DK164868C - Imidazooe4,5-baaquinolin-2-on-derivater, fremgangsmaade til fremstilling deraf samt farmaceutiske praeparater indeholdende disse - Google Patents

Imidazooe4,5-baaquinolin-2-on-derivater, fremgangsmaade til fremstilling deraf samt farmaceutiske praeparater indeholdende disse

Info

Publication number
DK164868C
DK164868C DK190986A DK190986A DK164868C DK 164868 C DK164868 C DK 164868C DK 190986 A DK190986 A DK 190986A DK 190986 A DK190986 A DK 190986A DK 164868 C DK164868 C DK 164868C
Authority
DK
Denmark
Prior art keywords
imidazooe4
baaquinolin
derivatives
preparing
procedure
Prior art date
Application number
DK190986A
Other languages
Danish (da)
English (en)
Other versions
DK190986D0 (da
DK190986A (da
DK164868B (da
Inventor
Nicholas A Meanwell
John J Wright
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of DK190986D0 publication Critical patent/DK190986D0/da
Publication of DK190986A publication Critical patent/DK190986A/da
Publication of DK164868B publication Critical patent/DK164868B/da
Application granted granted Critical
Publication of DK164868C publication Critical patent/DK164868C/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Cardiology (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Hospice & Palliative Care (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DK190986A 1985-04-25 1986-04-24 Imidazooe4,5-baaquinolin-2-on-derivater, fremgangsmaade til fremstilling deraf samt farmaceutiske praeparater indeholdende disse DK164868C (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US72686985A 1985-04-25 1985-04-25
US72686985 1985-04-25
US83221286 1986-02-26
US06/832,212 US4668686A (en) 1985-04-25 1986-02-26 Imidazoquinoline antithrombrogenic cardiotonic agents

Publications (4)

Publication Number Publication Date
DK190986D0 DK190986D0 (da) 1986-04-24
DK190986A DK190986A (da) 1986-10-26
DK164868B DK164868B (da) 1992-08-31
DK164868C true DK164868C (da) 1993-01-11

Family

ID=27111398

Family Applications (3)

Application Number Title Priority Date Filing Date
DK190986A DK164868C (da) 1985-04-25 1986-04-24 Imidazooe4,5-baaquinolin-2-on-derivater, fremgangsmaade til fremstilling deraf samt farmaceutiske praeparater indeholdende disse
DK080291A DK165248C (da) 1985-04-25 1991-04-30 1,3,9,9a-tetrahydro-imidazooe4,5-baaquinolin-2-oner samt fremgangsmaade til fremstilling deraf
DK081091A DK165249C (da) 1985-04-25 1991-05-01 Imidazooe4,5-baaquinolin-2-thionderivater samt fremgangsmaade til fremstilling deraf

Family Applications After (2)

Application Number Title Priority Date Filing Date
DK080291A DK165248C (da) 1985-04-25 1991-04-30 1,3,9,9a-tetrahydro-imidazooe4,5-baaquinolin-2-oner samt fremgangsmaade til fremstilling deraf
DK081091A DK165249C (da) 1985-04-25 1991-05-01 Imidazooe4,5-baaquinolin-2-thionderivater samt fremgangsmaade til fremstilling deraf

Country Status (32)

Country Link
US (1) US4668686A (cs)
KR (1) KR940000828B1 (cs)
CN (1) CN1016175B (cs)
AT (1) AT390257B (cs)
AU (1) AU592983B2 (cs)
BE (1) BE904671A (cs)
CA (1) CA1298836C (cs)
CH (1) CH675722A5 (cs)
CY (1) CY1641A (cs)
DE (1) DE3614132A1 (cs)
DK (3) DK164868C (cs)
EG (1) EG18104A (cs)
ES (3) ES8708229A1 (cs)
FI (1) FI83316C (cs)
FR (1) FR2581065B1 (cs)
GB (1) GB2174987B (cs)
GR (1) GR861086B (cs)
HK (1) HK64492A (cs)
HU (1) HU195813B (cs)
IL (1) IL78581A0 (cs)
IT (1) IT1215651B (cs)
LU (1) LU86406A1 (cs)
MY (1) MY102086A (cs)
NL (1) NL8601053A (cs)
NO (1) NO163406C (cs)
NZ (1) NZ215885A (cs)
OA (1) OA08242A (cs)
PT (1) PT82460B (cs)
SE (1) SE461468B (cs)
SG (1) SG29092G (cs)
SU (3) SU1450746A3 (cs)
YU (1) YU46054B (cs)

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US4775674A (en) * 1986-05-23 1988-10-04 Bristol-Myers Company Imidazoquinolinylether derivatives useful as phosphodiesterase and blood aggregation inhibitors
US4701459A (en) * 1986-07-08 1987-10-20 Bristol-Myers Company 7-amino-1,3-dihydro-2H-imidazo[4,5-b]quinolin 2-ones and method for inhibiting phosphodiesterase and blood platelet aggregation
US4803210A (en) * 1987-05-29 1989-02-07 Merrell Dow Pharmaceuticals Inc. Cardiotonic tricyclic oxazolones
US4743607A (en) * 1987-05-29 1988-05-10 Merrell Dow Pharmaceuticals Inc. Cardiotonic tricyclic imidazolones
US4943573A (en) * 1989-11-01 1990-07-24 Bristol-Myers Squibb Company Imidazo[4,5-b]quinolinyloxyalkanoic acid amides with enhanced water solubility
DE4035854C2 (de) * 1990-11-10 1996-10-02 Daimler Benz Ag Vorrichtung zum Fangen und Ableiten des von einem Fahrzeugrad hochgeschleuderten Spritzwassers
PH31245A (en) * 1991-10-30 1998-06-18 Janssen Pharmaceutica Nv 1,3-Dihydro-2H-imidazoÄ4,5-BÜ-quinolin-2-one derivatives.
US5348960A (en) * 1992-04-03 1994-09-20 Bristol-Myers Squibb Company Imidazo[4,5-b]quinolinyl oxy alkyl tetrazolyl piperidine derivatives
US5208237A (en) * 1992-04-03 1993-05-04 Bristol-Meyers Squibb Company 7-oxypropylsulfonamido-imidazo[4,5-b]quinolin-2-ones
US5552267A (en) * 1992-04-03 1996-09-03 The Trustees Of Columbia University In The City Of New York Solution for prolonged organ preservation
US5196428A (en) * 1992-04-03 1993-03-23 Bristol-Myers Squibb Company Imidazo[4,5-b]qinolinyl oxy alkyl ureas
US5158958A (en) * 1992-04-03 1992-10-27 Bristol-Myers Squibb Company Imidazo[4,5-b]quinolinyl oxy alkyl sulfonyl piperidine derivatives
TW593317B (en) * 1993-06-21 2004-06-21 Janssen Pharmaceutica Nv Positive cardiac inotropic and lusitropic pyrroloquinolinone derivatives
CZ3696A3 (en) * 1993-07-06 1997-06-11 Pfizer Bicyclic tetrahydropyrazolepyridines per se and for treating diseases, and pharmaceutical compositions based thereon
TW574214B (en) * 1994-06-08 2004-02-01 Pfizer Corticotropin releasing factor antagonists
US6664264B2 (en) * 2000-12-08 2003-12-16 3M Innovative Properties Company Thioether substituted imidazoquinolines
BRPI0412902A (pt) 2003-08-12 2006-09-26 3M Innovative Properties Co compostos contendo imidazo substituìdo por oxima
CA2536136C (en) 2003-08-27 2012-10-30 3M Innovative Properties Company Aryloxy and arylalkyleneoxy substituted imidazoquinolines
AU2004270201A1 (en) 2003-09-05 2005-03-17 3M Innovative Properties Company Treatment for CD5+ B cell lymphoma
CN1897948A (zh) 2003-10-03 2007-01-17 3M创新有限公司 烷氧基取代的咪唑并喹啉
US7544697B2 (en) 2003-10-03 2009-06-09 Coley Pharmaceutical Group, Inc. Pyrazolopyridines and analogs thereof
JP2007511527A (ja) 2003-11-14 2007-05-10 スリーエム イノベイティブ プロパティズ カンパニー オキシム置換イミダゾ環化合物
EP1682544A4 (en) * 2003-11-14 2009-05-06 3M Innovative Properties Co HYDROXYLAMINE SUBSTITUTED IMIDAZO RING COMPOUNDS
RU2409576C2 (ru) 2003-11-25 2011-01-20 3М Инновейтив Пропертиз Компани Системы, содержащие имидазольное кольцо с заместителями, и способы их получения
US8802853B2 (en) 2003-12-29 2014-08-12 3M Innovative Properties Company Arylalkenyl and arylalkynyl substituted imidazoquinolines
US8735421B2 (en) 2003-12-30 2014-05-27 3M Innovative Properties Company Imidazoquinolinyl sulfonamides
US8697873B2 (en) 2004-03-24 2014-04-15 3M Innovative Properties Company Amide substituted imidazopyridines, imidazoquinolines, and imidazonaphthyridines
WO2005123080A2 (en) 2004-06-15 2005-12-29 3M Innovative Properties Company Nitrogen-containing heterocyclyl substituted imidazoquinolines and imidazonaphthyridines
WO2006038923A2 (en) 2004-06-18 2006-04-13 3M Innovative Properties Company Aryl substituted imidazonaphthyridines
US8026366B2 (en) 2004-06-18 2011-09-27 3M Innovative Properties Company Aryloxy and arylalkyleneoxy substituted thiazoloquinolines and thiazolonaphthyridines
WO2006065280A2 (en) 2004-06-18 2006-06-22 3M Innovative Properties Company Isoxazole, dihydroisoxazole, and oxadiazole substituted imidazo ring compounds and methods
CA2580343A1 (en) * 2004-09-14 2006-03-23 Novartis Vaccines And Diagnostics, Inc. Imidazoquinoline compounds
AU2005326708C1 (en) 2004-12-30 2012-08-30 3M Innovative Properties Company Substituted chiral fused [1,2]imidazo[4,5-c] ring compounds
AU2005322898B2 (en) 2004-12-30 2011-11-24 3M Innovative Properties Company Chiral fused (1,2)imidazo(4,5-c) ring compounds
WO2006084251A2 (en) 2005-02-04 2006-08-10 Coley Pharmaceutical Group, Inc. Aqueous gel formulations containing immune reponse modifiers
AU2006213746A1 (en) 2005-02-11 2006-08-17 Coley Pharmaceutical Group, Inc. Oxime and hydroxylamine substituted imidazo(4,5-c) ring compounds and methods
US7943636B2 (en) 2005-04-01 2011-05-17 3M Innovative Properties Company 1-substituted pyrazolo (3,4-C) ring compounds as modulators of cytokine biosynthesis for the treatment of viral infections and neoplastic diseases
WO2006107853A2 (en) 2005-04-01 2006-10-12 Coley Pharmaceutical Group, Inc. Pyrazolopyridine-1,4-diamines and analogs thereof
WO2008008432A2 (en) 2006-07-12 2008-01-17 Coley Pharmaceutical Group, Inc. Substituted chiral fused( 1,2) imidazo (4,5-c) ring compounds and methods
US8227603B2 (en) 2006-08-01 2012-07-24 Cytokinetics, Inc. Modulating skeletal muscle
US8299248B2 (en) 2006-08-02 2012-10-30 Cytokinetics, Incorporated Certain 1H-imidazo[4,5-b]pyrazin-2(3H)-ones and 1H-imidazo[4,5-b]pyrazin-2-ols and methods for their use
ES2558517T3 (es) 2006-08-02 2016-02-04 Cytokinetics, Inc. Ciertas entidades químicas, composiciones y métodos que comprenden imidazopirimidinas
EP2139478A4 (en) * 2007-03-30 2010-05-05 Cytokinetics Inc CHEMICAL ENTITIES, COMPOSITIONS AND METHODS
CN109316480A (zh) 2011-07-13 2019-02-12 赛特凯恩蒂克公司 组合als疗法
CN120265631A (zh) * 2023-01-13 2025-07-04 上海超阳药业有限公司 喹啉酮化合物和萘啶酮化合物及其用途

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US3932407A (en) * 1973-11-19 1976-01-13 Bristol-Myers Company Optionally substituted 1,2,3,5-tetrahydroimidezo(2,1-b)-quinazolin-2-ones and 6(H)-1,2,3,4-tetrahydropyimido(2,1-b)quinazolin-2-ones

Also Published As

Publication number Publication date
HUT42089A (en) 1987-06-29
NO163406C (no) 1990-05-23
SU1470192A3 (ru) 1989-03-30
NO861617L (no) 1986-10-27
FR2581065B1 (fr) 1990-02-02
IT8620206A0 (it) 1986-04-24
SE461468B (sv) 1990-02-19
CN1016175B (zh) 1992-04-08
MY102086A (en) 1992-03-31
ATA112186A (de) 1989-09-15
ES8708229A1 (es) 1987-10-01
SE8601907L (sv) 1986-10-26
DK165249B (da) 1992-10-26
SG29092G (en) 1992-05-15
YU46054B (sh) 1992-12-21
BE904671A (fr) 1986-10-24
SU1450746A3 (ru) 1989-01-07
FI83316C (fi) 1991-06-25
SE8601907D0 (sv) 1986-04-24
SU1560056A3 (ru) 1990-04-23
CY1641A (en) 1992-11-06
CA1298836C (en) 1992-04-14
DK80291A (da) 1991-04-30
CH675722A5 (cs) 1990-10-31
GR861086B (en) 1986-09-01
YU116787A (en) 1988-04-30
DK165248C (da) 1993-03-22
DK81091A (da) 1991-05-01
NO163406B (no) 1990-02-12
DK190986D0 (da) 1986-04-24
DK165249C (da) 1993-03-22
OA08242A (en) 1987-10-30
ES554336A0 (es) 1987-10-01
HU195813B (en) 1988-07-28
EG18104A (en) 1992-09-30
DK165248B (da) 1992-10-26
LU86406A1 (fr) 1986-11-05
DK190986A (da) 1986-10-26
DK164868B (da) 1992-08-31
GB8610037D0 (en) 1986-05-29
ES557551A0 (es) 1988-02-16
FI861684A0 (fi) 1986-04-22
FI83316B (fi) 1991-03-15
GB2174987A (en) 1986-11-19
DE3614132A1 (de) 1986-11-27
ES557552A0 (es) 1988-07-16
HK64492A (en) 1992-09-04
US4668686A (en) 1987-05-26
AU5641386A (en) 1986-10-30
AU592983B2 (en) 1990-02-01
KR940000828B1 (ko) 1994-02-02
PT82460B (pt) 1988-11-30
FI861684L (fi) 1986-10-26
IL78581A0 (en) 1986-08-31
GB2174987B (en) 1989-08-02
DK81091D0 (da) 1991-05-01
DK80291D0 (da) 1991-04-30
ES8801829A1 (es) 1988-02-16
IT1215651B (it) 1990-02-22
NZ215885A (en) 1989-04-26
ES8802521A1 (es) 1988-07-16
FR2581065A1 (fr) 1986-10-31
NL8601053A (nl) 1986-11-17
PT82460A (en) 1986-05-01
CN86102747A (zh) 1987-02-04
KR860008177A (ko) 1986-11-12
AT390257B (de) 1990-04-10

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