DE3685668T2 - Peptide. - Google Patents

Peptide.

Info

Publication number
DE3685668T2
DE3685668T2 DE8686301755T DE3685668T DE3685668T2 DE 3685668 T2 DE3685668 T2 DE 3685668T2 DE 8686301755 T DE8686301755 T DE 8686301755T DE 3685668 T DE3685668 T DE 3685668T DE 3685668 T2 DE3685668 T2 DE 3685668T2
Authority
DE
Germany
Prior art keywords
insulin
charge
amino acid
neutral
insulin derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE8686301755T
Other languages
English (en)
Other versions
DE3685668D1 (en
Inventor
Jan Markussen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novo Nordisk AS
Original Assignee
Novo Industri AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Industri AS filed Critical Novo Industri AS
Publication of DE3685668D1 publication Critical patent/DE3685668D1/de
Application granted granted Critical
Publication of DE3685668T2 publication Critical patent/DE3685668T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
DE8686301755T 1985-03-12 1986-03-11 Peptide. Expired - Fee Related DE3685668T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DK113585A DK113585D0 (da) 1985-03-12 1985-03-12 Nye peptider

Publications (2)

Publication Number Publication Date
DE3685668D1 DE3685668D1 (en) 1992-07-23
DE3685668T2 true DE3685668T2 (de) 1993-01-14

Family

ID=8101410

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8686301755T Expired - Fee Related DE3685668T2 (de) 1985-03-12 1986-03-11 Peptide.

Country Status (22)

Country Link
EP (1) EP0194864B1 (de)
JP (1) JPS61212598A (de)
KR (1) KR930007433B1 (de)
CN (1) CN86101489A (de)
AT (1) ATE77391T1 (de)
AU (1) AU612964B2 (de)
CS (1) CS259536B2 (de)
DD (1) DD244345A5 (de)
DE (1) DE3685668T2 (de)
DK (2) DK113585D0 (de)
ES (1) ES8800276A1 (de)
FI (1) FI861007A (de)
GR (1) GR860687B (de)
HU (1) HU201097B (de)
IL (1) IL78103A0 (de)
MY (1) MY102102A (de)
NO (1) NO172441C (de)
NZ (1) NZ215445A (de)
PH (1) PH24260A (de)
PT (1) PT82173B (de)
YU (1) YU46001B (de)
ZA (1) ZA861432B (de)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK347086D0 (da) * 1986-07-21 1986-07-21 Novo Industri As Novel peptides
US5008241A (en) * 1985-03-12 1991-04-16 Novo Nordisk A/S Novel insulin peptides
DK119785D0 (da) * 1985-03-15 1985-03-15 Nordisk Gentofte Insulinpraeparat
DK437786D0 (da) * 1986-09-12 1986-09-12 Nordisk Gentofte Insulinprecursorer
EP0425482B1 (de) * 1988-07-20 1993-08-18 Novo Nordisk A/S Menschliche insulinanalage und zubereitungen daraus
DE3827533A1 (de) * 1988-08-13 1990-02-15 Hoechst Ag Pharmazeutische zubereitung zur behandlung des diabetes mellitus
DE3837825A1 (de) * 1988-11-08 1990-05-10 Hoechst Ag Neue insulinderivate, ihre verwendung und eine sie enthaltende pharmazeutische zubereitung
DK134189D0 (da) * 1989-03-20 1989-03-20 Nordisk Gentofte Insulinforbindelser
US5130298A (en) * 1989-05-16 1992-07-14 Ethicon, Inc. Stabilized compositions containing epidermal growth factor
DE3936876A1 (de) * 1989-11-06 1991-05-23 Hoechst Ag Neue insulinderivate, verfahren zu deren herstellung, ihre verwendung und eine sie enthaltende pharmazeutische zubereitung
AUPP609198A0 (en) * 1998-09-22 1998-10-15 Curtin University Of Technology Use of non-peptidyl compounds for the treatment of insulin related ailments
US6933272B1 (en) 1998-09-22 2005-08-23 Erik Helmerhorst Use of non-peptidyl compounds for the treatment of insulin related ailments
DE10114178A1 (de) 2001-03-23 2002-10-10 Aventis Pharma Gmbh Zinkfreie und zinkarme Insulinzubereitungen mit verbesserter Stabilität
DE10227232A1 (de) 2002-06-18 2004-01-15 Aventis Pharma Deutschland Gmbh Saure Insulinzubereitungen mit verbesserter Stabilität
CN1909930B (zh) 2004-01-21 2015-12-16 诺和诺德医疗保健公司 转谷氨酰胺酶介导的肽的接合
EP1969004B1 (de) 2005-12-28 2011-08-10 Novo Nordisk A/S Ein acyliertes insulin und zink enthaltende zusammensetzungen und verfahren zur herstellung dieser zusammensetzungen
DE102006031962A1 (de) * 2006-07-11 2008-01-17 Sanofi-Aventis Deutschland Gmbh Amidiertes Insulin Glargin
DE102006031955A1 (de) * 2006-07-11 2008-01-17 Sanofi-Aventis Deutschland Gmbh Verfahren zur Herstellung von Insulinanaloga mit dibasischem B-Kettenende
DE102008003566A1 (de) * 2008-01-09 2009-07-16 Sanofi-Aventis Deutschland Gmbh Neue Insulinderivate mit extrem verzögertem Zeit-/ Wirkungsprofil
CA2711752A1 (en) * 2008-01-09 2009-07-16 Sanofi-Aventis Deutschland Gmbh Novel insulin derivatives having an extremely delayed time-action profile
PL2229407T3 (pl) * 2008-01-09 2017-06-30 Sanofi-Aventis Deutschland Gmbh Nowe pochodne insuliny o ekstremalnie spowolnionym profilu czasu działania
PT3228320T (pt) 2008-10-17 2020-03-26 Sanofi Aventis Deutschland Combinação de uma insulina e de um agonista do glp-1
JP2012532177A (ja) * 2009-07-06 2012-12-13 サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング 熱及び振動安定性インスリン製剤
JP5973918B2 (ja) 2009-11-13 2016-08-23 サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング Ｇｌｐ−１アゴニスト及びメチオニンを含む薬学的組成物
TR201809460T4 (tr) 2009-11-13 2018-07-23 Sanofi Aventis Deutschland Bir GLP- 1-agonisti, bir insülin ve metiyonin içeren farmasötik bileşim.
MX2012012943A (es) * 2010-05-10 2012-11-29 Novo Nordisk As Proceso para preparacion de complejos de insulina-cinc.
JP6199186B2 (ja) 2010-08-30 2017-09-20 サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング ２型糖尿病の治療用の医薬の製造のためのａｖｅ００１０の使用
CN102174495A (zh) * 2011-01-20 2011-09-07 马忠仁 一种提取糜胰蛋白酶的方法
US9821032B2 (en) 2011-05-13 2017-11-21 Sanofi-Aventis Deutschland Gmbh Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin
AR087693A1 (es) 2011-08-29 2014-04-09 Sanofi Aventis Deutschland Combinacion farmaceutica para uso en el control glucemico en pacientes con diabetes de tipo 2
TWI559929B (en) 2011-09-01 2016-12-01 Sanofi Aventis Deutschland Pharmaceutical composition for use in the treatment of a neurodegenerative disease
CA2970200A1 (en) 2014-12-12 2016-06-16 Sanofi-Aventis Deutschland Gmbh Insulin glargine/lixisenatide fixed ratio formulation
TWI748945B (zh) 2015-03-13 2021-12-11 德商賽諾菲阿凡提斯德意志有限公司 第２型糖尿病病患治療
TW201705975A (zh) 2015-03-18 2017-02-16 賽諾菲阿凡提斯德意志有限公司 第２型糖尿病病患之治療

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK319780A (da) * 1980-07-24 1982-01-25 Forenede Bryggerier As Fremgangsmaade til enzymatisk udskiftning af b-30 aminosyren i insuliner
DE3326472A1 (de) * 1983-07-22 1985-02-14 Hoechst Ag, 6230 Frankfurt Neue insulin-derivate, verfahren zu deren herstellung und deren verwendung sowie pharmazeutische mittel zur behandlung des diabetes mellitus
DE3333640A1 (de) * 1983-09-17 1985-04-25 Hoechst Ag, 6230 Frankfurt Verfahren zur herstellung von insulin-derivaten, deren b-kette c-terminal verlaengert ist, neue basisch modifizierte insulin-derivate diese enthaltende mittel und ihre verwendung
DK119785D0 (da) * 1985-03-15 1985-03-15 Nordisk Gentofte Insulinpraeparat

Also Published As

Publication number Publication date
NZ215445A (en) 1989-07-27
DD244345A5 (de) 1987-04-01
EP0194864A2 (de) 1986-09-17
JPS61212598A (ja) 1986-09-20
DK158677C (da) 1990-12-31
PH24260A (en) 1990-05-04
CS166686A2 (en) 1987-12-17
IL78103A0 (en) 1986-07-31
PT82173B (pt) 1988-07-29
CS259536B2 (en) 1988-10-14
ZA861432B (en) 1986-11-26
MY102102A (en) 1992-03-31
KR860007288A (ko) 1986-10-10
AU5449586A (en) 1986-09-18
ES552879A0 (es) 1987-11-01
FI861007A (fi) 1986-09-13
AU612964B2 (en) 1991-07-25
DK107086A (da) 1986-11-07
DE3685668D1 (en) 1992-07-23
YU46001B (sh) 1992-12-21
EP0194864A3 (en) 1989-01-11
NO860920L (no) 1986-09-15
PT82173A (en) 1986-04-01
HUT41052A (en) 1987-03-30
NO172441B (no) 1993-04-13
NO172441C (no) 1993-07-21
EP0194864B1 (de) 1992-06-17
YU34586A (en) 1988-10-31
CN86101489A (zh) 1987-01-21
DK113585D0 (da) 1985-03-12
ES8800276A1 (es) 1987-11-01
DK158677B (da) 1990-07-02
HU201097B (en) 1990-09-28
FI861007A0 (fi) 1986-03-11
KR930007433B1 (ko) 1993-08-10
DK107086D0 (da) 1986-03-10
GR860687B (en) 1986-07-11
ATE77391T1 (de) 1992-07-15

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee