DK3725781T3 - Krystal og salt af 4-(naphthalen-1-yl)-4H-1,2,4-triazol-forbindelse og fremgangsmåde til fremstilling deraf - Google Patents
Krystal og salt af 4-(naphthalen-1-yl)-4H-1,2,4-triazol-forbindelse og fremgangsmåde til fremstilling deraf Download PDFInfo
- Publication number
- DK3725781T3 DK3725781T3 DK18888224.5T DK18888224T DK3725781T3 DK 3725781 T3 DK3725781 T3 DK 3725781T3 DK 18888224 T DK18888224 T DK 18888224T DK 3725781 T3 DK3725781 T3 DK 3725781T3
- Authority
- DK
- Denmark
- Prior art keywords
- naphthalen
- salt
- crystal
- preparation
- triazole compound
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D249/12—Oxygen or sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4196—1,2,4-Triazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711352291 | 2017-12-15 | ||
| CN201711376759 | 2017-12-19 | ||
| PCT/CN2018/121477 WO2019114838A1 (zh) | 2017-12-15 | 2018-12-17 | 一种4-(萘-1-基)-4h-1,2,4-三唑类类化合物的晶型、盐型及其制备方法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3725781T3 true DK3725781T3 (da) | 2022-12-19 |
Family
ID=66819954
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK18888224.5T DK3725781T3 (da) | 2017-12-15 | 2018-12-17 | Krystal og salt af 4-(naphthalen-1-yl)-4H-1,2,4-triazol-forbindelse og fremgangsmåde til fremstilling deraf |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US11352331B2 (da) |
| EP (1) | EP3725781B1 (da) |
| JP (1) | JP7282780B2 (da) |
| CN (1) | CN111527073B (da) |
| DK (1) | DK3725781T3 (da) |
| ES (1) | ES2934533T3 (da) |
| WO (1) | WO2019114838A1 (da) |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR069753A1 (es) * | 2007-11-27 | 2010-02-17 | Ardea Biosciences Inc | Compuestos de 1,2,4-triazol y composiciones, utiles en la modulacion de los niveles de acido urico sanguineo |
| DK2658846T3 (da) * | 2010-12-30 | 2017-02-13 | Ardea Biosciences Inc | Polymorfe former af 2-(5-brom-4-(4-cyclopropylnaphthalen-1-yl)-4h-1,2,4-triazol-3-ylthio)-eddikesyre og anvendelser deraf |
| CA2931430A1 (en) * | 2013-11-22 | 2015-05-28 | Crystal Pharmatech Co., Ltd. | Crystalline forms of lesinurad and its sodium salt |
| CN105294585B (zh) * | 2014-07-02 | 2019-02-12 | 成都海创药业有限公司 | 一种治疗痛风的化合物 |
| CN109053608A (zh) * | 2015-02-17 | 2018-12-21 | 华润赛科药业有限责任公司 | 一种旋光纯的硫代乙酸类化合物、其药物组合物和用途 |
| CN105622531A (zh) * | 2015-04-03 | 2016-06-01 | 南京明德新药研发股份有限公司 | 轴手性异构体及其制备方法和制药用途 |
| WO2017215589A1 (zh) * | 2016-06-17 | 2017-12-21 | 南京明德新药研发股份有限公司 | 一种卤代化合物及其轴手性异构体 |
| CN106220577A (zh) * | 2016-07-26 | 2016-12-14 | 苏州明锐医药科技有限公司 | 利新洛德的制备方法 |
-
2018
- 2018-12-17 JP JP2020532957A patent/JP7282780B2/ja active Active
- 2018-12-17 CN CN201880076729.3A patent/CN111527073B/zh active Active
- 2018-12-17 US US16/772,300 patent/US11352331B2/en active Active
- 2018-12-17 EP EP18888224.5A patent/EP3725781B1/en active Active
- 2018-12-17 ES ES18888224T patent/ES2934533T3/es active Active
- 2018-12-17 DK DK18888224.5T patent/DK3725781T3/da active
- 2018-12-17 WO PCT/CN2018/121477 patent/WO2019114838A1/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP7282780B2 (ja) | 2023-05-29 |
| EP3725781A4 (en) | 2021-08-04 |
| KR20200111173A (ko) | 2020-09-28 |
| CN111527073B (zh) | 2022-03-15 |
| WO2019114838A1 (zh) | 2019-06-20 |
| ES2934533T3 (es) | 2023-02-22 |
| US20210078960A1 (en) | 2021-03-18 |
| JP2021506826A (ja) | 2021-02-22 |
| EP3725781B1 (en) | 2022-11-30 |
| EP3725781A1 (en) | 2020-10-21 |
| US11352331B2 (en) | 2022-06-07 |
| CN111527073A (zh) | 2020-08-11 |
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