BR9909639A - Processos para reduzir a alergenicidade de uma proteìna não humana e para produzir uma proteìna tendo reduzida alergenicidade, proteìna mutante tendo reduzida alergenicidade, dna, vetor de expressão, células hospedeiras, composição farmacêutica, e, substilisina humana - Google Patents

Processos para reduzir a alergenicidade de uma proteìna não humana e para produzir uma proteìna tendo reduzida alergenicidade, proteìna mutante tendo reduzida alergenicidade, dna, vetor de expressão, células hospedeiras, composição farmacêutica, e, substilisina humana

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Publication number
BR9909639A
BR9909639A BR9909639-0A BR9909639A BR9909639A BR 9909639 A BR9909639 A BR 9909639A BR 9909639 A BR9909639 A BR 9909639A BR 9909639 A BR9909639 A BR 9909639A
Authority
BR
Brazil
Prior art keywords
protein
allergenicity
human
reduced
reduced allergenicity
Prior art date
Application number
BR9909639-0A
Other languages
English (en)
Inventor
David Estell
Original Assignee
Genencor Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genencor Int filed Critical Genencor Int
Publication of BR9909639A publication Critical patent/BR9909639A/pt

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
    • C12N9/54—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea bacteria being Bacillus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Plant Pathology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Detergent Compositions (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

"PROCESSOS PARA REDUZIR A ALERGENICIDADE DE UMA PROTEìNA NãO HUMANA E PARA PRODUZIR UMA PROTEìNA TENDO REDUZIDA ALERGENICIDADE, PROTEìNA MUTANTE TENDO REDUZIDA ALERGENICIDADE, DNA, VETOR DE EXPRESSãO, CéLULAS HOSPEDEIRAS, COMPOSIçãO FARMACêUTICA, E, SUBTILISINA HUMANA" A presente invenção refere-se a um processo para produzir novo mutante de proteína melhorado que produz baixa resposta alergênica em humanos comparado com o ascendente deste mutante. Especificamente, a presente invenção compreende a neutralização ou redução da alergenicidade de uma proteína por introdução na mesma, como substituição ou modificação de um epítopo em tal proteína, de uma seq³ência de subtilisina humana.
BR9909639-0A 1998-04-15 1999-04-15 Processos para reduzir a alergenicidade de uma proteìna não humana e para produzir uma proteìna tendo reduzida alergenicidade, proteìna mutante tendo reduzida alergenicidade, dna, vetor de expressão, células hospedeiras, composição farmacêutica, e, substilisina humana BR9909639A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/060,854 US6642011B2 (en) 1998-04-15 1998-04-15 Human protease and use of such protease for pharmaceutical applications and for reducing the allergenicity of non-human proteins
PCT/US1999/008177 WO1999053078A2 (en) 1998-04-15 1999-04-15 Human protease and use of such protease for pharmaceutical applications and for reducing the allergenicity of non-human proteins

Publications (1)

Publication Number Publication Date
BR9909639A true BR9909639A (pt) 2000-12-19

Family

ID=22032151

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9909639-0A BR9909639A (pt) 1998-04-15 1999-04-15 Processos para reduzir a alergenicidade de uma proteìna não humana e para produzir uma proteìna tendo reduzida alergenicidade, proteìna mutante tendo reduzida alergenicidade, dna, vetor de expressão, células hospedeiras, composição farmacêutica, e, substilisina humana

Country Status (14)

Country Link
US (2) US6642011B2 (pt)
EP (1) EP1071792B1 (pt)
JP (1) JP2002511272A (pt)
KR (1) KR20010034785A (pt)
CN (1) CN1297483A (pt)
AT (1) ATE342365T1 (pt)
AU (1) AU3643299A (pt)
BR (1) BR9909639A (pt)
CA (1) CA2325010A1 (pt)
DE (1) DE69933551T2 (pt)
DK (1) DK1071792T3 (pt)
NO (1) NO20005152L (pt)
PL (1) PL343711A1 (pt)
WO (1) WO1999053078A2 (pt)

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CA2249648A1 (en) * 1998-11-04 2000-05-04 Nabil G. Seidah Mammalian subtilisin/kexin isozyme ski-1: a proprotein convertase with a unique cleavage specificity
CN1300849A (zh) * 1999-12-21 2001-06-27 复旦大学 一种新的多肽－枯草蛋白酶10和编码这种多肽的多核苷酸
WO2001049864A1 (en) * 2000-01-06 2001-07-12 Lexicon Genetics Incorporated Novel human proteases and polynucleotides encoding the same
DE10041515A1 (de) * 2000-08-24 2002-03-14 Gerold Schuler Verfahren zur Herstellung gebrauchsfertiger, Antigen-beladener oder -unbeladener, kryokonservierter reifer dendritischer Zellen
DE60144399D1 (de) * 2000-10-02 2011-05-19 Danisco Us Inc Methode zur bestimmung der immunogenität von proteinen, die eine veränderte immunantwort hervorrufen
EP1239032A1 (en) * 2001-03-02 2002-09-11 Société des Produits Nestlé S.A. Lactic acid bacteria as agents for treating and preventing allergy
CN100489094C (zh) * 2001-03-23 2009-05-20 金克克国际有限公司 具有改变的免疫原性反应的蛋白质及制备和使用该蛋白质的方法
BR0215383A (pt) * 2001-12-31 2006-11-28 Genencor Int proteases que produzem resposta imunogênica alterada e métodos de fabricação e uso das mesmas
CA2476890C (en) * 2002-02-26 2013-07-16 Genencor International, Inc. Subtilisin carlsberg proteins with reduced immunogenicity
JP5009614B2 (ja) * 2003-07-03 2012-08-22 アバター バイオテクノロジーズ，インク． 免疫原性を低減した分子の取得方法
US20090060933A1 (en) * 2004-06-14 2009-03-05 Estell David A Proteases producing an altered immunogenic response and methods of making and using the same
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DK2510094T3 (en) * 2009-12-09 2017-03-13 Danisco Us Inc COMPOSITIONS AND METHODS OF COMPREHENSIVE PROTEASE VARIETIES
WO2016112350A1 (en) * 2015-01-09 2016-07-14 Oklahoma Medical Research Foundation Methods and compositions for diagnosing and treating lysosomal storage disorders

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Also Published As

Publication number Publication date
ATE342365T1 (de) 2006-11-15
US6642011B2 (en) 2003-11-04
CN1297483A (zh) 2001-05-30
US20020081703A1 (en) 2002-06-27
US20040063177A1 (en) 2004-04-01
DE69933551D1 (de) 2006-11-23
NO20005152L (no) 2000-12-11
WO1999053078A2 (en) 1999-10-21
PL343711A1 (en) 2001-08-27
EP1071792A2 (en) 2001-01-31
WO1999053078A3 (en) 2000-04-20
JP2002511272A (ja) 2002-04-16
CA2325010A1 (en) 1999-10-21
NO20005152D0 (no) 2000-10-13
DE69933551T2 (de) 2007-09-06
EP1071792B1 (en) 2006-10-11
DK1071792T3 (da) 2007-02-05
KR20010034785A (ko) 2001-04-25
AU3643299A (en) 1999-11-01

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Legal Events

Date Code Title Description
FA10 Dismissal: dismissal - article 33 of industrial property law
B11Y Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette]