DK2358720T3 - Heteroarylkinaseinhibitorer fused-ring - Google Patents

Info

Publication number

DK2358720T3

DK2358720T3 DK09821313.5T DK09821313T DK2358720T3 DK 2358720 T3 DK2358720 T3 DK 2358720T3 DK 09821313 T DK09821313 T DK 09821313T DK 2358720 T3 DK2358720 T3 DK 2358720T3

Authority

DK

Denmark

Prior art keywords

substituted

unsubstituted

leu

ser

glu

Prior art date

2008-10-16

Links

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• 150000001875 compounds Chemical class 0.000 claims description 190
• 125000000217 alkyl group Chemical group 0.000 claims description 172
• 125000001072 heteroaryl group Chemical group 0.000 claims description 147
• 125000003118 aryl group Chemical group 0.000 claims description 146
• 125000004404 heteroalkyl group Chemical group 0.000 claims description 140
• 125000000753 cycloalkyl group Chemical group 0.000 claims description 120
• 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 80
• 125000004093 cyano group Chemical group *C#N 0.000 claims description 71
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• 125000000592 heterocycloalkyl group Chemical group 0.000 claims description 61
• 229910052736 halogen Inorganic materials 0.000 claims description 55
• 150000002367 halogens Chemical class 0.000 claims description 55
• 229910052739 hydrogen Inorganic materials 0.000 claims description 51
• 239000001257 hydrogen Substances 0.000 claims description 51
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• WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 claims description 40
• 125000004474 heteroalkylene group Chemical group 0.000 claims description 39
• 125000002947 alkylene group Chemical group 0.000 claims description 35
• 150000002431 hydrogen Chemical class 0.000 claims description 34
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 33
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• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 16
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• 150000003839 salts Chemical class 0.000 description 22
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