DK3717476T3 - Fremgangsmåde til fremstilling af 2-(5-methoxyisochroman-1-yl)-4,5-dihydro-1H-imidazol og hydrogensulfatsaltet deraf - Google Patents
Fremgangsmåde til fremstilling af 2-(5-methoxyisochroman-1-yl)-4,5-dihydro-1H-imidazol og hydrogensulfatsaltet deraf Download PDFInfo
- Publication number
- DK3717476T3 DK3717476T3 DK18822414.1T DK18822414T DK3717476T3 DK 3717476 T3 DK3717476 T3 DK 3717476T3 DK 18822414 T DK18822414 T DK 18822414T DK 3717476 T3 DK3717476 T3 DK 3717476T3
- Authority
- DK
- Denmark
- Prior art keywords
- methoxyisochroman
- dihydro
- imidazole
- preparation
- hydrogen sulfate
- Prior art date
Links
- GHIKYGQWBRHEGU-UHFFFAOYSA-N 2-(5-methoxy-3,4-dihydro-1h-isochromen-1-yl)-4,5-dihydro-1h-imidazole Chemical compound O1CCC=2C(OC)=CC=CC=2C1C1=NCCN1 GHIKYGQWBRHEGU-UHFFFAOYSA-N 0.000 title 1
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical class OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/76—Benzo[c]pyrans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/10—Compounds having one or more C—Si linkages containing nitrogen having a Si-N linkage
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FI20176085 | 2017-12-01 | ||
| PCT/FI2018/050864 WO2019106238A1 (en) | 2017-12-01 | 2018-11-30 | Process for the preparation of 2-(5-methoxyisochroman-1 -yl)-4,5-dihydro-1 h-imidazole and the hydrogensulfate salt thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3717476T3 true DK3717476T3 (da) | 2022-09-05 |
Family
ID=64746580
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK18822414.1T DK3717476T3 (da) | 2017-12-01 | 2018-11-30 | Fremgangsmåde til fremstilling af 2-(5-methoxyisochroman-1-yl)-4,5-dihydro-1H-imidazol og hydrogensulfatsaltet deraf |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US11352346B2 (da) |
| EP (1) | EP3717476B1 (da) |
| JP (1) | JP7339946B2 (da) |
| KR (1) | KR20200095519A (da) |
| CN (1) | CN111630049B (da) |
| AU (1) | AU2018376872B2 (da) |
| BR (1) | BR112020010617A2 (da) |
| CA (1) | CA3083734A1 (da) |
| DK (1) | DK3717476T3 (da) |
| ES (1) | ES2927193T3 (da) |
| HR (1) | HRP20221247T1 (da) |
| HU (1) | HUE059849T2 (da) |
| IL (1) | IL274931B2 (da) |
| LT (1) | LT3717476T (da) |
| PL (1) | PL3717476T3 (da) |
| PT (1) | PT3717476T (da) |
| SI (1) | SI3717476T1 (da) |
| WO (1) | WO2019106238A1 (da) |
| ZA (1) | ZA202003981B (da) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2021020935A1 (ko) | 2019-07-31 | 2021-02-04 | 현대자동차주식회사 | 차량 내부 네트워크에 대한 sdn 기반의 침입 대응 방법 및 이를 이용한 시스템 |
| BR112023018979A2 (pt) * | 2021-03-19 | 2023-10-10 | Orion Corp | Formulações de tasipimidina e uso das mesmas |
| WO2023139313A1 (en) | 2022-01-24 | 2023-07-27 | Orion Corporation | Novel sulfate salt forms of isochroman-imidazole structured alpha-2a adrenoceptor agonist |
| WO2023148431A1 (en) | 2022-02-04 | 2023-08-10 | Orion Corporation | Novel salt forms of isochroman-imidazole structured alpha-2a adrenoceptor agonist |
| WO2024069050A1 (en) | 2022-09-28 | 2024-04-04 | Orion Corporation | Tasipimidine and cyp2d6 inhibitor combination treatment |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6410562B1 (en) * | 1998-12-18 | 2002-06-25 | Eli Lilly And Company | Hypoglycemic imidazoline compounds |
| AR090557A1 (es) * | 2012-04-02 | 2014-11-19 | Orion Corp | DERIVADOS IMIDAZOLICOS AGONISTAS ADRENERGICOS a2 |
-
2018
- 2018-11-30 SI SI201830738T patent/SI3717476T1/sl unknown
- 2018-11-30 KR KR1020207019100A patent/KR20200095519A/ko not_active Application Discontinuation
- 2018-11-30 DK DK18822414.1T patent/DK3717476T3/da active
- 2018-11-30 WO PCT/FI2018/050864 patent/WO2019106238A1/en active Application Filing
- 2018-11-30 BR BR112020010617-8A patent/BR112020010617A2/pt unknown
- 2018-11-30 PL PL18822414.1T patent/PL3717476T3/pl unknown
- 2018-11-30 US US16/768,093 patent/US11352346B2/en active Active
- 2018-11-30 EP EP18822414.1A patent/EP3717476B1/en active Active
- 2018-11-30 CN CN201880076883.0A patent/CN111630049B/zh active Active
- 2018-11-30 AU AU2018376872A patent/AU2018376872B2/en active Active
- 2018-11-30 IL IL274931A patent/IL274931B2/en unknown
- 2018-11-30 CA CA3083734A patent/CA3083734A1/en active Pending
- 2018-11-30 PT PT188224141T patent/PT3717476T/pt unknown
- 2018-11-30 JP JP2020529522A patent/JP7339946B2/ja active Active
- 2018-11-30 ES ES18822414T patent/ES2927193T3/es active Active
- 2018-11-30 LT LTEPPCT/FI2018/050864T patent/LT3717476T/lt unknown
- 2018-11-30 HU HUE18822414A patent/HUE059849T2/hu unknown
- 2018-11-30 HR HRP20221247TT patent/HRP20221247T1/hr unknown
-
2020
- 2020-06-30 ZA ZA2020/03981A patent/ZA202003981B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| BR112020010617A2 (pt) | 2020-11-10 |
| CN111630049B (zh) | 2023-06-20 |
| LT3717476T (lt) | 2022-09-26 |
| EP3717476A1 (en) | 2020-10-07 |
| HRP20221247T1 (hr) | 2022-12-09 |
| WO2019106238A1 (en) | 2019-06-06 |
| AU2018376872B2 (en) | 2023-12-07 |
| RU2020121597A (ru) | 2022-01-04 |
| KR20200095519A (ko) | 2020-08-10 |
| IL274931B1 (en) | 2023-07-01 |
| HUE059849T2 (hu) | 2023-01-28 |
| PT3717476T (pt) | 2022-08-23 |
| SI3717476T1 (sl) | 2022-10-28 |
| CA3083734A1 (en) | 2019-06-06 |
| PL3717476T3 (pl) | 2022-11-21 |
| ES2927193T3 (es) | 2022-11-03 |
| IL274931B2 (en) | 2023-11-01 |
| RU2020121597A3 (da) | 2022-01-04 |
| US20200308152A1 (en) | 2020-10-01 |
| IL274931A (en) | 2020-07-30 |
| CN111630049A (zh) | 2020-09-04 |
| JP7339946B2 (ja) | 2023-09-06 |
| EP3717476B1 (en) | 2022-08-03 |
| US11352346B2 (en) | 2022-06-07 |
| ZA202003981B (en) | 2021-07-28 |
| JP2021504418A (ja) | 2021-02-15 |
| AU2018376872A1 (en) | 2020-07-16 |
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