YU39595A - Dobijanje kristala stabilnog cinka insulinskog analoga - Google Patents
Dobijanje kristala stabilnog cinka insulinskog analogaInfo
- Publication number
- YU39595A YU39595A YU39595A YU39595A YU39595A YU 39595 A YU39595 A YU 39595A YU 39595 A YU39595 A YU 39595A YU 39595 A YU39595 A YU 39595A YU 39595 A YU39595 A YU 39595A
- Authority
- YU
- Yugoslavia
- Prior art keywords
- insulin analog
- obtaining stable
- zinc crystal
- stable zinc
- crystal insulin
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Endocrinology (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Toxicology (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Emergency Medicine (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Abstract
Ovaj pronalazak prikazuje postupak za dobijanje kristalnog insulinskog analoga. Ovaj postupak je koristan kod prečišćavanja i dobijanja LysB28ProB29 - ljudskog insulina. LysB28ProB29 -ljudski insulin je koristan u lečenju dijabetesa.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/260,647 US5504188A (en) | 1994-06-16 | 1994-06-16 | Preparation of stable zinc insulin analog crystals |
Publications (1)
Publication Number | Publication Date |
---|---|
YU39595A true YU39595A (sh) | 1997-08-22 |
Family
ID=22990041
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
YU39595A YU39595A (sh) | 1994-06-16 | 1995-06-13 | Dobijanje kristala stabilnog cinka insulinskog analoga |
Country Status (29)
Country | Link |
---|---|
US (1) | US5504188A (sh) |
EP (1) | EP0692489B1 (sh) |
JP (1) | JP3595607B2 (sh) |
KR (1) | KR100369951B1 (sh) |
CN (1) | CN1184234C (sh) |
AT (1) | ATE233278T1 (sh) |
AU (1) | AU697794B2 (sh) |
BR (1) | BR9502798A (sh) |
CA (1) | CA2151563C (sh) |
CO (1) | CO4410205A1 (sh) |
CZ (1) | CZ286066B6 (sh) |
DE (1) | DE69529708T2 (sh) |
DK (1) | DK0692489T3 (sh) |
ES (1) | ES2188637T3 (sh) |
FI (1) | FI952930A (sh) |
HU (1) | HUT73495A (sh) |
IL (1) | IL114152A (sh) |
IN (1) | IN178919B (sh) |
MY (1) | MY130551A (sh) |
NO (1) | NO952334L (sh) |
NZ (1) | NZ272358A (sh) |
PE (1) | PE21896A1 (sh) |
PL (1) | PL180968B1 (sh) |
RO (1) | RO113529B1 (sh) |
RU (1) | RU2156257C2 (sh) |
SI (1) | SI0692489T1 (sh) |
TW (1) | TW379228B (sh) |
YU (1) | YU39595A (sh) |
ZA (1) | ZA954942B (sh) |
Families Citing this family (83)
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US5869604A (en) * | 1995-11-09 | 1999-02-09 | Georgia Institute Of Technology | Crystallization and purification of polypeptides |
AU6611898A (en) * | 1997-03-20 | 1998-10-20 | Novo Nordisk A/S | Method for preparation of a therapeutic powder through coprecipitation of insulin and absorption enhancer |
US6043214A (en) * | 1997-03-20 | 2000-03-28 | Novo Nordisk A/S | Method for producing powder formulation comprising an insulin |
AU1375199A (en) * | 1997-11-12 | 1999-05-31 | Alza Corporation | Method for decreasing self-association of polypeptides |
RU2205188C2 (ru) | 1998-06-30 | 2003-05-27 | Ново Нордиск А/С | Затравочные кристаллы для получения пептидов или протеинов |
US6956021B1 (en) * | 1998-08-25 | 2005-10-18 | Advanced Inhalation Research, Inc. | Stable spray-dried protein formulations |
US6635617B1 (en) | 1998-10-16 | 2003-10-21 | Novo Nordisk A/S | Insulin preparations for pulmonary delivery containing menthol |
AU758108B2 (en) * | 1998-10-16 | 2003-03-13 | Novo Nordisk A/S | Insulin preparations for pulmonary delivery containing menthol |
US6211144B1 (en) | 1998-10-16 | 2001-04-03 | Novo Nordisk A/S | Stable concentrated insulin preparations for pulmonary delivery |
ATE277630T1 (de) * | 1998-10-16 | 2004-10-15 | Novo Nordisk As | Stabile konzentrierte insulin präparationen zur pulmonaren verabreichung |
US20040214747A1 (en) * | 1999-01-06 | 2004-10-28 | Dimarchi Richard Dennis | Method for administering monomeric insulin |
US7169889B1 (en) * | 1999-06-19 | 2007-01-30 | Biocon Limited | Insulin prodrugs hydrolyzable in vivo to yield peglylated insulin |
US7678364B2 (en) | 1999-08-25 | 2010-03-16 | Alkermes, Inc. | Particles for inhalation having sustained release properties |
CN1406131A (zh) * | 2000-12-25 | 2003-03-26 | 株式会社资生堂 | 活化交感神经的香料组合物 |
PL374181A1 (en) * | 2001-02-09 | 2005-10-03 | Genentech, Inc. | Crystallization of igf-1 |
US6867183B2 (en) * | 2001-02-15 | 2005-03-15 | Nobex Corporation | Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith |
US7060675B2 (en) | 2001-02-15 | 2006-06-13 | Nobex Corporation | Methods of treating diabetes mellitus |
US6835802B2 (en) * | 2001-06-04 | 2004-12-28 | Nobex Corporation | Methods of synthesizing substantially monodispersed mixtures of polymers having polyethylene glycol moieties |
US6858580B2 (en) * | 2001-06-04 | 2005-02-22 | Nobex Corporation | Mixtures of drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same |
US6828297B2 (en) | 2001-06-04 | 2004-12-07 | Nobex Corporation | Mixtures of insulin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same |
US6713452B2 (en) | 2001-06-04 | 2004-03-30 | Nobex Corporation | Mixtures of calcitonin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same |
US7713932B2 (en) * | 2001-06-04 | 2010-05-11 | Biocon Limited | Calcitonin drug-oligomer conjugates, and uses thereof |
US6828305B2 (en) * | 2001-06-04 | 2004-12-07 | Nobex Corporation | Mixtures of growth hormone drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same |
US7312192B2 (en) * | 2001-09-07 | 2007-12-25 | Biocon Limited | Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same |
US6913903B2 (en) * | 2001-09-07 | 2005-07-05 | Nobex Corporation | Methods of synthesizing insulin polypeptide-oligomer conjugates, and proinsulin polypeptide-oligomer conjugates and methods of synthesizing same |
US7030082B2 (en) * | 2001-09-07 | 2006-04-18 | Nobex Corporation | Pharmaceutical compositions of drug-oligomer conjugates and methods of treating disease therewith |
US7196059B2 (en) * | 2001-09-07 | 2007-03-27 | Biocon Limited | Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith |
US7166571B2 (en) * | 2001-09-07 | 2007-01-23 | Biocon Limited | Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same |
US6770625B2 (en) | 2001-09-07 | 2004-08-03 | Nobex Corporation | Pharmaceutical compositions of calcitonin drug-oligomer conjugates and methods of treating diseases therewith |
US20030068361A1 (en) * | 2001-10-09 | 2003-04-10 | Rimona Margalit | Liposome-encapsulated insulin formulations |
JP4563675B2 (ja) | 2001-10-12 | 2010-10-13 | ハイ・ポイント・ファーマスーティカルズ、エルエルシー | 置換ピペリジン類、およびヒスタミンh3受容体関連疾患の治療のためのその使用 |
AU2003236521A1 (en) * | 2002-06-13 | 2003-12-31 | Nobex Corporation | Methods of reducing hypoglycemic episodes in the treatment of diabetes mellitus |
WO2004089896A1 (en) | 2003-04-11 | 2004-10-21 | Novo Nordisk A/S | 11β-HYDROXYSTEROID DEHYDROGENASE TYPE 1 ACTIVE COMPOUNDS |
KR101243648B1 (ko) | 2003-11-20 | 2013-03-14 | 노보 노르디스크 에이/에스 | 제조 및 주사 장치용에 최적인 프로필렌 글리콜 함유펩티드 제제 |
US7605123B2 (en) | 2004-07-19 | 2009-10-20 | Biocon Ltd. | Fatty acid formulations for oral delivery of proteins and peptides, and uses thereof |
US7597884B2 (en) | 2004-08-09 | 2009-10-06 | Alios Biopharma, Inc. | Hyperglycosylated polypeptide variants and methods of use |
CA2576030A1 (en) * | 2004-08-09 | 2006-02-23 | Alios Biopharma Inc. | Synthetic hyperglycosylated, protease-resistant polypeptide variants, oral formulations and methods of using the same |
US7833513B2 (en) | 2004-12-03 | 2010-11-16 | Rhode Island Hospital | Treatment of Alzheimer's Disease |
ATE536344T1 (de) | 2005-07-04 | 2011-12-15 | High Point Pharmaceuticals Llc | Histamine h3 receptor antagonisten |
EP1910317B1 (en) | 2005-07-20 | 2013-07-03 | Eli Lilly And Company | 1-amino linked compounds |
PL1951658T3 (pl) | 2005-11-17 | 2013-02-28 | Lilly Co Eli | Antagoniści receptora glukagonu, preparatyka i zastosowania terapeutyczne |
EP1996224B1 (en) | 2006-03-15 | 2012-11-07 | Novo Nordisk A/S | Mixtures of amylin and insulin |
ES2388681T3 (es) | 2006-03-28 | 2012-10-17 | High Point Pharmaceuticals, Llc | Benzotiazoles con actividad de los receptores de histamina H3 |
US8927015B2 (en) * | 2006-04-12 | 2015-01-06 | Emisphere Technologies, Inc. | Formulations for delivering insulin |
JP5118692B2 (ja) | 2006-04-24 | 2013-01-16 | イーライ リリー アンド カンパニー | 11−β−ヒドロキシステロイドデヒドロゲナーゼ1の阻害剤としてのシクロヘキシル置換ピロリジノン |
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US20080260820A1 (en) * | 2007-04-19 | 2008-10-23 | Gilles Borrelly | Oral dosage formulations of protease-resistant polypeptides |
EP2514406A1 (en) | 2007-06-01 | 2012-10-24 | Novo Nordisk A/S | Spontaneously dispersible preconcentrates including a peptide drug in a solid or semisolid carrier |
JP5628026B2 (ja) | 2007-06-01 | 2014-11-19 | ノボ・ノルデイスク・エー/エス | 安定した非水性薬学的組成物 |
JP5552046B2 (ja) * | 2007-06-13 | 2014-07-16 | ノボ・ノルデイスク・エー/エス | インスリン誘導体を含有する薬学的製剤 |
JP5868594B2 (ja) * | 2007-10-16 | 2016-02-24 | バイオコン・リミテッドBiocon Limited | 経口投与可能な固形医薬組成物及びそのプロセス |
US20090271021A1 (en) * | 2008-04-28 | 2009-10-29 | Popp Shane M | Execution system for the monitoring and execution of insulin manufacture |
EP2337563B1 (en) | 2008-09-08 | 2014-04-09 | The Board of Trustees of The Leland Stanford Junior University | Modulators of aldehyde dehydrogenase activity and methods of use thereof |
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ES2625125T3 (es) * | 2009-08-11 | 2017-07-18 | Biocon Limited | Procesos cromatográficos |
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CN102219851B (zh) * | 2011-05-09 | 2012-05-30 | 甘李药业有限公司 | 甘精胰岛素结晶的制备方法 |
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CN105358531B (zh) | 2013-03-14 | 2017-11-14 | 利兰-斯坦福大学初级学院的董事会 | 线粒体醛脱氢酶‑2调节剂和其使用方法 |
CN103342746B (zh) * | 2013-07-26 | 2014-07-30 | 珠海联邦制药股份有限公司 | 一种制备稳定的门冬胰岛素结晶的方法 |
EP3077414B1 (en) | 2013-12-04 | 2020-06-17 | Merck Sharp & Dohme Corp. | Method for preparing crystalline insulin |
EP3185887B1 (en) | 2014-08-26 | 2021-03-10 | Merck Sharp & Dohme Corp. | Method for preparing crystalline insulin or insulin analog compositions |
EP2990033A1 (fr) * | 2014-08-26 | 2016-03-02 | Carlina Technologies | Procédé de préparation de nanoprécipites de peptide ou protéine de faible poids moléculaire |
CN104193819B (zh) * | 2014-09-03 | 2017-05-17 | 韩飞 | 胰岛素二聚体晶体的合成和保存方法 |
CN104761632A (zh) * | 2015-04-14 | 2015-07-08 | 珠海联邦制药股份有限公司 | 一种地特胰岛素结晶的制备方法及应用 |
CN106117345B (zh) * | 2015-05-05 | 2020-11-24 | 宜昌东阳光长江药业股份有限公司 | 一种制备甘精胰岛素结晶的方法 |
CN104892749B (zh) * | 2015-06-16 | 2019-02-05 | 珠海联邦制药股份有限公司 | 一种德谷胰岛素结晶的制备方法及应用 |
CN105753966A (zh) * | 2016-05-05 | 2016-07-13 | 通化东宝药业股份有限公司 | 一种重组人胰岛素结晶的制备方法 |
EP3740212A4 (en) | 2017-12-18 | 2021-10-27 | Merck Sharp & Dohme Corp. | CONJUGATE-BASED SYSTEMS FOR CONTROLLED INSULIN DELIVERY |
EP3727424A4 (en) | 2017-12-18 | 2021-10-27 | Merck Sharp & Dohme Corp. | CONJUGATE-BASED SYSTEMS FOR CONTROLLED INSULIN RELEASE |
AU2021247169A1 (en) | 2020-03-31 | 2022-10-20 | Protomer Technologies Inc. | Conjugates for selective responsiveness to vicinal diols |
KR20230110505A (ko) | 2020-11-19 | 2023-07-24 | 프로토머 테크놀로지스 인크. | 방향족 붕소-함유 화합물 및 인슐린 유사체 |
CN113896784B (zh) * | 2021-10-18 | 2024-04-16 | 合肥天麦生物科技发展有限公司 | 一种胰岛素结晶的制备方法及其产品 |
TW202409070A (zh) | 2022-05-18 | 2024-03-01 | 美商普羅托莫科技公司 | 芳族含硼化合物及相關胰島素類似物 |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BE533298A (sh) * | ||||
BE533252A (sh) * | ||||
BE515508A (sh) * | ||||
US2143590A (en) * | 1936-09-26 | 1939-01-10 | Univ Alberta | Insulin preparation and process of producing crystals of insulin |
US2626228A (en) * | 1945-05-17 | 1953-01-20 | Novo Terapeutisk Labor As | Method of producing crystalline insulin |
DK78069C (da) * | 1952-06-23 | 1954-09-06 | Novo Terapeutisk Labor As | Fremgangsmåde til fremstilling af krystallinsk insulin. |
US2920104A (en) | 1958-07-01 | 1960-01-05 | Vanderbilt Co R T | Stabilized solutions of a dithiocarbamate |
US3719655A (en) * | 1969-12-05 | 1973-03-06 | Lilly Co Eli | Process for the crystallization of the ammonium and alkali metal salts in insulin |
DE3326472A1 (de) * | 1983-07-22 | 1985-02-14 | Hoechst Ag, 6230 Frankfurt | Neue insulin-derivate, verfahren zu deren herstellung und deren verwendung sowie pharmazeutische mittel zur behandlung des diabetes mellitus |
DE3327709A1 (de) * | 1983-07-29 | 1985-02-07 | Hoechst Ag, 6230 Frankfurt | Insulin-derivat-kristallsuspensionen, verfahren zu deren herstellung und deren verwendung |
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-
1994
- 1994-06-16 US US08/260,647 patent/US5504188A/en not_active Expired - Lifetime
- 1994-06-29 TW TW083105905A patent/TW379228B/zh not_active IP Right Cessation
-
1995
- 1995-05-12 MY MYPI95001263A patent/MY130551A/en unknown
- 1995-06-12 CA CA002151563A patent/CA2151563C/en not_active Expired - Lifetime
- 1995-06-13 HU HU9501715A patent/HUT73495A/hu unknown
- 1995-06-13 NO NO952334A patent/NO952334L/no not_active Application Discontinuation
- 1995-06-13 YU YU39595A patent/YU39595A/sh unknown
- 1995-06-14 CN CNB951065556A patent/CN1184234C/zh not_active Expired - Lifetime
- 1995-06-14 SI SI9530647T patent/SI0692489T1/xx unknown
- 1995-06-14 RU RU95110107/04A patent/RU2156257C2/ru active
- 1995-06-14 KR KR1019950015780A patent/KR100369951B1/ko active IP Right Grant
- 1995-06-14 CZ CZ19951541A patent/CZ286066B6/cs not_active IP Right Cessation
- 1995-06-14 CO CO95026237A patent/CO4410205A1/es unknown
- 1995-06-14 AU AU21681/95A patent/AU697794B2/en not_active Ceased
- 1995-06-14 ZA ZA954942A patent/ZA954942B/xx unknown
- 1995-06-14 AT AT95304098T patent/ATE233278T1/de not_active IP Right Cessation
- 1995-06-14 ES ES95304098T patent/ES2188637T3/es not_active Expired - Lifetime
- 1995-06-14 IN IN674CA1995 patent/IN178919B/en unknown
- 1995-06-14 RO RO95-01139A patent/RO113529B1/ro unknown
- 1995-06-14 FI FI952930A patent/FI952930A/fi unknown
- 1995-06-14 DK DK95304098T patent/DK0692489T3/da active
- 1995-06-14 BR BR9502798A patent/BR9502798A/pt not_active Application Discontinuation
- 1995-06-14 EP EP95304098A patent/EP0692489B1/en not_active Expired - Lifetime
- 1995-06-14 JP JP14732095A patent/JP3595607B2/ja not_active Expired - Lifetime
- 1995-06-14 DE DE69529708T patent/DE69529708T2/de not_active Expired - Lifetime
- 1995-06-14 NZ NZ272358A patent/NZ272358A/en unknown
- 1995-06-14 PL PL95309099A patent/PL180968B1/pl unknown
- 1995-06-14 IL IL11415295A patent/IL114152A/xx not_active IP Right Cessation
- 1995-06-14 PE PE1995271264A patent/PE21896A1/es not_active Application Discontinuation
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