DK1997897T3 - Mutantproteiner med lavere allergenisk respons hos mennesker og fremgangsmåder til konstruktion, identifikation og fremstilling af sådanne proteiner - Google Patents

Mutantproteiner med lavere allergenisk respons hos mennesker og fremgangsmåder til konstruktion, identifikation og fremstilling af sådanne proteiner

Info

Publication number
DK1997897T3
DK1997897T3 DK08009499.8T DK08009499T DK1997897T3 DK 1997897 T3 DK1997897 T3 DK 1997897T3 DK 08009499 T DK08009499 T DK 08009499T DK 1997897 T3 DK1997897 T3 DK 1997897T3
Authority
DK
Denmark
Prior art keywords
proteins
humans
constructing
identifying
producing
Prior art date
Application number
DK08009499.8T
Other languages
English (en)
Inventor
David Estell
Fiona Harding
Original Assignee
Danisco Us Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22032273&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK1997897(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Danisco Us Inc filed Critical Danisco Us Inc
Application granted granted Critical
Publication of DK1997897T3 publication Critical patent/DK1997897T3/da

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6878—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids in eptitope analysis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
    • C12N9/54—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea bacteria being Bacillus
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5047—Cells of the immune system
    • G01N33/505—Cells of the immune system involving T-cells
DK08009499.8T 1998-04-15 1999-04-14 Mutantproteiner med lavere allergenisk respons hos mennesker og fremgangsmåder til konstruktion, identifikation og fremstilling af sådanne proteiner DK1997897T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/060,872 US6835550B1 (en) 1998-04-15 1998-04-15 Mutant proteins having lower allergenic response in humans and methods for constructing, identifying and producing such proteins
EP04016880A EP1586649B1 (en) 1998-04-15 1999-04-14 Mutant proteins having lower allergenic response in humans and methods for constructing, identifying and producing such proteins

Publications (1)

Publication Number Publication Date
DK1997897T3 true DK1997897T3 (da) 2013-02-11

Family

ID=22032273

Family Applications (3)

Application Number Title Priority Date Filing Date
DK99918575T DK1073754T3 (da) 1998-04-15 1999-04-14 Fremgangsmåde til fremstilling af proteinmutanter med lille allergen reaktion hos mennesker
DK08009499.8T DK1997897T3 (da) 1998-04-15 1999-04-14 Mutantproteiner med lavere allergenisk respons hos mennesker og fremgangsmåder til konstruktion, identifikation og fremstilling af sådanne proteiner
DK04016880.9T DK1586649T3 (da) 1998-04-15 1999-04-14 Mutantproteiner med lav allergen reaktion hos mennesker og fremgangsmåder til konstruktion, identificering og fremstilling af sådanne proteiner

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK99918575T DK1073754T3 (da) 1998-04-15 1999-04-14 Fremgangsmåde til fremstilling af proteinmutanter med lille allergen reaktion hos mennesker

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK04016880.9T DK1586649T3 (da) 1998-04-15 1999-04-14 Mutantproteiner med lav allergen reaktion hos mennesker og fremgangsmåder til konstruktion, identificering og fremstilling af sådanne proteiner

Country Status (20)

Country Link
US (4) US6835550B1 (da)
EP (3) EP1997897B1 (da)
JP (1) JP4447774B2 (da)
KR (1) KR20010034776A (da)
CN (1) CN1302113C (da)
AT (2) ATE452195T1 (da)
AU (1) AU752934B2 (da)
BR (1) BR9909640A (da)
CA (1) CA2327311C (da)
CZ (1) CZ20003789A3 (da)
DE (3) DE69941827D1 (da)
DK (3) DK1073754T3 (da)
ES (2) ES2229703T4 (da)
ID (1) ID26645A (da)
IL (2) IL138445A0 (da)
MX (2) MXPA05003288A (da)
NO (1) NO20005153L (da)
NZ (2) NZ524596A (da)
PL (1) PL343509A1 (da)
WO (1) WO1999053038A2 (da)

Families Citing this family (106)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6750329B1 (en) * 1989-05-05 2004-06-15 Research Development Foundation Antibody delivery system for biological response modifiers
US20050209121A1 (en) * 1990-12-05 2005-09-22 Novozymes A/S Proteins with changed epitopes and methods for the production thereof
US6967080B1 (en) * 1990-12-05 2005-11-22 Novozymes A/S Proteins with changed epitopes and methods for the production thereof
MA23346A1 (fr) * 1993-10-14 1995-04-01 Genencor Int Variantes de la subtilisine
US6936249B1 (en) 1998-04-15 2005-08-30 Genencor International, Inc. Proteins producing an altered immunogenic response and methods of making and using the same
US6642011B2 (en) * 1998-04-15 2003-11-04 Genencor International, Inc. Human protease and use of such protease for pharmaceutical applications and for reducing the allergenicity of non-human proteins
US6835550B1 (en) * 1998-04-15 2004-12-28 Genencor International, Inc. Mutant proteins having lower allergenic response in humans and methods for constructing, identifying and producing such proteins
US6838269B1 (en) * 1998-04-15 2005-01-04 Genencor International, Inc. Proteins producing an altered immunogenic response and methods of making and using the same
CA2249648A1 (en) * 1998-11-04 2000-05-04 Nabil G. Seidah Mammalian subtilisin/kexin isozyme ski-1: a proprotein convertase with a unique cleavage specificity
US6946128B1 (en) * 1999-07-22 2005-09-20 The Procter & Gamble Company Protease conjugates having sterically protected epitope regions
CZ2002212A3 (cs) * 1999-07-22 2002-07-17 The Procter & Gamble Company Varianty subtilisinové proteasy mající aminokyselinové substituce v definovaných epitopových oblastech
WO2001007575A2 (en) * 1999-07-22 2001-02-01 The Procter & Gamble Company Subtilisin protease variants having amino acid deletions and substitutions in defined epitope regions
WO2001040281A2 (en) * 1999-12-02 2001-06-07 Thromb-X N.V. Method for reducing the immunogenicity of heterologous proteins by elimination of t-cell epitopes
WO2001041786A1 (en) 1999-12-10 2001-06-14 The General Hospital Corporation METHODS TO STIMULATE INSULIN PRODUCTION BY PANCREATIC β-CELLS
US6960462B2 (en) 2000-02-08 2005-11-01 Dsm Ip Assets B.V Use of acid-stable subtilisin proteases in animal feed
MX261332B (es) * 2000-02-08 2008-10-14 Hoffmann La Roche Uso de proteasas estables en acido para alimento de animales.
US6855548B2 (en) 2000-02-08 2005-02-15 F. Hoffman-La Roche Ag Use of acid-stable proteases in animal feed
US20020192792A1 (en) * 2000-04-28 2002-12-19 Palle Schneider Laccase mutants
US6673580B2 (en) * 2000-10-27 2004-01-06 Genentech, Inc. Identification and modification of immunodominant epitopes in polypeptides
HUP0402071A2 (hu) * 2001-02-06 2005-01-28 Merck Patent Gmbh. Csökkentett immunogenitású, módosított leptin
ZA200305980B (en) * 2001-02-12 2007-01-31 Res Dev Foundation Modified proteins, designer toxins, and methods of making thereof
EP1239032A1 (en) * 2001-03-02 2002-09-11 Société des Produits Nestlé S.A. Lactic acid bacteria as agents for treating and preventing allergy
CN100489094C (zh) * 2001-03-23 2009-05-20 金克克国际有限公司 具有改变的免疫原性反应的蛋白质及制备和使用该蛋白质的方法
WO2002096454A1 (en) * 2001-05-31 2002-12-05 D. Collen Research Foundation Vzw Recombinant molecules with reduced immunogenicity, methods and intermediates for obtaining them and their use in pharmaceutical compositions and diagnostic tools
WO2002098454A2 (en) * 2001-05-31 2002-12-12 D. Collen Research Foundation Vzw Onderwijsen Navorsing Campus Gasthuisberg K.U. Leuven Recombinant molecules with reduced immunogenicity, methods and intermediates for obtaining them and their use in pharmaceutical compositions and diagnostic tools
JP2004535202A (ja) 2001-07-17 2004-11-25 リサーチ　ディベロップメント　ファンデーション アポトーシス促進性蛋白質を含む治療剤
US7157416B2 (en) * 2001-07-20 2007-01-02 Genencor International, Inc. Stabilization of enzymes
MXPA04004417A (es) * 2001-11-12 2004-08-11 Merck Patent Gmbh Anticuerpo anti-tnf alfa modificado.
US20040209312A1 (en) * 2001-11-13 2004-10-21 Harding Fiona A Identifying and reducing the allergenicity of food proteins
AU2002353178C1 (en) * 2001-12-31 2011-02-03 Genencor International, Inc. Proteases producing an altered immunological response and methods of making and using the same
CA2476890C (en) * 2002-02-26 2013-07-16 Genencor International, Inc. Subtilisin carlsberg proteins with reduced immunogenicity
NZ534198A (en) * 2002-02-26 2005-11-25 Genencor Int Population based assessments and means to rank the relative immunogenicity of proteins
EP2339017A3 (en) 2002-03-29 2011-10-12 Genencor International, Inc. Enhanced protein expression in bacillus
JP2005538694A (ja) * 2002-04-18 2005-12-22 メルク　パテント　ゲゼルシャフト　ミット　ベシュレンクテル　ハフトング 修飾されたｖｉｉｉ因子
DK1578772T3 (da) * 2002-05-01 2010-08-16 Danisco Us Inc Cytokiner og cytokinreceptorer med reduceret immunogenicitet
JP2006506964A (ja) * 2002-06-12 2006-03-02 リサーチ　ディベロップメント　ファンデーション 治療剤としての免疫毒素及びその利用
US20060228791A1 (en) * 2002-06-26 2006-10-12 Novozymes A/S Subtilases and subtilase variants having altered immunogenicity
US20040007251A1 (en) * 2002-07-10 2004-01-15 Kimberly-Clark Worldwide, Inc. Cleaners for the control and removal of allergens
US7566448B2 (en) * 2002-07-30 2009-07-28 Genencor International, Inc. Reduced aerosol generating formulations
WO2004014938A2 (en) * 2002-08-09 2004-02-19 Xencor Thrombopoiesis-stimulating proteins having reduced immunogenicity
BRPI0407294B1 (pt) 2003-02-07 2017-06-13 Novozymes A/S Use of a protease of the peptidases family s2a and / or peptidasis fmilia s1e, method for producing polipeptide, animal feed additive, animal feed composition, and, detergent composition
WO2004078960A1 (en) 2003-02-26 2004-09-16 Genencor International, Inc. Amylases producing an altered immunogenic response and methods of making and using the same
EP2500423B1 (en) 2003-02-26 2015-06-17 Danisco US Inc. Amylases producing an altered immunogenic response and methods of making and using the same
WO2005051975A2 (en) * 2003-07-03 2005-06-09 Avatar Biotechnologies, Inc. Methods for obtaining molecules with reduced immunogenicity
ES2358092T3 (es) 2003-10-10 2011-05-05 Novozymes A/S Variantes de proteasa.
ATE552276T1 (de) 2003-11-01 2012-04-15 Merck Patent Gmbh Modifizierter anti-cd52-antikörper
WO2005095592A2 (en) * 2004-04-02 2005-10-13 Novozymes A/S Subtilase variants having altered immunogenicity
JP2007532114A (ja) * 2004-04-09 2007-11-15 ジェネンコー・インターナショナル・インク バチルスにおけるｐｃｋＡ修飾および増強されたタンパク質発現
DE602005023138D1 (de) 2004-04-15 2010-10-07 Genencor Int Anti-cea scfv-beta-lactamase konstrukte (cab moleküle) in adept
EP1740952A2 (en) * 2004-04-26 2007-01-10 Genencor International, Inc. Population based prediction methods for immune response determinations and methods for verifying immunological response data
US8298824B2 (en) 2004-04-28 2012-10-30 Sanofi Pasteur Vaxdesign Corporation Methods of evaluating a test agent in a diseased cell model
US7709256B2 (en) * 2004-04-28 2010-05-04 Vaxdesign Corp. Disease model incorporation into an artificial immune system (AIS)
US20070141552A1 (en) * 2004-04-28 2007-06-21 Warren William L Automatable artificial immune system (AIS)
US7785806B2 (en) * 2004-04-28 2010-08-31 Vaxdesign Corporation Method for determining the immunogenicity of an antigen
US7771999B2 (en) * 2004-04-28 2010-08-10 Vaxdesign Corp. Disease model incorporation into an artificial immune system (AIS)
US20060275270A1 (en) * 2004-04-28 2006-12-07 Warren William L In vitro mucosal tissue equivalent
US7855074B2 (en) * 2004-04-28 2010-12-21 Vaxdesign Corp. Artificial immune system: methods for making and use
CA2564512C (en) 2004-04-28 2014-03-18 Vaxdesign Corporation Artificial immune system: methods for making and use
US7785883B2 (en) * 2004-04-28 2010-08-31 Vax Design Corp. Automatable artificial immune system (AIS)
US8030070B2 (en) * 2004-04-28 2011-10-04 Sanofi Pasteur Vaxdesign Corp. Artificial lymphoid tissue equivalent
US8071373B2 (en) 2004-04-28 2011-12-06 Sanofi Pasteur Vaxdesign Corp. Co-culture lymphoid tissue equivalent (LTE) for an artificial immune system (AIS)
US20090060933A1 (en) * 2004-06-14 2009-03-05 Estell David A Proteases producing an altered immunogenic response and methods of making and using the same
MXPA06014649A (es) 2004-06-21 2007-03-12 Novozymes As Proteasas.
AU2006210724A1 (en) * 2005-02-03 2006-08-10 Antitope Limited Human antibodies and proteins
JP5153613B2 (ja) * 2005-03-18 2013-02-27 メディミューン，エルエルシー 抗体のフレームワーク・シャッフル
AU2006236905B2 (en) * 2005-04-15 2010-06-03 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Methods and compositions for producing an enhanced immune response to a human papillomavirus immunogen
EP1904531B1 (en) * 2005-07-08 2010-10-06 Pfizer Limited Madcam antibodies
EP1919951B1 (en) * 2005-08-04 2015-01-28 Janssen Biotech, Inc. Anti-tnf-alpha antibodies and methods of use
WO2007031741A1 (en) * 2005-09-14 2007-03-22 Cambridge Antibody Technology Limited Pseudomonas exotoxin a cd4+ t-cell epitopes
EP1969366B1 (en) * 2005-12-21 2015-10-21 Sanofi Pasteur VaxDesign Corporation In vitro germinal centers
ATE495238T1 (de) * 2005-12-21 2011-01-15 Vaxdesign Corp Iin vitro methode um eine potentielle reaktion eines tieres an einen agenten zu bestimmen
EP2351830B1 (en) 2006-03-23 2014-04-23 Ajinomoto Co., Inc. A method for producing an L-amino acid using bacterium of the Enterobacteriaceae family with attenuated expression of a gene coding for small RNA
EP2409714A1 (en) * 2006-06-27 2012-01-25 Sanofi Pasteur VaxDesign Corporation Models for vaccine assessment
KR20090088852A (ko) 2006-09-05 2009-08-20 메다렉스, 인코포레이티드 골형성 단백질의 항체와 이의 수용체 및 이의 사용방법
US20080090745A1 (en) * 2006-10-13 2008-04-17 Fox Bryan P Expression of Streptomyces subtilism inhibitor (SSI) proteins in Bacillus and Streptomyces sp.
JP2010507001A (ja) * 2006-10-16 2010-03-04 ダニスコ・ユーエス・インク、ジェネンコー・ディビジョン 非リン酸系食器洗浄剤
MX2009006277A (es) 2006-12-14 2009-07-24 Medarex Inc Anticuerpos humanos que se enlazan a cd70 y usos de los mismos.
RU2496875C2 (ru) 2007-03-12 2013-10-27 ДАНИСКО ЮЭс ИНК. Мoдифицированные протеазы
ATE550348T1 (de) 2007-05-10 2012-04-15 Danisco Us Inc Modifiziertes ausscheidungssystem zur erhöhung der expression von polypeptiden in bakterien
JP2010530895A (ja) 2007-06-21 2010-09-16 アンジェリカ セラピューティックス，インク． 修飾毒素
WO2009048661A1 (en) 2007-07-16 2009-04-16 Vaxdesign Corporation Artificial tissue constructs comprising alveolar cells and methods for using the same
KR20100098652A (ko) 2007-12-21 2010-09-08 다니스코 유에스 인크. 바실루스 내에서의 향상된 단백질 생산
CA2717197C (en) * 2008-03-12 2016-12-20 Vaxdesign Corporation Disease model incorporation into an artificial immune system (ais)
DK2257629T3 (da) * 2008-03-28 2016-06-13 Danisco Us Inc Fremgangsmåde til locusamplifikation i en bakteriecelle
CN102245635B (zh) 2008-10-15 2016-08-31 丹尼斯科美国公司 修饰的变体bowman birk蛋白酶抑制剂
US7772181B2 (en) 2008-10-15 2010-08-10 Danisco Us Inc. Personal care compositions comprising modified variant Bowman Birk Protease Inhibitors
US7803902B2 (en) 2008-10-15 2010-09-28 Danisco Us Inc. Modified variant bowman birk protease inhibitors
RU2560978C2 (ru) 2008-11-11 2015-08-20 ДАНИСКО ЮЭс ИНК. Протеазы, содержащие одну или несколько комбинируемых мутаций
EP2647692A3 (en) * 2008-11-11 2014-01-22 The Procter and Gamble Company Compositions and methods comprising serine protease variants
FR2940451B1 (fr) 2008-12-18 2014-09-12 Proteus Procede d'evaluation de l'immunogenicite des proteines
AR076941A1 (es) 2009-06-11 2011-07-20 Danisco Us Inc Cepa de bacillus para una mayor produccion de proteina
BR112012006497A2 (pt) * 2009-09-25 2015-09-08 Novozymes As uso de uma variante de subtilisina, composição de lavagem de pratos, e, uso de uma composição.
EP2510092A1 (en) * 2009-12-09 2012-10-17 The Procter & Gamble Company Fabric and home care products
CA2902905A1 (en) 2013-03-15 2014-09-25 Claude Geoffrey Davis Modified toxins
US10287591B2 (en) 2013-12-31 2019-05-14 Danisco Us Inc Enhanced protein expression
CA2943569C (en) 2014-03-27 2021-02-23 British Columbia Cancer Agency Branch T-cell epitope identification
US10683528B2 (en) 2014-12-16 2020-06-16 Danisco Us Inc Enhanced protein expression
KR20170093247A (ko) 2014-12-19 2017-08-14 다니스코 유에스 인크. 향상된 단백질 발현
GB201501565D0 (en) * 2015-01-30 2015-03-18 Dupont Nutrition Biosci Aps Method
US11866713B2 (en) 2017-02-24 2024-01-09 Danisco Us Inc. Compositions and methods for increased protein production in bacillus licheniformis
EP3655537A1 (en) 2017-08-23 2020-05-27 Danisco US Inc. Methods and compositions for efficient genetic modifications of bacillus licheniformis strains
CN111094576A (zh) 2017-09-13 2020-05-01 丹尼斯科美国公司 用于增加芽胞杆菌属中蛋白质产生的经修饰的5′-非翻译区(utr)序列
WO2019089898A1 (en) 2017-11-02 2019-05-09 Danisco Us Inc Freezing point depressed solid matrix compositions for melt granulation of enzymes
KR20200105879A (ko) 2018-01-03 2020-09-09 다니스코 유에스 인크. 증가된 단백질 생산을 위한 돌연변이체 및 유전자 변형된 바실러스 세포 및 이의 방법
JP2023524334A (ja) 2020-01-15 2023-06-12 ダニスコ・ユーエス・インク バチルス・リケニフォルミス（ｂａｃｉｌｌｕｓ ｌｉｃｈｅｎｉｆｏｒｍｉｓ）における強化したタンパク質産生のための組成物及び方法
WO2023023644A1 (en) 2021-08-20 2023-02-23 Danisco Us Inc. Polynucleotides encoding novel nucleases, compositions thereof and methods thereof for eliminating dna from protein preparations

Family Cites Families (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5913187B2 (ja) 1978-07-04 1984-03-28 ノヴオ インダストリ エ−／エス プロテア−ゼ濃縮物
US4261868A (en) 1979-08-08 1981-04-14 Lever Brothers Company Stabilized enzymatic liquid detergent composition containing a polyalkanolamine and a boron compound
US4404128A (en) 1981-05-29 1983-09-13 The Procter & Gamble Company Enzyme detergent composition
JPS58144105A (ja) 1982-02-12 1983-08-27 Kurabo Ind Ltd スケ−ル除去獣毛繊維の製法
US4760025A (en) 1984-05-29 1988-07-26 Genencor, Inc. Modified enzymes and methods for making same
US5204015A (en) 1984-05-29 1993-04-20 Genencor International, Inc. Subtilisin mutants
US5801038A (en) * 1984-05-29 1998-09-01 Genencor International Inc. Modified subtilisins having amino acid alterations
US5185258A (en) 1984-05-29 1993-02-09 Genencor International, Inc. Subtilisin mutants
US5264366A (en) 1984-05-29 1993-11-23 Genencor, Inc. Protease deficient bacillus
US5182204A (en) 1984-05-29 1993-01-26 Genencor International, Inc. Non-human carbonyl hydrolase mutants, vectors encoding same and hosts transformed with said vectors
IE65767B1 (en) * 1986-04-30 1995-11-15 Genencor Int Non-human carbonyl hydrolase mutants DNA sequences and vectors encoding same and hosts transformed with said vectors
US5314692A (en) 1987-08-24 1994-05-24 Cultor Ltd. Enzyme premix for feed and method
EP0344259A4 (en) 1987-10-30 1991-04-24 Lsi Logic Corporation Method and means of fabricating a semiconductor device package
DK6488D0 (da) 1988-01-07 1988-01-07 Novo Industri As Enzymer
US4874070A (en) 1988-02-10 1989-10-17 Eaton Corporation Control for AMT system start from stop operation
DE3841152A1 (de) 1988-12-07 1990-06-13 Hoechst Ag Verwendung von bakterienlysierendem enzymprodukt als zusatzstoff zur verbesserung der futterverwertung in der tierproduktion
CA2331936C (en) 1990-12-05 2007-07-31 Novozymes A/S Proteins with changed epitopes and methods for the production thereof
US5766898A (en) * 1990-12-05 1998-06-16 Novo Nordisk A/S Proteins with changed epitopes and methods for the production thereof
ATE260971T1 (de) * 1992-04-01 2004-03-15 Univ Rockefeller Verfahren zur in vitro kultivierung dendritischer vorläuferzellen und deren verwendung zur immunogen herstellung
AU4678993A (en) * 1992-07-16 1994-02-14 Board Of Trustees Of The Leland Stanford Junior University Methods for using dendritic cells to activate t cells
DK132892D0 (da) 1992-10-30 1992-10-30 Novo Nordisk As Proteiner
US5593877A (en) * 1993-03-11 1997-01-14 The Rockefeller University Nucleic acid and recombinant production of vespid venom hyaluronidase
US5585250A (en) * 1993-08-20 1996-12-17 The United States Of America As Represented By The Department Of Health & Human Services Dampening of an immunodominant epitope of an antigen for use in plant, animal and human compositions and immunotherapies
US5820862A (en) * 1994-04-14 1998-10-13 Immulogic Pharmaceutical Corporation T cell epitopes of the major allergens from dermatophagoides (house dust mite)
CU22615A1 (es) 1994-06-30 2000-02-10 Centro Inmunologia Molecular Procedimiento de obtención de anticuerpos monoclonales murinos menos inmunogénicos. anticuerpos monoclonales obtenidos
GB9416841D0 (en) 1994-08-19 1994-10-12 Finnfeeds Int Ltd An enzyme feed additive and animal feed including it
US5648219A (en) * 1995-06-07 1997-07-15 Zymogenetics, Inc. Immortalized dendritic cells
WO1996016177A1 (en) 1994-11-24 1996-05-30 Novo Nordisk A/S A process for producing polypeptides with reduced allergenicity
US5856451A (en) 1994-12-07 1999-01-05 Novo Nordisk A/S Method for reducing respiratory allergenicity
US5951980A (en) * 1995-01-06 1999-09-14 Leuven Research & Development Vzw Identification, production and use of new staphylokinase derivatives with reduced immunogenicity
ATE429490T1 (de) 1995-05-05 2009-05-15 Novozymes As Protease-varianten und verbindungen
US5837517A (en) * 1995-05-05 1998-11-17 Novo Nordisk A/S Protease variants and compositions
AU5893696A (en) 1995-06-07 1996-12-30 Novo Nordisk A/S Modification of polypeptides
JP2000506119A (ja) 1996-02-15 2000-05-23 ノボ ノルディスク アクティーゼルスカブ ポリペプチドのコンジュゲーション
US5849589A (en) * 1996-03-11 1998-12-15 Duke University Culturing monocytes with IL-4, TNF-α and GM-CSF TO induce differentiation to dendric cells
CN1136311C (zh) 1996-11-04 2004-01-28 诺沃奇梅兹有限公司 枯草杆菌酶变异体和组合物
EP1724282B1 (en) 1997-05-21 2013-05-15 Merck Patent GmbH Method for the production of non-immunogenic proteins
US6495136B1 (en) * 1998-03-26 2002-12-17 The Procter & Gamble Company Proteases having modified amino acid sequences conjugated to addition moieties
US6835550B1 (en) 1998-04-15 2004-12-28 Genencor International, Inc. Mutant proteins having lower allergenic response in humans and methods for constructing, identifying and producing such proteins
CA2238660A1 (en) 1998-05-22 1999-11-22 Janet Chantler Gene sequences of rubella virus associated with attenuation
ES2220114T3 (es) * 1998-10-30 2004-12-01 Novozymes A/S Variantes de proteinas poco alergenicas.
GB9913425D0 (en) * 1999-06-09 1999-08-11 Universitu Libre De Bruxelles Identification and molecular characterisation of proteins expressed in the tick salivary glands

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WO1999053038A2 (en) 1999-10-21
CZ20003789A3 (cs) 2001-08-15
US20050137112A1 (en) 2005-06-23
WO1999053038A3 (en) 2000-02-10
EP1997897A1 (en) 2008-12-03
EP1073754A2 (en) 2001-02-07
ATE452195T1 (de) 2010-01-15
DE69920434D1 (de) 2004-10-28
DE69941827D1 (de) 2010-01-28
EP1586649B1 (en) 2009-12-16
EP1073754B9 (en) 2005-01-19
IL138445A0 (en) 2001-10-31
KR20010034776A (ko) 2001-04-25
EP1073754B1 (en) 2004-09-22
DK1586649T3 (da) 2010-04-26
NZ524596A (en) 2004-09-24
ATE277189T1 (de) 2004-10-15
CA2327311C (en) 2010-03-16
CN1297484A (zh) 2001-05-30
AU3645499A (en) 1999-11-01
NO20005153L (no) 2000-12-11
ID26645A (id) 2001-01-25
ES2229703T3 (es) 2005-04-16
ES2338319T3 (es) 2010-05-06
NO20005153D0 (no) 2000-10-13
EP1586649A2 (en) 2005-10-19
NZ506926A (en) 2003-10-31
CA2327311A1 (en) 1999-10-21
DE69920434T4 (de) 2006-07-27
PL343509A1 (en) 2001-08-27
US6218165B1 (en) 2001-04-17
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ES2229703T4 (es) 2006-07-16
US6596525B1 (en) 2003-07-22
US6835550B1 (en) 2004-12-28
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EP1586649A3 (en) 2005-11-02
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CN1302113C (zh) 2007-02-28
AU752934B2 (en) 2002-10-03
JP4447774B2 (ja) 2010-04-07
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EP1997897B1 (en) 2012-11-14
BR9909640A (pt) 2000-12-19

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