DK78069C - Fremgangsmåde til fremstilling af krystallinsk insulin. - Google Patents
Fremgangsmåde til fremstilling af krystallinsk insulin.Info
- Publication number
- DK78069C DK78069C DK198252AA DK528252A DK78069C DK 78069 C DK78069 C DK 78069C DK 198252A A DK198252A A DK 198252AA DK 528252 A DK528252 A DK 528252A DK 78069 C DK78069 C DK 78069C
- Authority
- DK
- Denmark
- Prior art keywords
- production
- crystalline insulin
- insulin
- crystalline
- Prior art date
Links
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title 2
- 102000004877 Insulin Human genes 0.000 title 1
- 108090001061 Insulin Proteins 0.000 title 1
- 229940125396 insulin Drugs 0.000 title 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D9/00—Crystallisation
- B01D9/005—Selection of auxiliary, e.g. for control of crystallisation nuclei, of crystal growth, of adherence to walls; Arrangements for introduction thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
- C07K14/625—Extraction from natural sources
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Endocrinology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Toxicology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Diabetes (AREA)
- Crystallography & Structural Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Priority Applications (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK198252AA DK78069C (da) | 1952-06-23 | 1952-06-23 | Fremgangsmåde til fremstilling af krystallinsk insulin. |
| GB16635/53A GB733740A (en) | 1952-06-23 | 1953-06-16 | Improvements in or relating to a process for the production of crystalline insulin |
| DEN7344A DE962637C (de) | 1952-06-23 | 1953-06-18 | Verfahren zur Herstellung von kristallinem Insulin |
| FR1167005D FR1167005A (fr) | 1952-06-23 | 1953-06-19 | Perfectionnements apportés aux procédés pour la production d'insuline cristallisée |
| CY16157A CY161A (en) | 1952-06-23 | 1957-06-26 | Improvements in or relating to a process for the production of crystalline insulin |
| US692612A US2920014A (en) | 1952-06-23 | 1957-10-28 | Insulin crystals and preparations and processes for producing them |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK198252AA DK78069C (da) | 1952-06-23 | 1952-06-23 | Fremgangsmåde til fremstilling af krystallinsk insulin. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK78069C true DK78069C (da) | 1954-09-06 |
Family
ID=8141106
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK198252AA DK78069C (da) | 1952-06-23 | 1952-06-23 | Fremgangsmåde til fremstilling af krystallinsk insulin. |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US2920014A (da) |
| CY (1) | CY161A (da) |
| DE (1) | DE962637C (da) |
| DK (1) | DK78069C (da) |
| FR (1) | FR1167005A (da) |
| GB (1) | GB733740A (da) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3327709A1 (de) * | 1983-07-29 | 1985-02-07 | Hoechst Ag, 6230 Frankfurt | Insulin-derivat-kristallsuspensionen, verfahren zu deren herstellung und deren verwendung |
| DE3327928A1 (de) * | 1983-08-03 | 1985-02-21 | Hoechst Ag, 6230 Frankfurt | Verfahren zur herstellung von insulin-derivaten |
| US4764592A (en) * | 1987-04-23 | 1988-08-16 | Eli Lilly And Company | Crystalline human proinsulin and process for its production |
| US5504188A (en) * | 1994-06-16 | 1996-04-02 | Eli Lilly And Company | Preparation of stable zinc insulin analog crystals |
| US5597893A (en) * | 1994-10-31 | 1997-01-28 | Eli Lilly And Company | Preparation of stable insulin analog crystals |
| AR002976A1 (es) * | 1995-03-31 | 1998-05-27 | Lilly Co Eli | Formulaciones farmaceuticas parenterales de efecto prolongado de insulina; cristales de dichos analogos aplicables en dichas formulaciones yprocedimiento de las formulaciones mencionadas |
| KR19990071255A (ko) | 1998-02-28 | 1999-09-15 | 성재갑 | 소마토트로핀과 비타민의 합제 조성물 |
| RU2527893C2 (ru) * | 2004-07-19 | 2014-09-10 | Биокон Лимитед | Инсулин-олигомерные конъюгаты, их препараты и применения |
| BRPI0818004B8 (pt) * | 2007-10-16 | 2021-05-25 | Biocon Ltd | composição farmacêutica sólida administrável por via oral e o processo da mesma. |
| GB201409451D0 (en) | 2014-05-28 | 2014-07-09 | Ipabc Ltd | Antimicrobial preparations, methods for preparing the same and uses thereof to combat microorganisms |
| WO2016032869A1 (en) | 2014-08-26 | 2016-03-03 | Merck Sharp & Dohme Corp. | Method for preparing crystalline insulin or insulin analog compositions |
| WO2019064125A1 (en) * | 2017-09-26 | 2019-04-04 | Biocon Limited | INTEGRATED AUTOMATED FILTRATION FOR THE SEPARATION, WASHING AND DRYING OF PEPTIDE CRYSTALS |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2143590A (en) * | 1936-09-26 | 1939-01-10 | Univ Alberta | Insulin preparation and process of producing crystals of insulin |
| US2143591A (en) * | 1936-09-26 | 1939-01-10 | Univ Alberta | Therapeutic preparation and process of making and using it |
| DE835499C (de) * | 1945-05-17 | 1952-03-31 | Novo Terapeutisk Labor As | Verfahren zur Herstellung von Inselhormon in kristallinischer Form |
| US2626228A (en) * | 1945-05-17 | 1953-01-20 | Novo Terapeutisk Labor As | Method of producing crystalline insulin |
| US2779706A (en) * | 1950-08-12 | 1957-01-29 | Organon | Insulin extraction |
| US2819999A (en) * | 1953-11-13 | 1958-01-14 | Novo Terapeutisk Labor As | Process for crystallization of insulin using freeze dried insulin as seeding material |
| US2799622A (en) * | 1953-11-14 | 1957-07-16 | Novo Terapeutisk Labor As | Process of producing insulin crystals of substantially uniform size and compositions thereof |
-
1952
- 1952-06-23 DK DK198252AA patent/DK78069C/da active
-
1953
- 1953-06-16 GB GB16635/53A patent/GB733740A/en not_active Expired
- 1953-06-18 DE DEN7344A patent/DE962637C/de not_active Expired
- 1953-06-19 FR FR1167005D patent/FR1167005A/fr not_active Expired
-
1957
- 1957-06-26 CY CY16157A patent/CY161A/xx unknown
- 1957-10-28 US US692612A patent/US2920014A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| FR1167005A (fr) | 1958-11-19 |
| CY161A (en) | 1957-06-26 |
| GB733740A (en) | 1955-07-20 |
| US2920014A (en) | 1960-01-05 |
| DE962637C (de) | 1957-04-25 |
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