DK158677C - Insulinderivater og anvendelsen deraf, injicerbar oploesning indeholdende insulinderivaterne samt fremgangsmaade til fremstilling af oploesningen. - Google Patents

Insulinderivater og anvendelsen deraf, injicerbar oploesning indeholdende insulinderivaterne samt fremgangsmaade til fremstilling af oploesningen.

Info

Publication number
DK158677C
DK158677C DK107086A DK107086A DK158677C DK 158677 C DK158677 C DK 158677C DK 107086 A DK107086 A DK 107086A DK 107086 A DK107086 A DK 107086A DK 158677 C DK158677 C DK 158677C
Authority
DK
Denmark
Prior art keywords
insulin derivatives
insulin
preparing
procedure
solution
Prior art date
Application number
DK107086A
Other languages
English (en)
Other versions
DK107086A (da
DK158677B (da
DK107086D0 (da
Inventor
Jan Markussen
Original Assignee
Novo Industri As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Industri As filed Critical Novo Industri As
Priority to DK107086A priority Critical patent/DK158677C/da
Publication of DK107086D0 publication Critical patent/DK107086D0/da
Publication of DK107086A publication Critical patent/DK107086A/da
Priority to US07/075,387 priority patent/US4946828A/en
Priority to US07/424,503 priority patent/US5008241A/en
Publication of DK158677B publication Critical patent/DK158677B/da
Application granted granted Critical
Publication of DK158677C publication Critical patent/DK158677C/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Diabetes (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DK107086A 1985-03-12 1986-03-10 Insulinderivater og anvendelsen deraf, injicerbar oploesning indeholdende insulinderivaterne samt fremgangsmaade til fremstilling af oploesningen. DK158677C (da)

Priority Applications (3)

Application Number Priority Date Filing Date Title
DK107086A DK158677C (da) 1985-03-12 1986-03-10 Insulinderivater og anvendelsen deraf, injicerbar oploesning indeholdende insulinderivaterne samt fremgangsmaade til fremstilling af oploesningen.
US07/075,387 US4946828A (en) 1985-03-12 1987-07-20 Novel insulin peptides
US07/424,503 US5008241A (en) 1985-03-12 1989-10-20 Novel insulin peptides

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DK113585 1985-03-12
DK113585A DK113585D0 (da) 1985-03-12 1985-03-12 Nye peptider
DK107086 1986-03-10
DK107086A DK158677C (da) 1985-03-12 1986-03-10 Insulinderivater og anvendelsen deraf, injicerbar oploesning indeholdende insulinderivaterne samt fremgangsmaade til fremstilling af oploesningen.

Publications (4)

Publication Number Publication Date
DK107086D0 DK107086D0 (da) 1986-03-10
DK107086A DK107086A (da) 1986-11-07
DK158677B DK158677B (da) 1990-07-02
DK158677C true DK158677C (da) 1990-12-31

Family

ID=8101410

Family Applications (2)

Application Number Title Priority Date Filing Date
DK113585A DK113585D0 (da) 1985-03-12 1985-03-12 Nye peptider
DK107086A DK158677C (da) 1985-03-12 1986-03-10 Insulinderivater og anvendelsen deraf, injicerbar oploesning indeholdende insulinderivaterne samt fremgangsmaade til fremstilling af oploesningen.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK113585A DK113585D0 (da) 1985-03-12 1985-03-12 Nye peptider

Country Status (22)

Country Link
EP (1) EP0194864B1 (da)
JP (1) JPS61212598A (da)
KR (1) KR930007433B1 (da)
CN (1) CN86101489A (da)
AT (1) ATE77391T1 (da)
AU (1) AU612964B2 (da)
CS (1) CS259536B2 (da)
DD (1) DD244345A5 (da)
DE (1) DE3685668T2 (da)
DK (2) DK113585D0 (da)
ES (1) ES8800276A1 (da)
FI (1) FI861007L (da)
GR (1) GR860687B (da)
HU (1) HU201097B (da)
IL (1) IL78103A0 (da)
MY (1) MY102102A (da)
NO (1) NO172441C (da)
NZ (1) NZ215445A (da)
PH (1) PH24260A (da)
PT (1) PT82173B (da)
YU (1) YU46001B (da)
ZA (1) ZA861432B (da)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK347086D0 (da) * 1986-07-21 1986-07-21 Novo Industri As Novel peptides
US5008241A (en) * 1985-03-12 1991-04-16 Novo Nordisk A/S Novel insulin peptides
DK119785D0 (da) * 1985-03-15 1985-03-15 Nordisk Gentofte Insulinpraeparat
DK437786D0 (da) * 1986-09-12 1986-09-12 Nordisk Gentofte Insulinprecursorer
ATE93238T1 (de) * 1988-07-20 1993-09-15 Novo Nordisk As Menschliche insulinanalage und zubereitungen daraus.
DE3827533A1 (de) * 1988-08-13 1990-02-15 Hoechst Ag Pharmazeutische zubereitung zur behandlung des diabetes mellitus
DE3837825A1 (de) * 1988-11-08 1990-05-10 Hoechst Ag Neue insulinderivate, ihre verwendung und eine sie enthaltende pharmazeutische zubereitung
DK134189D0 (da) * 1989-03-20 1989-03-20 Nordisk Gentofte Insulinforbindelser
US5130298A (en) * 1989-05-16 1992-07-14 Ethicon, Inc. Stabilized compositions containing epidermal growth factor
DE3936876A1 (de) * 1989-11-06 1991-05-23 Hoechst Ag Neue insulinderivate, verfahren zu deren herstellung, ihre verwendung und eine sie enthaltende pharmazeutische zubereitung
US6933272B1 (en) 1998-09-22 2005-08-23 Erik Helmerhorst Use of non-peptidyl compounds for the treatment of insulin related ailments
AUPP609198A0 (en) * 1998-09-22 1998-10-15 Curtin University Of Technology Use of non-peptidyl compounds for the treatment of insulin related ailments
DE10114178A1 (de) 2001-03-23 2002-10-10 Aventis Pharma Gmbh Zinkfreie und zinkarme Insulinzubereitungen mit verbesserter Stabilität
DE10227232A1 (de) 2002-06-18 2004-01-15 Aventis Pharma Deutschland Gmbh Saure Insulinzubereitungen mit verbesserter Stabilität
EP2368579A1 (en) 2004-01-21 2011-09-28 Novo Nordisk Health Care AG Transglutaminase mediated conjugation of peptides
US20090074882A1 (en) 2005-12-28 2009-03-19 Novo Nordisk A/S Insulin compositions and method of making a composition
DE102006031962A1 (de) * 2006-07-11 2008-01-17 Sanofi-Aventis Deutschland Gmbh Amidiertes Insulin Glargin
DE102006031955A1 (de) * 2006-07-11 2008-01-17 Sanofi-Aventis Deutschland Gmbh Verfahren zur Herstellung von Insulinanaloga mit dibasischem B-Kettenende
NZ586589A (en) * 2008-01-09 2012-04-27 Sanofi Aventis Deutschland Novel insulin analogues having an extremely delayed time-action profile
PL2229407T3 (pl) 2008-01-09 2017-06-30 Sanofi-Aventis Deutschland Gmbh Nowe pochodne insuliny o ekstremalnie spowolnionym profilu czasu działania
DE102008003566A1 (de) * 2008-01-09 2009-07-16 Sanofi-Aventis Deutschland Gmbh Neue Insulinderivate mit extrem verzögertem Zeit-/ Wirkungsprofil
EP3228320B1 (de) 2008-10-17 2019-12-18 Sanofi-Aventis Deutschland GmbH Kombination von einem insulin und einem glp-1-agonisten
EP3202394A1 (de) 2009-07-06 2017-08-09 Sanofi-Aventis Deutschland GmbH Wässrige insulinzubereitungen enthaltend methionin
US20120241356A1 (en) * 2009-07-06 2012-09-27 Sanofi-Aventis Deutschland Gmbh Heat- and vibration-stable insulin preparations
PE20121316A1 (es) 2009-11-13 2012-10-05 Sanofi Aventis Deutschland Composicion farmaceutica que comprende un agonista de glp-1 y metionina
PT2554183T (pt) 2009-11-13 2018-07-09 Sanofi Aventis Deutschland Composição farmacêutica que compreende um agonista de glp-1, uma insulina e metionina
EP2569002B1 (en) * 2010-05-10 2016-10-26 Novo Nordisk A/S Process for the preparation of insulin-zinc complexes
US20140148384A1 (en) 2010-08-30 2014-05-29 Sanofi-Aventis Deutschland Gmbh Use of ave0010 for the manufacture of a medicament for the treatment of diabetes mellitus type 2
CN102174495A (zh) * 2011-01-20 2011-09-07 马忠仁 一种提取糜胰蛋白酶的方法
US9821032B2 (en) 2011-05-13 2017-11-21 Sanofi-Aventis Deutschland Gmbh Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin
CN108079281A (zh) 2011-08-29 2018-05-29 赛诺菲-安万特德国有限公司 用于2型糖尿病患者中的血糖控制的药物组合
TWI559929B (en) 2011-09-01 2016-12-01 Sanofi Aventis Deutschland Pharmaceutical composition for use in the treatment of a neurodegenerative disease
TWI758239B (zh) 2014-12-12 2022-03-21 德商賽諾菲阿凡提斯德意志有限公司 甘精胰島素/利司那肽固定比率配製劑
TWI748945B (zh) 2015-03-13 2021-12-11 德商賽諾菲阿凡提斯德意志有限公司 第２型糖尿病病患治療
TW201705975A (zh) 2015-03-18 2017-02-16 賽諾菲阿凡提斯德意志有限公司 第２型糖尿病病患之治療
US10335464B1 (en) 2018-06-26 2019-07-02 Novo Nordisk A/S Device for titrating basal insulin
CN114096269B (zh) 2019-07-12 2024-06-11 诺和诺德股份有限公司 高浓度胰岛素制剂

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK319780A (da) * 1980-07-24 1982-01-25 Forenede Bryggerier As Fremgangsmaade til enzymatisk udskiftning af b-30 aminosyren i insuliner
DE3326472A1 (de) * 1983-07-22 1985-02-14 Hoechst Ag, 6230 Frankfurt Neue insulin-derivate, verfahren zu deren herstellung und deren verwendung sowie pharmazeutische mittel zur behandlung des diabetes mellitus
DE3333640A1 (de) * 1983-09-17 1985-04-25 Hoechst Ag, 6230 Frankfurt Verfahren zur herstellung von insulin-derivaten, deren b-kette c-terminal verlaengert ist, neue basisch modifizierte insulin-derivate diese enthaltende mittel und ihre verwendung
DK119785D0 (da) * 1985-03-15 1985-03-15 Nordisk Gentofte Insulinpraeparat

Also Published As

Publication number Publication date
AU612964B2 (en) 1991-07-25
ES8800276A1 (es) 1987-11-01
CN86101489A (zh) 1987-01-21
DK107086A (da) 1986-11-07
YU34586A (en) 1988-10-31
AU5449586A (en) 1986-09-18
NO172441C (no) 1993-07-21
DE3685668D1 (en) 1992-07-23
NO860920L (no) 1986-09-15
DE3685668T2 (de) 1993-01-14
YU46001B (sh) 1992-12-21
EP0194864A2 (en) 1986-09-17
CS259536B2 (en) 1988-10-14
KR860007288A (ko) 1986-10-10
PH24260A (en) 1990-05-04
MY102102A (en) 1992-03-31
KR930007433B1 (ko) 1993-08-10
DK113585D0 (da) 1985-03-12
HU201097B (en) 1990-09-28
HUT41052A (en) 1987-03-30
DD244345A5 (de) 1987-04-01
DK158677B (da) 1990-07-02
GR860687B (en) 1986-07-11
NZ215445A (en) 1989-07-27
EP0194864A3 (en) 1989-01-11
NO172441B (no) 1993-04-13
PT82173B (pt) 1988-07-29
JPS61212598A (ja) 1986-09-20
PT82173A (en) 1986-04-01
FI861007A0 (fi) 1986-03-11
ZA861432B (en) 1986-11-26
FI861007A7 (fi) 1986-09-13
EP0194864B1 (en) 1992-06-17
FI861007L (fi) 1986-09-13
CS166686A2 (en) 1987-12-17
IL78103A0 (en) 1986-07-31
ATE77391T1 (de) 1992-07-15
ES552879A0 (es) 1987-11-01
DK107086D0 (da) 1986-03-10

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