DK3255046T3 - Hydroxyethylsulfonat af cyclin-afhængig proteinkinasehæmmer, krystallinsk form deraf og fremgangsmåde til fremstilling deraf - Google Patents
Hydroxyethylsulfonat af cyclin-afhængig proteinkinasehæmmer, krystallinsk form deraf og fremgangsmåde til fremstilling deraf Download PDFInfo
- Publication number
- DK3255046T3 DK3255046T3 DK16746062.5T DK16746062T DK3255046T3 DK 3255046 T3 DK3255046 T3 DK 3255046T3 DK 16746062 T DK16746062 T DK 16746062T DK 3255046 T3 DK3255046 T3 DK 3255046T3
- Authority
- DK
- Denmark
- Prior art keywords
- cyclin
- preparing
- procedure
- crystallinic
- dependent
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/01—Sulfonic acids
- C07C309/02—Sulfonic acids having sulfo groups bound to acyclic carbon atoms
- C07C309/03—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C309/04—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing only one sulfo group
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510056995 | 2015-02-03 | ||
| PCT/CN2016/070636 WO2016124067A1 (zh) | 2015-02-03 | 2016-01-12 | 一种周期素依赖性蛋白激酶抑制剂的羟乙基磺酸盐、其结晶形式及制备方法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3255046T3 true DK3255046T3 (da) | 2020-01-20 |
Family
ID=56563428
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK16746062.5T DK3255046T3 (da) | 2015-02-03 | 2016-01-12 | Hydroxyethylsulfonat af cyclin-afhængig proteinkinasehæmmer, krystallinsk form deraf og fremgangsmåde til fremstilling deraf |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US10030018B2 (da) |
| EP (1) | EP3255046B1 (da) |
| JP (1) | JP6920993B2 (da) |
| CN (1) | CN106661025B (da) |
| AU (1) | AU2016214897B9 (da) |
| CA (1) | CA2974021A1 (da) |
| CY (1) | CY1122514T1 (da) |
| DK (1) | DK3255046T3 (da) |
| ES (1) | ES2764139T3 (da) |
| HR (1) | HRP20192286T1 (da) |
| HU (1) | HUE047626T2 (da) |
| LT (1) | LT3255046T (da) |
| MX (1) | MX2017009270A (da) |
| PL (1) | PL3255046T3 (da) |
| PT (1) | PT3255046T (da) |
| RS (1) | RS59782B1 (da) |
| SI (1) | SI3255046T1 (da) |
| TW (1) | TWI706951B (da) |
| WO (1) | WO2016124067A1 (da) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10449195B2 (en) | 2016-03-29 | 2019-10-22 | Shenzhen Pharmacin Co., Ltd. | Pharmaceutical formulation of palbociclib and a preparation method thereof |
| CN109384767B (zh) * | 2017-08-08 | 2020-05-05 | 江苏恒瑞医药股份有限公司 | 一种吡啶并嘧啶类衍生物的制备方法及其中间体 |
| MX2020012540A (es) | 2018-05-23 | 2021-02-16 | Jiangsu Hengrui Medicine Co | Uso de inhibidor de cdk4/6 en combinacion con inhibidor del egfr en la preparacion de medicamento para tratar enfermedades tumorales. |
| CN110790748B (zh) * | 2018-08-02 | 2022-04-19 | 江苏豪森药业集团有限公司 | 细胞周期蛋白依赖性激酶抑制剂的对甲苯磺酸盐晶型及其制备方法和用途 |
| US10857146B2 (en) | 2018-08-21 | 2020-12-08 | Jiangsu Hengrui Medicine Co., Ltd. | Method for preventing or treating tumor diseases with a combination of tyrosine kinase inhibitor and CDK4/6 inhibitor |
| AU2020214930A1 (en) | 2019-01-30 | 2021-09-16 | Jiangsu Hengrui Medicine Co., Ltd. | Use of composition containing CDK4/6 inhibitor in combination with anastrozole in preparation of medicament for treating tumor diseases |
| WO2021063332A1 (zh) * | 2019-09-30 | 2021-04-08 | 江苏恒瑞医药股份有限公司 | 一种ezh2抑制剂与cdk4/6抑制剂联合在制备治疗肿瘤药物中的用途 |
| CN114306245A (zh) | 2020-09-29 | 2022-04-12 | 深圳市药欣生物科技有限公司 | 无定形固体分散体的药物组合物及其制备方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI1648889T1 (sl) * | 2003-07-11 | 2009-02-28 | Warner Lambert Co | Izetionatna sol selektivnega CDK4 inhibitorja |
| KR20090052385A (ko) * | 2006-09-08 | 2009-05-25 | 화이자 프로덕츠 인크. | 2-（피리딘-2-일아미노）-피리도［2,3-ｄ］피리미딘-7-온의합성 |
| WO2014183520A1 (zh) * | 2013-05-17 | 2014-11-20 | 上海恒瑞医药有限公司 | 吡啶并嘧啶类衍生物、其制备方法及其在医药上的应用 |
-
2016
- 2016-01-12 CA CA2974021A patent/CA2974021A1/en active Pending
- 2016-01-12 AU AU2016214897A patent/AU2016214897B9/en active Active
- 2016-01-12 LT LTEP16746062.5T patent/LT3255046T/lt unknown
- 2016-01-12 PL PL16746062T patent/PL3255046T3/pl unknown
- 2016-01-12 JP JP2017536246A patent/JP6920993B2/ja active Active
- 2016-01-12 EP EP16746062.5A patent/EP3255046B1/en active Active
- 2016-01-12 DK DK16746062.5T patent/DK3255046T3/da active
- 2016-01-12 MX MX2017009270A patent/MX2017009270A/es unknown
- 2016-01-12 HU HUE16746062A patent/HUE047626T2/hu unknown
- 2016-01-12 WO PCT/CN2016/070636 patent/WO2016124067A1/zh active Application Filing
- 2016-01-12 RS RS20191639A patent/RS59782B1/sr unknown
- 2016-01-12 PT PT167460625T patent/PT3255046T/pt unknown
- 2016-01-12 CN CN201680001816.3A patent/CN106661025B/zh active Active
- 2016-01-12 US US15/546,405 patent/US10030018B2/en active Active
- 2016-01-12 ES ES16746062T patent/ES2764139T3/es active Active
- 2016-01-12 SI SI201630568T patent/SI3255046T1/sl unknown
- 2016-01-20 TW TW105101679A patent/TWI706951B/zh active
-
2018
- 2018-04-13 US US15/952,234 patent/US10160759B2/en active Active
-
2019
- 2019-12-11 CY CY20191101295T patent/CY1122514T1/el unknown
- 2019-12-19 HR HRP20192286TT patent/HRP20192286T1/hr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN106661025A (zh) | 2017-05-10 |
| HRP20192286T1 (hr) | 2020-03-20 |
| WO2016124067A1 (zh) | 2016-08-11 |
| EP3255046A4 (en) | 2018-10-10 |
| RS59782B1 (sr) | 2020-02-28 |
| AU2016214897B9 (en) | 2020-06-04 |
| US20180230147A1 (en) | 2018-08-16 |
| JP6920993B2 (ja) | 2021-08-18 |
| LT3255046T (lt) | 2020-01-10 |
| AU2016214897B2 (en) | 2020-05-21 |
| US10160759B2 (en) | 2018-12-25 |
| AU2016214897A1 (en) | 2017-08-10 |
| HUE047626T2 (hu) | 2020-05-28 |
| US10030018B2 (en) | 2018-07-24 |
| PL3255046T3 (pl) | 2020-05-18 |
| PT3255046T (pt) | 2020-01-06 |
| EP3255046B1 (en) | 2019-11-27 |
| CA2974021A1 (en) | 2016-08-11 |
| TW201629060A (zh) | 2016-08-16 |
| CN106661025B (zh) | 2019-08-16 |
| CY1122514T1 (el) | 2021-01-27 |
| TWI706951B (zh) | 2020-10-11 |
| JP2018503634A (ja) | 2018-02-08 |
| US20180009804A1 (en) | 2018-01-11 |
| EP3255046A1 (en) | 2017-12-13 |
| SI3255046T1 (sl) | 2020-02-28 |
| ES2764139T3 (es) | 2020-06-02 |
| MX2017009270A (es) | 2017-10-11 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DK3185868T3 (da) | Hidtil ukendte ULK1-inhibitorer og fremgangsmåder til anvendelse af samme | |
| DK3317284T3 (da) | Benzoxazepin-oxazolidinonforbindelser og fremgangsmåder til anvendelse | |
| DK3286181T3 (da) | Pyrazolforbindelser og fremgangsmåde til fremstilling og anvendelse af forbindelserne | |
| DK3280441T3 (da) | Anti-sortilin-antistoffer og fremgangsmåder til anvendelse deraf | |
| DK3295951T3 (da) | Anti-pvrig-antistoffer og fremgangsmåder for anvendelse | |
| DK3212778T3 (da) | Fremgangsmåder og sammensætninger til stabilisering af trans-splejsning af intein-modificerede proteaser | |
| DK3555070T3 (da) | Aminsubstituerede, heterocykliske forbindelser som ehmt2-hæmmere og fremgangsmåder til anvendelse deraf | |
| DK3557998T3 (da) | Sammensætninger, kompositioner og anvendelsesmetoder | |
| DK3426109T3 (da) | Samling og fremgangsmåde til opskumning af fluid | |
| DK3255046T3 (da) | Hydroxyethylsulfonat af cyclin-afhængig proteinkinasehæmmer, krystallinsk form deraf og fremgangsmåde til fremstilling deraf | |
| DK3137605T3 (da) | Sammensætninger og fremgangsmåder til modulering af angiopoietin-lignende-3-ekspression | |
| DK3262008T3 (da) | Partikelformede sammensætninger til dannelse af geopolymerer, deres anvendelse og fremgangsmåder til dannelse af geopolymere dermed | |
| DK3317400T3 (da) | Fremgangsmåde til kryokonservering af tumorinfiltrerende lymfocytter | |
| DK3368663T3 (da) | Virusfri cellelinjer og fremgangsmåder til opnåelse deraf | |
| DK3177608T3 (da) | Proteinkinase-C-hæmmere og fremgangsmåder til anvendelse deraf | |
| DK3519572T3 (da) | Forbindelser og fremgangsmåder til reduktion af tau-ekspression | |
| DK3215493T3 (da) | Syntese af copanlisib og dihydrochloridsalt deraf | |
| DK3429998T3 (da) | Fremgangsmåde til fremstilling af quinolin-2-yl-phenylaminderivater og disses salte | |
| DK3178324T3 (da) | Mikrobicid og fremgangsmåde til fremstilling af samme | |
| DK3089971T3 (da) | Forbindelser og fremgangsmåder til anvendelse | |
| DK3265443T3 (da) | Pyrrolidincarboxamidderivater og fremgangsmåde til fremstilling og anvendelse af samme | |
| DK3389669T3 (da) | Triterpensaponinvarianter, syntesefremgangsmåder og anvendelse deraf | |
| DK3397748T3 (da) | Fremgangsmåde til dyrkning og konservering af Eubacterium hallii | |
| DK3256479T3 (da) | 4-substituerede benzoxaborolforbindelser og anvendelser deraf | |
| DK3347342T3 (da) | Fremgangsmåde til fremstilling af biguanidin-salte og s-triaziner |