ATE79545T1 - Verwendung vom ''cartilage-inducing faktor b(cif- b)'' zur herstellung eines arzneimittels gegen das wachstum von tumoren. - Google Patents
Verwendung vom ''cartilage-inducing faktor b(cif- b)'' zur herstellung eines arzneimittels gegen das wachstum von tumoren.Info
- Publication number
- ATE79545T1 ATE79545T1 AT87309877T AT87309877T ATE79545T1 AT E79545 T1 ATE79545 T1 AT E79545T1 AT 87309877 T AT87309877 T AT 87309877T AT 87309877 T AT87309877 T AT 87309877T AT E79545 T1 ATE79545 T1 AT E79545T1
- Authority
- AT
- Austria
- Prior art keywords
- cif
- activity
- cartilage
- tumors
- growth
- Prior art date
Links
- 102000011117 Transforming Growth Factor beta2 Human genes 0.000 title abstract 5
- 101800000304 Transforming growth factor beta-2 Proteins 0.000 title abstract 5
- 206010028980 Neoplasm Diseases 0.000 title abstract 2
- 239000003814 drug Substances 0.000 title 1
- 229940079593 drug Drugs 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 230000000247 oncostatic effect Effects 0.000 abstract 2
- ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 abstract 2
- 201000009030 Carcinoma Diseases 0.000 abstract 1
- 206010025323 Lymphomas Diseases 0.000 abstract 1
- 208000009956 adenocarcinoma Diseases 0.000 abstract 1
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- 210000000988 bone and bone Anatomy 0.000 abstract 1
- 210000000845 cartilage Anatomy 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 230000001939 inductive effect Effects 0.000 abstract 1
- 201000001441 melanoma Diseases 0.000 abstract 1
- 229920001184 polypeptide Polymers 0.000 abstract 1
- 230000003389 potentiating effect Effects 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 229940072041 transforming growth factor beta 2 Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1841—Transforming growth factor [TGF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/12—Growth hormone, growth factor other than t-cell or b-cell growth factor, and growth hormone releasing factor; related peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/928,760 US4816442A (en) | 1986-11-07 | 1986-11-07 | Method of inhibiting tumor growth sensitive to CIF-βtreatment |
| EP87309877A EP0271211B1 (de) | 1986-11-07 | 1987-11-06 | Verwendung vom "Cartilage-inducing faktor B(CIF-B)" zur Herstellung eines Arzneimittels gegen das Wachstum von Tumoren |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE79545T1 true ATE79545T1 (de) | 1992-09-15 |
Family
ID=25456702
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT87309877T ATE79545T1 (de) | 1986-11-07 | 1987-11-06 | Verwendung vom ''cartilage-inducing faktor b(cif- b)'' zur herstellung eines arzneimittels gegen das wachstum von tumoren. |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US4816442A (de) |
| EP (1) | EP0271211B1 (de) |
| JP (1) | JP2573259B2 (de) |
| AT (1) | ATE79545T1 (de) |
| CA (1) | CA1294874C (de) |
| DE (1) | DE3781250T2 (de) |
| ES (1) | ES2032272T3 (de) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5705477A (en) * | 1982-09-24 | 1998-01-06 | The United States Of America As Represented By The Department Of Health And Human Services | Compositions of transforming growth factor β(TGF-β) which promotes wound healing and methods for their use |
| US5104977A (en) * | 1982-09-24 | 1992-04-14 | The United States Of America As Represented By The Department Of Health And Human Services | Purified transforming growth factor beta |
| US5656587A (en) * | 1982-09-24 | 1997-08-12 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Promotion of cell proliferation by use of transforming growth factor beta (TGF-β) |
| US6586394B1 (en) | 1985-04-19 | 2003-07-01 | Osi Pharmaceuticals, Inc. | Tissue-derived tumor growth inhibitor |
| US4931548A (en) * | 1987-01-30 | 1990-06-05 | Techne Corporation | Heterodimer form of transforming growth factor-beta |
| US5221734A (en) * | 1987-10-01 | 1993-06-22 | Ciba-Geigy Corporation | Process for preparing a polypeptide growth factor for milk |
| JPH04505607A (ja) * | 1988-04-06 | 1992-10-01 | セルトリックス ファーマシューティカルズ インコーポレイテッド | 骨誘導タンパク |
| US5061786A (en) * | 1989-05-25 | 1991-10-29 | Genentech, Inc. | Biologically active polypeptides based on transforming growth factor-β |
| US5268455A (en) * | 1989-05-25 | 1993-12-07 | Genentech, Inc. | Process for making biologically active polypeptides based on transforming growth factor-βsequences |
| US5100378A (en) * | 1989-06-09 | 1992-03-31 | Neorx Corporation | Enhancement of target cell localization of lymphoid cells |
| JPH05500503A (ja) * | 1989-08-21 | 1993-02-04 | セルトリックス ファーマシューティカルズ、インコーポレイテッド | 骨特異的タンパク質 |
| IL95500A (en) * | 1989-09-11 | 1997-03-18 | Matrix Pharma | ANTI-PROLIFERATIVE COMPOSITIONS CONTAINING TGF-b PROTEIN IN A VISCOUS MATRIX AND THEIR USE |
| US5147854A (en) * | 1990-05-22 | 1992-09-15 | Hoffmann-La Roche Inc. | Tgf-b compositions and method |
| US5322933A (en) * | 1992-05-07 | 1994-06-21 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Crystal structure of TGF-β-2 |
| US5888720A (en) * | 1992-10-27 | 1999-03-30 | Yissum Research And Development Company Of The Hebrew University Of Jerusalem | In vitro micro-organs |
| US5531791A (en) * | 1993-07-23 | 1996-07-02 | Bioscience Consultants | Composition for repair of defects in osseous tissues, method of making, and prosthesis |
| US6040431A (en) * | 1995-06-07 | 2000-03-21 | Stryker Corporation | Single chain analogs of the TGF-β superfamily (morphons) |
| RU2217196C2 (ru) * | 2002-02-28 | 2003-11-27 | Небольсин Владимир Евгеньевич | Способ индукции дифференцировки клеток |
| CA2550058C (en) * | 2003-12-19 | 2016-07-12 | Antisense Pharma Gmbh | Pharmaceutical composition comprising a tgf-beta2 antisense oligonucleotide and a chemotherapeutic |
| TWI299257B (en) * | 2005-05-16 | 2008-08-01 | Tung Hai Biotechnology Corp | γ-POLYGLUTAMIC ACID (γ-PGA, H FORM), γ-POLYGLUTAMATES AND γ-POLYGLUTAMATE HYDROGEL FOR USE AS NUTRITION SUPPLEMENTS IN DIETARY PRODUCTS |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0105014B1 (de) * | 1982-09-24 | 1992-05-20 | THE UNITED STATES OF AMERICA as represented by the Secretary United States Department of Commerce | Wiederherstellung von Gewebe bei Tieren |
| WO1984004924A1 (en) * | 1983-06-03 | 1984-12-20 | Us Commerce | Purified transforming growth factor-beta derived from human platelets and placentas |
| DE3588058T3 (de) * | 1984-07-16 | 2005-04-07 | Celtrix Pharmaceuticals, Inc., Palo Alto | Knorpel-induzierende Polypeptid-Faktoren aus Knochen |
| US4806523A (en) * | 1985-08-06 | 1989-02-21 | Collagen Corporation | Method of treating inflammation |
-
1986
- 1986-11-07 US US06/928,760 patent/US4816442A/en not_active Expired - Lifetime
-
1987
- 1987-11-03 CA CA000550941A patent/CA1294874C/en not_active Expired - Lifetime
- 1987-11-06 ES ES87309877T patent/ES2032272T3/es not_active Expired - Lifetime
- 1987-11-06 DE DE8787309877T patent/DE3781250T2/de not_active Expired - Lifetime
- 1987-11-06 AT AT87309877T patent/ATE79545T1/de not_active IP Right Cessation
- 1987-11-06 EP EP87309877A patent/EP0271211B1/de not_active Expired - Lifetime
- 1987-11-06 JP JP62281932A patent/JP2573259B2/ja not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| AU8067987A (en) | 1988-05-12 |
| EP0271211B1 (de) | 1992-08-19 |
| JPS63211236A (ja) | 1988-09-02 |
| CA1294874C (en) | 1992-01-28 |
| ES2032272T1 (es) | 1993-02-01 |
| EP0271211A2 (de) | 1988-06-15 |
| DE3781250D1 (de) | 1992-09-24 |
| DE3781250T2 (de) | 1992-12-17 |
| JP2573259B2 (ja) | 1997-01-22 |
| EP0271211A3 (en) | 1989-10-18 |
| US4816442A (en) | 1989-03-28 |
| ES2032272T3 (es) | 1994-01-16 |
| AU591358B2 (en) | 1989-11-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |