BR112015023399A8 - inibidores de hdac, seu uso e composição farmacêutica - Google Patents
inibidores de hdac, seu uso e composição farmacêutica Download PDFInfo
- Publication number
- BR112015023399A8 BR112015023399A8 BR112015023399A BR112015023399A BR112015023399A8 BR 112015023399 A8 BR112015023399 A8 BR 112015023399A8 BR 112015023399 A BR112015023399 A BR 112015023399A BR 112015023399 A BR112015023399 A BR 112015023399A BR 112015023399 A8 BR112015023399 A8 BR 112015023399A8
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- BR
- Brazil
- Prior art keywords
- pharmaceutical composition
- hdac inhibitors
- hdac
- compounds
- formula
- Prior art date
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- 239000003276 histone deacetylase inhibitor Substances 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 101150041489 HDAC3 gene Proteins 0.000 abstract 1
- 108090000353 Histone deacetylase Proteins 0.000 abstract 1
- 102000003964 Histone deacetylase Human genes 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
- C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Rheumatology (AREA)
- Virology (AREA)
- Hospice & Palliative Care (AREA)
- Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
"inibidores de hdac". são revelados aqui compostos de fórmula (i), (i). e métodos para inibir as enzimas histona desacetilase ("hdac") (por exemplo, hdac1, hdac2, e hdac3) usando os compostos de formula (i).
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361800170P | 2013-03-15 | 2013-03-15 | |
US201361863235P | 2013-08-07 | 2013-08-07 | |
PCT/US2014/027633 WO2014143666A1 (en) | 2013-03-15 | 2014-03-14 | Hdac inhibitors |
Publications (2)
Publication Number | Publication Date |
---|---|
BR112015023399A2 BR112015023399A2 (pt) | 2017-07-18 |
BR112015023399A8 true BR112015023399A8 (pt) | 2019-12-03 |
Family
ID=50680153
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112015023399A BR112015023399A8 (pt) | 2013-03-15 | 2014-03-14 | inibidores de hdac, seu uso e composição farmacêutica |
Country Status (18)
Country | Link |
---|---|
US (3) | US10029988B2 (pt) |
EP (1) | EP2970139B1 (pt) |
JP (1) | JP6503338B2 (pt) |
KR (1) | KR20150132345A (pt) |
CN (1) | CN105121415B (pt) |
AU (1) | AU2014228344C1 (pt) |
BR (1) | BR112015023399A8 (pt) |
CA (1) | CA2903490C (pt) |
DK (1) | DK2970139T3 (pt) |
ES (1) | ES2680224T3 (pt) |
HK (1) | HK1217702A1 (pt) |
IL (1) | IL240937B (pt) |
MX (1) | MX370142B (pt) |
NZ (1) | NZ711585A (pt) |
PT (1) | PT2970139T (pt) |
RU (1) | RU2665554C2 (pt) |
WO (1) | WO2014143666A1 (pt) |
ZA (1) | ZA201506516B (pt) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
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CN104876872B (zh) * | 2015-04-24 | 2017-07-07 | 昆明理工大学 | 一种制备1‑叔丁氧基羰基‑3‑羟甲基吲唑的方法及应用 |
US20170240535A1 (en) * | 2016-02-01 | 2017-08-24 | Regenacy Pharmaceuticals, Llc | Hdac1/2 inhibitors for the treatment of neurodegenerative and/or cognitive disorders |
CN114585609B (zh) * | 2019-06-27 | 2024-07-30 | 比奥根Ma公司 | 2h-吲唑衍生物及其在疾病治疗中的用途 |
KR102507397B1 (ko) | 2020-09-10 | 2023-03-07 | 계명대학교 산학협력단 | 히스톤 탈아세틸화효소 억제 활성을 갖는 신규 화합물 및 이의 용도 |
US11866405B2 (en) | 2020-12-10 | 2024-01-09 | Astrazeneca Ab | Substituted indazoles as IRAK4 inhibitors |
WO2023034440A1 (en) | 2021-09-01 | 2023-03-09 | Case Western Reserve University | Treatment of neurodegenerative diseases with hdac inhibitors |
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- 2014-03-14 KR KR1020157028913A patent/KR20150132345A/ko not_active Application Discontinuation
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DK2970139T3 (en) | 2018-08-13 |
US10029988B2 (en) | 2018-07-24 |
PT2970139T (pt) | 2018-08-01 |
AU2014228344C1 (en) | 2019-02-07 |
MX2015012615A (es) | 2016-05-31 |
JP2016516716A (ja) | 2016-06-09 |
US20180362472A1 (en) | 2018-12-20 |
CN105121415B (zh) | 2018-10-12 |
CA2903490A1 (en) | 2014-09-18 |
AU2014228344A1 (en) | 2015-09-17 |
RU2665554C2 (ru) | 2018-08-31 |
US20190382351A1 (en) | 2019-12-19 |
MX370142B (es) | 2019-12-03 |
CA2903490C (en) | 2021-04-13 |
EP2970139B1 (en) | 2018-05-30 |
IL240937B (en) | 2019-05-30 |
AU2014228344B2 (en) | 2018-08-09 |
RU2015143841A (ru) | 2017-05-05 |
NZ711585A (en) | 2020-05-29 |
KR20150132345A (ko) | 2015-11-25 |
IL240937A0 (en) | 2015-11-30 |
BR112015023399A2 (pt) | 2017-07-18 |
WO2014143666A1 (en) | 2014-09-18 |
ZA201506516B (en) | 2016-06-29 |
US20160031823A1 (en) | 2016-02-04 |
US10428028B2 (en) | 2019-10-01 |
RU2015143841A3 (pt) | 2018-03-01 |
JP6503338B2 (ja) | 2019-04-17 |
CN105121415A (zh) | 2015-12-02 |
HK1217702A1 (zh) | 2017-01-20 |
EP2970139A1 (en) | 2016-01-20 |
ES2680224T3 (es) | 2018-09-05 |
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