BR112013016982A2 - formas polimórficas de ácido 2-(5-bromo-4-(4-ciclopropilnaftalen-1-il)-4h-1,2,4-triazol-3-iltio)acético e usos destes - Google Patents

formas polimórficas de ácido 2-(5-bromo-4-(4-ciclopropilnaftalen-1-il)-4h-1,2,4-triazol-3-iltio)acético e usos destes

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Publication number
BR112013016982A2
BR112013016982A2 BR112013016982A BR112013016982A BR112013016982A2 BR 112013016982 A2 BR112013016982 A2 BR 112013016982A2 BR 112013016982 A BR112013016982 A BR 112013016982A BR 112013016982 A BR112013016982 A BR 112013016982A BR 112013016982 A2 BR112013016982 A2 BR 112013016982A2
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Prior art keywords
cyclopropylnaphthalen
ylthio
triazol
bromo
acetic acid
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BR112013016982A
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English (en)
Inventor
Gabriel Galvin
Irina Zamansky
Jean-Luc Girardet
Laszlo R Treiber
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Ardea Biosciences Inc
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Application filed by Ardea Biosciences Inc filed Critical Ardea Biosciences Inc
Publication of BR112013016982A2 publication Critical patent/BR112013016982A2/pt

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/426—1,3-Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
    • C07D249/06—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles with aryl radicals directly attached to ring atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D249/12—Oxygen or sulfur atoms

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
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  • Engineering & Computer Science (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

formas polimórficas de ácido 2-(5-bromo-4-(4-ciclopropilnaftalen-1-il)-4h-1,2,4-triazol-3-iltio)acético e usos destes são descritas formas polimórficas cristalinas de ácido 2-(5-bromo-4-(4-ciclopropilnaftalen-1-il)-4h-1,2,4-triazol-3-iltio) acético. também são apresentadas composições farmacêuticas e os usos desses compostos, formas do composto e composições para o tratamento diversas doenças e condições.
BR112013016982A 2010-12-30 2011-12-28 formas polimórficas de ácido 2-(5-bromo-4-(4-ciclopropilnaftalen-1-il)-4h-1,2,4-triazol-3-iltio)acético e usos destes BR112013016982A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201061428660P 2010-12-30 2010-12-30
PCT/US2011/067657 WO2012092395A2 (en) 2010-12-30 2011-12-28 Polymorphic forms of 2-(5-bromo-4-(4-cyclopropylnaphthalen-1-yl)-4h-1,2,4-triazol-3-ylthio) acetic acid and uses thereof

Publications (1)

Publication Number Publication Date
BR112013016982A2 true BR112013016982A2 (pt) 2016-10-25

Family

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BR112013016982A BR112013016982A2 (pt) 2010-12-30 2011-12-28 formas polimórficas de ácido 2-(5-bromo-4-(4-ciclopropilnaftalen-1-il)-4h-1,2,4-triazol-3-iltio)acético e usos destes

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US (6) US8546436B2 (pt)
EP (1) EP2658846B1 (pt)
JP (2) JP5781627B2 (pt)
KR (1) KR101541629B1 (pt)
CN (1) CN103298796B (pt)
AR (1) AR084639A1 (pt)
AU (1) AU2011352129B2 (pt)
BR (1) BR112013016982A2 (pt)
CA (1) CA2817249C (pt)
CY (1) CY1118621T1 (pt)
DK (1) DK2658846T3 (pt)
EA (1) EA022301B1 (pt)
ES (1) ES2614914T3 (pt)
HR (1) HRP20170187T1 (pt)
HU (1) HUE031766T2 (pt)
IL (1) IL226367A (pt)
LT (1) LT2658846T (pt)
MX (1) MX2013007505A (pt)
MY (1) MY172534A (pt)
NZ (1) NZ610104A (pt)
PL (1) PL2658846T3 (pt)
PT (1) PT2658846T (pt)
RS (1) RS55667B1 (pt)
SG (1) SG190902A1 (pt)
SI (1) SI2658846T1 (pt)
TW (1) TWI452037B (pt)
UA (1) UA109172C2 (pt)
WO (1) WO2012092395A2 (pt)
ZA (1) ZA201303253B (pt)

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EP2658846B1 (en) 2016-12-14
WO2012092395A3 (en) 2012-09-13
US20150105410A1 (en) 2015-04-16
HUE031766T2 (en) 2017-07-28
TW201302718A (zh) 2013-01-16
EP2658846A4 (en) 2014-07-02
CA2817249A1 (en) 2012-07-05
IL226367A (en) 2015-04-30
HRP20170187T1 (hr) 2017-03-24
CN103298796B (zh) 2016-06-15
MY172534A (en) 2019-11-29
SI2658846T1 (sl) 2017-03-31
ES2614914T3 (es) 2017-06-02
EP2658846A2 (en) 2013-11-06
LT2658846T (lt) 2017-02-27
RS55667B1 (sr) 2017-06-30
CN103298796A (zh) 2013-09-11
US20160250193A1 (en) 2016-09-01
US20190111028A1 (en) 2019-04-18
UA109172C2 (xx) 2015-07-27
SG190902A1 (en) 2013-07-31
US20120172405A1 (en) 2012-07-05
PT2658846T (pt) 2017-02-07
JP2015172053A (ja) 2015-10-01
KR101541629B1 (ko) 2015-08-03
US8546436B2 (en) 2013-10-01
JP2014501282A (ja) 2014-01-20
AU2011352129A1 (en) 2013-05-02
US9956205B2 (en) 2018-05-01
CY1118621T1 (el) 2017-07-12
JP5781627B2 (ja) 2015-09-24
PL2658846T3 (pl) 2017-05-31
AU2011352129B2 (en) 2015-01-22
WO2012092395A2 (en) 2012-07-05
US20180235939A1 (en) 2018-08-23
US20130331403A1 (en) 2013-12-12
CA2817249C (en) 2015-02-10
MX2013007505A (es) 2013-08-01
ZA201303253B (en) 2016-01-27
IL226367A0 (en) 2013-07-31
TWI452037B (zh) 2014-09-11
NZ610104A (en) 2014-09-26
KR20130105902A (ko) 2013-09-26
DK2658846T3 (en) 2017-02-13
EA022301B1 (ru) 2015-12-30
EA201370150A1 (ru) 2013-11-29
AR084639A1 (es) 2013-05-29

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