SI2658846T1 - Polimorfne oblike 2-(5-bromo-4-(4-ciklopropilnaftalen-1-il)-4H-1,2,4-triazol-3-iltio) ocetne kisline in njihove uporabe - Google Patents
Polimorfne oblike 2-(5-bromo-4-(4-ciklopropilnaftalen-1-il)-4H-1,2,4-triazol-3-iltio) ocetne kisline in njihove uporabeInfo
- Publication number
- SI2658846T1 SI2658846T1 SI201131098A SI201131098A SI2658846T1 SI 2658846 T1 SI2658846 T1 SI 2658846T1 SI 201131098 A SI201131098 A SI 201131098A SI 201131098 A SI201131098 A SI 201131098A SI 2658846 T1 SI2658846 T1 SI 2658846T1
- Authority
- SI
- Slovenia
- Prior art keywords
- cyclopropylnaphthalen
- ylthio
- triazol
- bromo
- acetic acid
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D249/12—Oxygen or sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4196—1,2,4-Triazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/426—1,3-Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
- A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
- C07D249/06—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles with aryl radicals directly attached to ring atoms
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201061428660P | 2010-12-30 | 2010-12-30 | |
PCT/US2011/067657 WO2012092395A2 (en) | 2010-12-30 | 2011-12-28 | Polymorphic forms of 2-(5-bromo-4-(4-cyclopropylnaphthalen-1-yl)-4h-1,2,4-triazol-3-ylthio) acetic acid and uses thereof |
EP11853861.0A EP2658846B1 (en) | 2010-12-30 | 2011-12-28 | Polymorphic forms of 2-(5-bromo-4-(4-cyclopropylnaphthalen-1-yl)-4h-1,2,4-triazol-3-ylthio) acetic acid and uses thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
SI2658846T1 true SI2658846T1 (sl) | 2017-03-31 |
Family
ID=46381300
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SI201131098A SI2658846T1 (sl) | 2010-12-30 | 2011-12-28 | Polimorfne oblike 2-(5-bromo-4-(4-ciklopropilnaftalen-1-il)-4H-1,2,4-triazol-3-iltio) ocetne kisline in njihove uporabe |
Country Status (29)
Country | Link |
---|---|
US (6) | US8546436B2 (sl) |
EP (1) | EP2658846B1 (sl) |
JP (2) | JP5781627B2 (sl) |
KR (1) | KR101541629B1 (sl) |
CN (1) | CN103298796B (sl) |
AR (1) | AR084639A1 (sl) |
AU (1) | AU2011352129B2 (sl) |
BR (1) | BR112013016982A2 (sl) |
CA (1) | CA2817249C (sl) |
CY (1) | CY1118621T1 (sl) |
DK (1) | DK2658846T3 (sl) |
EA (1) | EA022301B1 (sl) |
ES (1) | ES2614914T3 (sl) |
HR (1) | HRP20170187T1 (sl) |
HU (1) | HUE031766T2 (sl) |
IL (1) | IL226367A (sl) |
LT (1) | LT2658846T (sl) |
MX (1) | MX2013007505A (sl) |
MY (1) | MY172534A (sl) |
NZ (1) | NZ610104A (sl) |
PL (1) | PL2658846T3 (sl) |
PT (1) | PT2658846T (sl) |
RS (1) | RS55667B1 (sl) |
SG (1) | SG190902A1 (sl) |
SI (1) | SI2658846T1 (sl) |
TW (1) | TWI452037B (sl) |
UA (1) | UA109172C2 (sl) |
WO (1) | WO2012092395A2 (sl) |
ZA (1) | ZA201303253B (sl) |
Families Citing this family (38)
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EA020183B1 (ru) | 2010-01-08 | 2014-09-30 | Ардеа Биосайнсиз, Инк. | Полиморфная, кристаллическая и мезофазная формы 2-(5-бром-4-(4-циклопропилнафталинил-1-ил)-4н-1,2,4-триазол-3-илтио)ацетата натрия и их применение |
EP2560642A4 (en) | 2010-03-30 | 2013-12-18 | Ardea Biosciences Inc | TREATMENT OF GICHT |
SI2582683T1 (sl) * | 2010-06-15 | 2018-07-31 | Ardea Biosciences, Inc. | Zdravljenje protina in hiperurikemije |
AU2011352129B2 (en) | 2010-12-30 | 2015-01-22 | Ardea Biosciences, Inc. | Polymorphic forms of 2-(5-bromo-4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazol-3-ylthio)acetic acid and uses thereof |
AR091651A1 (es) * | 2012-07-03 | 2015-02-18 | Ardea Biosciences Inc | Elaboracion de acido 2-(5-bromo-4-(4-ciclopropilnaftalen-1-il)-4h-1,2,4-triazol-3-iltio)acetico |
JP6026914B2 (ja) | 2013-02-12 | 2016-11-16 | ルネサスエレクトロニクス株式会社 | 半導体装置の製造方法 |
CN104447589B (zh) * | 2013-11-20 | 2017-01-11 | 广东东阳光药业有限公司 | 一种尿酸调节剂的制备方法及其中间体 |
CN103588716A (zh) * | 2013-11-22 | 2014-02-19 | 苏州晶云药物科技有限公司 | 2-(5-溴-4-(4-环丙基萘-1-基)-4h-1,2,4-三唑-3-基硫基)乙酸的新晶型及其制备方法 |
CN103613552A (zh) * | 2013-12-02 | 2014-03-05 | 苏州晶云药物科技有限公司 | 2-(5-溴-4-(4-环丙基萘-1-基)-4h-1,2,4-三唑-3-基硫基)乙酸钠的新晶型及其制备方法 |
WO2015075561A2 (en) * | 2013-11-22 | 2015-05-28 | Crystal Pharmatech Co., Ltd. | Crystalline forms of lesinurad and its sodium salt |
CN103755651A (zh) * | 2013-12-23 | 2014-04-30 | 苏州晶云药物科技有限公司 | 2-(5-溴-4-(4-环丙基萘-1-基)-4h-1,2,4-三唑-3-基硫基)乙酸的盐的新晶型及其制备方法 |
US9969701B2 (en) | 2013-12-20 | 2018-05-15 | Crystal Pharmatech Co., Ltd. | Salts and co-crystals of lesinurad |
CN103626710A (zh) * | 2013-12-20 | 2014-03-12 | 苏州晶云药物科技有限公司 | 2-(5-溴-4-(4-环丙基萘-1-基)-4h-1,2,4-三唑-3-基硫基)乙酸的共晶及其制备方法 |
CN104557748A (zh) * | 2014-01-25 | 2015-04-29 | 广东东阳光药业有限公司 | 硫代-1,2,4-三唑衍生物的新的固体形态 |
CN105622531A (zh) | 2015-04-03 | 2016-06-01 | 南京明德新药研发股份有限公司 | 轴手性异构体及其制备方法和制药用途 |
WO2016203436A1 (en) * | 2015-06-19 | 2016-12-22 | Dr. Reddy's Laboratories Limited | Amorphous and amorphous solid dispersion of lesinurad and their preparation |
EP3112334A1 (en) | 2015-06-29 | 2017-01-04 | DPx Fine Chemicals Austria GmbH & CoKG | Process for manufacturing 1-cyclopropyl-naphthalenes |
CN105017169A (zh) * | 2015-06-30 | 2015-11-04 | 安徽万邦医药科技有限公司 | 一种4-(4-环丙基萘-1-基)-5-硫代-[1,2,4]三唑烷-3-酮的制备方法及其中间体(4-环丙基萘-1-基)-氨基甲酸乙酯 |
WO2017036884A1 (en) | 2015-08-28 | 2017-03-09 | Sandoz Ag | A lesinurad, free form / lesinurad ethyl ester co-crystal |
CN107176930B (zh) * | 2016-03-11 | 2020-12-01 | 广东赛烽医药科技有限公司 | 2-[5-溴-4-(4-氟代环丙基萘-1-基)-4h-1,2,4-三唑-3-基硫基]乙酸化合物及其应用 |
CN107266377A (zh) * | 2016-04-08 | 2017-10-20 | 浙江京新药业股份有限公司 | 一种urat1抑制剂的轴手性对映体的多晶型 |
CN107298660A (zh) * | 2016-04-15 | 2017-10-27 | 浙江京新药业股份有限公司 | 2-(5-溴-4-(4-环丙基萘-1-基)-4h-1,2,4-三唑-3-基硫基)乙酸轴手性对映体的晶型iii |
CN107298657A (zh) * | 2016-04-15 | 2017-10-27 | 浙江京新药业股份有限公司 | 2-(5-溴-4-(4-环丙基萘-1-基)-4h-1,2,4-三唑-3-基硫基)乙酸轴手性对映体的晶型ii |
CN107298659A (zh) * | 2016-04-15 | 2017-10-27 | 浙江京新药业股份有限公司 | 2-(5-溴-4-(4-环丙基萘-1-基)-4h-1,2,4-三唑-3-基硫基)乙酸轴手性对映体的晶型iv |
CN107298658A (zh) * | 2016-04-15 | 2017-10-27 | 浙江京新药业股份有限公司 | 2-(5-溴-4-(4-环丙基萘-1-基)-4h-1,2,4-三唑-3-基硫基)乙酸轴手性对映体的晶型v |
CN107337649B (zh) * | 2016-04-29 | 2020-10-16 | 四川科伦药物研究院有限公司 | 一种乙酸钠水合物无定型及其制备方法和用途 |
CN109562109A (zh) | 2016-07-29 | 2019-04-02 | 东丽株式会社 | 光稳定性提高的固体制剂 |
EP3281941B1 (en) | 2016-08-11 | 2019-07-24 | Zentiva K.S. | Process for preparing 2-(5-bromo-4-(1-cyclopropylnaphthalen-4-yl)-4h-1,2,4-triazol-3-ylthio)acetic acid |
WO2018085932A1 (en) * | 2016-11-10 | 2018-05-17 | Apotex Inc. | Novel crystalline forms of lesinurad |
CN106905250A (zh) * | 2017-03-07 | 2017-06-30 | 江苏艾立康药业股份有限公司 | 一种雷西纳德的新晶型 |
EP3372592A1 (en) | 2017-03-07 | 2018-09-12 | Zentiva, k.s. | Solid forms of lesinurad amine salts |
EP3315494A1 (en) | 2017-04-19 | 2018-05-02 | Química Sintética, S.A. | Amorphous form of lesinurad and processes for its preparation |
WO2018211532A1 (en) * | 2017-05-18 | 2018-11-22 | Msn Laboratories Private Limited, R&D Center | Novel solid state forms of 2-((5-bromo-4-(4-cyclopropylnaphthalen-1-yl)-4h-1,2,4-triazol-3-yl)thio)acetic acid and its process for preparation thereof |
WO2019001325A1 (zh) * | 2017-06-28 | 2019-01-03 | 苏州科睿思制药有限公司 | 雷西纳得的晶型xv及其制备方法 |
EP3498697A1 (en) | 2017-12-12 | 2019-06-19 | Química Sintética, S.A. | Novel salts and polymorphs of lesinurad |
CN111527073B (zh) * | 2017-12-15 | 2022-03-15 | 南京明德新药研发有限公司 | 一种4-(萘-1-基)-4h-1,2,4-三唑类类化合物的晶型、盐型及其制备方法 |
CN109970667A (zh) * | 2017-12-27 | 2019-07-05 | 徐州万邦金桥制药有限公司 | 一种雷西纳德的精制方法 |
CN111153862B (zh) * | 2020-01-19 | 2021-07-06 | 北京鑫开元医药科技有限公司海南分公司 | 一种雷西纳德的精制方法 |
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JP2004123642A (ja) | 2002-10-04 | 2004-04-22 | Shimizu Pharmaceutical Co Ltd | 電解質組成物 |
US20050100637A1 (en) | 2003-11-12 | 2005-05-12 | Robert Murray | Carbohydrate and electrolyte replacement composition |
WO2007050087A1 (en) | 2004-08-25 | 2007-05-03 | Ardea Biosciences, Inc. | N[S(4-aryl-triazol-3-yl)α -mercaptoacetyl]-p-amino benozoic acids AS HIV REVERSE TRANSCRIPTASE INHIBITORS |
JP4952943B2 (ja) | 2004-08-25 | 2012-06-13 | アーディア・バイオサイエンシーズ・インコーポレイテッド | HIV逆転写酵素のインヒビターとしてのS−トリアゾリルα−メルカプトアセトアニリド |
KR101291643B1 (ko) | 2007-11-27 | 2013-08-01 | 아디아 바이오사이언스즈 인크. | 신규한 화합물 및 조성물과 사용 방법 |
US8173690B2 (en) * | 2008-09-04 | 2012-05-08 | Ardea Biosciences, Inc. | Compounds, compositions and methods of using same for modulating uric acid levels |
EA023500B1 (ru) * | 2008-09-04 | 2016-06-30 | Ардеа Биосайнсиз, Инк. | Соединения, композиции и способы их применения для коррекции уровня мочевой кислоты |
US8242154B2 (en) | 2008-09-04 | 2012-08-14 | Ardea Biosciences, Inc. | Compounds, compositions and methods of using same for modulating uric acid levels |
EA020183B1 (ru) | 2010-01-08 | 2014-09-30 | Ардеа Биосайнсиз, Инк. | Полиморфная, кристаллическая и мезофазная формы 2-(5-бром-4-(4-циклопропилнафталинил-1-ил)-4н-1,2,4-триазол-3-илтио)ацетата натрия и их применение |
AU2011352129B2 (en) | 2010-12-30 | 2015-01-22 | Ardea Biosciences, Inc. | Polymorphic forms of 2-(5-bromo-4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazol-3-ylthio)acetic acid and uses thereof |
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2011
- 2011-12-28 AU AU2011352129A patent/AU2011352129B2/en not_active Ceased
- 2011-12-28 CA CA2817249A patent/CA2817249C/en not_active Expired - Fee Related
- 2011-12-28 UA UAA201309551A patent/UA109172C2/uk unknown
- 2011-12-28 KR KR1020137019939A patent/KR101541629B1/ko active IP Right Grant
- 2011-12-28 RS RS20170125A patent/RS55667B1/sr unknown
- 2011-12-28 DK DK11853861.0T patent/DK2658846T3/en active
- 2011-12-28 SI SI201131098A patent/SI2658846T1/sl unknown
- 2011-12-28 NZ NZ610104A patent/NZ610104A/en not_active IP Right Cessation
- 2011-12-28 WO PCT/US2011/067657 patent/WO2012092395A2/en active Application Filing
- 2011-12-28 PL PL11853861T patent/PL2658846T3/pl unknown
- 2011-12-28 PT PT118538610T patent/PT2658846T/pt unknown
- 2011-12-28 MX MX2013007505A patent/MX2013007505A/es active IP Right Grant
- 2011-12-28 ES ES11853861.0T patent/ES2614914T3/es active Active
- 2011-12-28 US US13/339,283 patent/US8546436B2/en active Active
- 2011-12-28 CN CN201180063328.2A patent/CN103298796B/zh not_active Expired - Fee Related
- 2011-12-28 EA EA201370150A patent/EA022301B1/ru not_active IP Right Cessation
- 2011-12-28 EP EP11853861.0A patent/EP2658846B1/en active Active
- 2011-12-28 LT LTEP11853861.0T patent/LT2658846T/lt unknown
- 2011-12-28 JP JP2013547653A patent/JP5781627B2/ja not_active Expired - Fee Related
- 2011-12-28 AR ARP110104990 patent/AR084639A1/es unknown
- 2011-12-28 HU HUE11853861A patent/HUE031766T2/en unknown
- 2011-12-28 MY MYPI2013001959A patent/MY172534A/en unknown
- 2011-12-28 SG SG2013040894A patent/SG190902A1/en unknown
- 2011-12-28 BR BR112013016982A patent/BR112013016982A2/pt not_active IP Right Cessation
- 2011-12-30 TW TW100149991A patent/TWI452037B/zh not_active IP Right Cessation
-
2013
- 2013-05-06 ZA ZA2013/03253A patent/ZA201303253B/en unknown
- 2013-05-16 IL IL226367A patent/IL226367A/en active IP Right Grant
- 2013-08-14 US US13/967,255 patent/US20130331403A1/en not_active Abandoned
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2014
- 2014-12-19 US US14/577,129 patent/US20150105410A1/en not_active Abandoned
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2015
- 2015-04-23 JP JP2015088794A patent/JP2015172053A/ja active Pending
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2016
- 2016-05-09 US US15/150,053 patent/US9956205B2/en active Active
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2017
- 2017-02-03 HR HRP20170187TT patent/HRP20170187T1/hr unknown
- 2017-02-08 CY CY20171100177T patent/CY1118621T1/el unknown
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2018
- 2018-04-20 US US15/958,333 patent/US20180235939A1/en not_active Abandoned
- 2018-12-13 US US16/218,856 patent/US20190111028A1/en not_active Abandoned
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