DE69429357T2 - Verfahren i - Google Patents
Verfahren iInfo
- Publication number
- DE69429357T2 DE69429357T2 DE69429357T DE69429357T DE69429357T2 DE 69429357 T2 DE69429357 T2 DE 69429357T2 DE 69429357 T DE69429357 T DE 69429357T DE 69429357 T DE69429357 T DE 69429357T DE 69429357 T2 DE69429357 T2 DE 69429357T2
- Authority
- DE
- Germany
- Prior art keywords
- agglomerates
- screw feeder
- size
- spheronization
- finely divided
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000000034 method Methods 0.000 title claims abstract description 67
- 239000000843 powder Substances 0.000 claims abstract description 38
- 238000005563 spheronization Methods 0.000 claims abstract description 27
- 230000002776 aggregation Effects 0.000 claims description 31
- 238000005054 agglomeration Methods 0.000 claims description 30
- 239000002245 particle Substances 0.000 claims description 27
- 239000003814 drug Substances 0.000 claims description 24
- 229940079593 drug Drugs 0.000 claims description 19
- 238000005469 granulation Methods 0.000 claims description 12
- 230000003179 granulation Effects 0.000 claims description 12
- 239000011164 primary particle Substances 0.000 claims description 11
- 239000000463 material Substances 0.000 claims description 10
- 239000000126 substance Substances 0.000 claims description 7
- 229940112141 dry powder inhaler Drugs 0.000 claims description 6
- 239000012467 final product Substances 0.000 claims description 5
- 239000008188 pellet Substances 0.000 claims description 5
- 230000002093 peripheral effect Effects 0.000 claims description 3
- 239000007795 chemical reaction product Substances 0.000 claims description 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 238000004513 sizing Methods 0.000 abstract 1
- 238000007873 sieving Methods 0.000 description 14
- 238000012360 testing method Methods 0.000 description 11
- 239000011295 pitch Substances 0.000 description 9
- 239000011230 binding agent Substances 0.000 description 7
- 238000002474 experimental method Methods 0.000 description 7
- 238000010586 diagram Methods 0.000 description 5
- 230000010006 flight Effects 0.000 description 5
- 230000015572 biosynthetic process Effects 0.000 description 4
- 238000009826 distribution Methods 0.000 description 4
- 230000009969 flowable effect Effects 0.000 description 4
- 229960005105 terbutaline sulfate Drugs 0.000 description 4
- KFVSLSTULZVNPG-UHFFFAOYSA-N terbutaline sulfate Chemical compound [O-]S([O-])(=O)=O.CC(C)(C)[NH2+]CC(O)C1=CC(O)=CC(O)=C1.CC(C)(C)[NH2+]CC(O)C1=CC(O)=CC(O)=C1 KFVSLSTULZVNPG-UHFFFAOYSA-N 0.000 description 4
- 230000000694 effects Effects 0.000 description 3
- 238000002664 inhalation therapy Methods 0.000 description 3
- 230000033001 locomotion Effects 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- 238000003860 storage Methods 0.000 description 3
- 238000004140 cleaning Methods 0.000 description 2
- HEFNNWSXXWATRW-UHFFFAOYSA-N Ibuprofen Chemical compound CC(C)CC1=CC=C(C(C)C(O)=O)C=C1 HEFNNWSXXWATRW-UHFFFAOYSA-N 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
- 238000004220 aggregation Methods 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 239000013583 drug formulation Substances 0.000 description 1
- 238000001125 extrusion Methods 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 230000005484 gravity Effects 0.000 description 1
- 238000000227 grinding Methods 0.000 description 1
- 229960001680 ibuprofen Drugs 0.000 description 1
- 230000001788 irregular Effects 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 229940071648 metered dose inhaler Drugs 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 239000011236 particulate material Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 210000002345 respiratory system Anatomy 0.000 description 1
- 238000005096 rolling process Methods 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 238000005029 sieve analysis Methods 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 230000009897 systematic effect Effects 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
- B01J2/20—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by expressing the material, e.g. through sieves and fragmenting the extruded length
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Otolaryngology (AREA)
- Pulmonology (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Control Of Multiple Motors (AREA)
- Saccharide Compounds (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
- Stereophonic System (AREA)
- Exchange Systems With Centralized Control (AREA)
- Control Of Motors That Do Not Use Commutators (AREA)
- Glanulating (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Electrical Discharge Machining, Electrochemical Machining, And Combined Machining (AREA)
- Mixers Of The Rotary Stirring Type (AREA)
- General Preparation And Processing Of Foods (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9303214A SE9303214D0 (sv) | 1993-10-01 | 1993-10-01 | Process I |
| SE9304271A SE9304271D0 (sv) | 1993-12-22 | 1993-12-22 | Process I |
| PCT/SE1994/000896 WO1995009615A1 (en) | 1993-10-01 | 1994-09-29 | Process i |
| US08/317,033 US5551489A (en) | 1993-10-01 | 1994-10-03 | Agglomeration of finely divided powders |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69429357D1 DE69429357D1 (de) | 2002-01-17 |
| DE69429357T2 true DE69429357T2 (de) | 2002-08-14 |
Family
ID=27355730
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69429357T Expired - Lifetime DE69429357T2 (de) | 1993-10-01 | 1994-09-29 | Verfahren i |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US5551489A (cs) |
| EP (1) | EP0721331B1 (cs) |
| JP (1) | JP3732508B2 (cs) |
| CN (1) | CN1110300C (cs) |
| AT (1) | ATE209903T1 (cs) |
| AU (1) | AU679789B2 (cs) |
| BR (1) | BR9407686A (cs) |
| CZ (1) | CZ289214B6 (cs) |
| DE (1) | DE69429357T2 (cs) |
| DK (1) | DK0721331T3 (cs) |
| EG (1) | EG20677A (cs) |
| ES (1) | ES2166786T3 (cs) |
| FI (1) | FI116364B (cs) |
| HU (1) | HU222355B1 (cs) |
| IL (1) | IL111080A (cs) |
| NO (1) | NO314836B1 (cs) |
| NZ (1) | NZ274277A (cs) |
| PL (1) | PL175564B1 (cs) |
| PT (1) | PT721331E (cs) |
| RU (1) | RU2170082C2 (cs) |
| SG (1) | SG48049A1 (cs) |
| SK (1) | SK283569B6 (cs) |
| WO (1) | WO1995009615A1 (cs) |
Families Citing this family (91)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9404945D0 (en) | 1994-03-15 | 1994-04-27 | Glaxo Group Ltd | Pharmaceutical composition |
| SE9700136D0 (sv) * | 1997-01-20 | 1997-01-20 | Astra Ab | New formulation |
| US5983956A (en) * | 1994-10-03 | 1999-11-16 | Astra Aktiebolag | Formulation for inhalation |
| US5980949A (en) * | 1994-10-03 | 1999-11-09 | Astra Aktiebolag | Formulation for inhalation |
| SE9700134D0 (sv) * | 1997-01-20 | 1997-01-20 | Astra Ab | New formulation |
| US5654007A (en) * | 1995-06-07 | 1997-08-05 | Inhale Therapeutic Systems | Methods and system for processing dispersible fine powders |
| DE19522899C1 (de) * | 1995-06-23 | 1996-12-19 | Hexal Pharmaforschung Gmbh | Verfahren zum kontinuierlichen Ersintern eines Granulats |
| US5826633A (en) | 1996-04-26 | 1998-10-27 | Inhale Therapeutic Systems | Powder filling systems, apparatus and methods |
| US5874064A (en) * | 1996-05-24 | 1999-02-23 | Massachusetts Institute Of Technology | Aerodynamically light particles for pulmonary drug delivery |
| US6652837B1 (en) | 1996-05-24 | 2003-11-25 | Massachusetts Institute Of Technology | Preparation of novel particles for inhalation |
| US20020052310A1 (en) * | 1997-09-15 | 2002-05-02 | Massachusetts Institute Of Technology The Penn State Research Foundation | Particles for inhalation having sustained release properties |
| GB9616047D0 (en) * | 1996-07-31 | 1996-09-11 | Glaxo Group Ltd | Medicament carrier with agglomerated large medicament particles and related method of manufacture thereof |
| SE9700135D0 (sv) * | 1997-01-20 | 1997-01-20 | Astra Ab | New formulation |
| SE9700133D0 (sv) * | 1997-01-20 | 1997-01-20 | Astra Ab | New formulation |
| CA2481868C (en) * | 1997-03-20 | 2010-06-15 | Schering Corporation | Preparation of powder agglomerates |
| US6495167B2 (en) | 1997-03-20 | 2002-12-17 | Schering Corporation | Preparation of powder agglomerates |
| US6503537B2 (en) | 1997-03-20 | 2003-01-07 | Schering Corporation | Preparation of powder agglomerates |
| EP0876814A1 (en) | 1997-05-07 | 1998-11-11 | "PHARLYSE", Société Anonyme | Dry powder inhaler excipient, process for its preparation and pharmaceutical compositions containing it |
| US6182712B1 (en) | 1997-07-21 | 2001-02-06 | Inhale Therapeutic Systems | Power filling apparatus and methods for their use |
| US7052678B2 (en) | 1997-09-15 | 2006-05-30 | Massachusetts Institute Of Technology | Particles for inhalation having sustained release properties |
| US20020010197A1 (en) * | 1998-01-13 | 2002-01-24 | John Dixon | Pharmaceutical compositions comprising a compound having dopamine (d2) receptor agonist activity and a compound (b) having beta2-adrenoreceptor agonist activity |
| SE9802073D0 (sv) | 1998-06-11 | 1998-06-11 | Astra Ab | New use |
| US6956021B1 (en) * | 1998-08-25 | 2005-10-18 | Advanced Inhalation Research, Inc. | Stable spray-dried protein formulations |
| US8722668B2 (en) * | 1998-12-23 | 2014-05-13 | Daryl W. Hochman | Methods and compositions for the treatment of neuropathic pain and neuropsychiatric disorders |
| US7678364B2 (en) | 1999-08-25 | 2010-03-16 | Alkermes, Inc. | Particles for inhalation having sustained release properties |
| US6749835B1 (en) | 1999-08-25 | 2004-06-15 | Advanced Inhalation Research, Inc. | Formulation for spray-drying large porous particles |
| EP1210067A2 (en) * | 1999-08-25 | 2002-06-05 | Advanced Inhalation Research, Inc. | Modulation of release from dry powder formulations |
| US20010036481A1 (en) * | 1999-08-25 | 2001-11-01 | Advanced Inhalation Research, Inc. | Modulation of release from dry powder formulations |
| US7304750B2 (en) | 1999-12-17 | 2007-12-04 | Nektar Therapeutics | Systems and methods for non-destructive mass sensing |
| US6499984B1 (en) * | 2000-05-22 | 2002-12-31 | Warner-Lambert Company | Continuous production of pharmaceutical granulation |
| US20020141946A1 (en) * | 2000-12-29 | 2002-10-03 | Advanced Inhalation Research, Inc. | Particles for inhalation having rapid release properties |
| EP1345629A2 (en) * | 2000-12-29 | 2003-09-24 | Advanced Inhalation Research, Inc. | Particles for inhalation having sustained release properties |
| DK1370543T3 (da) | 2001-02-14 | 2007-02-19 | Tibotec Pharm Ltd | Bredspektrede 2-(substitueret amino) benzothiazol- sulfonamid-HIV-proteaseinhibitorer |
| EP1397367A2 (en) | 2001-04-09 | 2004-03-17 | Tibotec Pharmaceuticals Ltd. | Broadspectrum 2-(substituted-amino)-benzoxazole sulfonamide hiv protease inhibitors |
| HRP20031026B1 (hr) | 2001-05-11 | 2012-07-31 | Tibotec@Pharmaceuticals@Ltd | Amino benzoksazol sulfonamidni inhibitori hiv proteaze širokog spektra |
| AU2002352836B2 (en) * | 2001-11-20 | 2005-09-29 | Alkermes, Inc. | Improved particulate compositions for pulmonary delivery |
| US20030129250A1 (en) * | 2001-11-20 | 2003-07-10 | Advanced Inhalation Research Inc. | Particulate compositions for improving solubility of poorly soluble agents |
| CA2470964C (en) | 2001-12-21 | 2013-07-02 | Tibotec Pharmaceuticals Ltd. | Broadspectrum heterocyclic substituted phenyl containing sulfonamide hiv protease inhibitors |
| MY142238A (en) | 2002-03-12 | 2010-11-15 | Tibotec Pharm Ltd | Broadspectrum substituted benzimidazole sulfonamide hiv protease inhibitors |
| IL165043A0 (en) | 2002-05-17 | 2005-12-18 | Tibotec Pharm Ltd | broadspectrum substituted benzisoxazole sulfonamide hiv protease inhibitors |
| NZ538714A (en) | 2002-08-14 | 2007-03-30 | Tibotec Pharm Ltd | Broadspectrum substituted oxindole sulfonamide HIV protease inhibitors |
| EP1417958A1 (en) * | 2002-11-08 | 2004-05-12 | Pari GmbH | Wet granulation process |
| EP1667675B1 (en) | 2003-09-11 | 2011-11-09 | Tibotec Pharmaceuticals | Entry inhibitors of the hiv virus |
| SE528121C2 (sv) * | 2004-03-29 | 2006-09-05 | Mederio Ag | Preparering av torrpulver för på förhand uppmätt DPI |
| AR048650A1 (es) | 2004-05-04 | 2006-05-10 | Tibotec Pharm Ltd | Derivados de (1,10b-dihidro-2-(aminocarbonil-fenil)-5h-pirazolo[1,5 c][1,3]benzoxazin-5-il)fenil metanona como inhibidores de la replicacion viral del vih |
| US7378441B2 (en) | 2004-05-07 | 2008-05-27 | Sequoia Pharmaceuticals, Inc. | Resistance-repellent retroviral protease inhibitors |
| MXPA06013315A (es) | 2004-05-17 | 2007-02-02 | Tibotec Pharm Ltd | 1,5-dihidro-pirido[3,2-b]indol-2-onas 4-sustituidas. |
| TW200607502A (en) | 2004-05-17 | 2006-03-01 | Tibotec Pharm Ltd | 6, 7, 8, 9-substituted 1-phenyl-1, 5-dihydro-pyrido[3, 2-b]indol-2-ones |
| AU2005243439B2 (en) | 2004-05-17 | 2011-09-29 | Tibotec Pharmaceuticals Ltd. | 1-heterocyclyl-1,5-dihydro-pyrido(3,2-b)indol-2-ones |
| TW200710091A (en) | 2005-04-11 | 2007-03-16 | Tibotec Pharm Ltd | (1,10B-dihydro-2-(aminoalkyl-phenyl)-5H-pyrazolo [1,5-c][1,3]benzoxazin-5-yl)phenyl methanone derivatives as HIV viral replication inhibitors |
| WO2007045496A1 (en) | 2005-10-21 | 2007-04-26 | Universiteit Antwerpen | Novel urokinase inhibitors |
| US7994187B2 (en) | 2006-04-03 | 2011-08-09 | Tibotec Pharmaceuticals Ltd. | HIV inhibiting 3,4-dihydro-imidazo[4,5-B]pyridin-5-ones |
| DE102007049931A1 (de) | 2007-10-18 | 2009-04-23 | Pharmatech Gmbh | Vorrichtung und Verfahren zur kontinuierlichen Herstellung von sphärischen Pulveragglomeraten |
| EP2116236A1 (en) | 2008-04-21 | 2009-11-11 | Université de Mons-Hainaut | Bisbenzamidine derivatives for use as antioxidant |
| AU2010238646A1 (en) * | 2009-04-24 | 2011-12-15 | Merck Sharp & Dohme Corp. | Agglomerate formulations including active pharmaceutical agents with targeted particle sizes |
| BR112012021889B1 (pt) | 2010-03-02 | 2022-01-11 | Ph Pharma Co., Ltd | Compostos de amidas heterocíclicas e composição que as compreende para a prevenção ou o tratamento de doenças oculares |
| WO2011110852A1 (en) | 2010-03-10 | 2011-09-15 | Astrazeneca Ab | Polymorphic forms of 6- [2- (4 -cyanophenyl) - 2h - pyrazol - 3 - yl] - 5 -methyl - 3 - oxo - 4 - (trifluoromethyl - phenyl) 3,4-dihydropyrazine-2-carboxylic acid ethylamide |
| GB201019043D0 (en) | 2010-11-10 | 2010-12-22 | Protea Biopharma N V | Use of 2',5'-oligoadenylate derivative compounds |
| GB201102237D0 (en) | 2011-02-09 | 2011-03-23 | Kuecept Ltd | Particle formulation |
| GB201108225D0 (en) | 2011-05-17 | 2011-06-29 | Amakem Nv | Novel KBC inhibitors |
| GB201113689D0 (en) | 2011-08-09 | 2011-09-21 | Amakem Nv | Novel PDE4 inhibitors |
| GB201114854D0 (en) | 2011-08-29 | 2011-10-12 | Amakem Nv | Novel rock inhibitors |
| EA024232B1 (ru) | 2011-08-31 | 2016-08-31 | Амакем Нв | Новые легкоразрушающиеся ингибиторы rock |
| KR20140078710A (ko) | 2011-09-30 | 2014-06-25 | 온코디자인 에스.에이. | 거대고리 flt3 키나제 억제제 |
| AU2012314035B2 (en) | 2011-09-30 | 2016-12-15 | Oncodesign S.A. | Macrocyclic LRRK2 kinase inhibitors |
| PL2810198T3 (pl) | 2012-01-30 | 2024-01-22 | Universiteit Gent | Związki przeciwinwazyjne |
| GB201204756D0 (en) | 2012-03-19 | 2012-05-02 | Lewi Paulus J | Triazines with suitable spacers for treatment and/or prevention of HIV infections |
| WO2014072419A1 (en) | 2012-11-08 | 2014-05-15 | Universiteit Antwerpen | Novel anti-hiv compounds |
| HK1219057A1 (zh) | 2013-03-15 | 2017-03-24 | 昂科迪塞恩股份有限公司 | 大环的盐可诱导的激酶抑制剂 |
| US9427376B2 (en) * | 2013-10-10 | 2016-08-30 | Chiesi Farmaceutici S.P.A. | Process for preparing pharmaceutical formulations for inhalation comprising a high-dosage strength active ingredient |
| WO2015150337A1 (en) | 2014-04-01 | 2015-10-08 | Amakem Nv | Lim kinase inhibitors |
| WO2016003450A1 (en) | 2014-07-01 | 2016-01-07 | The Regents Of The University Of California | Pkc-epsilon inhibitors |
| WO2016005340A1 (en) | 2014-07-08 | 2016-01-14 | Universiteit Gent | Hamamelitannin analogues and uses thereof |
| EA032872B1 (ru) | 2014-09-17 | 2019-07-31 | Онкодизайн С.А. | Макроциклические ингибиторы rip2-киназы |
| DK3194405T3 (en) | 2014-09-17 | 2019-04-15 | Oncodesign Sa | MACROCYCLIC LRRK2 KINase INHIBITORS |
| WO2016083490A1 (en) | 2014-11-27 | 2016-06-02 | Remynd Nv | Compounds for the treatment of amyloid-associated diseases |
| WO2016146651A1 (en) | 2015-03-16 | 2016-09-22 | Oncodesign Sa | Macrocyclic activin-like receptor kinase inhibitors |
| WO2017146994A1 (en) * | 2016-02-24 | 2017-08-31 | Merck Sharp & Dohme Corp. | Controlled agglomeration of micronized drug or drug-excipient mixtures |
| WO2017157882A1 (en) | 2016-03-14 | 2017-09-21 | Université Catholique de Louvain | Serine biosynthetic pathway inhibitors |
| WO2018065387A1 (en) | 2016-10-04 | 2018-04-12 | Universiteit Gent | Novel hamamelitannin analogues and uses thereof |
| WO2018096088A1 (en) | 2016-11-24 | 2018-05-31 | Universiteit Antwerpen | Halogenated benzotropolones as atg4b inhibitors |
| EP3656382A1 (en) | 2017-01-30 | 2020-05-27 | Université de Liège | Perk and ire-1a inhibitors against neurodevelopmental disorders |
| WO2018206757A1 (en) | 2017-05-11 | 2018-11-15 | Remynd N.V. | Inhibitors of pde6delta for use in the prevention and/or treatment of epilepsy and/or neurodegenerative disorders |
| EA201992397A1 (ru) | 2017-05-11 | 2020-03-16 | Реминд Н.В. | Соединения для лечения эпилепсии, нейродегенеративных нарушений и других нарушений цнс |
| WO2019193091A1 (en) | 2018-04-05 | 2019-10-10 | Universiteit Hasselt | Selective pde4d inhibitors against demyelinating diseases |
| CA3110661A1 (en) | 2018-08-29 | 2020-03-05 | University Of Massachusetts | Inhibition of protein kinases to treat friedreich ataxia |
| WO2020229595A1 (en) | 2019-05-14 | 2020-11-19 | Molecular Targeted Radiopharmaceuticals Holding Gmbh (Mtr) | Quinazoline-2,4-dione derivatives as parp inhibitors |
| WO2022157381A1 (en) | 2021-01-25 | 2022-07-28 | Universiteit Hasselt | Phloretin for use in the treatment of neurodegenerative and demyelinating diseases |
| WO2023021132A1 (en) | 2021-08-18 | 2023-02-23 | Katholieke Universiteit Leuven | 6-substituted- and 6,7-disubstituted-7-deazapurine ribonucleoside analogues |
| EP4405357A1 (en) | 2021-09-23 | 2024-07-31 | Katholieke Universiteit Leuven KU Leuven Research & Development | Ribonucleoside analogues against -sars-cov-2 |
| WO2023241799A1 (en) | 2022-06-15 | 2023-12-21 | Université Libre de Bruxelles | Flavanols for use in the treatment of retroviral infections |
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| US2609150A (en) * | 1949-11-05 | 1952-09-02 | Union Carbide & Carbon Corp | Mechanical pulverization of refrigerated plastics |
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| US4161516A (en) * | 1975-07-25 | 1979-07-17 | Fisons Limited | Composition for treating airway disease |
| US4161526A (en) * | 1978-07-20 | 1979-07-17 | Sterling Drug Inc. | Zinc salt prevention or removal of discoloration in pyrithione, pyrithione salt and dipyrithione compositions |
| DE3268533D1 (en) * | 1981-07-24 | 1986-02-27 | Fisons Plc | Inhalation drugs, methods for their production and pharmaceutical formulations containing them |
| US4688610A (en) * | 1985-03-19 | 1987-08-25 | Spiral Systems Inc. | Apparatus for dispensing particulate agglomerating solids |
| US4940556A (en) * | 1986-01-30 | 1990-07-10 | Syntex (U.S.A.) Inc. | Method of preparing long acting formulation |
| GB8606762D0 (en) * | 1986-03-19 | 1986-04-23 | Boots Co Plc | Therapeutic agents |
| JPS63116732A (ja) * | 1986-11-06 | 1988-05-21 | Fukae Kogyo Kk | 粉粒体処理装置 |
| GB8711005D0 (en) * | 1987-05-09 | 1987-06-10 | British Petroleum Co Plc | Chemical process |
| EP0441740B1 (de) * | 1990-01-29 | 1993-09-22 | Ciba-Geigy Ag | Verfahren und Vorrichtung zur Dosierung eines feinkörnigen Pulvers |
| GB9027018D0 (en) * | 1990-12-12 | 1991-01-30 | Ici Plc | Heterocyclic compounds |
| US5394868A (en) * | 1992-06-25 | 1995-03-07 | Schering Corporation | Inhalation device for powdered medicaments |
-
1994
- 1994-09-29 PL PL94313765A patent/PL175564B1/pl unknown
- 1994-09-29 AT AT94929076T patent/ATE209903T1/de active
- 1994-09-29 SG SG1996006659A patent/SG48049A1/en unknown
- 1994-09-29 RU RU96108803/14A patent/RU2170082C2/ru active
- 1994-09-29 SK SK391-96A patent/SK283569B6/sk not_active IP Right Cessation
- 1994-09-29 DK DK94929076T patent/DK0721331T3/da active
- 1994-09-29 ES ES94929076T patent/ES2166786T3/es not_active Expired - Lifetime
- 1994-09-29 EG EG60594A patent/EG20677A/xx active
- 1994-09-29 HU HU9600821A patent/HU222355B1/hu active IP Right Grant
- 1994-09-29 EP EP94929076A patent/EP0721331B1/en not_active Expired - Lifetime
- 1994-09-29 PT PT94929076T patent/PT721331E/pt unknown
- 1994-09-29 NZ NZ274277A patent/NZ274277A/en not_active IP Right Cessation
- 1994-09-29 IL IL11108094A patent/IL111080A/xx not_active IP Right Cessation
- 1994-09-29 BR BR9407686A patent/BR9407686A/pt not_active IP Right Cessation
- 1994-09-29 CZ CZ1996942A patent/CZ289214B6/cs not_active IP Right Cessation
- 1994-09-29 WO PCT/SE1994/000896 patent/WO1995009615A1/en active IP Right Grant
- 1994-09-29 DE DE69429357T patent/DE69429357T2/de not_active Expired - Lifetime
- 1994-09-29 AU AU78261/94A patent/AU679789B2/en not_active Expired
- 1994-09-29 CN CN94193634A patent/CN1110300C/zh not_active Expired - Lifetime
- 1994-09-29 JP JP51074895A patent/JP3732508B2/ja not_active Expired - Lifetime
- 1994-10-03 US US08/317,033 patent/US5551489A/en not_active Expired - Lifetime
-
1996
- 1996-03-29 NO NO19961290A patent/NO314836B1/no not_active IP Right Cessation
- 1996-03-29 FI FI961430A patent/FI116364B/fi not_active IP Right Cessation
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