DK1695708T3 - Highly concentrated minoxidil composition - Google Patents
Highly concentrated minoxidil composition Download PDFInfo
- Publication number
- DK1695708T3 DK1695708T3 DK06012033.4T DK06012033T DK1695708T3 DK 1695708 T3 DK1695708 T3 DK 1695708T3 DK 06012033 T DK06012033 T DK 06012033T DK 1695708 T3 DK1695708 T3 DK 1695708T3
- Authority
- DK
- Denmark
- Prior art keywords
- minoxidil
- acid
- composition
- pharmaceutical composition
- weight
- Prior art date
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- 239000000203 mixture Substances 0.000 title claims abstract description 47
- ZFMITUMMTDLWHR-UHFFFAOYSA-N Minoxidil Chemical compound NC1=[N+]([O-])C(N)=CC(N2CCCCC2)=N1 ZFMITUMMTDLWHR-UHFFFAOYSA-N 0.000 title claims description 66
- 229960003632 minoxidil Drugs 0.000 title claims description 63
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims abstract description 36
- 239000002253 acid Substances 0.000 claims abstract description 23
- 150000003839 salts Chemical class 0.000 claims abstract description 19
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 18
- 239000008194 pharmaceutical composition Substances 0.000 claims abstract description 18
- 239000006184 cosolvent Substances 0.000 claims abstract description 11
- 239000002904 solvent Substances 0.000 claims abstract description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 9
- 150000005846 sugar alcohols Polymers 0.000 claims abstract description 5
- 238000011200 topical administration Methods 0.000 claims abstract description 5
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims description 11
- 201000004384 Alopecia Diseases 0.000 claims description 6
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims description 6
- 230000003676 hair loss Effects 0.000 claims description 4
- -1 aromatic alcohols Chemical class 0.000 claims description 3
- 208000024963 hair loss Diseases 0.000 claims description 3
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- 125000003118 aryl group Chemical group 0.000 abstract description 3
- IAGROJPXACRRDT-UHFFFAOYSA-N 2-piperidin-1-ylpyrimidine Chemical class C1CCCCN1C1=NC=CC=N1 IAGROJPXACRRDT-UHFFFAOYSA-N 0.000 abstract 2
- WVDDGKGOMKODPV-UHFFFAOYSA-N Benzyl alcohol Chemical compound OCC1=CC=CC=C1 WVDDGKGOMKODPV-UHFFFAOYSA-N 0.000 description 27
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- 239000004006 olive oil Substances 0.000 description 1
- 235000008390 olive oil Nutrition 0.000 description 1
- 235000005985 organic acids Nutrition 0.000 description 1
- 229950006827 oxendolone Drugs 0.000 description 1
- FJCFFCXMEXZEIM-UHFFFAOYSA-N oxiniacic acid Chemical compound OC(=O)C1=CC=C[N+]([O-])=C1 FJCFFCXMEXZEIM-UHFFFAOYSA-N 0.000 description 1
- 235000019161 pantothenic acid Nutrition 0.000 description 1
- 239000011713 pantothenic acid Substances 0.000 description 1
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 1
- 239000012188 paraffin wax Substances 0.000 description 1
- 239000006072 paste Substances 0.000 description 1
- 229960003742 phenol Drugs 0.000 description 1
- WVDDGKGOMKODPV-ZQBYOMGUSA-N phenyl(114C)methanol Chemical compound O[14CH2]C1=CC=CC=C1 WVDDGKGOMKODPV-ZQBYOMGUSA-N 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 150000003013 phosphoric acid derivatives Chemical class 0.000 description 1
- 229920001467 poly(styrenesulfonates) Polymers 0.000 description 1
- 229920000058 polyacrylate Polymers 0.000 description 1
- 229920000447 polyanionic polymer Polymers 0.000 description 1
- 229940068918 polyethylene glycol 400 Drugs 0.000 description 1
- 229920005862 polyol Polymers 0.000 description 1
- 150000003077 polyols Chemical class 0.000 description 1
- 239000001205 polyphosphate Substances 0.000 description 1
- 235000011176 polyphosphates Nutrition 0.000 description 1
- 239000011970 polystyrene sulfonate Substances 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 239000001294 propane Substances 0.000 description 1
- 239000003507 refrigerant Substances 0.000 description 1
- 229930002330 retinoic acid Natural products 0.000 description 1
- 150000004492 retinoid derivatives Chemical class 0.000 description 1
- 229960004889 salicylic acid Drugs 0.000 description 1
- 239000002453 shampoo Substances 0.000 description 1
- 239000012301 solution-based formulation Substances 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 229940032094 squalane Drugs 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 1
- 150000003467 sulfuric acid derivatives Chemical class 0.000 description 1
- 229910021653 sulphate ion Inorganic materials 0.000 description 1
- 239000001117 sulphuric acid Substances 0.000 description 1
- 235000011149 sulphuric acid Nutrition 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 229940100613 topical solution Drugs 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- 229960001727 tretinoin Drugs 0.000 description 1
- ICUTUKXCWQYESQ-UHFFFAOYSA-N triclocarban Chemical compound C1=CC(Cl)=CC=C1NC(=O)NC1=CC=C(Cl)C(Cl)=C1 ICUTUKXCWQYESQ-UHFFFAOYSA-N 0.000 description 1
- 229960001325 triclocarban Drugs 0.000 description 1
- 229940086542 triethylamine Drugs 0.000 description 1
- 229960004418 trolamine Drugs 0.000 description 1
- 238000000870 ultraviolet spectroscopy Methods 0.000 description 1
- 229960002703 undecylenic acid Drugs 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 235000019156 vitamin B Nutrition 0.000 description 1
- 239000011720 vitamin B Substances 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
- 230000003313 weakening effect Effects 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
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- 229930007845 β-thujaplicin Natural products 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4953—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom containing pyrimidine ring derivatives, e.g. minoxidil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q7/00—Preparations for affecting hair growth
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Birds (AREA)
- Organic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cosmetics (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Compositions Of Macromolecular Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AUPP3107A AUPP310798A0 (en) | 1998-04-22 | 1998-04-22 | Vehicle system for a composition comprising a piperidinopyrimidine derivative |
| EP99914373A EP1073439B1 (en) | 1998-04-22 | 1999-04-20 | Pharmaceutical composition |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1695708T3 true DK1695708T3 (en) | 2018-04-23 |
Family
ID=3807366
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK06012033.4T DK1695708T3 (en) | 1998-04-22 | 1999-04-20 | Highly concentrated minoxidil composition |
| DK99914373T DK1073439T3 (da) | 1998-04-22 | 1999-04-20 | Farmaceutisk sammensætning |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK99914373T DK1073439T3 (da) | 1998-04-22 | 1999-04-20 | Farmaceutisk sammensætning |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US6946120B2 (enExample) |
| EP (2) | EP1695708B1 (enExample) |
| JP (3) | JP3710380B2 (enExample) |
| AT (1) | ATE331517T1 (enExample) |
| AU (1) | AUPP310798A0 (enExample) |
| BR (1) | BR9909796B1 (enExample) |
| CA (1) | CA2328950C (enExample) |
| CY (1) | CY1120513T1 (enExample) |
| DE (1) | DE69932158T2 (enExample) |
| DK (2) | DK1695708T3 (enExample) |
| ES (2) | ES2665271T3 (enExample) |
| PT (2) | PT1073439E (enExample) |
| WO (1) | WO1999053923A1 (enExample) |
Families Citing this family (107)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9504265D0 (en) | 1995-03-03 | 1995-04-19 | Medeva Plc | Corticosteroid-containing pharmaceutical composition |
| AUPO983897A0 (en) | 1997-10-17 | 1997-11-06 | Soltec Research Pty Ltd | Topical antifungal composition |
| AUPP310798A0 (en) | 1998-04-22 | 1998-05-14 | Soltec Research Pty Ltd | Vehicle system for a composition comprising a piperidinopyrimidine derivative |
| JPH11349451A (ja) * | 1998-06-08 | 1999-12-21 | Taisho Pharmaceut Co Ltd | 育毛剤 |
| US8263580B2 (en) | 1998-09-11 | 2012-09-11 | Stiefel Research Australia Pty Ltd | Vitamin formulation |
| US6342496B1 (en) * | 1999-03-01 | 2002-01-29 | Sepracor Inc. | Bupropion metabolites and methods of use |
| AU4473001A (en) * | 2000-04-07 | 2001-10-30 | Taisho Pharmaceutical Co Ltd | Hair growth stimulant compositions with sustained action |
| HUP0300417A2 (hu) * | 2000-04-07 | 2003-08-28 | Taisho Pharmaceutical Co., Ltd. | Hajnövesztő kompozíciók és eljárás azok stabilizálására a kristálykiválás gátlásával |
| JP4892786B2 (ja) * | 2000-04-07 | 2012-03-07 | 大正製薬株式会社 | 持続性育毛製剤 |
| US8512718B2 (en) | 2000-07-03 | 2013-08-20 | Foamix Ltd. | Pharmaceutical composition for topical application |
| US7442369B1 (en) * | 2000-08-09 | 2008-10-28 | Mcneil Ab | Compositions of minoxidil |
| AUPR048600A0 (en) * | 2000-10-02 | 2000-10-26 | Soltec Research Pty Ltd | Pharmaceutical vehicle |
| CA2448195A1 (en) * | 2001-05-15 | 2002-11-21 | Taisho Pharmaceutical Co., Ltd. | Minoxidil-containing liquid composition |
| SE0104421D0 (sv) * | 2001-12-21 | 2001-12-21 | Ponsus Pharma Ab | New composition |
| IL152486A0 (en) | 2002-10-25 | 2003-05-29 | Meir Eini | Alcohol-free cosmetic and pharmaceutical foam carrier |
| US8119109B2 (en) | 2002-10-25 | 2012-02-21 | Foamix Ltd. | Foamable compositions, kits and methods for hyperhidrosis |
| US8900554B2 (en) | 2002-10-25 | 2014-12-02 | Foamix Pharmaceuticals Ltd. | Foamable composition and uses thereof |
| US9265725B2 (en) | 2002-10-25 | 2016-02-23 | Foamix Pharmaceuticals Ltd. | Dicarboxylic acid foamable vehicle and pharmaceutical compositions thereof |
| US7700076B2 (en) | 2002-10-25 | 2010-04-20 | Foamix, Ltd. | Penetrating pharmaceutical foam |
| US10117812B2 (en) | 2002-10-25 | 2018-11-06 | Foamix Pharmaceuticals Ltd. | Foamable composition combining a polar solvent and a hydrophobic carrier |
| ES2532906T5 (es) | 2002-10-25 | 2022-03-23 | Foamix Pharmaceuticals Ltd | Espuma cosmética y farmacéutica |
| US20080138296A1 (en) | 2002-10-25 | 2008-06-12 | Foamix Ltd. | Foam prepared from nanoemulsions and uses |
| US7820145B2 (en) | 2003-08-04 | 2010-10-26 | Foamix Ltd. | Oleaginous pharmaceutical and cosmetic foam |
| US8119150B2 (en) | 2002-10-25 | 2012-02-21 | Foamix Ltd. | Non-flammable insecticide composition and uses thereof |
| US9668972B2 (en) | 2002-10-25 | 2017-06-06 | Foamix Pharmaceuticals Ltd. | Nonsteroidal immunomodulating kit and composition and uses thereof |
| US7704518B2 (en) | 2003-08-04 | 2010-04-27 | Foamix, Ltd. | Foamable vehicle and pharmaceutical compositions thereof |
| US9211259B2 (en) | 2002-11-29 | 2015-12-15 | Foamix Pharmaceuticals Ltd. | Antibiotic kit and composition and uses thereof |
| US8486376B2 (en) | 2002-10-25 | 2013-07-16 | Foamix Ltd. | Moisturizing foam containing lanolin |
| EP1592420B1 (en) | 2003-01-24 | 2014-01-01 | Stiefel Research Australia Pty Ltd | Clindamycin phosphate foam |
| US7575739B2 (en) | 2003-04-28 | 2009-08-18 | Foamix Ltd. | Foamable iodine composition |
| US7186416B2 (en) | 2003-05-28 | 2007-03-06 | Stiefel Laboratories, Inc. | Foamable pharmaceutical compositions and methods for treating a disorder |
| US8795693B2 (en) | 2003-08-04 | 2014-08-05 | Foamix Ltd. | Compositions with modulating agents |
| US8486374B2 (en) | 2003-08-04 | 2013-07-16 | Foamix Ltd. | Hydrophilic, non-aqueous pharmaceutical carriers and compositions and uses |
| PL1668105T3 (pl) | 2003-09-29 | 2019-03-29 | Deb Ip Limited | Kompozycje żelopodobne i pieniące o dużej zawartości alkoholu |
| GB0323908D0 (en) * | 2003-10-11 | 2003-11-12 | Nupharm Lab Ltd | Pharmaceutical foam formulation |
| WO2005067873A1 (en) * | 2003-12-22 | 2005-07-28 | Regrowth, Llc | Topical solutions comprising high concentrations of piperidinopyrimidine derivatives and methods of use thereof |
| US20050163811A1 (en) * | 2004-01-23 | 2005-07-28 | Richard Lee | Topical solutions comprising high concentrations of piperidinopyrimidine derivatives and methods of use thereof |
| US20060034779A1 (en) * | 2004-08-02 | 2006-02-16 | Agis Industries (1983) Ltd. | Foamable compositions containing vitamin D3 analogues, processes for preparing same and methods of treatment utilizng same |
| US20060057075A1 (en) * | 2004-08-02 | 2006-03-16 | Moshe Arkin | Pharmaceutical and cosmeceutical wash-off mousse shampoo compositions, processes for preparing the same and uses thereof |
| DE102004062775A1 (de) | 2004-12-21 | 2006-06-29 | Stockhausen Gmbh | Alkoholischer Pumpschaum |
| CN101170904A (zh) | 2005-03-07 | 2008-04-30 | 戴博全球保健有限公司 | 含有有机硅基表面活性剂的高醇含量发泡组合物 |
| CA2609953A1 (en) | 2005-05-09 | 2007-04-12 | Foamix Ltd. | Saccharide foamable compositions |
| JP5612263B2 (ja) | 2005-06-01 | 2014-10-22 | スティーフェル リサーチ オーストラリア ピーティーワイ リミテッド | ビタミン製剤 |
| US8147815B2 (en) * | 2005-12-16 | 2012-04-03 | Celmatrix Corporation | Topical administration carrier composition and therapeutic formulations comprising same |
| EP2206494B1 (en) | 2006-03-31 | 2015-12-02 | Stiefel Research Australia Pty Ltd | Foamable suspension gel |
| US20080260655A1 (en) | 2006-11-14 | 2008-10-23 | Dov Tamarkin | Substantially non-aqueous foamable petrolatum based pharmaceutical and cosmetic compositions and their uses |
| KR100893469B1 (ko) * | 2006-12-22 | 2009-04-17 | 씨제이제일제당 (주) | 피부 투과성이 우수한 미녹시딜 함유 발모용 외용액제조성물 |
| US8580860B2 (en) * | 2007-02-23 | 2013-11-12 | Gojo Industries, Inc. | Foamable alcoholic composition |
| US8021649B2 (en) * | 2007-02-22 | 2011-09-20 | Cronk Peter J | Continuous spray scalp therapy and dispensing systems for same |
| US8636982B2 (en) | 2007-08-07 | 2014-01-28 | Foamix Ltd. | Wax foamable vehicle and pharmaceutical compositions thereof |
| WO2009069006A2 (en) | 2007-11-30 | 2009-06-04 | Foamix Ltd. | Foam containing benzoyl peroxide |
| US8518376B2 (en) | 2007-12-07 | 2013-08-27 | Foamix Ltd. | Oil-based foamable carriers and formulations |
| WO2009090495A2 (en) | 2007-12-07 | 2009-07-23 | Foamix Ltd. | Oil and liquid silicone foamable carriers and formulations |
| CA2712120A1 (en) | 2008-01-14 | 2009-07-23 | Foamix Ltd. | Poloxamer foamable pharmaceutical compositions with active agents and/or therapeutic cells and uses |
| JP5420946B2 (ja) * | 2009-03-23 | 2014-02-19 | 富士フイルム株式会社 | 胆汁酸を含むミノキシジル水性組成物 |
| JP2010222317A (ja) * | 2009-03-25 | 2010-10-07 | Shiseido Co Ltd | 水中油型乳化化粧料 |
| US20120087872A1 (en) | 2009-04-28 | 2012-04-12 | Foamix Ltd. | Foamable Vehicles and Pharmaceutical Compositions Comprising Aprotic Polar Solvents and Uses Thereof |
| WO2011013008A2 (en) | 2009-07-29 | 2011-02-03 | Foamix Ltd. | Non surface active agent non polymeric agent hydro-alcoholic foamable compositions, breakable foams and their uses |
| CA2769625C (en) | 2009-07-29 | 2017-04-11 | Foamix Ltd. | Non surfactant hydro-alcoholic foamable compositions, breakable foams and their uses |
| WO2011026076A2 (en) | 2009-08-31 | 2011-03-03 | Dr. Reddy's Laboratories Ltd. | Topical formulations comprising a steroid |
| WO2011039637A2 (en) | 2009-10-02 | 2011-04-07 | Foamix Ltd. | Surfactant-free water-free foamable compositions, breakable foams and gels and their uses |
| US9849142B2 (en) | 2009-10-02 | 2017-12-26 | Foamix Pharmaceuticals Ltd. | Methods for accelerated return of skin integrity and for the treatment of impetigo |
| US20110189114A1 (en) * | 2010-01-29 | 2011-08-04 | Nyangenya Maniga | minoxidil composition and non-aerosol, non-spray foam method of delivery therefor |
| US9271917B2 (en) | 2010-01-29 | 2016-03-01 | Nyangenya Maniga | Method and apparatus for delivery of a measured dosage of a non-aerosol, non-spray foam composition of minoxidil |
| US20130324567A1 (en) * | 2010-09-21 | 2013-12-05 | Conrex Pharmaceutical Corporation | Restoration of hair |
| EP3178465A1 (en) | 2010-12-06 | 2017-06-14 | Follica, Inc. | Methods for treating baldness and promoting hair growth |
| US9717741B2 (en) | 2012-10-11 | 2017-08-01 | Anaplasi Pharmaceuticals Llc | Method and compositions for treating psoriasis |
| JP6059352B2 (ja) | 2012-10-11 | 2017-01-11 | アナプラシ ファーマシューティカルズ エルエルシー | 乾癬を治療するための方法及び組成物 |
| WO2014122436A1 (en) | 2013-02-07 | 2014-08-14 | Cipla House | Topical pharmaceutical compositions comprising minoxidil |
| US8642097B1 (en) | 2013-03-19 | 2014-02-04 | Nyangenya Maniga | Natural product energy drink and method of use thereof |
| WO2014184173A1 (en) | 2013-05-14 | 2014-11-20 | Montero Gida Sanayi Ve Ticaret A.S. | Hair care formulations |
| US20160184431A1 (en) | 2014-03-11 | 2016-06-30 | Promius Pharma Llc | Topical compositions comprising a corticosteroid |
| US9474699B2 (en) | 2014-03-31 | 2016-10-25 | Johnson & Johnson Consumer Inc. | Compostions and methods for enhancing the topical application of a basic benefit agent |
| US9468606B2 (en) | 2014-03-31 | 2016-10-18 | Johnson & Johnson Consumer Inc. | Compostions and methods for enhancing the topical application of an acidic benefit agent |
| CN106456467A (zh) | 2014-06-16 | 2017-02-22 | 强生消费者公司 | 用于增强有色化妆品的局部施用的组合物和方法 |
| WO2015195304A1 (en) | 2014-06-17 | 2015-12-23 | Johnson & Johnson Consumer Companies, Inc. | Compositions and methods for enhancing the topical application of a benefit agent including powder to liquid particles and a second powder |
| US9675537B2 (en) * | 2014-06-30 | 2017-06-13 | Johnson & Johnson Consumer Inc. | Hair growth composition and method |
| JP7072346B2 (ja) * | 2015-03-27 | 2022-05-20 | 大正製薬株式会社 | ローション剤 |
| WO2016159916A1 (en) * | 2015-03-31 | 2016-10-06 | Ogi̇g Sağlik Ürünleri̇ Ve Hi̇zmetleri̇ Sanayi̇ Ti̇caret Li̇mi̇ted Şi̇rketi̇ | A foamy pharmaceutical formulation used in dermatological diseases |
| GB2554000A (en) * | 2015-05-18 | 2018-03-21 | Perry Thrower Angelo | Hair regrowth treatment and growth stimulant |
| AU2016326143B2 (en) | 2015-09-27 | 2021-05-27 | Follica, Inc. | Needling device and drug applicator |
| ES2809704T3 (es) | 2015-10-06 | 2021-03-05 | Assos Ilac Kimya Gida Ueruenleri Ueretim Ve Tic A S | Composición tópica de minoxidil |
| US10561593B2 (en) * | 2015-12-28 | 2020-02-18 | Johnson & Johnson Consumer Inc. | Hair growth composition and method |
| CN105434352A (zh) * | 2015-12-31 | 2016-03-30 | 浙江万晟药业有限公司 | 一种米诺地尔泡沫剂及其制备方法与应用 |
| JP2018048105A (ja) * | 2016-01-22 | 2018-03-29 | 大正製薬株式会社 | 外用組成物 |
| JP2018048104A (ja) * | 2016-01-22 | 2018-03-29 | 大正製薬株式会社 | 外用組成物 |
| JP6848565B2 (ja) * | 2016-03-30 | 2021-03-24 | 大正製薬株式会社 | エアゾール剤 |
| US10398641B2 (en) | 2016-09-08 | 2019-09-03 | Foamix Pharmaceuticals Ltd. | Compositions and methods for treating rosacea and acne |
| US10736905B1 (en) | 2016-09-09 | 2020-08-11 | Shahin Fatholahi | Nefopam dosage forms and methods of treatment |
| JP7366515B2 (ja) * | 2016-09-15 | 2023-10-23 | 大正製薬株式会社 | 外用組成物 |
| US9962444B2 (en) | 2016-09-27 | 2018-05-08 | Shane Malek | Pharmacokinetically extended action topical hair growth formulation, and administration method |
| US10702495B2 (en) | 2017-02-20 | 2020-07-07 | Nexien Biopharma, Inc. | Method and compositions for treating dystrophies and myotonia |
| US10736874B1 (en) | 2017-09-08 | 2020-08-11 | Shahin Fatholahi | Methods for treating pain associated with sickle cell disease |
| US11446311B2 (en) | 2017-09-08 | 2022-09-20 | Shahin Fatholahi | Methods for treating pain associated with sickle cell disease |
| KR20210027271A (ko) | 2018-05-30 | 2021-03-10 | 폴리카 인코포레이티드 | 모발 성장을 촉진하는 방법 |
| JP2019210268A (ja) * | 2018-05-30 | 2019-12-12 | ダイヤ製薬株式会社 | 外用剤及び外用剤の製造方法 |
| WO2020206623A1 (en) * | 2019-04-10 | 2020-10-15 | Goldfinch Bio, Inc. | Crystal forms |
| US12409121B2 (en) | 2019-05-06 | 2025-09-09 | Spinart, LLC | Formulations and methods for preparing stable cosmetic compositions |
| EP3750528A1 (en) | 2019-06-11 | 2020-12-16 | Nexien Biopharma, Inc. | Compositions for treating dystrophies and myotonia |
| US20220249514A1 (en) | 2019-06-28 | 2022-08-11 | Regeus Limited Liability Company | Remedy for hair growth enhancing |
| MD3886799T2 (ro) | 2019-08-07 | 2024-01-31 | Aneira Pharma Inc | Compoziții pentru tratamentul căderii părului |
| BR102021003531A2 (pt) * | 2021-02-24 | 2022-08-30 | Eurofarma Laboratorios S.A. | Composição farmacêutica tópica espumável |
| IL320492A (en) | 2022-10-25 | 2025-06-01 | Veradermics Incorporated | Compositions and methods of use for modified release minoxidil |
| TW202444338A (zh) | 2023-04-07 | 2024-11-16 | 義大利商卡斯歐皮亞股份公司 | 克拉司酮與米諾地爾之組合療法 |
| CN116919892B (zh) * | 2023-08-03 | 2024-08-16 | 济南中海医药科技有限公司 | 一种米诺地尔外用溶液的制备方法 |
| WO2025172818A1 (en) * | 2024-02-14 | 2025-08-21 | Cassiopea S.P.A. | Pyrilutamide combination therapy |
| CN118908900B (zh) * | 2024-10-10 | 2025-01-28 | 山东则正医药技术有限公司 | 一种米诺地尔乳酸盐晶型及其制备方法和应用 |
Family Cites Families (69)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US515836A (en) * | 1894-03-06 | Basin-clamp | ||
| US4596812A (en) * | 1976-05-24 | 1986-06-24 | The Upjohn Company | Methods and solutions for treating male pattern alopecia |
| US4139619A (en) * | 1976-05-24 | 1979-02-13 | The Upjohn Company | 6-Amino-4-(substituted amino)-1,2-dihydro-1-hydroxy-2-iminopyrimidine, topical compositions and process for hair growth |
| IT1066697B (it) * | 1976-11-08 | 1985-03-12 | Manetti & Roberts Italo Brit | Attivatore per composizioni cosmetiche e composizioni cosmetiche che lo contengono |
| US5183817A (en) * | 1981-02-17 | 1993-02-02 | Bazzano Gail S | Combinations of retinoids and minoxidil-type compounds for hair growth |
| WO1983002558A1 (en) * | 1981-11-09 | 1983-08-04 | Gail Sansone Bazzano | The use of retinoids and minoxidil (2,4,-diamino-6-piperidino-pyrimidine-3-oxide) to increase the rate of growth of human scalp hair and to treat certain types of alopecias |
| EP0160051B1 (en) | 1983-10-24 | 1992-01-08 | Lockley Services Pty. Ltd. | Foamable biocide composition |
| WO1986000196A1 (en) | 1984-06-21 | 1986-01-16 | Soltec Research Pty. Ltd. | Aerosol product |
| JPS61197161A (ja) | 1985-02-25 | 1986-09-01 | Amada Co Ltd | ドレツシング装置 |
| IT1201436B (it) * | 1985-07-19 | 1989-02-02 | Vincenzo Zappia | Formulazioni topiche a lento rilascio |
| DE3781034T2 (de) * | 1986-06-13 | 1993-02-18 | Procter & Gamble | Topische pharmazeutische zubereitung mit besserer durchdringungsfaehigkeit. |
| US5041439A (en) * | 1986-06-13 | 1991-08-20 | The Procter & Gamble Company | Penetrating topical pharmaceutical compositions |
| LU86548A1 (fr) * | 1986-08-07 | 1988-03-02 | Oreal | Composition sous forme de gel pour induire et stimuler la croissance des cheveux et diminuer leur chute a base de derives de piperidino-pyrimidine |
| DE3777656D1 (de) * | 1986-08-08 | 1992-04-23 | Upjohn Co | Mittel zur behandlung von alopezien. |
| WO1988001863A1 (en) | 1986-09-12 | 1988-03-24 | The Upjohn Company | Foams for delivery of minoxidil |
| JPS63150211A (ja) | 1986-12-15 | 1988-06-22 | Taisho Pharmaceut Co Ltd | ミノキシジル配合外用剤 |
| AU618517B2 (en) | 1986-12-23 | 1992-01-02 | Eugene J. Van Scott | Additives enhancing topical actions of therapeutic agents |
| US5389677B1 (en) | 1986-12-23 | 1997-07-15 | Tristrata Inc | Method of treating wrinkles using glycalic acid |
| US4882182A (en) | 1987-01-08 | 1989-11-21 | Soltec Research Pty. Ltd. | Aerosol product |
| US4828837A (en) * | 1987-03-30 | 1989-05-09 | Liposome Technology, Inc. | Non-crystalline minoxidil composition, its production and application |
| US5030442A (en) * | 1987-03-30 | 1991-07-09 | Liposome Technology, Inc. | Non-crystalline minoxidil composition |
| JP2810041B2 (ja) | 1987-09-09 | 1998-10-15 | 株式会社資生堂 | 頭皮・頭髪用養毛料 |
| JPH0745387B2 (ja) | 1987-09-09 | 1995-05-17 | 株式会社資生堂 | 発毛、養毛促進剤 |
| JP2810040B2 (ja) * | 1987-09-09 | 1998-10-15 | 株式会社資生堂 | 頭皮・頭髪用養毛料 |
| KR910010018B1 (ko) * | 1987-10-02 | 1991-12-10 | 가부시기가이샤 시세이도 | 양모제 |
| US4866067A (en) * | 1987-12-07 | 1989-09-12 | Ricerche De Schiena s.n.c del Dr. Michele Giuseppe Di Schiena & C. | 6-piperidino-2,4-diaminopyrimidine-3-oxide salt of 3-carboxypyridine n-oxide and topical, related compositions |
| US4888354A (en) | 1987-12-21 | 1989-12-19 | Theratech, Inc. | Skin penetration enhancement using free base and acid addition salt combinations of active agents |
| EP0417075B1 (en) | 1988-02-18 | 1993-06-09 | The Upjohn Company | Minoxidil gel |
| US5225189A (en) * | 1988-02-18 | 1993-07-06 | The Upjohn Company | Minoxidil gel |
| AU619256B2 (en) | 1988-03-03 | 1992-01-23 | Connetics Australia Pty Ltd | Acne treatment |
| LU87249A1 (fr) * | 1988-06-17 | 1990-02-28 | Oreal | Composition pour induire et stimuler la croissance des cheveux et/ou freiner leur chute,a base d'un agent tensio-actif amphotere et d'un derive de pyrimidine |
| US4938953A (en) * | 1988-08-09 | 1990-07-03 | The Upjohn Company | Self-preserving conditioning shampoo formulation |
| US5104646A (en) * | 1989-08-07 | 1992-04-14 | The Procter & Gamble Company | Vehicle systems for use in cosmetic compositions |
| JP3004718B2 (ja) | 1990-08-10 | 2000-01-31 | ファルマシア・アンド・アップジョン・カンパニー | カリウムチャネルオープナーおよび５α―レダクターゼ抑制剤を用いる育毛刺激 |
| US5935554A (en) | 1990-09-03 | 1999-08-10 | Soltec Research Pty. Ltd. | Concentrated aerosol space spray that is not an emulsion |
| WO1992004419A1 (en) | 1990-09-03 | 1992-03-19 | Soltec Research Pty. Ltd. | A concentrated aerosol space spray |
| BR9205788A (pt) * | 1991-03-19 | 1994-06-07 | Procter & Gamble | Composiçoes para tratamento dos cabelos tendo um agente modelador/condicionador e um plastificante |
| ZA94170B (en) | 1993-01-20 | 1995-03-15 | Soltec Res Pty Ltd | Ectoparasiticidal formulation |
| JPH0748230A (ja) * | 1993-07-31 | 1995-02-21 | Hideo Horiuchi | 育毛剤の製造法 |
| FR2717683B1 (fr) | 1994-03-22 | 1996-06-28 | Fabre Pierre Cosmetique | Composition capillaire à base de minoxidil. |
| GB9504265D0 (en) | 1995-03-03 | 1995-04-19 | Medeva Plc | Corticosteroid-containing pharmaceutical composition |
| US5783202A (en) | 1995-03-14 | 1998-07-21 | Soltec Research Pty. Ltd. | Pediculicidal mousse composition for killing head lice |
| FR2736824B1 (fr) * | 1995-07-18 | 1997-10-10 | Fabre Pierre Dermo Cosmetique | Composition capillaire a base de minoxidil a faible teneur en solvant gras |
| JPH0971513A (ja) | 1995-09-07 | 1997-03-18 | Taisho Pharmaceut Co Ltd | 育毛剤 |
| JP3518096B2 (ja) | 1995-09-29 | 2004-04-12 | 松下電器産業株式会社 | 映像記録再生機器の製造方法 |
| US5834014A (en) * | 1995-10-06 | 1998-11-10 | The Regents Of The University Of Michigan | Stimulation of hair follicles |
| JP4467085B2 (ja) * | 1996-01-05 | 2010-05-26 | 大正製薬株式会社 | ヒノキチオール含有組成物 |
| JPH09188629A (ja) | 1996-01-06 | 1997-07-22 | Pola Chem Ind Inc | 抗体産生細胞抑制剤及びそれを含有する組成物 |
| US5788155A (en) | 1996-06-28 | 1998-08-04 | S. C. Johnson & Son, Inc. | Air freshener dispenser device with dual cartridge capacity |
| US5838669A (en) | 1996-08-28 | 1998-11-17 | At&T Corp. | Method of synchronizing satellite switched CDMA communication system |
| JP3061575B2 (ja) | 1996-10-17 | 2000-07-10 | 日立建機株式会社 | 孔掘削装置 |
| AUPO379596A0 (en) | 1996-11-22 | 1996-12-19 | Soltec Research Pty Ltd | Percutaneous delivery system |
| JPH10158782A (ja) | 1996-12-05 | 1998-06-16 | Nkk Corp | フォトエッチング時の穿孔性とプレス成形性に優れたシャドウマスク用鋼板及びその製造方法 |
| KR20000070370A (ko) | 1997-01-23 | 2000-11-25 | 우에하라 아끼라 | 지효성 발모제 |
| JPH10265343A (ja) | 1997-01-23 | 1998-10-06 | Taisho Pharmaceut Co Ltd | 持効性育毛剤 |
| JPH10279437A (ja) * | 1997-03-31 | 1998-10-20 | Shiseido Co Ltd | 頭髪用化粧料 |
| AUPO688997A0 (en) | 1997-05-20 | 1997-06-12 | Soltec Research Pty Ltd | Sunscreen composition |
| AUPO983897A0 (en) | 1997-10-17 | 1997-11-06 | Soltec Research Pty Ltd | Topical antifungal composition |
| US6231875B1 (en) | 1998-03-31 | 2001-05-15 | Johnson & Johnson Consumer Companies, Inc. | Acidified composition for topical treatment of nail and skin conditions |
| JPH11302131A (ja) * | 1998-04-15 | 1999-11-02 | Shiseido Co Ltd | 頭皮頭髪用化粧料 |
| AUPP310798A0 (en) | 1998-04-22 | 1998-05-14 | Soltec Research Pty Ltd | Vehicle system for a composition comprising a piperidinopyrimidine derivative |
| JPH11349451A (ja) | 1998-06-08 | 1999-12-21 | Taisho Pharmaceut Co Ltd | 育毛剤 |
| US6284234B1 (en) | 1998-08-04 | 2001-09-04 | Johnson & Johnson Consumer Companies, Inc. | Topical delivery systems for active agents |
| AUPP583198A0 (en) | 1998-09-11 | 1998-10-01 | Soltec Research Pty Ltd | Mousse composition |
| US6383471B1 (en) | 1999-04-06 | 2002-05-07 | Lipocine, Inc. | Compositions and methods for improved delivery of ionizable hydrophobic therapeutic agents |
| AUPQ002999A0 (en) | 1999-04-29 | 1999-05-20 | Soltec Research Pty Ltd | Non-aqueous shampoo composition |
| JP4780429B2 (ja) | 2000-04-07 | 2011-09-28 | 大正製薬株式会社 | ミノキシジル含有製剤 |
| US20030157046A1 (en) * | 2000-04-07 | 2003-08-21 | Koji Imamura | Minoxidil-containing preparations |
| HUP0300417A2 (hu) | 2000-04-07 | 2003-08-28 | Taisho Pharmaceutical Co., Ltd. | Hajnövesztő kompozíciók és eljárás azok stabilizálására a kristálykiválás gátlásával |
-
1998
- 1998-04-22 AU AUPP3107A patent/AUPP310798A0/en not_active Abandoned
-
1999
- 1999-04-20 EP EP06012033.4A patent/EP1695708B1/en not_active Expired - Lifetime
- 1999-04-20 ES ES06012033.4T patent/ES2665271T3/es not_active Expired - Lifetime
- 1999-04-20 ES ES99914373T patent/ES2268856T3/es not_active Expired - Lifetime
- 1999-04-20 DE DE69932158T patent/DE69932158T2/de not_active Expired - Lifetime
- 1999-04-20 AT AT99914373T patent/ATE331517T1/de active
- 1999-04-20 DK DK06012033.4T patent/DK1695708T3/en active
- 1999-04-20 PT PT99914373T patent/PT1073439E/pt unknown
- 1999-04-20 WO PCT/AU1999/000294 patent/WO1999053923A1/en not_active Ceased
- 1999-04-20 PT PT60120334T patent/PT1695708T/pt unknown
- 1999-04-20 JP JP2000544327A patent/JP3710380B2/ja not_active Expired - Lifetime
- 1999-04-20 BR BRPI9909796-6B1A patent/BR9909796B1/pt not_active IP Right Cessation
- 1999-04-20 CA CA002328950A patent/CA2328950C/en not_active Expired - Lifetime
- 1999-04-20 DK DK99914373T patent/DK1073439T3/da active
- 1999-04-20 EP EP99914373A patent/EP1073439B1/en not_active Expired - Lifetime
-
2002
- 2002-04-16 US US10/124,197 patent/US6946120B2/en not_active Expired - Lifetime
-
2003
- 2003-06-24 JP JP2003178898A patent/JP4338455B2/ja not_active Expired - Lifetime
-
2004
- 2004-09-10 US US10/949,116 patent/US20050037060A1/en not_active Abandoned
-
2007
- 2007-03-01 JP JP2007050885A patent/JP2007137899A/ja active Pending
-
2018
- 2018-05-18 CY CY20181100524T patent/CY1120513T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP1695708A3 (en) | 2012-07-18 |
| WO1999053923A1 (en) | 1999-10-28 |
| US20020172649A1 (en) | 2002-11-21 |
| PT1695708T (pt) | 2018-05-18 |
| ATE331517T1 (de) | 2006-07-15 |
| CA2328950C (en) | 2008-07-29 |
| PT1073439E (pt) | 2006-11-30 |
| US20050037060A1 (en) | 2005-02-17 |
| EP1695708B1 (en) | 2018-02-28 |
| US6946120B2 (en) | 2005-09-20 |
| CA2328950A1 (en) | 1999-10-28 |
| AUPP310798A0 (en) | 1998-05-14 |
| EP1073439A1 (en) | 2001-02-07 |
| ES2268856T3 (es) | 2007-03-16 |
| EP1695708A2 (en) | 2006-08-30 |
| EP1073439B1 (en) | 2006-06-28 |
| EP1073439A4 (en) | 2003-07-02 |
| DE69932158D1 (de) | 2006-08-10 |
| JP3710380B2 (ja) | 2005-10-26 |
| CY1120513T1 (el) | 2019-07-10 |
| JP2002512192A (ja) | 2002-04-23 |
| DE69932158T2 (de) | 2007-05-10 |
| BR9909796A (pt) | 2000-12-26 |
| JP2007137899A (ja) | 2007-06-07 |
| JP4338455B2 (ja) | 2009-10-07 |
| DK1073439T3 (da) | 2006-10-23 |
| JP2004059587A (ja) | 2004-02-26 |
| ES2665271T3 (es) | 2018-04-25 |
| BR9909796B1 (pt) | 2013-10-29 |
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