|
US5474978A
(en)
*
|
1994-06-16 |
1995-12-12 |
Eli Lilly And Company |
Insulin analog formulations
|
|
US5504188A
(en)
*
|
1994-06-16 |
1996-04-02 |
Eli Lilly And Company |
Preparation of stable zinc insulin analog crystals
|
|
YU18596A
(sh)
*
|
1995-03-31 |
1998-07-10 |
Eli Lilly And Company |
Analogne formulacije monomernog insulina
|
|
US5631347A
(en)
*
|
1995-06-07 |
1997-05-20 |
Eli Lilly And Company |
Reducing gelation of a fatty acid-acylated protein
|
|
US5869604A
(en)
*
|
1995-11-09 |
1999-02-09 |
Georgia Institute Of Technology |
Crystallization and purification of polypeptides
|
|
US6043214A
(en)
*
|
1997-03-20 |
2000-03-28 |
Novo Nordisk A/S |
Method for producing powder formulation comprising an insulin
|
|
JP2001518915A
(ja)
*
|
1997-03-20 |
2001-10-16 |
ノボ ノルディスク アクティーゼルスカブ |
インシュリンと吸収増強剤の共沈殿による治療用粉末の調整法
|
|
DE69826705T2
(de)
*
|
1997-11-12 |
2006-02-23 |
Alza Corp., Palo Alto |
Verfahren zur dermalen verabreichung von polypeptiden
|
|
RU2205188C2
(ru)
|
1998-06-30 |
2003-05-27 |
Ново Нордиск А/С |
Затравочные кристаллы для получения пептидов или протеинов
|
|
US6956021B1
(en)
*
|
1998-08-25 |
2005-10-18 |
Advanced Inhalation Research, Inc. |
Stable spray-dried protein formulations
|
|
HUP0103606A3
(en)
*
|
1998-10-16 |
2002-05-28 |
Novo Nordisk As |
Insulin preparations for pulmonary delivery containing menthol
|
|
US6635617B1
(en)
|
1998-10-16 |
2003-10-21 |
Novo Nordisk A/S |
Insulin preparations for pulmonary delivery containing menthol
|
|
US6211144B1
(en)
|
1998-10-16 |
2001-04-03 |
Novo Nordisk A/S |
Stable concentrated insulin preparations for pulmonary delivery
|
|
PT1121144E
(pt)
*
|
1998-10-16 |
2002-11-29 |
Novo Nordisk As |
Preparados de insulina concentrada estavel para administracao pulmonar
|
|
US20040214747A1
(en)
*
|
1999-01-06 |
2004-10-28 |
Dimarchi Richard Dennis |
Method for administering monomeric insulin
|
|
US7169889B1
(en)
*
|
1999-06-19 |
2007-01-30 |
Biocon Limited |
Insulin prodrugs hydrolyzable in vivo to yield peglylated insulin
|
|
US7678364B2
(en)
|
1999-08-25 |
2010-03-16 |
Alkermes, Inc. |
Particles for inhalation having sustained release properties
|
|
KR20030005204A
(ko)
*
|
2000-12-25 |
2003-01-17 |
가부시키가이샤 시세이도 |
교감신경 활성화 향료 조성물
|
|
NZ548358A
(en)
*
|
2001-02-09 |
2008-04-30 |
Genentech Inc |
Method of identifying agonists of insulin-like growth factor-1
|
|
US7060675B2
(en)
*
|
2001-02-15 |
2006-06-13 |
Nobex Corporation |
Methods of treating diabetes mellitus
|
|
US6867183B2
(en)
*
|
2001-02-15 |
2005-03-15 |
Nobex Corporation |
Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith
|
|
US6828297B2
(en)
|
2001-06-04 |
2004-12-07 |
Nobex Corporation |
Mixtures of insulin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
|
|
US6713452B2
(en)
*
|
2001-06-04 |
2004-03-30 |
Nobex Corporation |
Mixtures of calcitonin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
|
|
US6835802B2
(en)
*
|
2001-06-04 |
2004-12-28 |
Nobex Corporation |
Methods of synthesizing substantially monodispersed mixtures of polymers having polyethylene glycol moieties
|
|
US7713932B2
(en)
|
2001-06-04 |
2010-05-11 |
Biocon Limited |
Calcitonin drug-oligomer conjugates, and uses thereof
|
|
US6828305B2
(en)
*
|
2001-06-04 |
2004-12-07 |
Nobex Corporation |
Mixtures of growth hormone drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
|
|
US6858580B2
(en)
*
|
2001-06-04 |
2005-02-22 |
Nobex Corporation |
Mixtures of drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
|
|
US7030082B2
(en)
*
|
2001-09-07 |
2006-04-18 |
Nobex Corporation |
Pharmaceutical compositions of drug-oligomer conjugates and methods of treating disease therewith
|
|
US6770625B2
(en)
|
2001-09-07 |
2004-08-03 |
Nobex Corporation |
Pharmaceutical compositions of calcitonin drug-oligomer conjugates and methods of treating diseases therewith
|
|
US7166571B2
(en)
*
|
2001-09-07 |
2007-01-23 |
Biocon Limited |
Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
|
|
US7196059B2
(en)
*
|
2001-09-07 |
2007-03-27 |
Biocon Limited |
Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith
|
|
US6913903B2
(en)
*
|
2001-09-07 |
2005-07-05 |
Nobex Corporation |
Methods of synthesizing insulin polypeptide-oligomer conjugates, and proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
|
|
US7312192B2
(en)
*
|
2001-09-07 |
2007-12-25 |
Biocon Limited |
Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
|
|
US20030068361A1
(en)
*
|
2001-10-09 |
2003-04-10 |
Rimona Margalit |
Liposome-encapsulated insulin formulations
|
|
EP1444219A1
(en)
|
2001-10-12 |
2004-08-11 |
Novo Nordisk A/S |
Substituted piperidines and their use for the treatment of diseases related to the histamine h3 receptor
|
|
US7601688B2
(en)
*
|
2002-06-13 |
2009-10-13 |
Biocon Limited |
Methods of reducing hypoglycemic episodes in the treatment of diabetes mellitus
|
|
EP1618090A1
(en)
|
2003-04-11 |
2006-01-25 |
Novo Nordisk A/S |
11ß-HYDROXYSTEROID DEHYDROGENASE TYPE 1 ACTIVE COMPOUNDS
|
|
DK3300721T4
(da)
|
2003-11-20 |
2025-03-03 |
Novo Nordisk As |
Propylenglycol-holdige peptidformuleringer hvilke er optimale til fremstilling og til anvendelse i injektionsindretninger
|
|
MX2007000883A
(es)
|
2004-07-19 |
2007-04-02 |
Biocon Ltd |
Conjugados de insulina-oligomero, formulaciones y usos de los mismos.
|
|
US7597884B2
(en)
|
2004-08-09 |
2009-10-06 |
Alios Biopharma, Inc. |
Hyperglycosylated polypeptide variants and methods of use
|
|
EP1789074A4
(en)
*
|
2004-08-09 |
2009-08-12 |
Alios Biopharma Inc |
PROTEASE-RESISTANT HYPERGLYCOSYL SYNTHETIC POLYPEPTIDE VARIANTS, ORAL FORMULATIONS AND METHODS OF USING THE SAME
|
|
US7833513B2
(en)
|
2004-12-03 |
2010-11-16 |
Rhode Island Hospital |
Treatment of Alzheimer's Disease
|
|
MX2007015675A
(es)
|
2005-07-04 |
2008-02-20 |
Novo Nordisk As |
Antagonistas del receptor de histamina h3.
|
|
WO2007015805A1
(en)
|
2005-07-20 |
2007-02-08 |
Eli Lilly And Company |
1-amino linked compounds
|
|
WO2007123581A1
(en)
|
2005-11-17 |
2007-11-01 |
Eli Lilly And Company |
Glucagon receptor antagonists, preparation and therapeutic uses
|
|
ES2397659T3
(es)
|
2006-03-15 |
2013-03-08 |
Novo Nordisk A/S |
Mezclas de amilina e insulina
|
|
CN101410385B
(zh)
|
2006-03-28 |
2011-08-24 |
高点制药有限责任公司 |
具有组胺h3受体活性的苯并噻唑类
|
|
US8927015B2
(en)
*
|
2006-04-12 |
2015-01-06 |
Emisphere Technologies, Inc. |
Formulations for delivering insulin
|
|
JP5118692B2
(ja)
|
2006-04-24 |
2013-01-16 |
イーライ リリー アンド カンパニー |
１１−β−ヒドロキシステロイドデヒドロゲナーゼ１の阻害剤としてのシクロヘキシル置換ピロリジノン
|
|
KR20090040259A
(ko)
|
2006-05-29 |
2009-04-23 |
하이 포인트 파마슈티칼스, 엘엘씨 |
3-(1,3-벤조디옥솔-5-일)-6-(4-시클로프로필피페라진-1-일)-피리다진, 그것의 염과 용매화합물 및 그것의 히스타민 ｈ3 수용체 안타고니스트로서의 용도
|
|
US20080260820A1
(en)
*
|
2007-04-19 |
2008-10-23 |
Gilles Borrelly |
Oral dosage formulations of protease-resistant polypeptides
|
|
EP2164466A1
(en)
|
2007-06-01 |
2010-03-24 |
Novo Nordisk A/S |
Spontaneously dispersible preconcentrates including a peptide drug in a solid or semisolid carrier
|
|
US20100190706A1
(en)
|
2007-06-01 |
2010-07-29 |
Novo Nordisk A/S |
Stable Non-Aqueous Pharmaceutical Compositions
|
|
WO2008152106A1
(en)
*
|
2007-06-13 |
2008-12-18 |
Novo Nordisk A/S |
Pharmaceutical formulation comprising an insulin derivative
|
|
BRPI0818004B8
(pt)
*
|
2007-10-16 |
2021-05-25 |
Biocon Ltd |
composição farmacêutica sólida administrável por via oral e o processo da mesma.
|
|
US20090271021A1
(en)
*
|
2008-04-28 |
2009-10-29 |
Popp Shane M |
Execution system for the monitoring and execution of insulin manufacture
|
|
WO2010028175A1
(en)
|
2008-09-08 |
2010-03-11 |
The Board Of Trustees Of The Leland Stanford Junior University |
Modulators of aldehyde dehydrogenase activity and methods of use thereof
|
|
EP2349279A4
(en)
|
2008-10-28 |
2013-12-25 |
Univ Leland Stanford Junior |
MODIFIERS OF ALDEHYDE DEHYDROGENASE AND METHODS OF USE THEREOF
|
|
MX2011005037A
(es)
|
2008-11-21 |
2011-06-16 |
High Point Pharmaceuticals Llc |
Compuestos de adamantilo benzamida.
|
|
US8940690B2
(en)
|
2009-01-28 |
2015-01-27 |
National Institutes Of Health (Nih) |
Synthetic conjugates and uses thereof
|
|
US9050370B2
(en)
|
2009-01-28 |
2015-06-09 |
Smartcells, Inc. |
Conjugate based systems for controlled drug delivery
|
|
WO2010107519A1
(en)
|
2009-03-20 |
2010-09-23 |
Smartcells, Inc. |
Terminally-functionalized conjugates and uses thereof
|
|
PL2464655T3
(pl)
*
|
2009-08-11 |
2017-08-31 |
Biocon Limited |
Procesy chromatograficzne
|
|
JP6110312B2
(ja)
|
2011-02-01 |
2017-04-05 |
ノヴォ ノルディスク アー／エス |
インスリンの精製
|
|
EP2670368A4
(en)
|
2011-02-03 |
2015-04-15 |
Pharmedica Ltd |
NEW ORAL DISSOLUTION FILMS FOR INSULIN DELIVERY FOR THE TREATMENT OF DIABETES
|
|
WO2012115641A1
(en)
|
2011-02-23 |
2012-08-30 |
Elona Biotechnologies |
Lis-pro proinsulin compositions and methods of producing lis-pro insulin analogs therefrom
|
|
WO2012149106A1
(en)
|
2011-04-29 |
2012-11-01 |
The Board Of Trustees Of The Leland Stanford Junior University |
Compositions and methods for increasing proliferation of adult salivary stem cells
|
|
CN102219851B
(zh)
*
|
2011-05-09 |
2012-05-30 |
甘李药业有限公司 |
甘精胰岛素结晶的制备方法
|
|
JP6735561B2
(ja)
|
2012-12-03 |
2020-08-05 |
メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． |
Ｏ−グリコシル化カルボキシ末端部分（ｃｔｐ）ペプチド系のインスリンおよびインスリン類似体
|
|
KR20150135332A
(ko)
|
2013-03-14 |
2015-12-02 |
더 보드 오브 트러스티스 오브 더 리랜드 스탠포드 쥬니어 유니버시티 |
미토콘드리아 알데히드 탈수소효소-2 조절인자들 및 이들의 사용 방법
|
|
CN103342746B
(zh)
*
|
2013-07-26 |
2014-07-30 |
珠海联邦制药股份有限公司 |
一种制备稳定的门冬胰岛素结晶的方法
|
|
WO2015084694A2
(en)
|
2013-12-04 |
2015-06-11 |
Merck Sharp & Dohme Corp. |
Method for preparing crystalline insulin
|
|
US10124040B2
(en)
|
2014-08-26 |
2018-11-13 |
Merck Sharp & Dohme Corp. |
Method for preparing crystalline insulin or insulin analog compositions
|
|
EP2990033A1
(fr)
*
|
2014-08-26 |
2016-03-02 |
Carlina Technologies |
Procédé de préparation de nanoprécipites de peptide ou protéine de faible poids moléculaire
|
|
CN104193819B
(zh)
*
|
2014-09-03 |
2017-05-17 |
韩飞 |
胰岛素二聚体晶体的合成和保存方法
|
|
CN104761632A
(zh)
*
|
2015-04-14 |
2015-07-08 |
珠海联邦制药股份有限公司 |
一种地特胰岛素结晶的制备方法及应用
|
|
CN106117345B
(zh)
*
|
2015-05-05 |
2020-11-24 |
宜昌东阳光长江药业股份有限公司 |
一种制备甘精胰岛素结晶的方法
|
|
CN104892749B
(zh)
*
|
2015-06-16 |
2019-02-05 |
珠海联邦制药股份有限公司 |
一种德谷胰岛素结晶的制备方法及应用
|
|
CN105753966A
(zh)
*
|
2016-05-05 |
2016-07-13 |
通化东宝药业股份有限公司 |
一种重组人胰岛素结晶的制备方法
|
|
WO2019125878A1
(en)
|
2017-12-18 |
2019-06-27 |
Merck Sharp & Dohme Corp. |
Conjugate based systems for controlled insulin delivery
|
|
US11413352B2
(en)
|
2017-12-18 |
2022-08-16 |
Merck, Sharp & Dohme LLC |
Conjugate based systems for controlled insulin delivery
|
|
KR20220161422A
(ko)
|
2020-03-31 |
2022-12-06 |
프로토머 테크놀로지스 인크. |
비시날 디올에 대한 선택적인 반응을 위한 접합체
|
|
PE20231948A1
(es)
|
2020-11-19 |
2023-12-05 |
Protomer Tech Inc |
Compuestos aromaticos que contienen boro y analogos de insulina
|
|
CN113896784B
(zh)
*
|
2021-10-18 |
2024-04-16 |
合肥天麦生物科技发展有限公司 |
一种胰岛素结晶的制备方法及其产品
|
|
AR129357A1
(es)
|
2022-05-18 |
2024-08-14 |
Protomer Tech Inc |
Compuestos aromáticos que contienen boro y análogos de insulina relacionados
|