DE69318909T2 - Verfahren zur Herstellung von menschlichem Wachstumshormon - Google Patents

Verfahren zur Herstellung von menschlichem Wachstumshormon

Info

Publication number
DE69318909T2
DE69318909T2 DE69318909T DE69318909T DE69318909T2 DE 69318909 T2 DE69318909 T2 DE 69318909T2 DE 69318909 T DE69318909 T DE 69318909T DE 69318909 T DE69318909 T DE 69318909T DE 69318909 T2 DE69318909 T2 DE 69318909T2
Authority
DE
Germany
Prior art keywords
production
growth hormone
human growth
human
hormone
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69318909T
Other languages
English (en)
Other versions
DE69318909D1 (de
Inventor
Masaru Honjo
Setsuo Yoshino
Akira Nakayama
Naokazu Naito
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mitsui Chemicals Inc
Original Assignee
Mitsui Chemicals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mitsui Chemicals Inc filed Critical Mitsui Chemicals Inc
Application granted granted Critical
Publication of DE69318909D1 publication Critical patent/DE69318909D1/de
Publication of DE69318909T2 publication Critical patent/DE69318909T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/61—Growth hormone [GH], i.e. somatotropin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C12N15/625—DNA sequences coding for fusion proteins containing a sequence coding for a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DE69318909T 1992-09-09 1993-09-09 Verfahren zur Herstellung von menschlichem Wachstumshormon Expired - Lifetime DE69318909T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP24093692 1992-09-09
JP991193 1993-01-25

Publications (2)

Publication Number Publication Date
DE69318909D1 DE69318909D1 (de) 1998-07-09
DE69318909T2 true DE69318909T2 (de) 1998-12-24

Family

ID=26344726

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69318909T Expired - Lifetime DE69318909T2 (de) 1992-09-09 1993-09-09 Verfahren zur Herstellung von menschlichem Wachstumshormon

Country Status (3)

Country Link
US (1) US5496713A (de)
EP (1) EP0587427B1 (de)
DE (1) DE69318909T2 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ286241A (en) * 1995-03-29 1997-11-24 Mitsui Chemicals Inc Method of producing a peptide as a fusion protein intracellularly which is cleaved on passing the cell membrane
NZ286884A (en) 1995-06-29 1997-12-19 Mitsui Chemicals Inc Use of 20 kd human growth hormone in hrt, increasing serum igf-1 levels and stimulating lipolysis
KR100236393B1 (ko) * 1996-02-02 1999-12-15 나까니시 히로유끼 사람성장호르몬을 함유하는 의약제제
US5760187A (en) * 1996-02-22 1998-06-02 Mitsui Toatsu Chemicals, Inc. Purification process of a human growth hormone
EP0798380A3 (de) * 1996-03-28 1998-04-29 Mitsui Toatsu Chemicals, Inc. Verfahren zur Herstellung sekretischer Proteinprodukten
US5945296A (en) * 1996-03-29 1999-08-31 Pharmacia & Upjohn Ab Monoclonal antibody
US6197938B1 (en) 1996-06-18 2001-03-06 Mitsui Chemicals, Incorporated Monoclonal antibody specific for 20K human growth hormone and a cell line producing the monoclonal antibody
US6160089A (en) * 1998-07-08 2000-12-12 Mitsui Chemicals, Inc. Method for secretory production of human growth hormone
US20020150979A1 (en) * 2000-10-04 2002-10-17 Naokazu Naitou Process for producing a protein
US6995246B1 (en) * 2000-10-19 2006-02-07 Akzo Nobel N.V. Methods for removing suspended particles from soluble protein solutions
GB0319601D0 (en) * 2003-08-20 2003-09-24 Sandoz Ag Production process
JP2007502841A (ja) * 2003-08-20 2007-02-15 ニューレン ファーマシューティカルズ リミテッド 成長ホルモンの２０ｋＤａ胎盤性変種を用いる体形成療法
ATE502957T1 (de) 2004-06-23 2011-04-15 Usv Ltd Chimeres, von den placenta- und hypophysenisoformen abgeleitetes humanes wachstumshormon und verfahren zur gewinnung der chimere
US8282921B2 (en) * 2004-08-02 2012-10-09 Paul Glidden tRNA synthetase fragments
US20060024288A1 (en) * 2004-08-02 2006-02-02 Pfizer Inc. tRNA synthetase fragments

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61151015A (ja) * 1984-12-24 1986-07-09 Mitsui Toatsu Chem Inc 部分置換フルオロシランの製造方法
JPS61224988A (ja) * 1985-03-29 1986-10-06 Kunio Nakajima ヒト２０ｋ成長ホルモン相補鎖ｄｎａ増幅用大腸菌組換えプラスミド
EP0371041A1 (de) * 1987-06-24 1990-06-06 Novo Nordisk A/S Verfahren für die herstellung eines proteins oder polypeptides, dns-sequenz, die dieses polypeptid kodiert, mikroorganismus, der diese dns-sequenz beinhaltet, sowie das polypeptid und seine verwendung als pharmazeutisches präparat
JPH01273591A (ja) * 1987-08-19 1989-11-01 Agency Of Ind Science & Technol ヒト成長ホルモン分泌プラスミド、ならびにそれを用いた形質転換体および蛋白質分泌生産法

Also Published As

Publication number Publication date
US5496713A (en) 1996-03-05
DE69318909D1 (de) 1998-07-09
EP0587427A1 (de) 1994-03-16
EP0587427B1 (de) 1998-06-03

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Legal Events

Date Code Title Description
8327 Change in the person/name/address of the patent owner

Owner name: MITSUI CHEMICALS, INC., TOKIO/TOKYO, JP

8364 No opposition during term of opposition