DE69415320T2 - Verfahren und vorrichtung zur herstellung von partikeln unter verwendung eines superkritischen mediums - Google Patents
Verfahren und vorrichtung zur herstellung von partikeln unter verwendung eines superkritischen mediumsInfo
- Publication number
- DE69415320T2 DE69415320T2 DE69415320T DE69415320T DE69415320T2 DE 69415320 T2 DE69415320 T2 DE 69415320T2 DE 69415320 T DE69415320 T DE 69415320T DE 69415320 T DE69415320 T DE 69415320T DE 69415320 T2 DE69415320 T2 DE 69415320T2
- Authority
- DE
- Germany
- Prior art keywords
- pct
- screens
- date jan
- sec
- run
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D11/00—Solvent extraction
- B01D11/04—Solvent extraction of solutions which are liquid
- B01D11/0403—Solvent extraction of solutions which are liquid with a supercritical fluid
- B01D11/0411—Solvent extraction of solutions which are liquid with a supercritical fluid the supercritical fluid acting as solvent for the solvent and as anti-solvent for the solute, e.g. formation of particles from solutions
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
- B01F25/40—Static mixers
- B01F25/42—Static mixers in which the mixing is affected by moving the components jointly in changing directions, e.g. in tubes provided with baffles or obstructions
- B01F25/43—Mixing tubes, e.g. wherein the material is moved in a radial or partly reversed direction
- B01F25/435—Mixing tubes composed of concentric tubular members
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
- B01J2/02—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops
- B01J2/04—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops in a gaseous medium
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
- B05B7/00—Spraying apparatus for discharge of liquids or other fluent materials from two or more sources, e.g. of liquid and air, of powder and gas
- B05B7/02—Spray pistols; Apparatus for discharge
- B05B7/06—Spray pistols; Apparatus for discharge with at least one outlet orifice surrounding another approximately in the same plane
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05D—PROCESSES FOR APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05D2401/00—Form of the coating product, e.g. solution, water dispersion, powders or the like
- B05D2401/90—Form of the coating product, e.g. solution, water dispersion, powders or the like at least one component of the composition being in supercritical state or close to supercritical state
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB939313642A GB9313642D0 (en) | 1993-07-01 | 1993-07-01 | Method and apparatus for the formation of particles |
PCT/GB1994/001426 WO1995001221A1 (en) | 1993-07-01 | 1994-06-30 | Method and apparatus for the formation of particles |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69415320D1 DE69415320D1 (de) | 1999-01-28 |
DE69415320T2 true DE69415320T2 (de) | 1999-06-24 |
Family
ID=10738144
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69415320T Expired - Lifetime DE69415320T2 (de) | 1993-07-01 | 1994-06-30 | Verfahren und vorrichtung zur herstellung von partikeln unter verwendung eines superkritischen mediums |
Country Status (15)
Country | Link |
---|---|
US (1) | US5851453A (de) |
EP (1) | EP0706421B1 (de) |
JP (3) | JPH08511987A (de) |
AT (1) | ATE174530T1 (de) |
AU (1) | AU677345B2 (de) |
CA (1) | CA2166301C (de) |
DE (1) | DE69415320T2 (de) |
DK (1) | DK0706421T3 (de) |
ES (1) | ES2128564T3 (de) |
GB (1) | GB9313642D0 (de) |
GR (1) | GR3029612T3 (de) |
IN (1) | IN179851B (de) |
NZ (1) | NZ267697A (de) |
SG (1) | SG47392A1 (de) |
WO (1) | WO1995001221A1 (de) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19640027B4 (de) * | 1995-09-29 | 2008-04-30 | Karasawa, Yukihiko, Ohmiya | Verfahren und Vorrichtung zum Pulverisieren fester Teilchen |
Families Citing this family (160)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6063910A (en) * | 1991-11-14 | 2000-05-16 | The Trustees Of Princeton University | Preparation of protein microparticles by supercritical fluid precipitation |
DE69415998T2 (de) | 1993-11-08 | 1999-08-12 | Gillette Co | Verfahren zur formung von partikeln unter verwendung einer überkritischen flüssigkeit so hergestellte aerogelpartikel und aerogelpartikel enthaltenden antiperspirantien |
US6290991B1 (en) | 1994-12-02 | 2001-09-18 | Quandrant Holdings Cambridge Limited | Solid dose delivery vehicle and methods of making same |
US5874029A (en) * | 1996-10-09 | 1999-02-23 | The University Of Kansas | Methods for particle micronization and nanonization by recrystallization from organic solutions sprayed into a compressed antisolvent |
US5833891A (en) * | 1996-10-09 | 1998-11-10 | The University Of Kansas | Methods for a particle precipitation and coating using near-critical and supercritical antisolvents |
US6254854B1 (en) | 1996-05-24 | 2001-07-03 | The Penn Research Foundation | Porous particles for deep lung delivery |
US20020052310A1 (en) | 1997-09-15 | 2002-05-02 | Massachusetts Institute Of Technology The Penn State Research Foundation | Particles for inhalation having sustained release properties |
US6503480B1 (en) | 1997-05-23 | 2003-01-07 | Massachusetts Institute Of Technology | Aerodynamically light particles for pulmonary drug delivery |
US6652837B1 (en) | 1996-05-24 | 2003-11-25 | Massachusetts Institute Of Technology | Preparation of novel particles for inhalation |
US5874064A (en) * | 1996-05-24 | 1999-02-23 | Massachusetts Institute Of Technology | Aerodynamically light particles for pulmonary drug delivery |
FR2753639B1 (fr) † | 1996-09-25 | 1998-12-11 | Procede de preparation de microcapsules de matieres actives enrobees par un polymere et nouvelles microcapsules notamment obtenues selon le procede | |
GB9703673D0 (en) | 1997-02-21 | 1997-04-09 | Bradford Particle Design Ltd | Method and apparatus for the formation of particles |
SE9701956D0 (sv) * | 1997-05-23 | 1997-05-23 | Astra Ab | New composition of matter |
US7052678B2 (en) | 1997-09-15 | 2006-05-30 | Massachusetts Institute Of Technology | Particles for inhalation having sustained release properties |
US5989463A (en) | 1997-09-24 | 1999-11-23 | Alkermes Controlled Therapeutics, Inc. | Methods for fabricating polymer-based controlled release devices |
US20060165606A1 (en) | 1997-09-29 | 2006-07-27 | Nektar Therapeutics | Pulmonary delivery particles comprising water insoluble or crystalline active agents |
US6565885B1 (en) | 1997-09-29 | 2003-05-20 | Inhale Therapeutic Systems, Inc. | Methods of spray drying pharmaceutical compositions |
DE19748069A1 (de) * | 1997-10-31 | 1999-05-06 | Messer Griesheim Gmbh | Verfahren und Vorrichtung zum Abkühlen und Zerstäuben von flüssigen oder pastösen Stoffen |
GB9804379D0 (en) * | 1998-03-02 | 1998-04-22 | Bradford Particle Design Ltd | Method of particle formation |
GB9810559D0 (en) * | 1998-05-15 | 1998-07-15 | Bradford Particle Design Ltd | Method and apparatus for particle formation |
US6048369A (en) * | 1998-06-03 | 2000-04-11 | North Carolina State University | Method of dyeing hydrophobic textile fibers with colorant materials in supercritical fluid carbon dioxide |
US6956021B1 (en) | 1998-08-25 | 2005-10-18 | Advanced Inhalation Research, Inc. | Stable spray-dried protein formulations |
GB9824298D0 (en) * | 1998-11-05 | 1998-12-30 | Smithkline Beecham Plc | Novel process |
US6113795A (en) * | 1998-11-17 | 2000-09-05 | The University Of Kansas | Process and apparatus for size selective separation of micro- and nano-particles |
SE9804000D0 (sv) * | 1998-11-23 | 1998-11-23 | Astra Ab | New composition of matter |
SE9804001D0 (sv) * | 1998-11-23 | 1998-11-23 | Astra Ab | New process |
GB9828204D0 (en) * | 1998-12-21 | 1999-02-17 | Smithkline Beecham Plc | Process |
US6630121B1 (en) | 1999-06-09 | 2003-10-07 | The Regents Of The University Of Colorado | Supercritical fluid-assisted nebulization and bubble drying |
US6858199B1 (en) | 2000-06-09 | 2005-02-22 | Advanced Inhalation Research, Inc. | High efficient delivery of a large therapeutic mass aerosol |
GB9915975D0 (en) * | 1999-07-07 | 1999-09-08 | Bradford Particle Design Ltd | Method for the formation of particles |
US7678364B2 (en) | 1999-08-25 | 2010-03-16 | Alkermes, Inc. | Particles for inhalation having sustained release properties |
US6749835B1 (en) | 1999-08-25 | 2004-06-15 | Advanced Inhalation Research, Inc. | Formulation for spray-drying large porous particles |
GB9920558D0 (en) * | 1999-08-31 | 1999-11-03 | Bradford Particle Design Ltd | Methods for particle formation and their products |
EP1090894A1 (de) * | 1999-10-06 | 2001-04-11 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Verfahren zur Herstellung feinpartikulärer Explosivstoffe |
GB9927011D0 (en) | 1999-11-16 | 2000-01-12 | Advanced Phytonics Ltd | Method for the production of particles |
FR2802445B1 (fr) * | 1999-12-15 | 2002-02-15 | Separex Sa | Procede et dispositif de captage de fines particules par piegeage au sein d'un melange solide de type neige carbonique |
FR2803538B1 (fr) * | 1999-12-15 | 2002-06-07 | Separex Sa | Procede et dispositif de captage de fines particules par percolation dans un lit de granules |
US6761909B1 (en) | 1999-12-21 | 2004-07-13 | Rxkinetix, Inc. | Particulate insulin-containing products and method of manufacture |
AU2729101A (en) * | 1999-12-21 | 2001-07-03 | Rxkinetix, Inc. | Particulate drug-containing products and method of manufacture |
US6261326B1 (en) | 2000-01-13 | 2001-07-17 | North Carolina State University | Method for introducing dyes and other chemicals into a textile treatment system |
US7029700B2 (en) * | 2000-01-14 | 2006-04-18 | Brown University Research Foundation | Micronized freeze-dried particles |
US7833549B2 (en) * | 2000-01-19 | 2010-11-16 | Mannkind Corporation | Dry powder formulations of antihistamine for nasal administration |
JP2003525731A (ja) | 2000-03-03 | 2003-09-02 | ベーリンガー インゲルハイム ファーマシューティカルズ インコーポレイテッド | 溶剤膨張−収縮の繰り返しによる物質処理方法 |
CH694686A5 (it) | 2000-03-04 | 2005-06-15 | Eco2 Sa | Prodotto di micronizzazione di sostanze farmaceutiche. |
US8404217B2 (en) | 2000-05-10 | 2013-03-26 | Novartis Ag | Formulation for pulmonary administration of antifungal agents, and associated methods of manufacture and use |
US7871598B1 (en) | 2000-05-10 | 2011-01-18 | Novartis Ag | Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery and methods of use |
WO2001085136A2 (en) | 2000-05-10 | 2001-11-15 | Alliance Pharmaceutical Corporation | Phospholipid-based powders for drug delivery |
US6620351B2 (en) | 2000-05-24 | 2003-09-16 | Auburn University | Method of forming nanoparticles and microparticles of controllable size using supercritical fluids with enhanced mass transfer |
TWI236930B (en) | 2000-05-26 | 2005-08-01 | Pfizer Prod Inc | Reactive crystallization method to improve particle size |
GB0016002D0 (en) * | 2000-06-29 | 2000-08-23 | Glaxo Group Ltd | Novel process for preparing crystalline particles |
WO2002020538A2 (en) * | 2000-09-06 | 2002-03-14 | Bristol-Myers Squibb Company | Stavudine polymorphic form 1 process |
US6521258B1 (en) * | 2000-09-08 | 2003-02-18 | Ferro Corporation | Polymer matrices prepared by supercritical fluid processing techniques |
US6676710B2 (en) | 2000-10-18 | 2004-01-13 | North Carolina State University | Process for treating textile substrates |
FR2815540B1 (fr) † | 2000-10-19 | 2005-06-10 | Separex Sa | Procede de fabrication de tres fines particules constituees d'un principe insere dans une molecule hote |
US8551526B2 (en) * | 2000-11-03 | 2013-10-08 | Board Of Regents, The University Of Texas System | Preparation of drug particles using evaporation precipitation into aqueous solutions |
US6756062B2 (en) | 2000-11-03 | 2004-06-29 | Board Of Regents University Of Texas System | Preparation of drug particles using evaporation precipitation into aqueous solutions |
GB0027357D0 (en) * | 2000-11-09 | 2000-12-27 | Bradford Particle Design Plc | Particle formation methods and their products |
AU2002221320B2 (en) * | 2000-12-08 | 2006-06-15 | The University Of Sydney | Synthesis of small particles |
AUPR197000A0 (en) | 2000-12-08 | 2001-01-11 | Unisearch Limited | Synthesis of small particles |
JP2005504715A (ja) | 2000-12-29 | 2005-02-17 | アドバンスト インハレーション リサーチ,インコーポレイテッド | 持続放出特性を有する吸入用粒子 |
US20110301569A1 (en) | 2001-01-20 | 2011-12-08 | Gordon Wayne Dyer | Methods and apparatus for the CVCS |
GB0102075D0 (en) * | 2001-01-26 | 2001-03-14 | Astrazeneca Ab | Process |
CA2438275C (en) * | 2001-02-26 | 2010-05-25 | Dompe S.P.A. | Apparatus and method for micron and submicron particle formation |
WO2002089851A1 (fr) * | 2001-03-06 | 2002-11-14 | Separex (Societe Anonyme) | Procede de fabrication de complexes hote-client |
FR2824754B1 (fr) * | 2001-05-15 | 2004-05-28 | Separex Sa | Procede d'obtention de particules solides a partir d'au moins un produit hydrosoluble |
WO2003004142A1 (en) * | 2001-07-02 | 2003-01-16 | Micro & Nano Materials Sagl | Process for the production of micro and/or nano particles |
WO2003006223A1 (en) * | 2001-07-10 | 2003-01-23 | University Technology Corporation | Devices and methods for the production of particles |
TW586963B (en) * | 2001-07-20 | 2004-05-11 | Nektar Therapeutics Uk Ltd | Method and apparatus for preparing target substance in particulate form and fluid inlet assembly for said apparatus |
GB0208742D0 (en) * | 2002-04-17 | 2002-05-29 | Bradford Particle Design Ltd | Particulate materials |
GB0117696D0 (en) | 2001-07-20 | 2001-09-12 | Bradford Particle Design Plc | Particle information |
EA006064B1 (ru) | 2001-10-10 | 2005-08-25 | Бёрингер Ингельхайм Фармасьютиклз, Инк. | Способ обработки порошков сжиженными газами |
FR2830760B1 (fr) | 2001-10-12 | 2004-06-04 | Pf Medicament | Procede de preparation d'un compose d'interaction de substances actives avec un support poreux par fluide supercritique |
PT1440082E (pt) | 2001-10-22 | 2011-12-07 | Dompe Spa | Processamento de fluidos supercríticos: preparação de micropartículas de proteína e sua estabilização |
ES2415654T3 (es) | 2001-11-20 | 2013-07-26 | Civitas Therapeutics, Inc. | Composiciones particuladas mejoradas para suministro pulmonar |
US7641823B2 (en) | 2001-12-07 | 2010-01-05 | Map Pharmaceuticals, Inc. | Synthesis of small particles |
EP1458360B1 (de) | 2001-12-19 | 2011-05-11 | Novartis AG | Pulmonale verabreichung von aminoglykosiden |
EP1463574A1 (de) * | 2002-01-08 | 2004-10-06 | Extractis International Ltd | Ölextraktionsverfahren und vorrichtung dafür |
DE10203629A1 (de) * | 2002-01-30 | 2003-07-31 | Ulrich Zimmermann | Vorrichtung und Verfahren zur Herstellung von Mikrokapseln sowie verbesserte Mikrokapsel |
CA2478327A1 (en) * | 2002-03-20 | 2003-10-02 | Advanced Inhalation Research, Inc. | Hgh (human growth hormone) formulations for pulmonary administration |
US7008644B2 (en) * | 2002-03-20 | 2006-03-07 | Advanced Inhalation Research, Inc. | Method and apparatus for producing dry particles |
US20050163725A1 (en) * | 2002-03-20 | 2005-07-28 | Blizzard Charles D. | Method for administration of growth hormone via pulmonary delivery |
GB2405334B (en) * | 2002-04-17 | 2006-02-15 | Nektar Therapeutics Uk Ltd | Particulate materials |
GB0216562D0 (en) | 2002-04-25 | 2002-08-28 | Bradford Particle Design Ltd | Particulate materials |
WO2003090715A2 (en) * | 2002-04-25 | 2003-11-06 | Nektar Therapeutics Uk Ltd | Particulate materials |
US9339459B2 (en) | 2003-04-24 | 2016-05-17 | Nektar Therapeutics | Particulate materials |
US6998051B2 (en) * | 2002-07-03 | 2006-02-14 | Ferro Corporation | Particles from supercritical fluid extraction of emulsion |
AU2003297391B2 (en) * | 2002-12-19 | 2010-02-25 | Baxter International, Inc. | Process for preparing combination pharmaceutical formulations using supercritical fluids |
CA2508870C (en) | 2002-12-30 | 2012-10-16 | Nektar Therapeutics | Prefilming atomizer |
JP2004264346A (ja) * | 2003-02-05 | 2004-09-24 | Sharp Corp | 現像剤及びその製造方法 |
WO2004071645A2 (en) * | 2003-02-07 | 2004-08-26 | Ferro Corporation | Method and apparatus for supercritical fluid assisted particle production |
US7083748B2 (en) * | 2003-02-07 | 2006-08-01 | Ferro Corporation | Method and apparatus for continuous particle production using supercritical fluid |
FR2854079B1 (fr) | 2003-04-25 | 2007-11-30 | Pf Medicament | Procede de preparation de complexes moleculaires |
MY147403A (en) * | 2003-04-29 | 2012-11-30 | Kowa Co | Composition containing medicine extremely slightly solube in water and method for preparation thereof |
US20060008531A1 (en) | 2003-05-08 | 2006-01-12 | Ferro Corporation | Method for producing solid-lipid composite drug particles |
JP2006525303A (ja) * | 2003-05-08 | 2006-11-09 | ネクター セラピューティクス ユーケー リミティド | 微粒子物質 |
US7767118B2 (en) | 2003-06-03 | 2010-08-03 | Ferro Corporation | Nanoparticles from supercritical fluid antisolvent process using particle growth and agglomeration retardants |
JP3663408B2 (ja) * | 2003-06-30 | 2005-06-22 | 株式会社アイテック | 高温高圧水を用いる微粒子製造方法および微粒子製造装置 |
GB0327723D0 (en) | 2003-09-15 | 2003-12-31 | Vectura Ltd | Pharmaceutical compositions |
AU2004277419B2 (en) * | 2003-09-30 | 2007-10-11 | Brown University Research Foundation | Nanoparticulate therapeutic biologically active agents |
WO2005042219A1 (en) * | 2003-10-24 | 2005-05-12 | Ferro Corporation | Method of forming particles |
SE0303476D0 (sv) | 2003-12-22 | 2003-12-22 | Censdelivery Ab | Device, method and use for the formation of small particles |
EP1729729B1 (de) * | 2004-03-23 | 2014-04-23 | Novartis AG | Pharmazeutische zusammensetzungen |
US7220456B2 (en) | 2004-03-31 | 2007-05-22 | Eastman Kodak Company | Process for the selective deposition of particulate material |
US7223445B2 (en) * | 2004-03-31 | 2007-05-29 | Eastman Kodak Company | Process for the deposition of uniform layer of particulate material |
KR101054129B1 (ko) * | 2004-03-31 | 2011-08-03 | 이스트맨 코닥 캄파니 | 균일한 미립자 물질층의 침착 |
US20050218076A1 (en) * | 2004-03-31 | 2005-10-06 | Eastman Kodak Company | Process for the formation of particulate material |
US7507823B2 (en) | 2004-05-06 | 2009-03-24 | Bristol-Myers Squibb Company | Process of making aripiprazole particles |
US8513204B2 (en) | 2004-06-21 | 2013-08-20 | Novartis Ag | Compositions comprising amphotericin B, mehods and systems |
MXPA06015220A (es) | 2004-06-21 | 2007-12-13 | Nektar Therapeutics | Composiciones comprendiendo anfotericina b, metodos y sistemas. |
WO2006076097A2 (en) * | 2004-12-07 | 2006-07-20 | Nektar Therapeutics | Stable non-crystalline formulation comprising losartan |
WO2006063025A1 (en) * | 2004-12-07 | 2006-06-15 | Nektar Therapeutics | Stable non-crystalline formulation comprising donepezil |
JP5016785B2 (ja) * | 2004-12-28 | 2012-09-05 | 株式会社奈良機械製作所 | 微細粒子の生成装置 |
JP4635154B2 (ja) * | 2005-02-22 | 2011-02-16 | 日本工機株式会社 | 微粒子化合火薬類の微粒子生成装置、微粒子化合火薬類の製造装置および微粒子化合火薬類の製造方法 |
US8079838B2 (en) * | 2005-03-16 | 2011-12-20 | Horiba, Ltd. | Pure particle generator |
WO2006132242A1 (ja) * | 2005-06-09 | 2006-12-14 | Toss Ltd. | 超微小粒子の製造方法 |
CA2615378C (en) * | 2005-07-15 | 2015-02-17 | Map Pharmaceuticals, Inc. | Multiple active pharmaceutical ingredients combined in discrete inhalation particles and formulations thereof |
US8475845B2 (en) * | 2005-07-15 | 2013-07-02 | Map Pharmaceuticals, Inc. | Method of particle formation |
EP1782839A1 (de) | 2005-11-03 | 2007-05-09 | Genetic S.p.A. | Verfahren zur Sterilisation von Glucocorticosteroiden mit überkritischem CO2 |
FR2898516B1 (fr) * | 2006-03-17 | 2008-05-30 | Innov Ia Sa | Procede de preparation d'une composition pulverulente et produit tel qu'obtenu |
JP2010505605A (ja) * | 2006-10-06 | 2010-02-25 | ニューサウス イノベーションズ ピーティーワイ リミテッド | 粒子の形成 |
EP2476412B1 (de) * | 2006-10-11 | 2014-03-19 | Crititech, Inc. | Apparat zur Abscheidung kleiner Medikamententeilchen in einen Behälter |
KR20090089838A (ko) * | 2006-12-01 | 2009-08-24 | 데이진 화이바 가부시키가이샤 | 고분자 성형물에 대한 기능 부여 방법 및 그 장치 |
US20080260852A1 (en) * | 2007-01-23 | 2008-10-23 | Ferro Pfanstiehl Laboratories, Inc. | Supercritical fluid extraction produced by in-line homogenization |
US7745566B2 (en) * | 2007-01-23 | 2010-06-29 | Ferro Corporation | Methods for the purification of polymers |
GB0702402D0 (en) | 2007-02-08 | 2007-03-21 | Thar Pharmaceuticals Inc | Method of creating crystalline substances |
EP2425820B1 (de) | 2007-02-11 | 2015-04-08 | MAP Pharmaceuticals Inc | Verfahren zur therapeutischen Verabreichung von DHE zur schnellen Linderung von Migräne bei gleichzeitiger Minimierung von Nebenwirkungsprofilen |
FR2915405B1 (fr) * | 2007-04-30 | 2011-09-09 | Areva Np | Preparation de particules minerales en milieu co2 supercritique |
WO2009047935A1 (ja) * | 2007-10-12 | 2009-04-16 | Ono Pharmaceutical Co., Ltd. | 微粒子 |
PL2229233T3 (pl) | 2007-12-07 | 2020-03-31 | Xspray Pharma Ab (Publ) | Sposób wytwarzania cząstek |
EP2258748B1 (de) | 2008-03-24 | 2019-05-08 | Sanyo Chemical Industries, Ltd. | Kunstharzpartikel und verfahren zu ihrer herstellung |
CA2725578A1 (en) * | 2008-04-24 | 2009-10-29 | Evestra, Inc. | Oral contraceptive dosage forms comprising a progestogen dispersed in an enteric polymer and further comprising an estrogen |
WO2009140587A1 (en) | 2008-05-15 | 2009-11-19 | Novartis Ag | Pulmonary delivery of a fluoroquinolone |
US20100047292A1 (en) * | 2008-08-20 | 2010-02-25 | Baxter International Inc. | Methods of processing microparticles and compositions produced thereby |
EP2191821A1 (de) | 2008-11-26 | 2010-06-02 | CHIESI FARMACEUTICI S.p.A. | Mikropartikel enthaltend ein Salz von 8-Hydroxy-2-[[(1R)-2-(4-methoxyphenyl)-1-methylethyl]amino]ethyl]-2(1H)-quinolinone mit verbesserten Adhesionseigenschaften zur Trockenpulver-Inhalation |
FR2945110B1 (fr) * | 2009-04-30 | 2012-09-21 | Air Liquide | Procede et installation de melange et de refroidissement d'un produit |
US20100291221A1 (en) * | 2009-05-15 | 2010-11-18 | Robert Owen Cook | Method of administering dose-sparing amounts of formoterol fumarate-budesonide combination particles by inhalation |
US20100298602A1 (en) * | 2009-05-19 | 2010-11-25 | Massachusetts Institute Of Technology | Systems and methods for microfluidic crystallization |
US20100294986A1 (en) * | 2009-05-19 | 2010-11-25 | Massachusetts Institute Of Technology | Supercritical fluid facilitated particle formation in microfluidic systems |
DK2435024T3 (en) | 2009-05-29 | 2016-10-24 | Pearl Therapeutics Inc | Compositions for the respiratory delivery of active agents and related methods and systems |
US8815258B2 (en) | 2009-05-29 | 2014-08-26 | Pearl Therapeutics, Inc. | Compositions, methods and systems for respiratory delivery of two or more active agents |
KR100924236B1 (ko) * | 2009-06-23 | 2009-10-29 | 충남대학교산학협력단 | 균일한 입도분포를 가지는 초미세입자의 신규한 제조방법 및 장치 |
ES2623328T3 (es) * | 2009-09-18 | 2017-07-11 | Sitec Pharmabio Sl | Procedimiento para la deshidratación de productos en polvo |
WO2011116763A1 (de) * | 2010-03-22 | 2011-09-29 | Mjr Pharmjet Gmbh | Verfahren und vorrichtung zur herstellung von mikro- oder nanopartikeln |
HUE037788T2 (hu) | 2010-04-01 | 2018-09-28 | Univ Alberta | Nagy molekulatömegû biopolimerek kezelése szuperkritikus folyadékkal |
MX350838B (es) | 2011-02-11 | 2017-09-18 | Grain Proc Corporation * | Composicion de sal. |
JP5933234B2 (ja) * | 2011-11-24 | 2016-06-08 | 国立大学法人東北大学 | 微粒子作製装置 |
US8778181B1 (en) * | 2013-03-14 | 2014-07-15 | Crititech, Inc. | Equipment assembly for and method of processing particles |
US20140275517A1 (en) | 2013-03-15 | 2014-09-18 | Pearl Therapeutics, Inc. | Methods and systems for conditioning of particulate crystalline materials |
US20170050337A1 (en) * | 2013-05-02 | 2017-02-23 | Melior Innovations, Inc. | Formation apparatus, systems and methods for manufacturing polymer derived ceramic structures |
RU2015154720A (ru) | 2013-05-22 | 2017-06-27 | Перл Терапьютикс, Инк. | Композиции, способы и системы для респираторной доставки трех или более активных средств |
EP3054921A4 (de) * | 2013-10-10 | 2017-03-15 | New York University | Effiziente erfassung von nanopartikeln |
GB201402556D0 (en) | 2014-02-13 | 2014-04-02 | Crystec Ltd | Improvements relating to inhalable particles |
JP6921759B2 (ja) | 2015-06-04 | 2021-08-18 | クリティテック・インコーポレイテッド | 捕集装置および使用法 |
DE102015007604A1 (de) * | 2015-06-12 | 2016-12-29 | Messer France S.A.S | Vorrichtung und Verfahren zum Kühlen und Zerstäuben flüssiger oder pastöser Stoffe |
CN108026059A (zh) | 2015-07-22 | 2018-05-11 | 阿纳韦克斯生命科学公司 | 四氢-n,n-二甲基-2,2-二苯基-3-呋喃甲胺盐酸盐的晶型,制备这样晶型的方法,及其药物组合物 |
PL3353232T3 (pl) * | 2015-09-25 | 2021-05-04 | Sappi Netherlands Services B.V. | Suszenie rozpyłowe celulozy nadkrytycznym CO2 |
TW202317080A (zh) | 2021-07-09 | 2023-05-01 | 美商阿斯特捷利康有限責任公司 | 用於氣溶膠遞送之組合物、方法及系統 |
EP4190437A1 (de) | 2021-12-03 | 2023-06-07 | SiTec PharmaBio SL | Verfahren und vorrichtung zur herstellung von festen mikropartikeln |
WO2023119093A1 (en) | 2021-12-20 | 2023-06-29 | Astrazeneca Ab | Compositions, methods and systems for aerosol drug delivery |
WO2023212191A1 (en) | 2022-04-28 | 2023-11-02 | Astrazeneca Ab | Combination of albuterol and budesonide for the treatment of asthma |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1078283B (de) * | 1958-06-12 | 1960-03-24 | Bayer Ag | Verfahren zur Umhuellung oder Einbettung von pharmazeutischen Wirkstoffen |
BE795724A (fr) * | 1972-02-25 | 1973-08-21 | Basf Ag | Procede et dispositif de fabrication de fibres courtes en matieres synthetiques thermoplastiques |
US4422985A (en) * | 1982-09-24 | 1983-12-27 | Morishita Jintan Co., Ltd. | Method and apparatus for encapsulation of a liquid or meltable solid material |
US4734227A (en) * | 1983-09-01 | 1988-03-29 | Battelle Memorial Institute | Method of making supercritical fluid molecular spray films, powder and fibers |
DE3744329A1 (de) * | 1987-12-28 | 1989-07-06 | Schwarz Pharma Gmbh | Verfahren zur herstellung einer mindestens einen wirkstoff und einen traeger umfassenden zubereitung |
FR2663223B1 (fr) * | 1990-06-14 | 1994-12-02 | Af Aplicaciones Far Lab | Forme galenique parenterale. |
DE4041563A1 (de) * | 1990-12-22 | 1992-06-25 | Sanol Arznei Schwarz Gmbh | Verfahren zur herstellung wirkstoffhaltiger mikropartikel aus hydrolytisch abbaubaren polymeren |
DE4319990A1 (de) * | 1993-06-17 | 1994-12-22 | Messer Griesheim Gmbh | Verfahren zum Herstellen von Teilchen aus Kunststoffen |
-
1993
- 1993-07-01 GB GB939313642A patent/GB9313642D0/en active Pending
-
1994
- 1994-06-30 EP EP94918983A patent/EP0706421B1/de not_active Expired - Lifetime
- 1994-06-30 SG SG1996000509A patent/SG47392A1/en unknown
- 1994-06-30 IN IN578MA1994 patent/IN179851B/en unknown
- 1994-06-30 DK DK94918983T patent/DK0706421T3/da active
- 1994-06-30 CA CA002166301A patent/CA2166301C/en not_active Expired - Lifetime
- 1994-06-30 US US08/578,700 patent/US5851453A/en not_active Expired - Lifetime
- 1994-06-30 JP JP7503369A patent/JPH08511987A/ja active Pending
- 1994-06-30 DE DE69415320T patent/DE69415320T2/de not_active Expired - Lifetime
- 1994-06-30 ES ES94918983T patent/ES2128564T3/es not_active Expired - Lifetime
- 1994-06-30 NZ NZ267697A patent/NZ267697A/en not_active IP Right Cessation
- 1994-06-30 WO PCT/GB1994/001426 patent/WO1995001221A1/en active IP Right Grant
- 1994-06-30 AU AU70071/94A patent/AU677345B2/en not_active Ceased
- 1994-06-30 AT AT94918983T patent/ATE174530T1/de active
-
1999
- 1999-03-08 GR GR990400699T patent/GR3029612T3/el unknown
-
2003
- 2003-08-13 JP JP2003293173A patent/JP3806107B2/ja not_active Expired - Lifetime
-
2006
- 2006-03-13 JP JP2006068418A patent/JP2006239686A/ja active Pending
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19640027B4 (de) * | 1995-09-29 | 2008-04-30 | Karasawa, Yukihiko, Ohmiya | Verfahren und Vorrichtung zum Pulverisieren fester Teilchen |
Also Published As
Publication number | Publication date |
---|---|
AU7007194A (en) | 1995-01-24 |
JP2006239686A (ja) | 2006-09-14 |
ES2128564T3 (es) | 1999-05-16 |
JP2004105953A (ja) | 2004-04-08 |
DE69415320D1 (de) | 1999-01-28 |
ATE174530T1 (de) | 1999-01-15 |
SG47392A1 (en) | 1998-04-17 |
GB9313642D0 (en) | 1993-08-18 |
WO1995001221A1 (en) | 1995-01-12 |
CA2166301C (en) | 2003-01-14 |
US5851453A (en) | 1998-12-22 |
IN179851B (de) | 1997-12-27 |
JPH08511987A (ja) | 1996-12-17 |
EP0706421B1 (de) | 1998-12-16 |
AU677345B2 (en) | 1997-04-17 |
EP0706421A1 (de) | 1996-04-17 |
CA2166301A1 (en) | 1995-01-12 |
GR3029612T3 (en) | 1999-06-30 |
JP3806107B2 (ja) | 2006-08-09 |
NZ267697A (en) | 1997-05-26 |
DK0706421T3 (da) | 1999-08-23 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE69415320T2 (de) | Verfahren und vorrichtung zur herstellung von partikeln unter verwendung eines superkritischen mediums | |
BR9407611A (pt) | Processo de produção de papel papel documento de segurança e aparelho para a produção de papel | |
ATE170578T1 (de) | Mahlgarnitur | |
ATE203389T1 (de) | Verfahren und vorrichtung zur herstellung einer aus cellulose-fasern bestehenden faserstoffbahn für die verwendung in hygieneartikeln | |
HUT71186A (en) | A method of producing visible, continous streaks and/or delimited fields in paper | |
ATE40431T1 (de) | Verfahren und vorrichtung zum praegen eines trockengefertigten faserbandes, zum beispiel einer kuechenpapierrolle. | |
GB2300429B (en) | Non-woven fabric manufacture | |
DE69530679D1 (de) | Vorrichtung zur durchbiegungssteuerung der walzen in einer maschine zum krumpfen von warenbahnen | |
ATE209600T1 (de) | Verfahren und wickelmaschine zum aufwickeln von papier- oder kartonbahnen | |
ATE157411T1 (de) | Vorrichtung und verfahren zum behandeln eines abfallpapierstoffbreis | |
DE69715984T2 (de) | Apparat zur Herstellung eines Filtermediums in Blattform | |
DE69220160D1 (de) | Verfahren und vorrichtung zur verbesserten doppelsiebformation | |
FR2171033A2 (en) | Fibrous non-woven web - formed by filtering fibrous suspension on inclined screen |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
8327 | Change in the person/name/address of the patent owner |
Owner name: BRADFORD PARTICLE DESIGN LTD., BRADFORD, GB |
|
8363 | Opposition against the patent | ||
R082 | Change of representative |
Ref document number: 706421 Country of ref document: EP Representative=s name: LEINWEBER & ZIMMERMANN, DE |
|
R081 | Change of applicant/patentee |
Ref document number: 706421 Country of ref document: EP Owner name: NEKTAR THERAPEUTICS, US Free format text: FORMER OWNER: BRADFORD PARTICLE DESIGN LTD., BRADFORD, GB Effective date: 20121113 |
|
R082 | Change of representative |
Ref document number: 706421 Country of ref document: EP Representative=s name: LEINWEBER & ZIMMERMANN, DE Effective date: 20121113 |