DK1071792T3 - Human protease og anvendelse af en sådan protease til farmaceutiske anvendelser og til reducering af allergeniciteten af ikke-humane proteiner - Google Patents

Human protease og anvendelse af en sådan protease til farmaceutiske anvendelser og til reducering af allergeniciteten af ikke-humane proteiner

Info

Publication number
DK1071792T3
DK1071792T3 DK99918548T DK99918548T DK1071792T3 DK 1071792 T3 DK1071792 T3 DK 1071792T3 DK 99918548 T DK99918548 T DK 99918548T DK 99918548 T DK99918548 T DK 99918548T DK 1071792 T3 DK1071792 T3 DK 1071792T3
Authority
DK
Denmark
Prior art keywords
protease
human
allergenicity
reducing
pharmaceutical applications
Prior art date
Application number
DK99918548T
Other languages
English (en)
Inventor
David Estell
Original Assignee
Genencor Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genencor Int filed Critical Genencor Int
Application granted granted Critical
Publication of DK1071792T3 publication Critical patent/DK1071792T3/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
    • C12N9/54—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea bacteria being Bacillus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Plant Pathology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Detergent Compositions (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DK99918548T 1998-04-15 1999-04-15 Human protease og anvendelse af en sådan protease til farmaceutiske anvendelser og til reducering af allergeniciteten af ikke-humane proteiner DK1071792T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/060,854 US6642011B2 (en) 1998-04-15 1998-04-15 Human protease and use of such protease for pharmaceutical applications and for reducing the allergenicity of non-human proteins
PCT/US1999/008177 WO1999053078A2 (en) 1998-04-15 1999-04-15 Human protease and use of such protease for pharmaceutical applications and for reducing the allergenicity of non-human proteins

Publications (1)

Publication Number Publication Date
DK1071792T3 true DK1071792T3 (da) 2007-02-05

Family

ID=22032151

Family Applications (1)

Application Number Title Priority Date Filing Date
DK99918548T DK1071792T3 (da) 1998-04-15 1999-04-15 Human protease og anvendelse af en sådan protease til farmaceutiske anvendelser og til reducering af allergeniciteten af ikke-humane proteiner

Country Status (14)

Country Link
US (2) US6642011B2 (da)
EP (1) EP1071792B1 (da)
JP (1) JP2002511272A (da)
KR (1) KR20010034785A (da)
CN (1) CN1297483A (da)
AT (1) ATE342365T1 (da)
AU (1) AU3643299A (da)
BR (1) BR9909639A (da)
CA (1) CA2325010A1 (da)
DE (1) DE69933551T2 (da)
DK (1) DK1071792T3 (da)
NO (1) NO20005152L (da)
PL (1) PL343711A1 (da)
WO (1) WO1999053078A2 (da)

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US6642011B2 (en) * 1998-04-15 2003-11-04 Genencor International, Inc. Human protease and use of such protease for pharmaceutical applications and for reducing the allergenicity of non-human proteins
CA2249648A1 (en) * 1998-11-04 2000-05-04 Nabil G. Seidah Mammalian subtilisin/kexin isozyme ski-1: a proprotein convertase with a unique cleavage specificity
CN1300849A (zh) * 1999-12-21 2001-06-27 复旦大学 一种新的多肽－枯草蛋白酶10和编码这种多肽的多核苷酸
AU783923B2 (en) * 2000-01-06 2005-12-22 Lexicon Genetics Incorporated Novel human proteases and polynucleotides encoding the same
DE10041515A1 (de) * 2000-08-24 2002-03-14 Gerold Schuler Verfahren zur Herstellung gebrauchsfertiger, Antigen-beladener oder -unbeladener, kryokonservierter reifer dendritischer Zellen
CA2424720C (en) * 2000-10-02 2012-04-03 Genencor International, Inc. Proteins producing an altered immunogenic response and methods of making and using the same
EP1239032A1 (en) * 2001-03-02 2002-09-11 Société des Produits Nestlé S.A. Lactic acid bacteria as agents for treating and preventing allergy
CA2441595C (en) 2001-03-23 2012-07-03 Genencor International, Inc. Proteins producing an altered immunogenic response and methods of making and using the same
EP1554378A4 (en) * 2001-12-31 2006-01-11 Genencor Int PROTEASES PRODUCING MODIFIED IMMUNOGEN RESPONSE AND METHODS OF PRODUCTION AND USE
ATE457352T1 (de) * 2002-02-26 2010-02-15 Genencor Int Subtilisin-carlsberg-proteine mit verminderter immunogenität
EP1641813B1 (en) * 2003-07-03 2011-11-09 Avatar Biotechnologies, Inc. Methods for obtaining molecules with reduced immunogenicity
US20090060933A1 (en) * 2004-06-14 2009-03-05 Estell David A Proteases producing an altered immunogenic response and methods of making and using the same
RU2420578C2 (ru) * 2005-06-24 2011-06-10 Новозимс А/С Протеазы для фармацевтического применения
CN101243182B (zh) * 2005-08-16 2014-08-06 诺维信公司 枯草蛋白酶
DK2510094T3 (da) * 2009-12-09 2017-03-13 Danisco Us Inc Sammensætninger og fremgangsmåder omfattende proteasevarianter
WO2016112350A1 (en) * 2015-01-09 2016-07-14 Oklahoma Medical Research Foundation Methods and compositions for diagnosing and treating lysosomal storage disorders

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US4404128A (en) 1981-05-29 1983-09-13 The Procter & Gamble Company Enzyme detergent composition
JPS58144105A (ja) 1982-02-12 1983-08-27 Kurabo Ind Ltd スケ−ル除去獣毛繊維の製法
US4760025A (en) 1984-05-29 1988-07-26 Genencor, Inc. Modified enzymes and methods for making same
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Also Published As

Publication number Publication date
JP2002511272A (ja) 2002-04-16
NO20005152L (no) 2000-12-11
WO1999053078A3 (en) 2000-04-20
EP1071792B1 (en) 2006-10-11
DE69933551T2 (de) 2007-09-06
BR9909639A (pt) 2000-12-19
US20040063177A1 (en) 2004-04-01
US6642011B2 (en) 2003-11-04
DE69933551D1 (de) 2006-11-23
ATE342365T1 (de) 2006-11-15
WO1999053078A2 (en) 1999-10-21
CN1297483A (zh) 2001-05-30
PL343711A1 (en) 2001-08-27
CA2325010A1 (en) 1999-10-21
EP1071792A2 (en) 2001-01-31
NO20005152D0 (no) 2000-10-13
AU3643299A (en) 1999-11-01
US20020081703A1 (en) 2002-06-27
KR20010034785A (ko) 2001-04-25

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