DE602005023138D1 - Anti-cea scfv-beta-lactamase konstrukte (cab moleküle) in adept - Google Patents
Anti-cea scfv-beta-lactamase konstrukte (cab moleküle) in adeptInfo
- Publication number
- DE602005023138D1 DE602005023138D1 DE602005023138T DE602005023138T DE602005023138D1 DE 602005023138 D1 DE602005023138 D1 DE 602005023138D1 DE 602005023138 T DE602005023138 T DE 602005023138T DE 602005023138 T DE602005023138 T DE 602005023138T DE 602005023138 D1 DE602005023138 D1 DE 602005023138D1
- Authority
- DE
- Germany
- Prior art keywords
- adept
- lactamate
- constructs
- beta
- cea scfv
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 238000010913 antigen-directed enzyme pro-drug therapy Methods 0.000 title abstract 2
- 230000002494 anti-cea effect Effects 0.000 title 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3007—Carcino-embryonic Antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US56238604P | 2004-04-15 | 2004-04-15 | |
US63600204P | 2004-12-14 | 2004-12-14 | |
PCT/US2005/012270 WO2005111078A2 (en) | 2004-04-15 | 2005-04-12 | Anti-cea scfv-beta-lactamase contructs (cab molecules) in adept |
Publications (1)
Publication Number | Publication Date |
---|---|
DE602005023138D1 true DE602005023138D1 (de) | 2010-10-07 |
Family
ID=35394728
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE602005023138T Active DE602005023138D1 (de) | 2004-04-15 | 2005-04-12 | Anti-cea scfv-beta-lactamase konstrukte (cab moleküle) in adept |
Country Status (7)
Country | Link |
---|---|
US (2) | US8088609B2 (de) |
EP (1) | EP1735350B1 (de) |
JP (1) | JP4699450B2 (de) |
AT (1) | ATE478894T1 (de) |
CA (1) | CA2562711C (de) |
DE (1) | DE602005023138D1 (de) |
WO (1) | WO2005111078A2 (de) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10370680B2 (en) | 2014-02-24 | 2019-08-06 | Sangamo Therapeutics, Inc. | Method of treating factor IX deficiency using nuclease-mediated targeted integration |
CN107164412B (zh) * | 2017-06-30 | 2020-10-23 | 山东兴瑞生物科技有限公司 | 一种安全型抗cea嵌合抗原受体修饰t细胞的制备方法及其应用 |
EP4148065A1 (de) * | 2020-05-08 | 2023-03-15 | SMT Bio Co., Ltd. | Chimärer antigenrezeptor zur behandlung von krebs |
Family Cites Families (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4458066A (en) | 1980-02-29 | 1984-07-03 | University Patents, Inc. | Process for preparing polynucleotides |
US4522811A (en) | 1982-07-08 | 1985-06-11 | Syntex (U.S.A.) Inc. | Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides |
US4522611A (en) * | 1982-12-27 | 1985-06-11 | Esco Corporation | Sprocket assembly with replaceable teeth |
US4675187A (en) | 1983-05-16 | 1987-06-23 | Bristol-Myers Company | BBM-1675, a new antibiotic complex |
US4711845A (en) | 1984-08-31 | 1987-12-08 | Cetus Corporation | Portable temperature-sensitive control cassette |
EP0196864A3 (de) | 1985-03-25 | 1988-03-23 | Cetus Corporation | Behandlung und Sekretion von rekombinanten Proteinen mittels alkalischer Phosphatase, dazu verwendbare DNA-Sequenzen und mittels dieser Sequenzen transformierte Zellen |
NZ225599A (en) * | 1987-08-04 | 1991-09-25 | Bristol Myers Co | Antibody-enzyme conjugates and combinations with prodrugs for the treatment of tumour cells |
US5773435A (en) | 1987-08-04 | 1998-06-30 | Bristol-Myers Squibb Company | Prodrugs for β-lactamase and uses thereof |
US4975278A (en) | 1988-02-26 | 1990-12-04 | Bristol-Myers Company | Antibody-enzyme conjugates in combination with prodrugs for the delivery of cytotoxic agents to tumor cells |
US5766883A (en) | 1989-04-29 | 1998-06-16 | Delta Biotechnology Limited | Polypeptides |
US5081235A (en) | 1989-07-26 | 1992-01-14 | City Of Hope | Chimeric anti-cea antibody |
US5843440A (en) | 1990-10-03 | 1998-12-01 | Redcell Canada, Inc. | Cellular and serum protein anchors for modulating pharmacokinetics |
AU649275B2 (en) * | 1990-11-06 | 1994-05-19 | Bristol-Myers Squibb Company | Prodrugs for beta-lactamase and uses thereof |
PT730470E (pt) | 1993-11-10 | 2002-08-30 | Enzon Inc | Conjugados melhorados de interferao-polimero |
CA2250579A1 (en) * | 1996-05-04 | 1997-11-13 | Zeneca Limited | Monoclonal antibody to cea, conjugates comprising said antibody, and their therapeutic use in an adept system |
US6835550B1 (en) | 1998-04-15 | 2004-12-28 | Genencor International, Inc. | Mutant proteins having lower allergenic response in humans and methods for constructing, identifying and producing such proteins |
US6660843B1 (en) | 1998-10-23 | 2003-12-09 | Amgen Inc. | Modified peptides as therapeutic agents |
TWI310684B (en) | 2000-03-27 | 2009-06-11 | Bristol Myers Squibb Co | Synergistic pharmaceutical kits for treating cancer |
US20030068792A1 (en) | 2000-12-14 | 2003-04-10 | Yiyou Chen | Targeted enzymes |
US20030147874A1 (en) | 2000-12-14 | 2003-08-07 | Volker Schellenberger | Targeted enzyme prodrug therapy |
WO2002048372A2 (en) | 2000-12-14 | 2002-06-20 | Genencor International, Inc. | Target enzymes |
JP4688343B2 (ja) * | 2001-05-16 | 2011-05-25 | ルネサスエレクトロニクス株式会社 | 強誘電体メモリ装置 |
US20030100467A1 (en) | 2001-09-12 | 2003-05-29 | Wolfgang Aehle | Binding phenol oxidizing enzyme-peptide complexes |
EP1461085A2 (de) * | 2002-01-03 | 2004-09-29 | Vlaams Interuniversitair Instituut voor Biotechnologie vzw. | Immunokonjugate zur behandlung von tumoren |
AU2003256266A1 (en) | 2002-06-12 | 2003-12-31 | Genencor International, Inc. | Methods and compositions for milieu-dependent binding of a targeted agent to a target |
US20110160440A1 (en) * | 2003-12-12 | 2011-06-30 | Genencor International, Inc. | Cab Molecules |
-
2005
- 2005-04-12 CA CA2562711A patent/CA2562711C/en not_active Expired - Fee Related
- 2005-04-12 JP JP2007508444A patent/JP4699450B2/ja not_active Expired - Fee Related
- 2005-04-12 DE DE602005023138T patent/DE602005023138D1/de active Active
- 2005-04-12 US US10/590,870 patent/US8088609B2/en not_active Expired - Fee Related
- 2005-04-12 AT AT05778159T patent/ATE478894T1/de not_active IP Right Cessation
- 2005-04-12 EP EP05778159A patent/EP1735350B1/de not_active Not-in-force
- 2005-04-12 WO PCT/US2005/012270 patent/WO2005111078A2/en active Application Filing
-
2011
- 2011-11-02 US US13/287,642 patent/US8728470B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
EP1735350A2 (de) | 2006-12-27 |
US8088609B2 (en) | 2012-01-03 |
CA2562711C (en) | 2013-09-17 |
WO2005111078A9 (en) | 2006-03-30 |
CA2562711A1 (en) | 2005-11-24 |
JP2008501313A (ja) | 2008-01-24 |
EP1735350B1 (de) | 2010-08-25 |
JP4699450B2 (ja) | 2011-06-08 |
WO2005111078A3 (en) | 2006-07-27 |
US20080096810A1 (en) | 2008-04-24 |
US8728470B2 (en) | 2014-05-20 |
ATE478894T1 (de) | 2010-09-15 |
US20120107314A1 (en) | 2012-05-03 |
WO2005111078A2 (en) | 2005-11-24 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8327 | Change in the person/name/address of the patent owner |
Owner name: DANISCO US INC., PALO ALTO, CALIF., US |