DE69529708T2 - Herstellung von stabilen Zink-Insulinanalogen-Kristallen - Google Patents
Herstellung von stabilen Zink-Insulinanalogen-KristallenInfo
- Publication number
- DE69529708T2 DE69529708T2 DE69529708T DE69529708T DE69529708T2 DE 69529708 T2 DE69529708 T2 DE 69529708T2 DE 69529708 T DE69529708 T DE 69529708T DE 69529708 T DE69529708 T DE 69529708T DE 69529708 T2 DE69529708 T2 DE 69529708T2
- Authority
- DE
- Germany
- Prior art keywords
- preparation
- insulin analog
- zinc insulin
- stable zinc
- analog crystals
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/260,647 US5504188A (en) | 1994-06-16 | 1994-06-16 | Preparation of stable zinc insulin analog crystals |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69529708D1 DE69529708D1 (de) | 2003-04-03 |
DE69529708T2 true DE69529708T2 (de) | 2003-10-16 |
Family
ID=22990041
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69529708T Expired - Lifetime DE69529708T2 (de) | 1994-06-16 | 1995-06-14 | Herstellung von stabilen Zink-Insulinanalogen-Kristallen |
Country Status (29)
Country | Link |
---|---|
US (1) | US5504188A (de) |
EP (1) | EP0692489B1 (de) |
JP (1) | JP3595607B2 (de) |
KR (1) | KR100369951B1 (de) |
CN (1) | CN1184234C (de) |
AT (1) | ATE233278T1 (de) |
AU (1) | AU697794B2 (de) |
BR (1) | BR9502798A (de) |
CA (1) | CA2151563C (de) |
CO (1) | CO4410205A1 (de) |
CZ (1) | CZ286066B6 (de) |
DE (1) | DE69529708T2 (de) |
DK (1) | DK0692489T3 (de) |
ES (1) | ES2188637T3 (de) |
FI (1) | FI952930A (de) |
HU (1) | HUT73495A (de) |
IL (1) | IL114152A (de) |
IN (1) | IN178919B (de) |
MY (1) | MY130551A (de) |
NO (1) | NO952334L (de) |
NZ (1) | NZ272358A (de) |
PE (1) | PE21896A1 (de) |
PL (1) | PL180968B1 (de) |
RO (1) | RO113529B1 (de) |
RU (1) | RU2156257C2 (de) |
SI (1) | SI0692489T1 (de) |
TW (1) | TW379228B (de) |
YU (1) | YU39595A (de) |
ZA (1) | ZA954942B (de) |
Families Citing this family (83)
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YU18596A (sh) * | 1995-03-31 | 1998-07-10 | Eli Lilly And Company | Analogne formulacije monomernog insulina |
US5631347A (en) * | 1995-06-07 | 1997-05-20 | Eli Lilly And Company | Reducing gelation of a fatty acid-acylated protein |
US5869604A (en) * | 1995-11-09 | 1999-02-09 | Georgia Institute Of Technology | Crystallization and purification of polypeptides |
EP0969860B1 (de) * | 1997-03-20 | 2002-07-17 | Novo Nordisk A/S | Verfahren zur herstellung eines therapeutischen puders durch copräzipitation von insulin und einem absorptionsverstärker |
US6043214A (en) * | 1997-03-20 | 2000-03-28 | Novo Nordisk A/S | Method for producing powder formulation comprising an insulin |
CN1278737A (zh) * | 1997-11-12 | 2001-01-03 | 阿尔萨公司 | 减少多肽自结合的方法 |
RU2205188C2 (ru) | 1998-06-30 | 2003-05-27 | Ново Нордиск А/С | Затравочные кристаллы для получения пептидов или протеинов |
US6956021B1 (en) * | 1998-08-25 | 2005-10-18 | Advanced Inhalation Research, Inc. | Stable spray-dried protein formulations |
DK1121144T3 (da) * | 1998-10-16 | 2002-09-23 | Novo Nordisk As | Stabile koncentrerede insulinpræparater til pulmonar indgivelse |
US6211144B1 (en) | 1998-10-16 | 2001-04-03 | Novo Nordisk A/S | Stable concentrated insulin preparations for pulmonary delivery |
US6635617B1 (en) | 1998-10-16 | 2003-10-21 | Novo Nordisk A/S | Insulin preparations for pulmonary delivery containing menthol |
ATE216258T1 (de) * | 1998-10-16 | 2002-05-15 | Novo Nordisk As | Insulin präparationen enthaltend methanol zur pulmonaren verabreichung |
US20040214747A1 (en) * | 1999-01-06 | 2004-10-28 | Dimarchi Richard Dennis | Method for administering monomeric insulin |
US7169889B1 (en) | 1999-06-19 | 2007-01-30 | Biocon Limited | Insulin prodrugs hydrolyzable in vivo to yield peglylated insulin |
US7678364B2 (en) | 1999-08-25 | 2010-03-16 | Alkermes, Inc. | Particles for inhalation having sustained release properties |
KR20030005204A (ko) * | 2000-12-25 | 2003-01-17 | 가부시키가이샤 시세이도 | 교감신경 활성화 향료 조성물 |
HUP0500733A3 (en) * | 2001-02-09 | 2010-01-28 | Genentech Inc | Crystallization of igf-1 |
US6867183B2 (en) * | 2001-02-15 | 2005-03-15 | Nobex Corporation | Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith |
US7060675B2 (en) * | 2001-02-15 | 2006-06-13 | Nobex Corporation | Methods of treating diabetes mellitus |
US7713932B2 (en) * | 2001-06-04 | 2010-05-11 | Biocon Limited | Calcitonin drug-oligomer conjugates, and uses thereof |
US6828305B2 (en) * | 2001-06-04 | 2004-12-07 | Nobex Corporation | Mixtures of growth hormone drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same |
US6713452B2 (en) * | 2001-06-04 | 2004-03-30 | Nobex Corporation | Mixtures of calcitonin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same |
US6835802B2 (en) * | 2001-06-04 | 2004-12-28 | Nobex Corporation | Methods of synthesizing substantially monodispersed mixtures of polymers having polyethylene glycol moieties |
US6828297B2 (en) * | 2001-06-04 | 2004-12-07 | Nobex Corporation | Mixtures of insulin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same |
US6858580B2 (en) * | 2001-06-04 | 2005-02-22 | Nobex Corporation | Mixtures of drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same |
US6913903B2 (en) * | 2001-09-07 | 2005-07-05 | Nobex Corporation | Methods of synthesizing insulin polypeptide-oligomer conjugates, and proinsulin polypeptide-oligomer conjugates and methods of synthesizing same |
US7030082B2 (en) * | 2001-09-07 | 2006-04-18 | Nobex Corporation | Pharmaceutical compositions of drug-oligomer conjugates and methods of treating disease therewith |
US6770625B2 (en) | 2001-09-07 | 2004-08-03 | Nobex Corporation | Pharmaceutical compositions of calcitonin drug-oligomer conjugates and methods of treating diseases therewith |
US7196059B2 (en) * | 2001-09-07 | 2007-03-27 | Biocon Limited | Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith |
US7312192B2 (en) * | 2001-09-07 | 2007-12-25 | Biocon Limited | Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same |
US7166571B2 (en) * | 2001-09-07 | 2007-01-23 | Biocon Limited | Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same |
US20030068361A1 (en) * | 2001-10-09 | 2003-04-10 | Rimona Margalit | Liposome-encapsulated insulin formulations |
JP4563675B2 (ja) | 2001-10-12 | 2010-10-13 | ハイ・ポイント・ファーマスーティカルズ、エルエルシー | 置換ピペリジン類、およびヒスタミンh3受容体関連疾患の治療のためのその使用 |
AU2003236521A1 (en) * | 2002-06-13 | 2003-12-31 | Nobex Corporation | Methods of reducing hypoglycemic episodes in the treatment of diabetes mellitus |
EP1615698B1 (de) | 2003-04-11 | 2010-09-29 | High Point Pharmaceuticals, LLC | Neue amide derivate und deren pharmazeutische verwendungen |
CN104826116A (zh) | 2003-11-20 | 2015-08-12 | 诺沃挪第克公司 | 对于生产和用于注射装置中是最佳的含有丙二醇的肽制剂 |
CA2580313C (en) * | 2004-07-19 | 2016-03-15 | Biocon Limited | Insulin-oligomer conjugates, formulations and uses thereof |
EP1789074A4 (de) * | 2004-08-09 | 2009-08-12 | Alios Biopharma Inc | Synthetische hyperglycosylierte, protease-resistente polypeptid-varianten, orale formulierungen und anwendungsverfahren dafür |
US7597884B2 (en) | 2004-08-09 | 2009-10-06 | Alios Biopharma, Inc. | Hyperglycosylated polypeptide variants and methods of use |
US7833513B2 (en) | 2004-12-03 | 2010-11-16 | Rhode Island Hospital | Treatment of Alzheimer's Disease |
AU2006264966B2 (en) | 2005-07-04 | 2013-02-21 | High Point Pharmaceuticals, Llc | Histamine H3 receptor antagonists |
ES2426345T3 (es) | 2005-07-20 | 2013-10-22 | Eli Lilly And Company | Compuesto unidos en posición 1-amino |
PL1951658T3 (pl) | 2005-11-17 | 2013-02-28 | Lilly Co Eli | Antagoniści receptora glukagonu, preparatyka i zastosowania terapeutyczne |
EP1996224B1 (de) | 2006-03-15 | 2012-11-07 | Novo Nordisk A/S | Mischungen aus amylin und insulin |
KR101280333B1 (ko) | 2006-03-28 | 2013-07-02 | 하이 포인트 파마슈티칼스, 엘엘씨 | 히스타민 h3 수용체 활성을 갖는 벤조티아졸 |
WO2007121318A2 (en) * | 2006-04-12 | 2007-10-25 | Emisphere Technologies, Inc. | Formulations for delivering insulin |
WO2007127704A1 (en) | 2006-04-24 | 2007-11-08 | Eli Lilly And Company | Cyclohexyl substituted pyrrolidinones as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1 |
CA2659570C (en) | 2006-05-29 | 2015-10-06 | High Point Pharmaceuticals, Llc | 3-(1,3-benzodioxol-5-yl)-6-(4-cyclopropylpiperazin-1-yl)-pyridazine, its salts and solvates and its use as histamine h3 receptor antagonist |
US20080260820A1 (en) * | 2007-04-19 | 2008-10-23 | Gilles Borrelly | Oral dosage formulations of protease-resistant polypeptides |
EP2514406A1 (de) | 2007-06-01 | 2012-10-24 | Novo Nordisk A/S | Spontan dispergierbare Vorkonzentrate mit einem Peptidwirkstoff in einem festen oder halbfesten Träger |
WO2008145730A1 (en) | 2007-06-01 | 2008-12-04 | Novo Nordisk A/S | Stable non-aqueous pharmaceutical compositions |
WO2008152106A1 (en) * | 2007-06-13 | 2008-12-18 | Novo Nordisk A/S | Pharmaceutical formulation comprising an insulin derivative |
BRPI0818004B8 (pt) * | 2007-10-16 | 2021-05-25 | Biocon Ltd | composição farmacêutica sólida administrável por via oral e o processo da mesma. |
US20090271021A1 (en) * | 2008-04-28 | 2009-10-29 | Popp Shane M | Execution system for the monitoring and execution of insulin manufacture |
ES2477552T3 (es) | 2008-09-08 | 2014-07-17 | The Board Of Trustees Of The Leland Stanford Junior University | Moduladores de la actividad de la aldehidodeshidrogenasa y métodos de uso de los mismos |
EP2349279A4 (de) | 2008-10-28 | 2013-12-25 | Univ Leland Stanford Junior | Aldehyddehydrogenase-modulatoren und anwendungsverfahren dafür |
AU2009316802B2 (en) | 2008-11-21 | 2015-02-26 | Vtv Therapeutics Llc | Adamantyl benzamide compounds |
CA2750252A1 (en) | 2009-01-28 | 2010-08-05 | Smartcells, Inc. | Synthetic conjugates and uses thereof |
SG173112A1 (en) | 2009-01-28 | 2011-08-29 | Smartcells Inc | Conjugate based systems for controlled drug delivery |
AU2010226243A1 (en) | 2009-03-20 | 2011-09-22 | Smartcells, Inc. | Terminally-functionalized conjugates and uses thereof |
BR112012002934B1 (pt) * | 2009-08-11 | 2021-12-21 | Biocon Limited | Processos cromatográficos e seus compostos purificados |
AU2012213432B2 (en) | 2011-02-01 | 2016-10-13 | Novo Nordisk A/S | Purification of insulin |
EP2670368A4 (de) | 2011-02-03 | 2015-04-15 | Pharmedica Ltd | Neue im mund zersetzbare filme zur insulinverabreichung zwecks behandlung von diabetes |
WO2012115641A1 (en) | 2011-02-23 | 2012-08-30 | Elona Biotechnologies | Lis-pro proinsulin compositions and methods of producing lis-pro insulin analogs therefrom |
US10457659B2 (en) | 2011-04-29 | 2019-10-29 | The Board Of Trustees Of The Leland Stanford Junior University | Compositions and methods for increasing proliferation of adult salivary stem cells |
CN102219851B (zh) * | 2011-05-09 | 2012-05-30 | 甘李药业有限公司 | 甘精胰岛素结晶的制备方法 |
CA2890048C (en) | 2012-12-03 | 2022-05-03 | Merck Sharp & Dohme Corp. | O-glycosylated carboxy terminal portion (ctp) peptide-based insulin and insulin analogues |
CN105358531B (zh) | 2013-03-14 | 2017-11-14 | 利兰-斯坦福大学初级学院的董事会 | 线粒体醛脱氢酶‑2调节剂和其使用方法 |
CN103342746B (zh) * | 2013-07-26 | 2014-07-30 | 珠海联邦制药股份有限公司 | 一种制备稳定的门冬胰岛素结晶的方法 |
WO2015084694A2 (en) | 2013-12-04 | 2015-06-11 | Merck Sharp & Dohme Corp. | Method for preparing crystalline insulin |
US10124040B2 (en) | 2014-08-26 | 2018-11-13 | Merck Sharp & Dohme Corp. | Method for preparing crystalline insulin or insulin analog compositions |
EP2990033A1 (de) * | 2014-08-26 | 2016-03-02 | Carlina Technologies | Verfahren aus Nanoausfällung von niedrige molekulargewichte Proteinen und Peptiden |
CN104193819B (zh) * | 2014-09-03 | 2017-05-17 | 韩飞 | 胰岛素二聚体晶体的合成和保存方法 |
CN104761632A (zh) * | 2015-04-14 | 2015-07-08 | 珠海联邦制药股份有限公司 | 一种地特胰岛素结晶的制备方法及应用 |
CN106117345B (zh) * | 2015-05-05 | 2020-11-24 | 宜昌东阳光长江药业股份有限公司 | 一种制备甘精胰岛素结晶的方法 |
CN104892749B (zh) * | 2015-06-16 | 2019-02-05 | 珠海联邦制药股份有限公司 | 一种德谷胰岛素结晶的制备方法及应用 |
CN105753966A (zh) * | 2016-05-05 | 2016-07-13 | 通化东宝药业股份有限公司 | 一种重组人胰岛素结晶的制备方法 |
EP3740212A4 (de) | 2017-12-18 | 2021-10-27 | Merck Sharp & Dohme Corp. | Konjugatbasierte systeme für kontrollierte insulinabgabe |
EP3727424A4 (de) | 2017-12-18 | 2021-10-27 | Merck Sharp & Dohme Corp. | Konjugatbasierte systeme für kontrollierte insulinfreisetzung |
PE20230457A1 (es) | 2020-03-31 | 2023-03-10 | Protomer Tech Inc | Conjugados para reactividad selectiva a dioles vecinales |
EP4247429A1 (de) | 2020-11-19 | 2023-09-27 | Protomer Technologies Inc. | Aromatische borhaltige verbindungen und insulinanaloga |
CN113896784B (zh) * | 2021-10-18 | 2024-04-16 | 合肥天麦生物科技发展有限公司 | 一种胰岛素结晶的制备方法及其产品 |
WO2023225534A1 (en) | 2022-05-18 | 2023-11-23 | Protomer Technologies Inc. | Aromatic boron-containing compounds and related insulin analogs |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BE515508A (de) * | ||||
BE533298A (de) * | ||||
BE533252A (de) * | ||||
US2143590A (en) * | 1936-09-26 | 1939-01-10 | Univ Alberta | Insulin preparation and process of producing crystals of insulin |
US2626228A (en) * | 1945-05-17 | 1953-01-20 | Novo Terapeutisk Labor As | Method of producing crystalline insulin |
DK78069C (da) * | 1952-06-23 | 1954-09-06 | Novo Terapeutisk Labor As | Fremgangsmåde til fremstilling af krystallinsk insulin. |
US2920104A (en) | 1958-07-01 | 1960-01-05 | Vanderbilt Co R T | Stabilized solutions of a dithiocarbamate |
US3719655A (en) * | 1969-12-05 | 1973-03-06 | Lilly Co Eli | Process for the crystallization of the ammonium and alkali metal salts in insulin |
DE3326472A1 (de) * | 1983-07-22 | 1985-02-14 | Hoechst Ag, 6230 Frankfurt | Neue insulin-derivate, verfahren zu deren herstellung und deren verwendung sowie pharmazeutische mittel zur behandlung des diabetes mellitus |
DE3327709A1 (de) * | 1983-07-29 | 1985-02-07 | Hoechst Ag, 6230 Frankfurt | Insulin-derivat-kristallsuspensionen, verfahren zu deren herstellung und deren verwendung |
PH25772A (en) * | 1985-08-30 | 1991-10-18 | Novo Industri As | Insulin analogues, process for their preparation |
US4764592A (en) * | 1987-04-23 | 1988-08-16 | Eli Lilly And Company | Crystalline human proinsulin and process for its production |
DE3717370A1 (de) * | 1987-05-22 | 1988-12-01 | Hoechst Ag | Mischkristalle aus insulin und insulinderivaten, verfahren zur herstellung dieser mischkristalle, diese mischkristalle enthaltende pharmazeutische mittel und ihre verwendung zur behandlung von diabetes mellitus |
AU616205B2 (en) * | 1988-07-20 | 1991-10-24 | Novo Nordisk A/S | Human insulin analogs and preparations containing them |
KR910700262A (ko) * | 1988-12-23 | 1991-03-14 | 안네 제케르 | 사람 인슐린 유사체 |
NZ232375A (en) | 1989-02-09 | 1992-04-28 | Lilly Co Eli | Insulin analogues modified at b29 |
-
1994
- 1994-06-16 US US08/260,647 patent/US5504188A/en not_active Expired - Lifetime
- 1994-06-29 TW TW083105905A patent/TW379228B/zh not_active IP Right Cessation
-
1995
- 1995-05-12 MY MYPI95001263A patent/MY130551A/en unknown
- 1995-06-12 CA CA002151563A patent/CA2151563C/en not_active Expired - Lifetime
- 1995-06-13 HU HU9501715A patent/HUT73495A/hu unknown
- 1995-06-13 NO NO952334A patent/NO952334L/no not_active Application Discontinuation
- 1995-06-13 YU YU39595A patent/YU39595A/sh unknown
- 1995-06-14 JP JP14732095A patent/JP3595607B2/ja not_active Expired - Lifetime
- 1995-06-14 PE PE1995271264A patent/PE21896A1/es not_active Application Discontinuation
- 1995-06-14 NZ NZ272358A patent/NZ272358A/en unknown
- 1995-06-14 IN IN674CA1995 patent/IN178919B/en unknown
- 1995-06-14 DE DE69529708T patent/DE69529708T2/de not_active Expired - Lifetime
- 1995-06-14 DK DK95304098T patent/DK0692489T3/da active
- 1995-06-14 AU AU21681/95A patent/AU697794B2/en not_active Ceased
- 1995-06-14 CN CNB951065556A patent/CN1184234C/zh not_active Expired - Lifetime
- 1995-06-14 IL IL11415295A patent/IL114152A/xx not_active IP Right Cessation
- 1995-06-14 ZA ZA954942A patent/ZA954942B/xx unknown
- 1995-06-14 BR BR9502798A patent/BR9502798A/pt not_active Application Discontinuation
- 1995-06-14 PL PL95309099A patent/PL180968B1/pl unknown
- 1995-06-14 EP EP95304098A patent/EP0692489B1/de not_active Expired - Lifetime
- 1995-06-14 ES ES95304098T patent/ES2188637T3/es not_active Expired - Lifetime
- 1995-06-14 CZ CZ19951541A patent/CZ286066B6/cs not_active IP Right Cessation
- 1995-06-14 AT AT95304098T patent/ATE233278T1/de not_active IP Right Cessation
- 1995-06-14 KR KR1019950015780A patent/KR100369951B1/ko active IP Right Grant
- 1995-06-14 CO CO95026237A patent/CO4410205A1/es unknown
- 1995-06-14 RU RU95110107/04A patent/RU2156257C2/ru active
- 1995-06-14 FI FI952930A patent/FI952930A/fi unknown
- 1995-06-14 SI SI9530647T patent/SI0692489T1/xx unknown
- 1995-06-14 RO RO95-01139A patent/RO113529B1/ro unknown
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