ATE87828T1 - Verwendung des transformationswachstumsfaktors zur foerderung der wundheilung und zusammensetzung dafuer. - Google Patents
Verwendung des transformationswachstumsfaktors zur foerderung der wundheilung und zusammensetzung dafuer.Info
- Publication number
- ATE87828T1 ATE87828T1 AT86300486T AT86300486T ATE87828T1 AT E87828 T1 ATE87828 T1 AT E87828T1 AT 86300486 T AT86300486 T AT 86300486T AT 86300486 T AT86300486 T AT 86300486T AT E87828 T1 ATE87828 T1 AT E87828T1
- Authority
- AT
- Austria
- Prior art keywords
- composition
- growth factor
- wound healing
- promote wound
- transformational growth
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 2
- 239000003102 growth factor Substances 0.000 title 1
- 230000029663 wound healing Effects 0.000 title 1
- 206010052428 Wound Diseases 0.000 abstract 2
- 208000027418 Wounds and injury Diseases 0.000 abstract 2
- NMWKYTGJWUAZPZ-WWHBDHEGSA-N (4S)-4-[[(4R,7S,10S,16S,19S,25S,28S,31R)-31-[[(2S)-2-[[(1R,6R,9S,12S,18S,21S,24S,27S,30S,33S,36S,39S,42R,47R,53S,56S,59S,62S,65S,68S,71S,76S,79S,85S)-47-[[(2S)-2-[[(2S)-4-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-3-methylbutanoyl]amino]-3-methylbutanoyl]amino]-3-hydroxypropanoyl]amino]-3-(1H-imidazol-4-yl)propanoyl]amino]-3-phenylpropanoyl]amino]-4-oxobutanoyl]amino]-3-carboxypropanoyl]amino]-18-(4-aminobutyl)-27,68-bis(3-amino-3-oxopropyl)-36,71,76-tribenzyl-39-(3-carbamimidamidopropyl)-24-(2-carboxyethyl)-21,56-bis(carboxymethyl)-65,85-bis[(1R)-1-hydroxyethyl]-59-(hydroxymethyl)-62,79-bis(1H-imidazol-4-ylmethyl)-9-methyl-33-(2-methylpropyl)-8,11,17,20,23,26,29,32,35,38,41,48,54,57,60,63,66,69,72,74,77,80,83,86-tetracosaoxo-30-propan-2-yl-3,4,44,45-tetrathia-7,10,16,19,22,25,28,31,34,37,40,49,55,58,61,64,67,70,73,75,78,81,84,87-tetracosazatetracyclo[40.31.14.012,16.049,53]heptaoctacontane-6-carbonyl]amino]-3-methylbutanoyl]amino]-7-(3-carbamimidamidopropyl)-25-(hydroxymethyl)-19-[(4-hydroxyphenyl)methyl]-28-(1H-imidazol-4-ylmethyl)-10-methyl-6,9,12,15,18,21,24,27,30-nonaoxo-16-propan-2-yl-1,2-dithia-5,8,11,14,17,20,23,26,29-nonazacyclodotriacontane-4-carbonyl]amino]-5-[[(2S)-1-[[(2S)-1-[[(2S)-3-carboxy-1-[[(2S)-1-[[(2S)-1-[[(1S)-1-carboxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]amino]-3-(1H-imidazol-4-yl)-1-oxopropan-2-yl]amino]-5-oxopentanoic acid Chemical compound CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H]2CSSC[C@@H]3NC(=O)[C@H](Cc4ccccc4)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc4c[nH]cn4)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H]4CCCN4C(=O)[C@H](CSSC[C@H](NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](Cc4c[nH]cn4)NC(=O)[C@H](Cc4ccccc4)NC3=O)[C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N3CCC[C@H]3C(=O)N[C@@H](C)C(=O)N2)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H](N)C(C)C)C(C)C)[C@@H](C)O)C(C)C)C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1)C(=O)N[C@@H](C)C(O)=O NMWKYTGJWUAZPZ-WWHBDHEGSA-N 0.000 abstract 1
- 102400001320 Transforming growth factor alpha Human genes 0.000 abstract 1
- 101800004564 Transforming growth factor alpha Proteins 0.000 abstract 1
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 1
- 229920001184 polypeptide Polymers 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 230000000699 topical effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
- A61L26/0028—Polypeptides; Proteins; Degradation products thereof
- A61L26/0047—Specific proteins or polypeptides not covered by groups A61L26/0033 - A61L26/0042
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/495—Transforming growth factor [TGF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Gastroenterology & Hepatology (AREA)
- Biophysics (AREA)
- Epidemiology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Materials Engineering (AREA)
- Biochemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Materials For Medical Uses (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US69598385A | 1985-01-29 | 1985-01-29 | |
| EP86300486A EP0190018B1 (de) | 1985-01-29 | 1986-01-24 | Verwendung des Transformationswachstumsfaktors zur Förderung der Wundheilung und Zusammensetzung dafür |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE87828T1 true ATE87828T1 (de) | 1993-04-15 |
Family
ID=24795239
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT86300486T ATE87828T1 (de) | 1985-01-29 | 1986-01-24 | Verwendung des transformationswachstumsfaktors zur foerderung der wundheilung und zusammensetzung dafuer. |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP0190018B1 (de) |
| JP (1) | JPS61218525A (de) |
| AT (1) | ATE87828T1 (de) |
| AU (2) | AU5249786A (de) |
| CA (1) | CA1253071A (de) |
| DE (1) | DE3688203T2 (de) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5240912A (en) * | 1983-05-09 | 1993-08-31 | Todaro George J | Transforming growth factor (TGF) peptides |
| US4863899A (en) * | 1983-05-09 | 1989-09-05 | Todaro George J | Biologically active polypeptides |
| US5165938A (en) * | 1984-11-29 | 1992-11-24 | Regents Of The University Of Minnesota | Wound healing agents derived from platelets |
| US5130300A (en) * | 1986-03-07 | 1992-07-14 | Monsanto Company | Method for enhancing growth of mammary parenchyma |
| US4981841A (en) * | 1986-04-04 | 1991-01-01 | Allergan, Inc. | Methods and materials for use in corneal wound healing |
| US4983580A (en) * | 1986-04-04 | 1991-01-08 | Allergan, Inc. | Methods and materials for use in corneal wound healing |
| US5527772A (en) * | 1987-10-20 | 1996-06-18 | Holick; Michael F. | Regulation of cell proliferation and differentiation using peptides |
| GB8806893D0 (en) * | 1988-03-23 | 1988-04-27 | Unilever Plc | Cosmetic composition |
| EP0339905A3 (de) * | 1988-04-25 | 1991-05-08 | Ethicon, Inc. | Wachstumfaktoren und Retinoiden enthaltende Wundheilungzusammensetzungen |
| US4939135A (en) * | 1988-10-03 | 1990-07-03 | Alcon Laboratories, Inc. | Pharmaceutical compositions and methods of treatment to prevent and treat corneal scar formation produced by laser irradiation |
| US5271939A (en) * | 1988-10-03 | 1993-12-21 | Alcon Laboratories, Inc. | Pharmaceutical compositions and methods of treatment to prevent and treat corneal scar formation produced by laser irradiation |
| US5124392A (en) * | 1988-10-03 | 1992-06-23 | Alcon Laboratories, Inc. | Pharmaceutical compositions and methods of treatment to prevent and treat corneal scar formation produced by laser irradiation |
| US5360611A (en) * | 1988-10-03 | 1994-11-01 | Alcon Laboratories, Inc. | Pharmaceutical compositions and methods of treatment of the cornea following ultraviolet laser irradiation |
| US5102870A (en) * | 1989-04-14 | 1992-04-07 | Schering Ag | Treatment and prevention of oral mucositis with growth factors |
| US5182261A (en) * | 1989-07-13 | 1993-01-26 | The Rockefeller University | Modified transforming growth factor alpha oligopeptides and pharmaceutical compositions thereof |
| US5242902A (en) * | 1989-09-06 | 1993-09-07 | The Regents Of The University Of California | Defensin peptide compositions and methods for their use |
| US5824297A (en) * | 1990-06-25 | 1998-10-20 | Oncogene Science, Inc. | Tissue-derived tumor growth inhibitors, methods of preparation and uses thereof |
| AU8532691A (en) * | 1990-08-01 | 1992-03-02 | Chiron Ophthalmics Inc. | Method for treating corneal endothelial wounds |
| US5817625A (en) * | 1992-09-21 | 1998-10-06 | Oncogene Science, Inc. | Methods of prevention of oral mucositis with transforming growth factor beta |
| JPH08503968A (ja) * | 1993-09-29 | 1996-04-30 | アルコン ラボラトリーズ，インコーポレイテッド | 増殖因子と代謝拮抗物質を含有する組成物 |
| US5624893A (en) * | 1993-10-14 | 1997-04-29 | Alcon Laboratories, Inc. | Pharmaceutical compositions and methods of treatment of the cornea following laser irradiation |
| US6063757A (en) * | 1995-11-29 | 2000-05-16 | Urso; Richard G. | Wound treatment method with nerve growth factor |
| US6979307B2 (en) | 1997-06-24 | 2005-12-27 | Cascade Medical Enterprises Llc | Systems and methods for preparing autologous fibrin glue |
| US7745106B2 (en) | 1997-06-24 | 2010-06-29 | Cascade Medical Enterprises, Llc | Methods and devices for separating liquid components |
| WO1999066797A1 (en) | 1998-06-22 | 1999-12-29 | Worden Charles E | Enriched platelet wound healant |
| AU4679300A (en) * | 1999-04-26 | 2000-11-10 | Stem Cell Pharmaceuticals, Inc. | Tgf-alpha polypeptides, functional fragments and methods of use therefor |
| US6649072B2 (en) | 2001-11-16 | 2003-11-18 | Robert Brandt | Method for producing autologous platelet-rich plasma |
| KR101021197B1 (ko) * | 2008-04-11 | 2011-03-11 | (주)케어젠 | 성장인자―미미킹 펩타이드 및 그의 용도 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0105014B1 (de) * | 1982-09-24 | 1992-05-20 | THE UNITED STATES OF AMERICA as represented by the Secretary United States Department of Commerce | Wiederherstellung von Gewebe bei Tieren |
| IE57724B1 (en) * | 1983-05-09 | 1993-03-24 | Todaro George Joseph | Biologically active polypeptides |
| EP0154434B1 (de) * | 1984-02-17 | 1993-01-27 | Genentech, Inc. | Menschlicher Transformationswachstumsfaktor und Vorläufer oder Fragment hiervon, Zellen, DNA, Vektoren und Verfahren zu ihrer Herstellung, Zusammensetzungen und Produkte, die diese enthalten, sowie davon abgeleitete Antikörper und Diagnostizierverfahren |
-
1986
- 1986-01-20 AU AU52497/86A patent/AU5249786A/en not_active Abandoned
- 1986-01-24 AT AT86300486T patent/ATE87828T1/de not_active IP Right Cessation
- 1986-01-24 DE DE8686300486T patent/DE3688203T2/de not_active Expired - Fee Related
- 1986-01-24 EP EP86300486A patent/EP0190018B1/de not_active Expired - Lifetime
- 1986-01-28 CA CA000500553A patent/CA1253071A/en not_active Expired
- 1986-01-28 JP JP61014906A patent/JPS61218525A/ja active Pending
-
1989
- 1989-12-29 AU AU47384/89A patent/AU4738489A/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| DE3688203T2 (de) | 1993-07-22 |
| EP0190018B1 (de) | 1993-04-07 |
| EP0190018A2 (de) | 1986-08-06 |
| CA1253071A (en) | 1989-04-25 |
| AU4738489A (en) | 1990-05-03 |
| DE3688203D1 (de) | 1993-05-13 |
| EP0190018A3 (en) | 1988-01-27 |
| AU5249786A (en) | 1986-08-07 |
| JPS61218525A (ja) | 1986-09-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |