DE69415320D1 - Verfahren und vorrichtung zur herstellung von partikeln unter verwendung eines superkritischen mediums - Google Patents
Verfahren und vorrichtung zur herstellung von partikeln unter verwendung eines superkritischen mediumsInfo
- Publication number
- DE69415320D1 DE69415320D1 DE69415320T DE69415320T DE69415320D1 DE 69415320 D1 DE69415320 D1 DE 69415320D1 DE 69415320 T DE69415320 T DE 69415320T DE 69415320 T DE69415320 T DE 69415320T DE 69415320 D1 DE69415320 D1 DE 69415320D1
- Authority
- DE
- Germany
- Prior art keywords
- pct
- screens
- date jan
- sec
- run
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
- B01F25/40—Static mixers
- B01F25/42—Static mixers in which the mixing is affected by moving the components jointly in changing directions, e.g. in tubes provided with baffles or obstructions
- B01F25/43—Mixing tubes, e.g. wherein the material is moved in a radial or partly reversed direction
- B01F25/435—Mixing tubes composed of concentric tubular members
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D11/00—Solvent extraction
- B01D11/04—Solvent extraction of solutions which are liquid
- B01D11/0403—Solvent extraction of solutions which are liquid with a supercritical fluid
- B01D11/0411—Solvent extraction of solutions which are liquid with a supercritical fluid the supercritical fluid acting as solvent for the solvent and as anti-solvent for the solute, e.g. formation of particles from solutions
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
- B01J2/02—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops
- B01J2/04—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops in a gaseous medium
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
- B05B7/00—Spraying apparatus for discharge of liquids or other fluent materials from two or more sources, e.g. of liquid and air, of powder and gas
- B05B7/02—Spray pistols; Apparatus for discharge
- B05B7/06—Spray pistols; Apparatus for discharge with at least one outlet orifice surrounding another approximately in the same plane
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05D—PROCESSES FOR APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05D2401/00—Form of the coating product, e.g. solution, water dispersion, powders or the like
- B05D2401/90—Form of the coating product, e.g. solution, water dispersion, powders or the like at least one component of the composition being in supercritical state or close to supercritical state
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Dispersion Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pulmonology (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
- Extraction Or Liquid Replacement (AREA)
- Medicinal Preparation (AREA)
- Paper (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Glanulating (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Manufacturing Of Micro-Capsules (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB939313642A GB9313642D0 (en) | 1993-07-01 | 1993-07-01 | Method and apparatus for the formation of particles |
PCT/GB1994/001426 WO1995001221A1 (en) | 1993-07-01 | 1994-06-30 | Method and apparatus for the formation of particles |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69415320D1 true DE69415320D1 (de) | 1999-01-28 |
DE69415320T2 DE69415320T2 (de) | 1999-06-24 |
Family
ID=10738144
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69415320T Expired - Lifetime DE69415320T2 (de) | 1993-07-01 | 1994-06-30 | Verfahren und vorrichtung zur herstellung von partikeln unter verwendung eines superkritischen mediums |
Country Status (15)
Country | Link |
---|---|
US (1) | US5851453A (de) |
EP (1) | EP0706421B1 (de) |
JP (3) | JPH08511987A (de) |
AT (1) | ATE174530T1 (de) |
AU (1) | AU677345B2 (de) |
CA (1) | CA2166301C (de) |
DE (1) | DE69415320T2 (de) |
DK (1) | DK0706421T3 (de) |
ES (1) | ES2128564T3 (de) |
GB (1) | GB9313642D0 (de) |
GR (1) | GR3029612T3 (de) |
IN (1) | IN179851B (de) |
NZ (1) | NZ267697A (de) |
SG (1) | SG47392A1 (de) |
WO (1) | WO1995001221A1 (de) |
Families Citing this family (161)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6063910A (en) * | 1991-11-14 | 2000-05-16 | The Trustees Of Princeton University | Preparation of protein microparticles by supercritical fluid precipitation |
ES2126867T3 (es) | 1993-11-08 | 1999-04-01 | Gillette Co | Metodo de formacion de particulas que emplea un fluido supercritico, particulas de aerogel asi formadas y antisudorantes que contienen particulas de aerogel. |
US6290991B1 (en) | 1994-12-02 | 2001-09-18 | Quandrant Holdings Cambridge Limited | Solid dose delivery vehicle and methods of making same |
JP3368117B2 (ja) * | 1995-09-29 | 2003-01-20 | 幸彦 唐澤 | 固体粒子の破砕方法および装置 |
US5874029A (en) * | 1996-10-09 | 1999-02-23 | The University Of Kansas | Methods for particle micronization and nanonization by recrystallization from organic solutions sprayed into a compressed antisolvent |
US5833891A (en) * | 1996-10-09 | 1998-11-10 | The University Of Kansas | Methods for a particle precipitation and coating using near-critical and supercritical antisolvents |
US20020052310A1 (en) | 1997-09-15 | 2002-05-02 | Massachusetts Institute Of Technology The Penn State Research Foundation | Particles for inhalation having sustained release properties |
US6254854B1 (en) | 1996-05-24 | 2001-07-03 | The Penn Research Foundation | Porous particles for deep lung delivery |
US6652837B1 (en) | 1996-05-24 | 2003-11-25 | Massachusetts Institute Of Technology | Preparation of novel particles for inhalation |
US5874064A (en) | 1996-05-24 | 1999-02-23 | Massachusetts Institute Of Technology | Aerodynamically light particles for pulmonary drug delivery |
US6503480B1 (en) | 1997-05-23 | 2003-01-07 | Massachusetts Institute Of Technology | Aerodynamically light particles for pulmonary drug delivery |
FR2753639B1 (fr) † | 1996-09-25 | 1998-12-11 | Procede de preparation de microcapsules de matieres actives enrobees par un polymere et nouvelles microcapsules notamment obtenues selon le procede | |
GB9703673D0 (en) * | 1997-02-21 | 1997-04-09 | Bradford Particle Design Ltd | Method and apparatus for the formation of particles |
SE9701956D0 (sv) | 1997-05-23 | 1997-05-23 | Astra Ab | New composition of matter |
US7052678B2 (en) | 1997-09-15 | 2006-05-30 | Massachusetts Institute Of Technology | Particles for inhalation having sustained release properties |
US5989463A (en) | 1997-09-24 | 1999-11-23 | Alkermes Controlled Therapeutics, Inc. | Methods for fabricating polymer-based controlled release devices |
US20060165606A1 (en) | 1997-09-29 | 2006-07-27 | Nektar Therapeutics | Pulmonary delivery particles comprising water insoluble or crystalline active agents |
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US6048369A (en) * | 1998-06-03 | 2000-04-11 | North Carolina State University | Method of dyeing hydrophobic textile fibers with colorant materials in supercritical fluid carbon dioxide |
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US6113795A (en) * | 1998-11-17 | 2000-09-05 | The University Of Kansas | Process and apparatus for size selective separation of micro- and nano-particles |
SE9804000D0 (sv) * | 1998-11-23 | 1998-11-23 | Astra Ab | New composition of matter |
SE9804001D0 (sv) * | 1998-11-23 | 1998-11-23 | Astra Ab | New process |
GB9828204D0 (en) † | 1998-12-21 | 1999-02-17 | Smithkline Beecham Plc | Process |
CN1198593C (zh) | 1999-06-09 | 2005-04-27 | 罗伯特·E·希弗斯 | 超临界流体辅助的喷雾和鼓泡干燥 |
US6858199B1 (en) | 2000-06-09 | 2005-02-22 | Advanced Inhalation Research, Inc. | High efficient delivery of a large therapeutic mass aerosol |
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US6749835B1 (en) | 1999-08-25 | 2004-06-15 | Advanced Inhalation Research, Inc. | Formulation for spray-drying large porous particles |
US7678364B2 (en) | 1999-08-25 | 2010-03-16 | Alkermes, Inc. | Particles for inhalation having sustained release properties |
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US6261326B1 (en) | 2000-01-13 | 2001-07-17 | North Carolina State University | Method for introducing dyes and other chemicals into a textile treatment system |
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AU2001231000A1 (en) | 2000-01-19 | 2001-07-31 | Pharmaceutical Discovery Corporation | Dry powder formulations of antihistamine for nasal administration |
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US8404217B2 (en) | 2000-05-10 | 2013-03-26 | Novartis Ag | Formulation for pulmonary administration of antifungal agents, and associated methods of manufacture and use |
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US8551526B2 (en) * | 2000-11-03 | 2013-10-08 | Board Of Regents, The University Of Texas System | Preparation of drug particles using evaporation precipitation into aqueous solutions |
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DE4319990A1 (de) * | 1993-06-17 | 1994-12-22 | Messer Griesheim Gmbh | Verfahren zum Herstellen von Teilchen aus Kunststoffen |
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1993
- 1993-07-01 GB GB939313642A patent/GB9313642D0/en active Pending
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1994
- 1994-06-30 AU AU70071/94A patent/AU677345B2/en not_active Ceased
- 1994-06-30 CA CA002166301A patent/CA2166301C/en not_active Expired - Lifetime
- 1994-06-30 AT AT94918983T patent/ATE174530T1/de active
- 1994-06-30 US US08/578,700 patent/US5851453A/en not_active Expired - Lifetime
- 1994-06-30 JP JP7503369A patent/JPH08511987A/ja active Pending
- 1994-06-30 IN IN578MA1994 patent/IN179851B/en unknown
- 1994-06-30 EP EP94918983A patent/EP0706421B1/de not_active Expired - Lifetime
- 1994-06-30 DE DE69415320T patent/DE69415320T2/de not_active Expired - Lifetime
- 1994-06-30 ES ES94918983T patent/ES2128564T3/es not_active Expired - Lifetime
- 1994-06-30 DK DK94918983T patent/DK0706421T3/da active
- 1994-06-30 NZ NZ267697A patent/NZ267697A/en not_active IP Right Cessation
- 1994-06-30 WO PCT/GB1994/001426 patent/WO1995001221A1/en active IP Right Grant
- 1994-06-30 SG SG1996000509A patent/SG47392A1/en unknown
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1999
- 1999-03-08 GR GR990400699T patent/GR3029612T3/el unknown
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2003
- 2003-08-13 JP JP2003293173A patent/JP3806107B2/ja not_active Expired - Lifetime
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Also Published As
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---|---|
EP0706421A1 (de) | 1996-04-17 |
JP3806107B2 (ja) | 2006-08-09 |
GR3029612T3 (en) | 1999-06-30 |
CA2166301A1 (en) | 1995-01-12 |
AU7007194A (en) | 1995-01-24 |
WO1995001221A1 (en) | 1995-01-12 |
ES2128564T3 (es) | 1999-05-16 |
DE69415320T2 (de) | 1999-06-24 |
GB9313642D0 (en) | 1993-08-18 |
NZ267697A (en) | 1997-05-26 |
JP2004105953A (ja) | 2004-04-08 |
CA2166301C (en) | 2003-01-14 |
IN179851B (de) | 1997-12-27 |
DK0706421T3 (da) | 1999-08-23 |
JPH08511987A (ja) | 1996-12-17 |
SG47392A1 (en) | 1998-04-17 |
ATE174530T1 (de) | 1999-01-15 |
US5851453A (en) | 1998-12-22 |
JP2006239686A (ja) | 2006-09-14 |
EP0706421B1 (de) | 1998-12-16 |
AU677345B2 (en) | 1997-04-17 |
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