BR0212654A - Ativação e expansão de células - Google Patents

Ativação e expansão de células

Info

Publication number
BR0212654A
BR0212654A BR0212654-0A BR0212654A BR0212654A BR 0212654 A BR0212654 A BR 0212654A BR 0212654 A BR0212654 A BR 0212654A BR 0212654 A BR0212654 A BR 0212654A
Authority
BR
Brazil
Prior art keywords
expansion
cell activation
cells
activated
expanded
Prior art date
Application number
BR0212654-0A
Other languages
English (en)
Inventor
Ronald Berenson
Che Law
Mark Bonyhadi
Narinder Saund
Stewart Craig
Alan R Hardwick
Dale Kalamasz
David Mcmillen
Harjinder Singh Chana
Original Assignee
Xcyte Therapies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/960,264 external-priority patent/US6797514B2/en
Priority claimed from US10/133,236 external-priority patent/US6867041B2/en
Application filed by Xcyte Therapies Inc filed Critical Xcyte Therapies Inc
Publication of BR0212654A publication Critical patent/BR0212654A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
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    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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    • C07K16/2806—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD2
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    • C07K16/2845—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily against integrin beta2-subunit-containing molecules, e.g. CD11, CD18
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Abstract

"ATIVAçãO E EXPANSãO DE CéLULAS". A presente invenção se refere em linhas gerais a processos para a ativação e expansão de células e mais especificamente a um processo inédito para a ativação e/ou estimulação de células que maximiza a expansão de tais células para se obter densidades extremamente altas. Nas diversas modalidades, as células são ativadas e expandidas até densidades muito altas em um curto período de tempo. Em determinadas modalidades, as células são ativadas e expandidas até números muito altos de células em um período de tempo curto. São também propostas composições de células ativadas e expandidas pelos processos da presente invenção.
BR0212654-0A 2001-09-20 2002-09-04 Ativação e expansão de células BR0212654A (pt)

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US09/960,264 US6797514B2 (en) 2000-02-24 2001-09-20 Simultaneous stimulation and concentration of cells
US10/133,236 US6867041B2 (en) 2000-02-24 2002-04-26 Simultaneous stimulation and concentration of cells
US10/187,467 US20030119185A1 (en) 2000-02-24 2002-06-28 Activation and expansion of cells
PCT/US2002/028161 WO2003024989A2 (en) 2001-09-20 2002-09-04 Activation and expansion of cells

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Families Citing this family (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7541184B2 (en) * 2000-02-24 2009-06-02 Invitrogen Corporation Activation and expansion of cells
US20030235908A1 (en) * 2000-02-24 2003-12-25 Xcyte Therapies, Inc. Activation and expansion of cells
JP2005517025A (ja) * 2002-02-08 2005-06-09 エクサイト セラピーズ， インコーポレイテッド 免疫学的欠損を有する患者において免疫応答性を回復するための、組成物および方法
US20050084967A1 (en) * 2002-06-28 2005-04-21 Xcyte Therapies, Inc. Compositions and methods for eliminating undesired subpopulations of T cells in patients with immunological defects related to autoimmunity and organ or hematopoietic stem cell transplantation
AU2003253684A1 (en) * 2002-06-28 2004-01-19 Xcyte Therapies, Inc. Compositions and methods for restoring immune repertoire in patients with immunological defects related to autoimmunity and organ or hematopoietic stem cell transplantation
US20040175373A1 (en) * 2002-06-28 2004-09-09 Xcyte Therapies, Inc. Compositions and methods for eliminating undesired subpopulations of T cells in patients with immunological defects related to autoimmunity and organ or hematopoietic stem cell transplantation
US7651855B2 (en) * 2003-04-17 2010-01-26 The Trustees Of The University Of Pennsylvania Regulatory T cells and their use in immunotherapy and suppression of autoimmune responses
AU2003300359A1 (en) * 2003-05-08 2004-12-13 Xcyte Therapies, Inc. Generation and isolation of antigen-specific t cells
US7435592B2 (en) 2003-05-13 2008-10-14 Immunovative Therapies, Ltd. Compositions for allogeneic cell therapy
US7402431B2 (en) * 2004-03-01 2008-07-22 Immunovative Therapies, Ltd. T-cell therapy formulation
AU2003238273A1 (en) * 2003-06-17 2005-02-04 Centocor, Inc. Method and apparatus for filtration of bioreactor recombinant proteins
WO2005045009A1 (en) * 2003-07-23 2005-05-19 President And Fellows Of Harvard College Methods for isolating t cells and uses thereof
WO2005030251A1 (en) * 2003-09-22 2005-04-07 Xcyte Therapies, Inc. Compositions and methods to accelerate hematologic recovery
US20050186207A1 (en) * 2004-01-08 2005-08-25 The Regents Of The University Of California Regulatory T cells suppress autoimmunity
US7875448B2 (en) * 2004-01-12 2011-01-25 Single Use Brx, Llc Bioreactor systems and disposable bioreactor
EP1776583A4 (en) 2004-02-26 2009-04-29 Immunovative Therapies Ltd PROCESSES FOR THE PREPARATION OF T CELLS FOR CELL THERAPY
US7592431B2 (en) 2004-02-26 2009-09-22 Immunovative Therapies, Ltd. Biodegradable T-cell Activation device
CA2530514C (en) * 2004-03-01 2017-01-31 Immunovative Therapies, Ltd. Cell therapy formulation method and composition
KR100735083B1 (ko) * 2005-04-21 2007-07-06 고려대학교 산학협력단 Ｃｄ8 ｔ 세포 활성화 방법
KR100735081B1 (ko) * 2005-04-21 2007-07-06 고려대학교 산학협력단 Ｃｄ4 ｔ 세포 활성화 방법
US8603805B2 (en) 2005-04-22 2013-12-10 Hyclone Laboratories, Inc. Gas spargers and related container systems
US9109193B2 (en) * 2007-07-30 2015-08-18 Ge Healthcare Bio-Sciences Corp. Continuous perfusion bioreactor system
US20140161782A1 (en) * 2008-06-09 2014-06-12 Targazyme, Inc. Augmentation of cell therapy efficacy including treatment with alpha 1-3 fucoslytransferase
WO2010062742A2 (en) * 2008-11-03 2010-06-03 The Johns Hopkins University Methods for freparation and use of marrow infiltrating lymphocytes (mils)
US8415150B2 (en) * 2009-02-24 2013-04-09 The Trustees Of The University Of Pennsylvania Methods for treating progressive multifocal leukoencephalopathy (PML)
CN102428173B (zh) * 2009-03-26 2014-07-30 细胞维护北欧制药公司 Nk细胞的扩增
BR112013028285A2 (pt) 2011-05-03 2017-01-10 Immunovative Therapies Ltd indução de il-12 usando imunoterapia
HUE034995T2 (en) 2011-05-03 2018-05-02 Immunovative Therapies Ltd A method for treating biological agents comprising living cells
US9376655B2 (en) 2011-09-29 2016-06-28 Life Technologies Corporation Filter systems for separating microcarriers from cell culture solutions
US9643133B2 (en) 2011-09-30 2017-05-09 Life Technologies Corporation Container with film sparger
JP6429191B2 (ja) * 2012-03-06 2018-11-28 セレクト バイオセラピューティクス リミテッド アポトーシスシグナル伝達抵抗性細胞を選択する装置および方法ならびにその使用
CN102732480A (zh) * 2012-06-11 2012-10-17 中山大学 N-乙酰半胱氨酸对中央记忆性t细胞的绝对数量在体外扩增上的应用
EP4119662A1 (en) 2013-05-10 2023-01-18 Whitehead Institute For Biomedical Research Protein modification of living cells using sortase
CA2952241A1 (en) 2014-06-18 2015-12-23 Medimmune, Llc Cell culture methods and media comprising n-acetylcysteine
US9079690B1 (en) 2014-06-26 2015-07-14 Advanced Scientifics, Inc. Freezer bag, storage system, and method of freezing
CN107532149A (zh) * 2015-02-26 2018-01-02 生物磁溶液有限公司 通过各成分基本上同时孵育和通用载体以分离细胞
US11708572B2 (en) 2015-04-29 2023-07-25 Flodesign Sonics, Inc. Acoustic cell separation techniques and processes
GB201509202D0 (en) 2015-05-28 2015-07-15 Ge Healthcare Bio Sciences Ab Semi-static cell culture
US9920292B2 (en) 2015-08-31 2018-03-20 General Electric Company System and method for initiating a cell culture
MX2018010445A (es) 2016-03-01 2019-10-17 Yissum Res Dev Co Of Hebrew Univ Jerusalem Ltd Anticuerpos especificos del receptor de poliovirus humano (rvp).
US10294454B2 (en) 2016-08-24 2019-05-21 General Electric Company Methods and kits for cell activation
CN107151654B (zh) * 2016-10-11 2020-05-05 深圳宾德生物技术有限公司 一种人源t淋巴细胞的培养基及其制备方法和应用
JP2020513248A (ja) 2016-10-19 2020-05-14 フロデザイン ソニックス， インク．Ｆｌｏｄｅｓｉｇｎ Ｓｏｎｉｃｓ， Ｉｎｃ． 音響による親和性細胞抽出
CA3042692A1 (en) * 2016-11-03 2018-05-31 Cell Microsystems, Inc. Automated collection of a specified number of cells
CN115232745A (zh) 2016-12-01 2022-10-25 生命科技股份有限公司 微载体过滤袋总成和使用方法
AU2017367003B2 (en) * 2016-12-02 2021-03-25 EMULATE, Inc. In vitro gastrointestinal model comprising lamina propria-derived cells
CN107099603A (zh) * 2017-05-31 2017-08-29 成都克里斯博生物科技有限公司 肿瘤免疫t细胞检测试剂盒和检测方法
US11149244B2 (en) * 2018-04-04 2021-10-19 Southwest Research Institute Three-dimensional bioreactor for T-cell activation and expansion for immunotherapy
SG11202102986XA (en) 2018-09-24 2021-04-29 Southwest Res Inst Three-dimensional bioreactors
WO2020191084A1 (en) * 2019-03-18 2020-09-24 The Regents Of The University Of California Augmentation of t-cell activation by oscillatory forces and engineered antigen-presenting cells
WO2021062267A1 (en) * 2019-09-26 2021-04-01 Nantbio, Inc. Primary t-cell expansion
CN112574952A (zh) * 2019-09-30 2021-03-30 英基生物医药(香港)有限公司 一种工程化人体免疫细胞、其制备方法及应用
CN110643574A (zh) * 2019-10-30 2020-01-03 西南医科大学 用于肿瘤浸润性淋巴细胞快速培养的饲养细胞的制备方法
CN111154648B (zh) * 2019-12-27 2022-10-25 新乡医学院三全学院 一种干细胞源性外泌体培养装置
CN111534489B (zh) * 2020-04-29 2022-07-12 清华大学 一种基于3d打印的t淋巴细胞扩增方法
CN111849919A (zh) * 2020-07-24 2020-10-30 英基生物医药(香港)有限公司 一种具有抗病毒活性的工程化免疫细胞及其构建方法和应用

Family Cites Families (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5081029A (en) * 1985-09-25 1992-01-14 Oncogen Methods of adoptive immunotherapy for treatment of aids
WO1988000970A2 (en) * 1986-08-08 1988-02-11 Regents Of The University Of Minnesota Method of culturing leukocytes
US6010902A (en) * 1988-04-04 2000-01-04 Bristol-Meyers Squibb Company Antibody heteroconjugates and bispecific antibodies for use in regulation of lymphocyte activity
US6352694B1 (en) * 1994-06-03 2002-03-05 Genetics Institute, Inc. Methods for inducing a population of T cells to proliferate using agents which recognize TCR/CD3 and ligands which stimulate an accessory molecule on the surface of the T cells
US5858358A (en) * 1992-04-07 1999-01-12 The United States Of America As Represented By The Secretary Of The Navy Methods for selectively stimulating proliferation of T cells
US5763266A (en) * 1989-06-15 1998-06-09 The Regents Of The University Of Michigan Methods, compositions and devices for maintaining and growing human stem and/or hematopoietics cells
DE3923279A1 (de) * 1989-07-14 1990-01-18 Will W Prof Dr Minuth Minusheets ist ein neues produkt, um zellen in beliebigen behaeltnissen in hochdifferenzierter form auf einer moeglichst natuerlichen unterlage zu kultivieren
JP2546544B2 (ja) * 1989-10-27 1996-10-23 アーチ ディベラップメント コーポレイション 免疫強化を促進するための方法と組成物
US5470730A (en) * 1990-09-28 1995-11-28 Immunex Method for producing TH -independent cytotoxic T lymphocytes
US6129916A (en) * 1991-04-19 2000-10-10 Tanox, Inc. Method of Increasing activation on proliferation of T cells using antibody-microbead conjugates
US6197298B1 (en) * 1991-04-19 2001-03-06 Tanox, Inc. Modified binding molecules specific for T lymphocytes and their use as in vivo immune modulators in animals
GB9120508D0 (en) * 1991-09-26 1991-11-06 Nycomed As Diagnostic agents
WO1994007138A1 (en) * 1992-09-14 1994-03-31 Fodstad Oystein Detection of specific target cells in specialized or mixed cell population and solutions containing mixed cell populations
US5837477A (en) * 1993-01-15 1998-11-17 The United States Of America As Represented By The Department Of Health And Human Services T cell receptor ligands and methods of using same
US7211259B1 (en) * 1993-05-07 2007-05-01 Immunex Corporation 4-1BB polypeptides and DNA encoding 4-1BB polypeptides
WO1994026290A1 (en) * 1993-05-07 1994-11-24 Immunex Corporation Cytokine designated 4-1bb ligand and human receptor that binds thereto
US5942607A (en) * 1993-07-26 1999-08-24 Dana-Farber Cancer Institute B7-2: a CTLA4/CD28 ligand
US5672505A (en) * 1993-09-27 1997-09-30 Becton, Dickinson And Company Insert for a issue culture vessel
JPH10504703A (ja) 1994-06-03 1998-05-12 アメリカ合衆国 Ｔ細胞の選択的刺激増殖方法
FR2729570A1 (fr) * 1995-01-24 1996-07-26 Idm Immuno Designed Molecules Procede de preparation de macrophages actives, trousses et compositions pour la mise en oeuvre de ce procede
US6096532A (en) * 1995-06-07 2000-08-01 Aastrom Biosciences, Inc. Processor apparatus for use in a system for maintaining and growing biological cells
US5985653A (en) * 1995-06-07 1999-11-16 Aastrom Biosciences, Inc. Incubator apparatus for use in a system for maintaining and growing biological cells
US20020182730A1 (en) * 1995-07-26 2002-12-05 Micheal L. Gruenberg Autologous immune cell therapy: cell compositions, methods and applications to treatment of human disease
JP4767371B2 (ja) * 1996-01-17 2011-09-07 インペリアル・イノベイションズ・リミテッド 細胞障害性ｔリンパ球（ｃｔｌ）を用いた免疫療法
ATE476496T1 (de) * 1996-03-04 2010-08-15 Calyx Bio Ventures Inc Modifizierte schnellvermehrungsmethode ('modified-rem') zur in vitro vermehrung von t-lymphozyten
US5972721A (en) * 1996-03-14 1999-10-26 The United States Of America As Represented By The Secretary Of The Air Force Immunomagnetic assay system for clinical diagnosis and other purposes
US5962319A (en) * 1997-05-19 1999-10-05 Bml, Inc. Human-Th1-specific protein, gene encoding the protein, transformants, recombinant vectors, and antibodies related to the gene
US20010031253A1 (en) * 1996-07-24 2001-10-18 Gruenberg Micheal L. Autologous immune cell therapy: cell compositions, methods and applications to treatment of human disease
US5766944A (en) * 1996-12-31 1998-06-16 Ruiz; Margaret Eileen T cell differentiation of CD34+ stem cells in cultured thymic epithelial fragments
AU738538B2 (en) * 1997-01-31 2001-09-20 Hemosol Inc. Method for the production of selected lymphocytes
JP2004500095A (ja) * 2000-02-24 2004-01-08 エクサイト　セラピーズ，　インコーポレイテッド 細胞の同時の刺激および濃縮
US20020081635A1 (en) * 2000-05-11 2002-06-27 Thomas Terry E. Novel antibody compositions for preparing enriched T cell preparations
US6544788B2 (en) * 2001-02-15 2003-04-08 Vijay Singh Disposable perfusion bioreactor for cell culture
WO2003024312A2 (en) * 2001-09-17 2003-03-27 Valeocyte Therapies Llc Cell therapy system
US20030134341A1 (en) * 2001-09-19 2003-07-17 Medcell Biologics, Llc. Th1 cell adoptive immunotherapy
US20030194395A1 (en) * 2001-09-17 2003-10-16 Gruenberg Micheal L. Th1 cell adoptive immunotherapy
US20030134415A1 (en) * 2001-09-19 2003-07-17 Gruenberg Micheal L. Th1 cell adoptive immunotherapy
US20030170238A1 (en) * 2002-03-07 2003-09-11 Gruenberg Micheal L. Re-activated T-cells for adoptive immunotherapy
US20030175272A1 (en) * 2002-03-07 2003-09-18 Medcell Biologics, Inc. Re-activated T-cells for adoptive immunotherapy

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HK1067660A1 (en) 2005-04-15
US20050214942A1 (en) 2005-09-29
US20030119185A1 (en) 2003-06-26
WO2003024989A3 (en) 2003-06-26
WO2003024989A2 (en) 2003-03-27
EP1434856A4 (en) 2006-11-15
AU2002331808B2 (en) 2008-01-24
WO2003024989A9 (en) 2004-04-01
US20050153447A1 (en) 2005-07-14
CN1556854A (zh) 2004-12-22
ES2434916T3 (es) 2013-12-18
MXPA04002581A (es) 2005-08-26
IL160591A0 (en) 2004-07-25
EP1434856B1 (en) 2013-07-24
KR20040053133A (ko) 2004-06-23
MX2018010240A (es) 2021-12-08
EP1434856A2 (en) 2004-07-07
CA2459587A1 (en) 2003-03-27

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