RS59782B1 - Hidroksietil sulfonat od ciklina zavisnog inhibitora kinaze proteina, njegov kristalni oblik, i postupak za njegovo dobijanje - Google Patents
Hidroksietil sulfonat od ciklina zavisnog inhibitora kinaze proteina, njegov kristalni oblik, i postupak za njegovo dobijanjeInfo
- Publication number
- RS59782B1 RS59782B1 RS20191639A RSP20191639A RS59782B1 RS 59782 B1 RS59782 B1 RS 59782B1 RS 20191639 A RS20191639 A RS 20191639A RS P20191639 A RSP20191639 A RS P20191639A RS 59782 B1 RS59782 B1 RS 59782B1
- Authority
- RS
- Serbia
- Prior art keywords
- cyclin
- preparation
- crystalline form
- protein kinase
- kinase inhibitor
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/01—Sulfonic acids
- C07C309/02—Sulfonic acids having sulfo groups bound to acyclic carbon atoms
- C07C309/03—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C309/04—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing only one sulfo group
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510056995 | 2015-02-03 | ||
| PCT/CN2016/070636 WO2016124067A1 (zh) | 2015-02-03 | 2016-01-12 | 一种周期素依赖性蛋白激酶抑制剂的羟乙基磺酸盐、其结晶形式及制备方法 |
| EP16746062.5A EP3255046B1 (en) | 2015-02-03 | 2016-01-12 | Hydroxyethyl sulfonate of cyclin-dependent protein kinase inhibitor, crystalline form thereof and preparation method therefor |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RS59782B1 true RS59782B1 (sr) | 2020-02-28 |
Family
ID=56563428
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RS20191639A RS59782B1 (sr) | 2015-02-03 | 2016-01-12 | Hidroksietil sulfonat od ciklina zavisnog inhibitora kinaze proteina, njegov kristalni oblik, i postupak za njegovo dobijanje |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US10030018B2 (sr) |
| EP (1) | EP3255046B1 (sr) |
| JP (1) | JP6920993B2 (sr) |
| CN (1) | CN106661025B (sr) |
| AU (1) | AU2016214897B9 (sr) |
| CA (1) | CA2974021A1 (sr) |
| CY (1) | CY1122514T1 (sr) |
| DK (1) | DK3255046T3 (sr) |
| ES (1) | ES2764139T3 (sr) |
| HR (1) | HRP20192286T1 (sr) |
| HU (1) | HUE047626T2 (sr) |
| LT (1) | LT3255046T (sr) |
| MX (1) | MX2017009270A (sr) |
| PL (1) | PL3255046T3 (sr) |
| PT (1) | PT3255046T (sr) |
| RS (1) | RS59782B1 (sr) |
| SI (1) | SI3255046T1 (sr) |
| TW (1) | TWI706951B (sr) |
| WO (1) | WO2016124067A1 (sr) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10449195B2 (en) | 2016-03-29 | 2019-10-22 | Shenzhen Pharmacin Co., Ltd. | Pharmaceutical formulation of palbociclib and a preparation method thereof |
| CN109384767B (zh) * | 2017-08-08 | 2020-05-05 | 江苏恒瑞医药股份有限公司 | 一种吡啶并嘧啶类衍生物的制备方法及其中间体 |
| KR20210013155A (ko) | 2018-05-23 | 2021-02-03 | 지앙수 헨그루이 메디슨 컴퍼니 리미티드 | 종양 질환 치료용 약제의 제조에서 egfr 억제제와 조합된 cdk4/6 억제제의 용도 |
| CN110790748B (zh) * | 2018-08-02 | 2022-04-19 | 江苏豪森药业集团有限公司 | 细胞周期蛋白依赖性激酶抑制剂的对甲苯磺酸盐晶型及其制备方法和用途 |
| CN110840892A (zh) * | 2018-08-21 | 2020-02-28 | 江苏恒瑞医药股份有限公司 | 酪氨酸激酶抑制剂与cdk4/6抑制剂联合在制备预防或治疗肿瘤疾病的药物中的用途 |
| BR112021014820A2 (pt) | 2019-01-30 | 2021-09-28 | Jiangsu Hengrui Medicine Co., Ltd. | Uso da composição contendo inibidor de cdk4/6 em combinação com anastrozol na preparação de medicamento para tratar doenças tumorais |
| TW202114670A (zh) * | 2019-09-30 | 2021-04-16 | 大陸商江蘇恒瑞醫藥股份有限公司 | 一種ezh2抑制劑與cdk4/6抑制劑聯合在製備治療腫瘤藥物中的用途 |
| CN114306245A (zh) | 2020-09-29 | 2022-04-12 | 深圳市药欣生物科技有限公司 | 无定形固体分散体的药物组合物及其制备方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4053073B2 (ja) | 2003-07-11 | 2008-02-27 | ワーナー−ランバート カンパニー リミテッド ライアビリティー カンパニー | 選択的ｃｄｋ４阻害剤のイセチオン酸塩 |
| BRPI0716880A2 (pt) * | 2006-09-08 | 2013-10-15 | Pfizer Prod Inc | Síntese de 2-(piridin-2-ilamino)-pirido[2,3-d]pirimidin-7-onas |
| WO2014183520A1 (zh) * | 2013-05-17 | 2014-11-20 | 上海恒瑞医药有限公司 | 吡啶并嘧啶类衍生物、其制备方法及其在医药上的应用 |
-
2016
- 2016-01-12 RS RS20191639A patent/RS59782B1/sr unknown
- 2016-01-12 JP JP2017536246A patent/JP6920993B2/ja active Active
- 2016-01-12 MX MX2017009270A patent/MX2017009270A/es unknown
- 2016-01-12 HU HUE16746062A patent/HUE047626T2/hu unknown
- 2016-01-12 WO PCT/CN2016/070636 patent/WO2016124067A1/zh active Application Filing
- 2016-01-12 LT LTEP16746062.5T patent/LT3255046T/lt unknown
- 2016-01-12 US US15/546,405 patent/US10030018B2/en active Active
- 2016-01-12 CN CN201680001816.3A patent/CN106661025B/zh active Active
- 2016-01-12 EP EP16746062.5A patent/EP3255046B1/en active Active
- 2016-01-12 CA CA2974021A patent/CA2974021A1/en active Pending
- 2016-01-12 DK DK16746062.5T patent/DK3255046T3/da active
- 2016-01-12 ES ES16746062T patent/ES2764139T3/es active Active
- 2016-01-12 SI SI201630568T patent/SI3255046T1/sl unknown
- 2016-01-12 AU AU2016214897A patent/AU2016214897B9/en active Active
- 2016-01-12 PT PT167460625T patent/PT3255046T/pt unknown
- 2016-01-12 PL PL16746062T patent/PL3255046T3/pl unknown
- 2016-01-20 TW TW105101679A patent/TWI706951B/zh active
-
2018
- 2018-04-13 US US15/952,234 patent/US10160759B2/en active Active
-
2019
- 2019-12-11 CY CY20191101295T patent/CY1122514T1/el unknown
- 2019-12-19 HR HRP20192286TT patent/HRP20192286T1/hr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2016214897A1 (en) | 2017-08-10 |
| SI3255046T1 (sl) | 2020-02-28 |
| JP6920993B2 (ja) | 2021-08-18 |
| ES2764139T3 (es) | 2020-06-02 |
| HUE047626T2 (hu) | 2020-05-28 |
| AU2016214897B9 (en) | 2020-06-04 |
| US20180230147A1 (en) | 2018-08-16 |
| PL3255046T3 (pl) | 2020-05-18 |
| US10160759B2 (en) | 2018-12-25 |
| EP3255046A4 (en) | 2018-10-10 |
| CN106661025A (zh) | 2017-05-10 |
| EP3255046B1 (en) | 2019-11-27 |
| US20180009804A1 (en) | 2018-01-11 |
| CY1122514T1 (el) | 2021-01-27 |
| AU2016214897B2 (en) | 2020-05-21 |
| CN106661025B (zh) | 2019-08-16 |
| WO2016124067A1 (zh) | 2016-08-11 |
| EP3255046A1 (en) | 2017-12-13 |
| JP2018503634A (ja) | 2018-02-08 |
| LT3255046T (lt) | 2020-01-10 |
| HRP20192286T1 (hr) | 2020-03-20 |
| TWI706951B (zh) | 2020-10-11 |
| DK3255046T3 (da) | 2020-01-20 |
| PT3255046T (pt) | 2020-01-06 |
| CA2974021A1 (en) | 2016-08-11 |
| US10030018B2 (en) | 2018-07-24 |
| MX2017009270A (es) | 2017-10-11 |
| TW201629060A (zh) | 2016-08-16 |
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