DK1170292T3 - Fremgangsmåde til selektiv derivatisering af taxaner - Google Patents

Fremgangsmåde til selektiv derivatisering af taxaner

Info

Publication number
DK1170292T3
DK1170292T3 DK01203287T DK01203287T DK1170292T3 DK 1170292 T3 DK1170292 T3 DK 1170292T3 DK 01203287 T DK01203287 T DK 01203287T DK 01203287 T DK01203287 T DK 01203287T DK 1170292 T3 DK1170292 T3 DK 1170292T3
Authority
DK
Denmark
Prior art keywords
sup
taxanes
hydroxytaxane
acyloxy
selective derivatization
Prior art date
Application number
DK01203287T
Other languages
Danish (da)
English (en)
Inventor
Paul A Clark
Robert A Holton
Zhuming Zhang
Original Assignee
Univ Florida State
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27368950&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK1170292(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Univ Florida State filed Critical Univ Florida State
Application granted granted Critical
Publication of DK1170292T3 publication Critical patent/DK1170292T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D305/00Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02Silicon compounds
    • C07F7/08Compounds having one or more C—Si linkages
    • C07F7/18Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804Compounds having Si-O-C linkages
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02Silicon compounds
    • C07F7/08Compounds having one or more C—Si linkages
    • C07F7/18Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804Compounds having Si-O-C linkages
    • C07F7/1872Preparation; Treatments not provided for in C07F7/20
    • C07F7/1892Preparation; Treatments not provided for in C07F7/20 by reactions not provided for in C07F7/1876 - C07F7/1888

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epoxy Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Soil Working Implements (AREA)
  • Fats And Perfumes (AREA)
  • Percussion Or Vibration Massage (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DK01203287T 1997-08-18 1998-08-17 Fremgangsmåde til selektiv derivatisering af taxaner DK1170292T3 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US5600097P 1997-08-18 1997-08-18
US8126598P 1998-04-09 1998-04-09
US09/063,477 US7288665B1 (en) 1997-08-18 1998-04-20 Process for selective derivatization of taxanes
PCT/US1998/017016 WO1999009021A1 (en) 1997-08-18 1998-08-17 Process for selective derivatization of taxanes

Publications (1)

Publication Number Publication Date
DK1170292T3 true DK1170292T3 (da) 2007-08-27

Family

ID=27368950

Family Applications (3)

Application Number Title Priority Date Filing Date
DK01203288T DK1170293T3 (da) 1997-08-18 1998-08-17 Fremgangsmåde til selektiv derivatisering af taxaner
DK01203287T DK1170292T3 (da) 1997-08-18 1998-08-17 Fremgangsmåde til selektiv derivatisering af taxaner
DK98942080T DK0956284T3 (da) 1997-08-18 1998-08-17 Fremgangsmåde til selektiv derivatisering af taxaner

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK01203288T DK1170293T3 (da) 1997-08-18 1998-08-17 Fremgangsmåde til selektiv derivatisering af taxaner

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK98942080T DK0956284T3 (da) 1997-08-18 1998-08-17 Fremgangsmåde til selektiv derivatisering af taxaner

Country Status (25)

Country Link
US (5) US7288665B1 (de)
EP (6) EP0956284B1 (de)
JP (1) JP2001504864A (de)
KR (1) KR100596989B1 (de)
CN (3) CN1974563A (de)
AT (3) ATE341540T1 (de)
AU (1) AU744987B2 (de)
BR (1) BR9806145A (de)
CA (2) CA2597799A1 (de)
CY (1) CY1105399T1 (de)
CZ (1) CZ296580B6 (de)
DE (3) DE69837684T2 (de)
DK (3) DK1170293T3 (de)
ES (3) ES2286073T3 (de)
HU (1) HUP0300425A3 (de)
ID (1) ID21654A (de)
IL (3) IL129386A0 (de)
NO (4) NO325139B1 (de)
NZ (1) NZ335156A (de)
PL (3) PL193674B1 (de)
PT (3) PT956284E (de)
RU (1) RU2225402C2 (de)
SG (1) SG97986A1 (de)
WO (1) WO1999009021A1 (de)
ZA (1) ZA987394B (de)

Families Citing this family (74)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5750736A (en) * 1996-07-11 1998-05-12 Napro Biotherapeutics, Inc. Method for acylating 10-deacetylbaccatin III selectively at the c-10 position
US7288665B1 (en) 1997-08-18 2007-10-30 Florida State University Process for selective derivatization of taxanes
IT1308636B1 (it) * 1999-03-02 2002-01-09 Indena Spa Procedimento per la preparazione di tassani da 10-desacetilbaccatinaiii.
AR030188A1 (es) 2000-02-02 2003-08-13 Univ Florida State Res Found Compuestos de taxano sustituidos con esteres en el c7; composiciones farmaceuticas que los contienen y proceso para tratar un sujeto mamifero que sufre de una condicion que responde a los taxanos
BR0104352A (pt) 2000-02-02 2002-01-02 Univ Florida State Res Found Taxanos substituìdos por c10 carbamoilóxi como agentes antitumorais
WO2001057028A1 (en) 2000-02-02 2001-08-09 Florida State University Research Foundation, Inc. C7 carbamoyloxy substituted taxanes as antitumor agents
RO121271B1 (ro) 2000-02-02 2007-02-28 Florida State University Research Foundation, Inc. Taxani substituiţi cu carbonat la c7, ca agenţiantitumorali
MXPA01009924A (es) 2000-02-02 2003-08-01 Univ Florida State Res Found Taxanos de acetato heteosustituido en c10 como agentes antitumorales.
US6649632B2 (en) 2000-02-02 2003-11-18 Fsu Research Foundation, Inc. C10 ester substituted taxanes
MXPA01009922A (es) 2000-02-02 2003-07-14 Univ Florida State Res Found Taxanos de acetato heterosustituido en c7 como agentes antitumorales.
US6660866B2 (en) 2000-02-02 2003-12-09 Psu Research Foundation, Inc. C10 carbonate substituted taxanes
US6362217B2 (en) * 2000-03-17 2002-03-26 Bristol-Myers Squibb Company Taxane anticancer agents
IT1320107B1 (it) * 2000-11-28 2003-11-18 Indena Spa Procedimento per la preparazione di derivati tassanici.
IT1319682B1 (it) * 2000-12-06 2003-10-23 Indena Spa Procedimento di sintesi del paclitaxel.
US7351542B2 (en) 2002-05-20 2008-04-01 The Regents Of The University Of California Methods of modulating tubulin deacetylase activity
DK2286795T3 (en) 2002-06-26 2017-02-06 Syncore Biotechnology Co Ltd PROCEDURE FOR PREPARING A Cationic LIPOSOMAL PREPARATION INCLUDING A LIPOPHIL COMPOUND
CN101039957A (zh) 2003-05-16 2007-09-19 因特缪恩公司 合成的趋化因子受体配体及其使用方法
CN1303077C (zh) * 2004-01-16 2007-03-07 桂林晖昂生化药业有限责任公司 合成紫杉烷的制备工艺
SV2006002010A (es) 2004-02-13 2006-08-23 Univ Florida State Res Found Taxanos sustituidos con esteres de ciclopentilo en c10
PA8625301A1 (es) 2004-03-05 2006-06-02 Univ Florida State Res Found Taxanos con sustituyente lactiloxilo en el c7
KR20070013300A (ko) * 2004-05-14 2007-01-30 이뮤노젠 아이엔씨 박카틴 ⅲ 화합물의 합성 방법
WO2006089209A2 (en) 2005-02-17 2006-08-24 The Board Of Trustees Of The Leland Stanford Junior University Txr1 and enhanced taxane sensitivity based on the modulation of a pathway mediated thereby
US7667055B2 (en) * 2005-06-10 2010-02-23 Florida State University Research Foundation, Inc. Processes for the production of polycyclic fused ring compounds
CA2610908A1 (en) * 2005-06-10 2006-12-21 Florida State University Research Foundation, Inc. Processes for the preparation of paclitaxel
EP3056196A1 (de) 2006-03-22 2016-08-17 SynCore Biotechnology CO., LTD Behandlung von dreifach rezeptor-negativem brustkrebs
US7847111B2 (en) * 2006-06-19 2010-12-07 Canada Inc. Semi-synthetic route for the preparation of paclitaxel, docetaxel, and 10-deacetylbaccatin III from 9-dihydro-13-acetylbaccatin III
PL210984B1 (pl) * 2006-10-31 2012-03-30 Inst Farmaceutyczny Sposób wytwarzania docetakselu
WO2008106491A2 (en) * 2007-02-27 2008-09-04 University Of Utah Research Foundation Peptides that interact with topoisomerase i and methods thereof
JP4833126B2 (ja) * 2007-03-26 2011-12-07 Ntn株式会社 潤滑剤劣化検出装置および検出装置付き軸受
CN101274923B (zh) * 2007-03-27 2011-02-02 中国科学院大连化学物理研究所 一种制备紫杉醇,巴卡亭ⅲ及其衍生物的方法
CN101274924B (zh) * 2007-03-27 2010-11-10 中国科学院大连化学物理研究所 一种制备紫杉醇及其衍生物的方法
WO2009040829A1 (en) * 2007-09-27 2009-04-02 Benzochem Lifescience (P) Limited A novel process for the preparation of docetaxel
US8242166B2 (en) 2008-03-31 2012-08-14 Florida State University Research Foundation, Inc. C(10) ethyl ester and C(10) cyclopropyl ester substituted taxanes
CA2724550C (en) 2008-05-22 2017-01-03 Kereos, Inc. Combination antitumor therapy
US20110172293A1 (en) 2008-07-08 2011-07-14 Fish Jason E Methods and Compositions for Modulating Angiogenesis
CN101863861A (zh) * 2009-04-16 2010-10-20 山东靶点药物研究有限公司 一种简便高效地制备紫杉醇类似物Larotaxel的方法
US8791279B2 (en) * 2010-12-13 2014-07-29 Yung Shin Pharm. Ind. Co., Ltd. Process for preparing taxoids from baccatin derivatives using lewis acid catalyst
WO2012131698A1 (en) 2011-04-01 2012-10-04 Shilpa Medicare Limited Process for preparing docetaxel and its hydrate
US20130090484A1 (en) * 2011-10-11 2013-04-11 Scinopharm Taiwan Ltd. Process for making an intermediate of cabazitaxel
CN103159704B (zh) * 2011-12-12 2015-06-10 上海佰霖国际贸易有限公司 卡巴他赛中间体及卡巴他赛中间体的制备方法
KR102165464B1 (ko) 2012-07-19 2020-10-14 레드우드 바이오사이언스 인코포레이티드 Cd22에 대해 특이적인 항체 및 이들의 사용 방법
EP2916835A4 (de) 2012-11-12 2016-07-27 Redwood Bioscience Inc Verbindungen und verfahren zur herstellung eines konjugats
EP2956175B1 (de) 2013-02-15 2017-10-04 The Regents of the University of California Chimärer antigen-rezeptor und verfahren zur verwendung davon
JP6410790B2 (ja) 2013-03-14 2018-10-24 ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー ミトコンドリアアルデヒドデヒドロゲナーゼ−2調節因子およびその使用方法
CN103145654A (zh) * 2013-04-12 2013-06-12 江苏斯威森生物医药工程研究中心有限公司 一种多西他赛的半合成方法
WO2014191989A1 (en) * 2013-05-26 2014-12-04 Idd Therapeutics Ltd. Conjugate of a taxane and biotin and uses thereof
EP3074010A4 (de) 2013-11-27 2017-10-25 Redwood Bioscience, Inc. Hydrazinylpyrrolverbindungen und verfahren zur herstellung eines konjugats
CN106458910B (zh) 2014-02-19 2020-11-06 亚倍生技制药公司 线粒体醛脱氢酶2(aldh2)结合多环酰胺和其用于治疗癌症的用途
CN110845616A (zh) 2014-03-21 2020-02-28 艾伯维公司 抗-egfr抗体及抗体药物偶联物
EP3373977A4 (de) 2015-11-12 2019-07-17 The Board of Trustees of the Leland Stanford Junior University Zellenpenetrierende, guanidiniumreiche oligophosphotriester zur wirkstoff- und sondenfreisetzung
TWI760319B (zh) 2015-12-30 2022-04-11 杏國新藥股份有限公司 乳癌治療
EP3231421A1 (de) 2016-04-11 2017-10-18 Greenaltech, S.L. Verwendungen eines carotenoids bei der behandlung oder prävention von durch stress verursachten störungen
CA3019398A1 (en) 2016-04-26 2017-11-02 R.P. Scherer Technologies, Llc Antibody conjugates and methods of making and using the same
LT3463308T (lt) 2016-06-01 2022-02-10 Servier IP UK Limited Polialkilenoksido-asparaginazės vaisto formos ir jų gamybos būdai bei panaudojimas
MX2018015285A (es) 2016-06-08 2019-09-18 Abbvie Inc Anticuerpos anti-b7-h3 y conjugados de anticuerpo y farmaco.
JP2019526529A (ja) 2016-06-08 2019-09-19 アッヴィ・インコーポレイテッド 抗b7−h3抗体及び抗体薬物コンジュゲート
AU2017279550A1 (en) 2016-06-08 2019-01-03 Abbvie Inc. Anti-B7-H3 antibodies and antibody drug conjugates
EP3468599A2 (de) 2016-06-08 2019-04-17 AbbVie Inc. Anti-cd98-antikörper und antikörperwirkstoffkonjugate
JP2019524651A (ja) 2016-06-08 2019-09-05 アッヴィ・インコーポレイテッド 抗cd98抗体及び抗体薬物コンジュゲート
TWI852903B (zh) 2017-01-05 2024-08-21 杏國新藥股份有限公司 胰臟癌治療
US20190367621A1 (en) 2017-01-18 2019-12-05 F1 Oncology, Inc. Chimeric antigen receptors against axl or ror2 and methods of use thereof
EP3388082A1 (de) 2017-04-13 2018-10-17 Galera Labs, LLC Kombinationskrebsimmuntherapie mit makrocyclischem pentaaza-ringkomplex
BR112020015520A2 (pt) 2018-01-31 2021-02-02 Galera Labs, Llc terapia de combinação para câncer com complexo de anel macrocíclico pentaaza e agente anticâncer à base de platina
CN112368011A (zh) 2018-04-11 2021-02-12 俄亥俄州创新基金会 缓释微粒用于眼用药物递送的方法和组合物
JP2021530507A (ja) 2018-07-18 2021-11-11 マンザニータ ファーマシューティカルズ,インク. 神経細胞に抗がん剤を送達するためのコンジュゲート、その使用方法及び製造方法
AU2020253449A1 (en) 2019-04-02 2021-11-18 Kenjockety Biotechnology, Inc. Efflux pump-cancer antigen multi-specific antibodies and compositions, reagents, kits and methods related thereto
MX2022009355A (es) 2020-01-29 2022-09-02 Kenjockety Biotechnology Inc Anticuerpo anti-mdr1 y uso del mismo.
WO2021247423A1 (en) 2020-06-04 2021-12-09 Kenjockety Biotechnology, Inc. Abcg2 efflux pump-cancer antigen multi-specific antibodies and compositions, reagents, kits and methods related thereto
WO2021247426A1 (en) 2020-06-04 2021-12-09 Kenjockety Biotechnology, Inc. Anti-abcg2 antibodies and uses thereof
US20230272117A1 (en) 2020-09-02 2023-08-31 Kenjockety Biotechnology, Inc. Anti abcc1 antibodies and uses thereof
EP4244257A1 (de) 2020-11-13 2023-09-20 Kenjockety Biotechnology, Inc. Anti-mrp4 (codiert durch abcc4-gen) antikörper und verwendungen davon
UY39610A (es) 2021-01-20 2022-08-31 Abbvie Inc Conjugados anticuerpo-fármaco anti-egfr
CA3238353A1 (en) 2021-12-13 2023-06-22 William Robert ARATHOON Anti-abcb1 antibodies
WO2023159220A1 (en) 2022-02-18 2023-08-24 Kenjockety Biotechnology, Inc. Anti-cd47 antibodies

Family Cites Families (63)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US569666A (en) * 1896-10-20 Brake-beam
FR2601676B1 (fr) 1986-07-17 1988-09-23 Rhone Poulenc Sante Procede de preparation du taxol et du desacetyl-10 taxol
USRE34277E (en) 1988-04-06 1993-06-08 Centre National De La Recherche Scientifique Process for preparing taxol
FR2629818B1 (fr) * 1988-04-06 1990-11-16 Centre Nat Rech Scient Procede de preparation du taxol
JPH01309997A (ja) * 1988-06-09 1989-12-14 Kanto Kasei Kogyo Kk 耐食性に優れた銅−ニッケル−クロム光沢電気めっき方法およびそれにより得られためっき皮膜
US4960790A (en) 1989-03-09 1990-10-02 University Of Kansas Derivatives of taxol, pharmaceutical compositions thereof and methods for the preparation thereof
US5175315A (en) * 1989-05-31 1992-12-29 Florida State University Method for preparation of taxol using β-lactam
US5136060A (en) 1989-11-14 1992-08-04 Florida State University Method for preparation of taxol using an oxazinone
FR2678930B1 (fr) * 1991-07-10 1995-01-13 Rhone Poulenc Rorer Sa Procede de preparation de derives de la baccatine iii et de la desacetyl-10 baccatine iii.
US5489601A (en) 1991-09-23 1996-02-06 Florida State University Taxanes having a pyridyl substituted side-chain and pharmaceutical compositions containing them
US5714513A (en) 1991-09-23 1998-02-03 Florida State University C10 taxane derivatives and pharmaceutical compositions
SG46582A1 (en) 1991-09-23 1998-02-20 Univ Florida State 10-Desacetoxytaxol derivatives
US5229526A (en) * 1991-09-23 1993-07-20 Florida State University Metal alkoxides
US5284865A (en) 1991-09-23 1994-02-08 Holton Robert A Cyclohexyl substituted taxanes and pharmaceutical compositions containing them
US5654447A (en) 1991-09-23 1997-08-05 Florida State University Process for the preparation of 10-desacetoxybaccatin III
US5399726A (en) 1993-01-29 1995-03-21 Florida State University Process for the preparation of baccatin III analogs bearing new C2 and C4 functional groups
US5990325A (en) 1993-03-05 1999-11-23 Florida State University Process for the preparation of 9-desoxotaxol, 9-desoxobaccatin III and analogs thereof
US5430160A (en) 1991-09-23 1995-07-04 Florida State University Preparation of substituted isoserine esters using β-lactams and metal or ammonium alkoxides
FR2687145B1 (fr) 1992-02-07 1994-03-25 Rhone Poulenc Rorer Sa Nouveaux anhydrides d'acides, leur preparation et leur emplot et
US5200534A (en) 1992-03-13 1993-04-06 University Of Florida Process for the preparation of taxol and 10-deacetyltaxol
US5416225A (en) 1992-03-30 1995-05-16 Sloan-Kettering Institute For Cancer Research Total synthesis of taxol
US5254703A (en) 1992-04-06 1993-10-19 Florida State University Semi-synthesis of taxane derivatives using metal alkoxides and oxazinones
US5440056A (en) 1992-04-17 1995-08-08 Abbott Laboratories 9-deoxotaxane compounds
CA2130578A1 (en) 1992-04-17 1993-10-28 Geewananda P. Gunawardana Taxol derivatives
US5269442A (en) * 1992-05-22 1993-12-14 The Cornelius Company Nozzle for a beverage dispensing valve
US5470866A (en) 1992-08-18 1995-11-28 Virginia Polytechnic Institute And State University Method for the conversion of cephalomannine to taxol and for the preparation of n-acyl analogs of taxol
WO1994005282A1 (en) 1992-09-04 1994-03-17 The Scripps Research Institute Water soluble taxol derivatives
US5478854A (en) 1992-10-01 1995-12-26 Bristol-Myers Squibb Company Deoxy taxols
FR2696458B1 (fr) 1992-10-05 1994-11-10 Rhone Poulenc Rorer Sa Procédé de préparation de dérivés du taxane.
FR2696460B1 (fr) 1992-10-05 1994-11-25 Rhone Poulenc Rorer Sa Procédé de préparation de dérivés du taxane.
US5412116A (en) 1992-11-06 1995-05-02 Hauser Chemical Research, Inc. Oxidation of glycoside substituted taxanes to taxol or taxol precursors and new taxane compounds formed as intermediates
FR2698363B1 (fr) 1992-11-23 1994-12-30 Rhone Poulenc Rorer Sa Nouveaux dérivés du taxane, leur préparation et les compositions qui les contiennent.
US5380751A (en) 1992-12-04 1995-01-10 Bristol-Myers Squibb Company 6,7-modified paclitaxels
FR2698871B1 (fr) 1992-12-09 1995-02-24 Rhone Poulenc Rorer Sa Nouveau taxoïdes, leur préparation et les compositions pharmaceutiques qui les contiennent.
US5646176A (en) 1992-12-24 1997-07-08 Bristol-Myers Squibb Company Phosphonooxymethyl ethers of taxane derivatives
US5948919A (en) * 1993-02-05 1999-09-07 Napro Biotherapeutics, Inc. Paclitaxel synthesis from precursor compounds and methods of producing the same
FR2702212B1 (fr) 1993-03-02 1995-04-07 Rhone Poulenc Rorer Sa Nouveaux taxoïdes, leur préparation et les compositions pharmaceutiques qui les contiennent.
US5547981A (en) 1993-03-09 1996-08-20 Enzon, Inc. Taxol-7-carbazates
US5703247A (en) 1993-03-11 1997-12-30 Virginia Tech Intellectual Properties, Inc. 2-Debenzoyl-2-acyl taxol derivatives and methods for making same
US5475011A (en) 1993-03-26 1995-12-12 The Research Foundation Of State University Of New York Anti-tumor compounds, pharmaceutical compositions, methods for preparation thereof and for treatment
US5336684A (en) 1993-04-26 1994-08-09 Hauser Chemical Research, Inc. Oxidation products of cephalomannine
IL109926A (en) * 1993-06-15 2000-02-29 Bristol Myers Squibb Co Methods for the preparation of taxanes and microorganisms and enzymes utilized therein
US5405972A (en) * 1993-07-20 1995-04-11 Florida State University Synthetic process for the preparation of taxol and other tricyclic and tetracyclic taxanes
FR2718137B1 (fr) 1994-04-05 1996-04-26 Rhone Poulenc Rorer Sa Procédé de préparation de trialcoylsilyl-7 baccatine III.
US6100411A (en) * 1994-10-28 2000-08-08 The Research Foundation Of State University Of New York Taxoid anti-tumor agents and pharmaceutical compositions thereof
JPH10508022A (ja) * 1994-10-28 1998-08-04 ザ リサーチ ファウンデーション オブ ステート ユニバーシティ オブ ニューヨーク タキソイド誘導体、それらの製造、およびそれらの抗腫瘍薬としての使用
US5489589A (en) 1994-12-07 1996-02-06 Bristol-Myers Squibb Company Amino acid derivatives of paclitaxel
JPH08253465A (ja) * 1995-03-17 1996-10-01 Dai Ichi Seiyaku Co Ltd 四環性化合物
MA23823A1 (fr) * 1995-03-27 1996-10-01 Aventis Pharma Sa Nouveaux taxoides, leur preparation et les compositions qui les contiennent
US5847170A (en) * 1995-03-27 1998-12-08 Rhone-Poulenc Rorer, S.A. Taxoids, their preparation and pharmaceutical compositions containing them
US5780653A (en) 1995-06-07 1998-07-14 Vivorx Pharmaceuticals, Inc. Nitrophenyl, 10-deacetylated substituted taxol derivatives as dual functional cytotoxic/radiosensitizers
US5760251A (en) 1995-08-11 1998-06-02 Sepracor, Inc. Taxol process and compounds
FR2743074B1 (fr) * 1995-12-27 1998-03-27 Seripharm Procede de protection selective des derives de la baccatine et son utilisation dans la synthese des taxanes
US5688977A (en) 1996-02-29 1997-11-18 Napro Biotherapeutics, Inc. Method for docetaxel synthesis
ES2151277T3 (es) * 1996-05-22 2000-12-16 Protarga Inc Composiciones que comprenden conjugados de acido cis-docosahexaenoico y taxotere.
US5773461A (en) 1996-06-06 1998-06-30 Bristol-Myers Squibb Company 7-deoxy-6-substituted paclitaxels
FR2750989B1 (fr) 1996-07-09 1998-09-25 Rhone Poulenc Rorer Sa Procede de monoacylation d'hydroxy taxanes
US5750736A (en) 1996-07-11 1998-05-12 Napro Biotherapeutics, Inc. Method for acylating 10-deacetylbaccatin III selectively at the c-10 position
US5811452A (en) 1997-01-08 1998-09-22 The Research Foundation Of State University Of New York Taxoid reversal agents for drug-resistance in cancer chemotherapy and pharmaceutical compositions thereof
US6017935A (en) * 1997-04-24 2000-01-25 Bristol-Myers Squibb Company 7-sulfur substituted paclitaxels
DK0875508T3 (da) 1997-05-02 2004-01-26 Pharmachemie Bv Fremgangsmåde til fremstilling af baccatin lll og derivater ud fra 10-deacetylbaccatin lll
US7288665B1 (en) 1997-08-18 2007-10-30 Florida State University Process for selective derivatization of taxanes
US5914411A (en) 1998-01-21 1999-06-22 Napro Biotherapeutics, Inc. Alternate method for acylating 10-deacetylbaccatin III selectively at the C-10 position

Also Published As

Publication number Publication date
WO1999009021A1 (en) 1999-02-25
CZ133299A3 (cs) 1999-11-17
US7288665B1 (en) 2007-10-30
EP1170292B1 (de) 2007-04-25
IL184321A0 (en) 2007-10-31
EP1170292A2 (de) 2002-01-09
CZ296580B6 (cs) 2006-04-12
PT1170292E (pt) 2007-05-31
PL201641B1 (pl) 2009-04-30
ATE360624T1 (de) 2007-05-15
CY1105399T1 (el) 2010-04-28
NZ335156A (en) 2001-10-26
ZA987394B (en) 1999-05-14
EP1170293B1 (de) 2006-05-17
ES2286073T3 (es) 2007-12-01
KR20000068782A (ko) 2000-11-25
HUP0300425A3 (en) 2005-12-28
ES2259646T3 (es) 2006-10-16
ATE341540T1 (de) 2006-10-15
DK0956284T3 (da) 2007-02-12
KR100596989B1 (ko) 2006-07-07
RU2225402C2 (ru) 2004-03-10
IL129386A0 (en) 2000-02-17
ID21654A (id) 1999-07-08
DE69836072T2 (de) 2007-01-11
DE69834584D1 (de) 2006-06-22
JP2001504864A (ja) 2001-04-10
NO20054513L (no) 1999-06-18
AU9021198A (en) 1999-03-08
NO20054514L (no) 1999-06-18
EP0956284A1 (de) 1999-11-17
DE69837684D1 (de) 2007-06-06
EP1170292A3 (de) 2002-04-03
CN1974563A (zh) 2007-06-06
DE69834584T2 (de) 2006-11-23
NO20054512L (no) 1999-06-18
US6191287B1 (en) 2001-02-20
AU744987B2 (en) 2002-03-07
ATE326455T1 (de) 2006-06-15
US6291691B1 (en) 2001-09-18
NO991838L (no) 1999-06-18
EP1795528A1 (de) 2007-06-13
US20050272944A1 (en) 2005-12-08
NO991838D0 (no) 1999-04-16
CA2597799A1 (en) 1999-02-25
CA2268662A1 (en) 1999-02-25
CN100351246C (zh) 2007-11-28
US6706896B1 (en) 2004-03-16
NO325139B1 (no) 2008-02-11
CN1205196C (zh) 2005-06-08
HUP0300425A2 (hu) 2003-09-29
PL193674B1 (pl) 2007-03-30
PT956284E (pt) 2006-12-29
SG97986A1 (en) 2003-08-20
EP0956284A4 (de) 2001-12-05
ES2274579T3 (es) 2007-05-16
CN1690053A (zh) 2005-11-02
DK1170293T3 (da) 2006-09-11
DE69836072D1 (de) 2006-11-16
BR9806145A (pt) 2000-01-18
EP1170293A2 (de) 2002-01-09
PT1170293E (pt) 2006-07-31
DE69837684T2 (de) 2007-09-06
EP1193262A1 (de) 2002-04-03
PL332723A1 (en) 1999-10-11
EP1671960A2 (de) 2006-06-21
EP1170293A3 (de) 2002-04-03
IL184320A0 (en) 2007-10-31
CN1239476A (zh) 1999-12-22
EP0956284B1 (de) 2006-10-04

Similar Documents

Publication Publication Date Title
DK0956284T3 (da) Fremgangsmåde til selektiv derivatisering af taxaner
AR070946A2 (es) Proceso para la preparacion de dihidroxiesteres y derivados de los mismos
ES2080119T3 (es) Composicion suavizante de tejidos.
ATE180488T1 (de) Synthese von 4-alkoxy-n-acetylneuraminsäure
KR870001834A (ko) 일본뇌염 바이러스의 정제방법
ES2145452T3 (es) Metodo para preparar ureas ciclicas n,n'-disustituidas.
IT1261489B (it) Procedimento per la produzione di r amminocarnitina e s amminocarnitina.
BR9916648A (pt) Processo para preparar ésteres glioxìlicos ou seus hidratos
FI956025A0 (fi) Menetelmä oksatsolidiinikarboksyylihapon valmistamiseksi, joka on hyödyllinen valmistettaessa terapeuttisesti vaikuttavia taksoideja
JPS5358589A (en) Pullulan aminoalkyl ether
JPS52156867A (en) Preparation of piperonal
ES2051765T3 (es) 13 alfa-alquilgon-delta9(11)-en-5,10-epoxidos.
JPS51136375A (en) Treating method for fibrous waste material
KR920021571A (ko) 3'및/또는 4'oh기에서 엘사마이신 a의 화학적 변형
JPS52151175A (en) Gamma-pyrone and gamma-pyridone derivatives
DE69600686D1 (de) Verfahren zur herstellung von butanonderivaten
JPS51138650A (en) Process for preparing optically active trans-cyclopentene-3,5,-diolmon oester
JPS53129441A (en) Aeration method
JPS5431960A (en) Method of dehydrating organic sludge
RU98122552A (ru) Способ получения 2,3-замещенных 1,4-диоксанов
IT8222004A0 (it) Sali di n-cicloesil-piperazino-acetammide ad azione anti-infiammatoria, processo per ottenerli e composizioni farmaceutiche contenenti detti sali.
KR890001568A (ko) 돼지 이질의 예방 및 치료제
JPS5398919A (en) Preparation of glucosides
JPS52154886A (en) Purification of high-crystallinity polyolefin