BR9909639A - Processos para reduzir a alergenicidade de uma proteìna não humana e para produzir uma proteìna tendo reduzida alergenicidade, proteìna mutante tendo reduzida alergenicidade, dna, vetor de expressão, células hospedeiras, composição farmacêutica, e, substilisina humana - Google Patents
Processos para reduzir a alergenicidade de uma proteìna não humana e para produzir uma proteìna tendo reduzida alergenicidade, proteìna mutante tendo reduzida alergenicidade, dna, vetor de expressão, células hospedeiras, composição farmacêutica, e, substilisina humanaInfo
- Publication number
- BR9909639A BR9909639A BR9909639-0A BR9909639A BR9909639A BR 9909639 A BR9909639 A BR 9909639A BR 9909639 A BR9909639 A BR 9909639A BR 9909639 A BR9909639 A BR 9909639A
- Authority
- BR
- Brazil
- Prior art keywords
- protein
- allergenicity
- human
- reduced
- reduced allergenicity
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
- C12N9/54—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea bacteria being Bacillus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Abstract
"PROCESSOS PARA REDUZIR A ALERGENICIDADE DE UMA PROTEìNA NãO HUMANA E PARA PRODUZIR UMA PROTEìNA TENDO REDUZIDA ALERGENICIDADE, PROTEìNA MUTANTE TENDO REDUZIDA ALERGENICIDADE, DNA, VETOR DE EXPRESSãO, CéLULAS HOSPEDEIRAS, COMPOSIçãO FARMACêUTICA, E, SUBTILISINA HUMANA" A presente invenção refere-se a um processo para produzir novo mutante de proteína melhorado que produz baixa resposta alergênica em humanos comparado com o ascendente deste mutante. Especificamente, a presente invenção compreende a neutralização ou redução da alergenicidade de uma proteína por introdução na mesma, como substituição ou modificação de um epítopo em tal proteína, de uma seq³ência de subtilisina humana.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/060,854 US6642011B2 (en) | 1998-04-15 | 1998-04-15 | Human protease and use of such protease for pharmaceutical applications and for reducing the allergenicity of non-human proteins |
PCT/US1999/008177 WO1999053078A2 (en) | 1998-04-15 | 1999-04-15 | Human protease and use of such protease for pharmaceutical applications and for reducing the allergenicity of non-human proteins |
Publications (1)
Publication Number | Publication Date |
---|---|
BR9909639A true BR9909639A (pt) | 2000-12-19 |
Family
ID=22032151
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR9909639-0A BR9909639A (pt) | 1998-04-15 | 1999-04-15 | Processos para reduzir a alergenicidade de uma proteìna não humana e para produzir uma proteìna tendo reduzida alergenicidade, proteìna mutante tendo reduzida alergenicidade, dna, vetor de expressão, células hospedeiras, composição farmacêutica, e, substilisina humana |
Country Status (14)
Country | Link |
---|---|
US (2) | US6642011B2 (pt) |
EP (1) | EP1071792B1 (pt) |
JP (1) | JP2002511272A (pt) |
KR (1) | KR20010034785A (pt) |
CN (1) | CN1297483A (pt) |
AT (1) | ATE342365T1 (pt) |
AU (1) | AU3643299A (pt) |
BR (1) | BR9909639A (pt) |
CA (1) | CA2325010A1 (pt) |
DE (1) | DE69933551T2 (pt) |
DK (1) | DK1071792T3 (pt) |
NO (1) | NO20005152L (pt) |
PL (1) | PL343711A1 (pt) |
WO (1) | WO1999053078A2 (pt) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6642011B2 (en) * | 1998-04-15 | 2003-11-04 | Genencor International, Inc. | Human protease and use of such protease for pharmaceutical applications and for reducing the allergenicity of non-human proteins |
US6838269B1 (en) * | 1998-04-15 | 2005-01-04 | Genencor International, Inc. | Proteins producing an altered immunogenic response and methods of making and using the same |
CA2249648A1 (en) * | 1998-11-04 | 2000-05-04 | Nabil G. Seidah | Mammalian subtilisin/kexin isozyme ski-1: a proprotein convertase with a unique cleavage specificity |
CN1300849A (zh) * | 1999-12-21 | 2001-06-27 | 复旦大学 | 一种新的多肽-枯草蛋白酶10和编码这种多肽的多核苷酸 |
WO2001049864A1 (en) * | 2000-01-06 | 2001-07-12 | Lexicon Genetics Incorporated | Novel human proteases and polynucleotides encoding the same |
DE10041515A1 (de) * | 2000-08-24 | 2002-03-14 | Gerold Schuler | Verfahren zur Herstellung gebrauchsfertiger, Antigen-beladener oder -unbeladener, kryokonservierter reifer dendritischer Zellen |
AU2002237646A1 (en) * | 2000-10-02 | 2002-05-27 | Genencor International, Inc. | Production and use of proteins producing an altered immunogenic response |
EP1239032A1 (en) * | 2001-03-02 | 2002-09-11 | Société des Produits Nestlé S.A. | Lactic acid bacteria as agents for treating and preventing allergy |
RU2311458C2 (ru) | 2001-03-23 | 2007-11-27 | Джененкор Интернэшнл, Инк. | Белки, вызывающие измененную иммуногенную реакцию, и способы их получения и использования |
WO2003057713A2 (en) * | 2001-12-31 | 2003-07-17 | Genencor International, Inc. | Proteases producing an altered immunogenic response and methods of making and using the same |
MXPA04008144A (es) * | 2002-02-26 | 2004-11-26 | Genencor Int | Proteinas de subtilisina carlsberg con inmunogenicidad reducida. |
ATE532793T1 (de) * | 2003-07-03 | 2011-11-15 | Avatar Biotechnologies Inc | Verfahren zur herstellung von molekülen mit verminderter immunogenität |
US20090060933A1 (en) * | 2004-06-14 | 2009-03-05 | Estell David A | Proteases producing an altered immunogenic response and methods of making and using the same |
WO2006136160A2 (en) * | 2005-06-24 | 2006-12-28 | Novozymes A/S | Proteases for pharmaceutical use |
CN101243182B (zh) * | 2005-08-16 | 2014-08-06 | 诺维信公司 | 枯草蛋白酶 |
AR079338A1 (es) | 2009-12-09 | 2012-01-18 | Danisco Us Inc | Variantes de proteasa de bacillus y acidos nucleicos que codifican dichas variantes |
WO2016112350A1 (en) * | 2015-01-09 | 2016-07-14 | Oklahoma Medical Research Foundation | Methods and compositions for diagnosing and treating lysosomal storage disorders |
Family Cites Families (34)
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US4261868A (en) | 1979-08-08 | 1981-04-14 | Lever Brothers Company | Stabilized enzymatic liquid detergent composition containing a polyalkanolamine and a boron compound |
US4404128A (en) | 1981-05-29 | 1983-09-13 | The Procter & Gamble Company | Enzyme detergent composition |
JPS58144105A (ja) | 1982-02-12 | 1983-08-27 | Kurabo Ind Ltd | スケ−ル除去獣毛繊維の製法 |
US4760025A (en) | 1984-05-29 | 1988-07-26 | Genencor, Inc. | Modified enzymes and methods for making same |
US5155033A (en) | 1989-01-06 | 1992-10-13 | Genencor, Inc. | Subtilisins modified at position 225 resulting in a shift in catalytic activity |
US5763257A (en) * | 1984-05-29 | 1998-06-09 | Genencor International, Inc. | Modified subtilisins having amino acid alterations |
US5204015A (en) | 1984-05-29 | 1993-04-20 | Genencor International, Inc. | Subtilisin mutants |
US5264366A (en) | 1984-05-29 | 1993-11-23 | Genencor, Inc. | Protease deficient bacillus |
US5185258A (en) | 1984-05-29 | 1993-02-09 | Genencor International, Inc. | Subtilisin mutants |
US5182204A (en) | 1984-05-29 | 1993-01-26 | Genencor International, Inc. | Non-human carbonyl hydrolase mutants, vectors encoding same and hosts transformed with said vectors |
SG30639G (en) * | 1986-04-30 | 1995-09-01 | Genencor Int | Non-human carbonyl hydrolase mutants DNA sequences and vectors encoding same and hosts transformed with said vectors |
US4914031A (en) | 1987-04-10 | 1990-04-03 | Amgen, Inc. | Subtilisin analogs |
US5314692A (en) | 1987-08-24 | 1994-05-24 | Cultor Ltd. | Enzyme premix for feed and method |
DK6488D0 (da) | 1988-01-07 | 1988-01-07 | Novo Industri As | Enzymer |
CN1056187C (zh) | 1988-02-11 | 2000-09-06 | 金克克国际有限公司 | 新的蛋白水解酶及其在洗涤剂中的应用 |
DE3841152A1 (de) | 1988-12-07 | 1990-06-13 | Hoechst Ag | Verwendung von bakterienlysierendem enzymprodukt als zusatzstoff zur verbesserung der futterverwertung in der tierproduktion |
SE8903427L (sv) | 1989-10-18 | 1991-04-19 | Vest Nova Ab | Staedapparat |
JP4236698B2 (ja) * | 1990-11-26 | 2009-03-11 | ジェネティックス インスティチュート,リミテッド ライアビリティ カンパニー | 宿主細胞でのpaceの発現およびその使用法 |
DE69130113T2 (de) | 1990-12-05 | 1999-05-12 | Novo Nordisk As | Proteine mit geänderten epitopen und verfahren zur deren herstellung |
US5766898A (en) * | 1990-12-05 | 1998-06-16 | Novo Nordisk A/S | Proteins with changed epitopes and methods for the production thereof |
US5766886A (en) * | 1991-12-13 | 1998-06-16 | Xoma Corporation | Modified antibody variable domains |
EP0632833A1 (en) * | 1992-03-09 | 1995-01-11 | Chiron Corporation | Compositions and methods for pace 4 and 4.1 gene and polypeptides in cells |
DK132892D0 (da) | 1992-10-30 | 1992-10-30 | Novo Nordisk As | Proteiner |
US5585250A (en) * | 1993-08-20 | 1996-12-17 | The United States Of America As Represented By The Department Of Health & Human Services | Dampening of an immunodominant epitope of an antigen for use in plant, animal and human compositions and immunotherapies |
US5840299A (en) * | 1994-01-25 | 1998-11-24 | Athena Neurosciences, Inc. | Humanized antibodies against leukocyte adhesion molecule VLA-4 |
GB9416841D0 (en) | 1994-08-19 | 1994-10-12 | Finnfeeds Int Ltd | An enzyme feed additive and animal feed including it |
JPH10510516A (ja) | 1994-12-07 | 1998-10-13 | ノボ ノルディスク アクティーゼルスカブ | アレルゲン性を減らしたポリペプチド |
US5837517A (en) * | 1995-05-05 | 1998-11-17 | Novo Nordisk A/S | Protease variants and compositions |
EP0824585B1 (en) * | 1995-05-05 | 2009-04-22 | Novozymes A/S | Protease variants and compositions |
CZ283972B6 (cs) * | 1995-05-17 | 1998-07-15 | František Mudr. Trnka | Farmaceutický prostředek s modulačním účinkem na zhoubné nádory a jeho použití |
AU5893696A (en) | 1995-06-07 | 1996-12-30 | Novo Nordisk A/S | Modification of polypeptides |
JP2000506119A (ja) | 1996-02-15 | 2000-05-23 | ノボ ノルディスク アクティーゼルスカブ | ポリペプチドのコンジュゲーション |
US6642011B2 (en) * | 1998-04-15 | 2003-11-04 | Genencor International, Inc. | Human protease and use of such protease for pharmaceutical applications and for reducing the allergenicity of non-human proteins |
US6835550B1 (en) * | 1998-04-15 | 2004-12-28 | Genencor International, Inc. | Mutant proteins having lower allergenic response in humans and methods for constructing, identifying and producing such proteins |
-
1998
- 1998-04-15 US US09/060,854 patent/US6642011B2/en not_active Expired - Lifetime
-
1999
- 1999-04-15 PL PL99343711A patent/PL343711A1/xx unknown
- 1999-04-15 AU AU36432/99A patent/AU3643299A/en not_active Abandoned
- 1999-04-15 CA CA002325010A patent/CA2325010A1/en not_active Abandoned
- 1999-04-15 EP EP99918548A patent/EP1071792B1/en not_active Expired - Lifetime
- 1999-04-15 JP JP2000543625A patent/JP2002511272A/ja not_active Withdrawn
- 1999-04-15 BR BR9909639-0A patent/BR9909639A/pt not_active Application Discontinuation
- 1999-04-15 CN CN99805051A patent/CN1297483A/zh active Pending
- 1999-04-15 DE DE69933551T patent/DE69933551T2/de not_active Expired - Lifetime
- 1999-04-15 AT AT99918548T patent/ATE342365T1/de not_active IP Right Cessation
- 1999-04-15 DK DK99918548T patent/DK1071792T3/da active
- 1999-04-15 KR KR1020007011440A patent/KR20010034785A/ko not_active Application Discontinuation
- 1999-04-15 WO PCT/US1999/008177 patent/WO1999053078A2/en active IP Right Grant
-
2000
- 2000-10-13 NO NO20005152A patent/NO20005152L/no not_active Application Discontinuation
-
2003
- 2003-09-18 US US10/665,689 patent/US20040063177A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
AU3643299A (en) | 1999-11-01 |
ATE342365T1 (de) | 2006-11-15 |
DE69933551D1 (de) | 2006-11-23 |
DE69933551T2 (de) | 2007-09-06 |
CA2325010A1 (en) | 1999-10-21 |
KR20010034785A (ko) | 2001-04-25 |
JP2002511272A (ja) | 2002-04-16 |
EP1071792A2 (en) | 2001-01-31 |
US20020081703A1 (en) | 2002-06-27 |
DK1071792T3 (da) | 2007-02-05 |
NO20005152L (no) | 2000-12-11 |
US6642011B2 (en) | 2003-11-04 |
WO1999053078A2 (en) | 1999-10-21 |
EP1071792B1 (en) | 2006-10-11 |
CN1297483A (zh) | 2001-05-30 |
NO20005152D0 (no) | 2000-10-13 |
WO1999053078A3 (en) | 2000-04-20 |
US20040063177A1 (en) | 2004-04-01 |
PL343711A1 (en) | 2001-08-27 |
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Legal Events
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FA10 | Dismissal: dismissal - article 33 of industrial property law | ||
B11Y | Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette] |