DE602004031641D1 - Die replikation von hiv hemmende purinderivate - Google Patents

Die replikation von hiv hemmende purinderivate

Info

Publication number
DE602004031641D1
DE602004031641D1 DE602004031641T DE602004031641T DE602004031641D1 DE 602004031641 D1 DE602004031641 D1 DE 602004031641D1 DE 602004031641 T DE602004031641 T DE 602004031641T DE 602004031641 T DE602004031641 T DE 602004031641T DE 602004031641 D1 DE602004031641 D1 DE 602004031641D1
Authority
DE
Germany
Prior art keywords
hiv
replication
purine derivatives
inhibiting purine
inhibiting
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE602004031641T
Other languages
English (en)
Inventor
Paulus Joannes Lewi
Jonge Marc Rene De
Lucien Maria H Koymans
Frederik F D Daeyaert
Jan Heeres
Hendrik Maarten Vinkers
Ruben Gerardus George Leenders
Dirk Alfons Leo Vandenput
Paul Adriaan Janssen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Janssen Pharmaceutica NV
Original Assignee
Janssen Pharmaceutica NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica NV filed Critical Janssen Pharmaceutica NV
Publication of DE602004031641D1 publication Critical patent/DE602004031641D1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/16—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
DE602004031641T 2003-09-25 2004-09-21 Die replikation von hiv hemmende purinderivate Active DE602004031641D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP0350659 2003-09-25
PCT/EP2004/052262 WO2005028479A2 (en) 2003-09-25 2004-09-21 Hiv replication inhibiting purine derivatives

Publications (1)

Publication Number Publication Date
DE602004031641D1 true DE602004031641D1 (de) 2011-04-14

Family

ID=34354400

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602004031641T Active DE602004031641D1 (de) 2003-09-25 2004-09-21 Die replikation von hiv hemmende purinderivate

Country Status (19)

Country Link
US (1) US8026245B2 (de)
EP (1) EP1668011B1 (de)
JP (1) JP5506751B2 (de)
KR (1) KR20060121878A (de)
CN (1) CN100475815C (de)
AP (1) AP2006003517A0 (de)
AT (1) ATE500254T1 (de)
AU (1) AU2004274185B2 (de)
BR (1) BRPI0414791A (de)
CA (1) CA2535313C (de)
DE (1) DE602004031641D1 (de)
EA (1) EA009734B1 (de)
ES (1) ES2361835T3 (de)
IL (1) IL174467A0 (de)
MX (1) MXPA06002069A (de)
NO (1) NO20061788L (de)
TW (1) TW200518758A (de)
WO (1) WO2005028479A2 (de)
ZA (1) ZA200602440B (de)

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AR051094A1 (es) 2004-09-20 2006-12-20 Xenon Pharmaceuticals Inc Derivados heterociclicos y su uso como inhibidores de la estearoil-coa desaturasa
AU2005286648A1 (en) 2004-09-20 2006-03-30 Xenon Pharmaceuticals Inc. Heterocyclic derivatives and their use as stearoyl-CoA desaturase inhibitors
EP1830837B1 (de) 2004-09-20 2013-09-04 Xenon Pharmaceuticals Inc. Heterozyklische derivate zur behandlung von durch stearoyl-coa-desaturase-enzymen verursachte krankheiten
AR051090A1 (es) 2004-09-20 2006-12-20 Xenon Pharmaceuticals Inc Derivados heterociclicos y su uso como inhibidores de la estearoil-coa desaturasa
BRPI0515482A (pt) 2004-09-20 2008-07-22 Xenon Pharmaceuticals Inc derivados heterocìclicos e seus usos como agentes terapêuticos
JP2008534609A (ja) 2005-03-30 2008-08-28 コンフォーマ・セラピューティクス・コーポレイション Ｈｓｐ９０阻害剤としてのアルキニルピロロピリミジンおよび関連類似体
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JP2009513563A (ja) 2005-06-03 2009-04-02 ゼノン・ファーマシューティカルズ・インコーポレイテッド ヒトのステアロイル−ＣｏＡデサチュラーゼ阻害剤としてのアミノチアゾール誘導体
RU2485106C2 (ru) 2005-06-08 2013-06-20 Райджел Фамэсьютикэлз, Инк. Соединения, проявляющие активность в отношении jak-киназы (варианты), способ лечения заболеваний, опосредованных jak-киназой, способ ингибирования активности jak-киназы (варианты), фармацевтическая композиция на основе указанных соединений
US20070203161A1 (en) 2006-02-24 2007-08-30 Rigel Pharmaceuticals, Inc. Compositions and methods for inhibition of the jak pathway
WO2007098507A2 (en) 2006-02-24 2007-08-30 Rigel Pharmaceuticals, Inc. Compositions and methods for inhibition of the jak pathway
MX2009005009A (es) 2006-11-09 2009-09-22 Ardea Biosciences Inc Compuestos heterociclicos biciclicos 4-cianofenilamino sustituidos como inhibidores del virus de inmunodeficiencia humana.
EP2121613A2 (de) 2007-01-31 2009-11-25 Vertex Pharmaceuticals, Inc. 2-aminopyridinderivate als kinaseinhibitoren
EP2217577B1 (de) 2007-11-27 2014-08-06 Ardea Biosciences, Inc. Neue verbindungen und zusammensetzungen sowie ihre verwendung
CA2709176C (en) 2007-12-14 2013-02-05 Ardea Biosciences, Inc. Reverse transcriptase inhibitors
US8569337B2 (en) 2008-07-23 2013-10-29 Vertex Pharmaceuticals Incorporated Tri-cyclic pyrazolopyridine kinase inhibitors
JP5631310B2 (ja) 2008-07-23 2014-11-26 バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ 三環式ピラゾロピリジンキナーゼ阻害剤
JP2011529062A (ja) 2008-07-23 2011-12-01 バーテックス ファーマシューティカルズ インコーポレイテッド ピラゾロピリジンキナーゼ阻害剤
JP2011530527A (ja) 2008-08-06 2011-12-22 バーテックス ファーマシューティカルズ インコーポレイテッド アミノピリジンキナーゼ阻害剤
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EP2528917B1 (de) 2010-01-27 2016-10-19 Vertex Pharmaceuticals Incorporated Zur behandlung von autoimmun-, entzündlichen oder (hyper)proliferativen erkrankungen geeignete pyrazolopyridine
AU2011209649A1 (en) 2010-01-27 2012-08-09 Vertex Pharmaceuticals Incorporated Pyrazolopyrazine kinase inhibitors
AU2011209651A1 (en) 2010-01-27 2012-08-09 Vertex Pharmaceuticals Incorporated Pyrazolopyrimidine kinase inhibitors
US20140018379A1 (en) 2010-02-18 2014-01-16 Concert Pharmaceuticals Inc. Pyrimidine derivatives
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FR2962438B1 (fr) 2010-07-06 2012-08-17 Sanofi Aventis Derives d'indolizines, procedes de preparation et application en therapeutique
CN103570688B (zh) * 2012-07-19 2016-06-08 中国科学院上海药物研究所 2，5-二氨甲基吡嗪类化合物、其药物组合物、制备方法和用途
US10016439B2 (en) 2014-01-31 2018-07-10 Ono Pharmaceutical Co., Ltd. Fused imidazole compounds
EP4053097A1 (de) 2014-12-18 2022-09-07 Corteva Agriscience LLC Keton verbindung als herbizid
EP3528816A4 (de) * 2016-10-21 2020-04-08 Nimbus Lakshmi, Inc. Tyk2-inhibitoren und verwendungen davon
WO2020084142A1 (en) * 2018-10-25 2020-04-30 Minakem Process for the preparation of rilpivirine
CN110526873B (zh) * 2019-08-15 2022-09-16 复旦大学 氰乙烯基取代的苯并二芳基嘧啶类化合物及其制备方法和用途
CN114805369B (zh) * 2022-05-30 2023-05-16 自贡市第四人民医院(自贡市急救中心) 一种2，6-二取代嘌呤类化合物及制备方法及应用

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Also Published As

Publication number Publication date
EA200600648A1 (ru) 2006-08-25
CA2535313A1 (en) 2005-03-31
MXPA06002069A (es) 2006-05-19
ZA200602440B (en) 2007-09-26
JP2012006945A (ja) 2012-01-12
ES2361835T3 (es) 2011-06-22
AU2004274185A1 (en) 2005-03-31
CN1856496A (zh) 2006-11-01
EA009734B1 (ru) 2008-02-28
JP5506751B2 (ja) 2014-05-28
WO2005028479A2 (en) 2005-03-31
JP4825672B2 (ja) 2011-11-30
CA2535313C (en) 2012-07-17
EP1668011A2 (de) 2006-06-14
ATE500254T1 (de) 2011-03-15
WO2005028479A3 (en) 2005-06-16
CN100475815C (zh) 2009-04-08
AU2004274185B2 (en) 2009-12-10
US8026245B2 (en) 2011-09-27
JP2007506707A (ja) 2007-03-22
IL174467A0 (en) 2006-08-01
KR20060121878A (ko) 2006-11-29
NO20061788L (no) 2006-04-24
BRPI0414791A (pt) 2006-11-21
US20060293330A1 (en) 2006-12-28
AP2006003517A0 (en) 2006-02-28
EP1668011B1 (de) 2011-03-02
TW200518758A (en) 2005-06-16

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