JP5819195B2 - 融合環ヘテロアリールキナーゼ阻害剤 - Google Patents

融合環ヘテロアリールキナーゼ阻害剤 Download PDF

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Publication number
JP5819195B2
JP5819195B2 JP2011532279A JP2011532279A JP5819195B2 JP 5819195 B2 JP5819195 B2 JP 5819195B2 JP 2011532279 A JP2011532279 A JP 2011532279A JP 2011532279 A JP2011532279 A JP 2011532279A JP 5819195 B2 JP5819195 B2 JP 5819195B2
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substituted
unsubstituted
compound
alkyl
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JP2012505916A (ja
JP2012505916A5 (enExample
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ダル，アルヴィン
エム． ショカット，ケバン
エム． ショカット，ケバン
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University of California
University of California Los Angeles UCLA
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University of California San Diego UCSD
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2011532279A 2008-10-16 2009-10-16 融合環ヘテロアリールキナーゼ阻害剤 Expired - Fee Related JP5819195B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US10613708P 2008-10-16 2008-10-16
US61/106,137 2008-10-16
US10645308P 2008-10-17 2008-10-17
US61/106,453 2008-10-17
PCT/US2009/060985 WO2010045542A2 (en) 2008-10-16 2009-10-16 Fused ring heteroaryl kinase inhibitors

Related Child Applications (1)

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JP2014125313A Division JP2014193925A (ja) 2008-10-16 2014-06-18 融合環ヘテロアリールキナーゼ阻害剤

Publications (3)

Publication Number Publication Date
JP2012505916A JP2012505916A (ja) 2012-03-08
JP2012505916A5 JP2012505916A5 (enExample) 2012-11-29
JP5819195B2 true JP5819195B2 (ja) 2015-11-18

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JP2011532279A Expired - Fee Related JP5819195B2 (ja) 2008-10-16 2009-10-16 融合環ヘテロアリールキナーゼ阻害剤
JP2014125313A Withdrawn JP2014193925A (ja) 2008-10-16 2014-06-18 融合環ヘテロアリールキナーゼ阻害剤

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US (1) US8697709B2 (enExample)
EP (1) EP2358720B1 (enExample)
JP (2) JP5819195B2 (enExample)
AU (4) AU2009305669A1 (enExample)
CA (1) CA2740885C (enExample)
DK (1) DK2358720T3 (enExample)
ES (1) ES2570429T3 (enExample)
WO (1) WO2010045542A2 (enExample)

Cited By (1)

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JP2014525464A (ja) * 2011-09-02 2014-09-29 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 置換ピラゾロ［３，４−ｄ］ピリミジンおよびその用途

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