1-ил)-4н-[1,2,4]триазол-3-илсульфанил]уксусная кислота и ее метиловый эфир |
NZ601774A (en) * | 2007-11-27 | 2013-07-26 | Ardea Biosciences Inc | Substituted diazole and triazole compounds and compositions and methods of use |
AR073964A1 (es) | 2008-10-24 | 2010-12-15 | Ardea Biosciences Inc | Composiciones que comprenden acido 4-(2-(5-bromo-4-(1-ciclopropilnaftalen -4-il) -4h- 1,2,4-triazol-3-il tio ) acetamido)-3-clorobenzoico y sus sales farmaceuticamente aceptables y metodos de preparacion y uso delos mismos |
WO2010048592A1 (fr) | 2008-10-24 | 2010-04-29 | Ardea Biosciences, Inc. | Compositions comprenant l'acide 4-(2-(5-bromo-4-(1- cyclopropylnaphtalén-4-yl)-4h-1,2,4-triazol-3-ylthio)acétamido-3- chlorobenzoïque et ses sels de qualité pharmaceutique |
TWM377707U (en) * | 2009-09-16 | 2010-04-01 | Nat Energy Technology Co Ltd | Assembly of power supply |
-
2005
- 2005-08-25 EA EA200901186A patent/EA015846B1/ru not_active IP Right Cessation
- 2005-08-25 IN IN3762CHN2014 patent/IN2014CN03762A/en unknown
- 2005-08-25 BR BRPI0514630A patent/BRPI0514630B8/pt active IP Right Grant
- 2005-08-25 EP EP11184025A patent/EP2433633A1/fr not_active Withdrawn
- 2005-08-25 EA EA200700488A patent/EA014737B1/ru not_active IP Right Cessation
- 2005-08-25 ME MEP-2013-18A patent/ME01512B/me unknown
- 2005-08-25 AT AT05790722T patent/ATE540677T1/de active
- 2005-08-25 AU AU2005280130A patent/AU2005280130C9/en active Active
- 2005-08-25 EP EP05790722A patent/EP1789039B1/fr active Active
- 2005-08-25 SG SG200905668-0A patent/SG155246A1/en unknown
- 2005-08-25 US US11/661,079 patent/US7947721B2/en active Active
- 2005-08-25 PT PT09170772T patent/PT2135608E/pt unknown
- 2005-08-25 AT AT09170772T patent/ATE528001T1/de active
- 2005-08-25 BR BRPI0520870A patent/BRPI0520870B8/pt active IP Right Grant
- 2005-08-25 EP EP12187096.8A patent/EP2609917A1/fr not_active Withdrawn
- 2005-08-25 PL PL09170772T patent/PL2135608T3/pl unknown
- 2005-08-25 KR KR1020077006746A patent/KR101241716B1/ko active IP Right Grant
- 2005-08-25 EP EP09170772A patent/EP2135608B8/fr active Active
- 2005-08-25 NZ NZ581376A patent/NZ581376A/en not_active IP Right Cessation
- 2005-08-25 NZ NZ553534A patent/NZ553534A/en not_active IP Right Cessation
- 2005-08-25 CN CN2005800363729A patent/CN101083987B/zh active Active
- 2005-08-25 ES ES05790722T patent/ES2380604T3/es active Active
- 2005-08-25 CN CN200910205213.7A patent/CN101817793B/zh active Active
- 2005-08-25 CA CA2578068A patent/CA2578068C/fr active Active
- 2005-08-25 SI SI200531426T patent/SI2135608T1/sl unknown
- 2005-08-25 ES ES09170772T patent/ES2374773T3/es active Active
- 2005-08-25 EP EP11177941A patent/EP2402011B1/fr active Active
- 2005-08-25 DK DK09170772.9T patent/DK2135608T3/da active
- 2005-08-25 MX MX2007002236A patent/MX2007002236A/es active IP Right Grant
- 2005-08-25 WO PCT/US2005/030259 patent/WO2006026356A2/fr active Application Filing
- 2005-08-25 RS RS20130029A patent/RS52632B/en unknown
- 2005-08-25 JP JP2007530127A patent/JP4952943B2/ja active Active
- 2005-08-25 SG SG2012083366A patent/SG185992A1/en unknown
-
2007
- 2007-02-22 IL IL181523A patent/IL181523A/en active IP Right Grant
- 2007-03-15 EC EC2007007322A patent/ECSP077322A/es unknown
-
2009
- 2009-09-23 AU AU2009217458A patent/AU2009217458B2/en active Active
- 2009-10-15 IL IL201546A patent/IL201546A/en not_active IP Right Cessation
- 2009-11-13 US US12/618,604 patent/US20100069645A1/en not_active Abandoned
- 2009-12-08 US US12/633,638 patent/US8003681B2/en active Active
-
2010
- 2010-01-22 HK HK10100716.1A patent/HK1133582A1/xx unknown
-
2011
- 2011-04-06 US US13/081,398 patent/US8946273B2/en active Active
- 2011-06-30 US US13/174,538 patent/US8252828B2/en active Active
-
2012
- 2012-01-05 JP JP2012000790A patent/JP5457472B2/ja active Active
- 2012-01-11 CY CY20121100023T patent/CY1112221T1/el unknown
- 2012-04-15 IL IL219131A patent/IL219131A0/en unknown
- 2012-07-18 US US13/552,443 patent/US8481581B2/en active Active
-
2013
- 2013-01-29 HR HRP20130075TT patent/HRP20130075T1/hr unknown
-
2014
- 2014-12-03 US US14/559,803 patent/US20150094284A1/en not_active Abandoned
-
2016
- 2016-07-26 LT LTPA2016024C patent/LTC2135608I2/lt unknown
- 2016-07-28 NL NL300825C patent/NL300825I2/nl unknown
- 2016-07-29 FR FR16C0031C patent/FR16C0031I2/fr active Active
- 2016-08-10 LU LU93169C patent/LU93169I2/fr unknown
- 2016-08-10 CY CY2016028C patent/CY2016028I2/el unknown
- 2016-08-17 HU HUS1600034C patent/HUS1600034I1/hu unknown
-
2017
- 2017-02-16 US US15/435,119 patent/US20180002296A1/en not_active Abandoned
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
LU93169I2 (fr) | Lésinurad , ou un sel pharmaceutiquement acceptable de celui-ci | |
NO2017047I1 (no) | Tofacitinib, evt. i form av et farmasøytisk akseptabelt salt, inkludert citratsalt | |
ATE494893T1 (de) | Sulfonamide, sulfamate und sulfamide als gamma- secretase-hemmer | |
USD536756S1 (en) | Ball | |
ATE336995T1 (de) | Aminocyclohexenchinoline und ihre azaisosterischen analoga mit antibakterieller wirkung | |
MY142948A (en) | Benzophenones as inhibitors of reverse transcriptase | |
IS2714B (is) | Uppsöfnun í frumu á phosphomate hliðstæðum á HIV próteasa hindrandi efnasamböndum | |
WO2005032488A3 (fr) | Sulfonylurees 2,4-dioxo-3-quinazolinylaryl | |
ATE373005T1 (de) | Thienopyrrole als antivirale mittel | |
ATE402176T1 (de) | Pyrrolidin- und azetidinverbindungen alsccr5- antagonisten | |
ATE414092T1 (de) | Phosphoindole als hiv-inhibitoren | |
RU2007122284A (ru) | Предотвращениеи вертикальных инфекций, вызываемых эндопаразитами | |
DE50112436D1 (de) | Notaus-tastensystem | |
AU2003243765A8 (en) | 2,4-disubstituted-pyridine n-oxides useful as hiv reverse transcriptase inhibitors | |
DE602006013953D1 (de) | 9a-carbamoyl-y-aminopropyl- und 9a-thiocarbamoyl-y-aminopropyl-azalide mit antimalaria-aktivität | |
USD497998S1 (en) | Pear-shaped bath sponge massager | |
DE602004030265D1 (de) | Behandlung von gastrointestinalen stromatumoren mit imatinib und midostaurin | |
ES2195905T3 (es) | Compuestos de tiofen-etil-tiourea y su uso en el tratamiento de sida. | |
CY1111067T1 (el) | Χρηση της ν-(διβενζ (β,f) οξεπιν-10-υλμεθυλ) -ν-μεθυλ-ν-προπ-2-υνυλαμινης (omigapil) στην προληψη και/ή την θεραπεια της μυϊκης δυστροφiας | |
USD475098S1 (en) | Craft kit construction component—leg form | |
AU2003265223A1 (en) | Mappicine analogs, methods of inhibiting retroviral reverse transcriptase and methods of treating retroviruses | |
RU2004124585A (ru) | Способ пластики вращательной манжеты плеча | |
DE50301462D1 (de) | (Tief)Kühltruhe | |
RU2001127549A (ru) | Монолитный каблук |