DE69529708T2 - Herstellung von stabilen Zink-Insulinanalogen-Kristallen - Google Patents

Herstellung von stabilen Zink-Insulinanalogen-Kristallen

Info

Publication number
DE69529708T2
DE69529708T2 DE69529708T DE69529708T DE69529708T2 DE 69529708 T2 DE69529708 T2 DE 69529708T2 DE 69529708 T DE69529708 T DE 69529708T DE 69529708 T DE69529708 T DE 69529708T DE 69529708 T2 DE69529708 T2 DE 69529708T2
Authority
DE
Germany
Prior art keywords
human insulin
solution
zinc
insulin
phenol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69529708T
Other languages
German (de)
English (en)
Other versions
DE69529708D1 (de
Inventor
Jeffrey Clayton Baker
Nancy Delores Carter
Bruce Hill Frank
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22990041&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69529708(T2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of DE69529708D1 publication Critical patent/DE69529708D1/de
Application granted granted Critical
Publication of DE69529708T2 publication Critical patent/DE69529708T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Endocrinology (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Toxicology (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Emergency Medicine (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE69529708T 1994-06-16 1995-06-14 Herstellung von stabilen Zink-Insulinanalogen-Kristallen Expired - Lifetime DE69529708T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/260,647 US5504188A (en) 1994-06-16 1994-06-16 Preparation of stable zinc insulin analog crystals

Publications (2)

Publication Number Publication Date
DE69529708D1 DE69529708D1 (de) 2003-04-03
DE69529708T2 true DE69529708T2 (de) 2003-10-16

Family

ID=22990041

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69529708T Expired - Lifetime DE69529708T2 (de) 1994-06-16 1995-06-14 Herstellung von stabilen Zink-Insulinanalogen-Kristallen

Country Status (29)

Country Link
US (1) US5504188A (enExample)
EP (1) EP0692489B1 (enExample)
JP (1) JP3595607B2 (enExample)
KR (1) KR100369951B1 (enExample)
CN (1) CN1184234C (enExample)
AT (1) ATE233278T1 (enExample)
AU (1) AU697794B2 (enExample)
BR (1) BR9502798A (enExample)
CA (1) CA2151563C (enExample)
CO (1) CO4410205A1 (enExample)
CZ (1) CZ286066B6 (enExample)
DE (1) DE69529708T2 (enExample)
DK (1) DK0692489T3 (enExample)
ES (1) ES2188637T3 (enExample)
FI (1) FI952930A7 (enExample)
HU (1) HUT73495A (enExample)
IL (1) IL114152A (enExample)
IN (1) IN178919B (enExample)
MY (1) MY130551A (enExample)
NO (1) NO952334L (enExample)
NZ (1) NZ272358A (enExample)
PE (1) PE21896A1 (enExample)
PL (1) PL180968B1 (enExample)
RO (1) RO113529B1 (enExample)
RU (1) RU2156257C2 (enExample)
SI (1) SI0692489T1 (enExample)
TW (1) TW379228B (enExample)
YU (1) YU39595A (enExample)
ZA (1) ZA954942B (enExample)

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US5474978A (en) * 1994-06-16 1995-12-12 Eli Lilly And Company Insulin analog formulations
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US5631347A (en) * 1995-06-07 1997-05-20 Eli Lilly And Company Reducing gelation of a fatty acid-acylated protein
US5869604A (en) * 1995-11-09 1999-02-09 Georgia Institute Of Technology Crystallization and purification of polypeptides
ATE220555T1 (de) * 1997-03-20 2002-08-15 Novo Nordisk As Verfahren zur herstellung eines therapeutischen puders durch copräzipitation von insulin und einem absorptionsverstärker
US6043214A (en) * 1997-03-20 2000-03-28 Novo Nordisk A/S Method for producing powder formulation comprising an insulin
AU1375199A (en) * 1997-11-12 1999-05-31 Alza Corporation Method for decreasing self-association of polypeptides
RU2205188C2 (ru) 1998-06-30 2003-05-27 Ново Нордиск А/С Затравочные кристаллы для получения пептидов или протеинов
US6956021B1 (en) * 1998-08-25 2005-10-18 Advanced Inhalation Research, Inc. Stable spray-dried protein formulations
PL197504B1 (pl) * 1998-10-16 2008-04-30 Novo Nordisk As Trwałe stężone preparaty insulinowe do podawania do płuc
US6211144B1 (en) 1998-10-16 2001-04-03 Novo Nordisk A/S Stable concentrated insulin preparations for pulmonary delivery
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US6713452B2 (en) * 2001-06-04 2004-03-30 Nobex Corporation Mixtures of calcitonin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
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US7196059B2 (en) * 2001-09-07 2007-03-27 Biocon Limited Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith
US6770625B2 (en) 2001-09-07 2004-08-03 Nobex Corporation Pharmaceutical compositions of calcitonin drug-oligomer conjugates and methods of treating diseases therewith
US7312192B2 (en) * 2001-09-07 2007-12-25 Biocon Limited Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
US7030082B2 (en) * 2001-09-07 2006-04-18 Nobex Corporation Pharmaceutical compositions of drug-oligomer conjugates and methods of treating disease therewith
US6913903B2 (en) * 2001-09-07 2005-07-05 Nobex Corporation Methods of synthesizing insulin polypeptide-oligomer conjugates, and proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
US7166571B2 (en) * 2001-09-07 2007-01-23 Biocon Limited Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
US20030068361A1 (en) * 2001-10-09 2003-04-10 Rimona Margalit Liposome-encapsulated insulin formulations
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CN106117345B (zh) * 2015-05-05 2020-11-24 宜昌东阳光长江药业股份有限公司 一种制备甘精胰岛素结晶的方法
CN104892749B (zh) * 2015-06-16 2019-02-05 珠海联邦制药股份有限公司 一种德谷胰岛素结晶的制备方法及应用
CN105753966A (zh) * 2016-05-05 2016-07-13 通化东宝药业股份有限公司 一种重组人胰岛素结晶的制备方法
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CN113896784B (zh) * 2021-10-18 2024-04-16 合肥天麦生物科技发展有限公司 一种胰岛素结晶的制备方法及其产品
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YU18596A (sh) * 1995-03-31 1998-07-10 Eli Lilly And Company Analogne formulacije monomernog insulina

Also Published As

Publication number Publication date
PL309099A1 (en) 1995-12-27
YU39595A (sh) 1997-08-22
ZA954942B (en) 1996-12-17
SI0692489T1 (en) 2003-06-30
ES2188637T3 (es) 2003-07-01
PL180968B1 (pl) 2001-05-31
HUT73495A (en) 1996-08-28
AU2168195A (en) 1996-01-04
RO113529B1 (ro) 1998-08-28
JPH08169899A (ja) 1996-07-02
KR100369951B1 (ko) 2003-03-28
ATE233278T1 (de) 2003-03-15
CA2151563C (en) 2007-08-07
EP0692489A1 (en) 1996-01-17
NZ272358A (en) 1996-12-20
AU697794B2 (en) 1998-10-15
CZ286066B6 (cs) 2000-01-12
IL114152A0 (en) 1995-10-31
DK0692489T3 (da) 2003-03-31
HU9501715D0 (en) 1995-08-28
CO4410205A1 (es) 1997-01-09
DE69529708D1 (de) 2003-04-03
CA2151563A1 (en) 1995-12-17
RU2156257C2 (ru) 2000-09-20
MY130551A (en) 2007-06-29
CZ154195A3 (en) 1996-02-14
KR960000922A (ko) 1996-01-25
IL114152A (en) 1999-12-31
BR9502798A (pt) 1996-06-04
FI952930A0 (fi) 1995-06-14
EP0692489B1 (en) 2003-02-26
RU95110107A (ru) 1997-05-10
US5504188A (en) 1996-04-02
FI952930L (fi) 1995-12-17
NO952334D0 (no) 1995-06-13
IN178919B (enExample) 1997-07-19
TW379228B (en) 2000-01-11
CN1184234C (zh) 2005-01-12
CN1128271A (zh) 1996-08-07
NO952334L (no) 1995-12-18
JP3595607B2 (ja) 2004-12-02
PE21896A1 (es) 1996-06-15
FI952930A7 (fi) 1995-12-17

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