DE68907062T2 - Feinverteiltes feste kristalline pulver durch niederschlag in einem anti-lösungsmittel. - Google Patents

Feinverteiltes feste kristalline pulver durch niederschlag in einem anti-lösungsmittel.

Info

Publication number
DE68907062T2
DE68907062T2 DE89910390T DE68907062T DE68907062T2 DE 68907062 T2 DE68907062 T2 DE 68907062T2 DE 89910390 T DE89910390 T DE 89910390T DE 68907062 T DE68907062 T DE 68907062T DE 68907062 T2 DE68907062 T2 DE 68907062T2
Authority
DE
Germany
Prior art keywords
deposit
solvent
crystalline powder
solid crystalline
distributed solid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE89910390T
Other languages
English (en)
Other versions
DE68907062D1 (de
Inventor
William Schmitt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Application granted granted Critical
Publication of DE68907062D1 publication Critical patent/DE68907062D1/de
Publication of DE68907062T2 publication Critical patent/DE68907062T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A01N25/12—Powders or granules
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/04—Specific aggregation state of one or more of the phases to be mixed
    • B01F23/043—Mixing fluids or with fluids in a supercritical state, in supercritical conditions or variable density fluids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/09—Mixing systems, i.e. flow charts or diagrams for components having more than two different of undetermined agglomeration states, e.g. supercritical states
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/40—Mixing liquids with liquids; Emulsifying
    • B01F23/48—Mixing liquids with liquids; Emulsifying characterised by the nature of the liquids
    • B01F23/481—Mixing liquids with liquids; Emulsifying characterised by the nature of the liquids using liquefied or cryogenic gases
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F2215/00—Auxiliary or complementary information in relation with mixing
    • B01F2215/04—Technical information in relation with mixing
    • B01F2215/0404—Technical information in relation with mixing theories or general explanations of phenomena associated with mixing or generalizations of a concept by comparison of equivalent methods
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/20—Mixing gases with liquids
    • B01F23/21—Mixing gases with liquids by introducing liquids into gaseous media
DE89910390T 1988-10-05 1989-09-06 Feinverteiltes feste kristalline pulver durch niederschlag in einem anti-lösungsmittel. Expired - Lifetime DE68907062T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US25384988A 1988-10-05 1988-10-05

Publications (2)

Publication Number Publication Date
DE68907062D1 DE68907062D1 (de) 1993-07-15
DE68907062T2 true DE68907062T2 (de) 1993-10-07

Family

ID=22961959

Family Applications (1)

Application Number Title Priority Date Filing Date
DE89910390T Expired - Lifetime DE68907062T2 (de) 1988-10-05 1989-09-06 Feinverteiltes feste kristalline pulver durch niederschlag in einem anti-lösungsmittel.

Country Status (10)

Country Link
EP (1) EP0437451B1 (de)
JP (1) JP2843857B2 (de)
KR (1) KR0132576B1 (de)
AU (1) AU624421B2 (de)
CA (1) CA1338106C (de)
DE (1) DE68907062T2 (de)
DK (1) DK175208B1 (de)
HK (1) HK89396A (de)
HU (1) HU209603B (de)
WO (1) WO1990003782A2 (de)

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US6063910A (en) * 1991-11-14 2000-05-16 The Trustees Of Princeton University Preparation of protein microparticles by supercritical fluid precipitation
US5639441A (en) * 1992-03-06 1997-06-17 Board Of Regents Of University Of Colorado Methods for fine particle formation
US5301664A (en) * 1992-03-06 1994-04-12 Sievers Robert E Methods and apparatus for drug delivery using supercritical solutions
US5389263A (en) * 1992-05-20 1995-02-14 Phasex Corporation Gas anti-solvent recrystallization and application for the separation and subsequent processing of RDX and HMX
EP0868942A1 (de) 1993-11-08 1998-10-07 The Gillette Company Verfahren zur Formung von Partiklen unter Verwendung eine überkritischen Flüssigkeit und so hergestellte Aerogelpartikel
IT1265473B1 (it) * 1993-12-30 1996-11-22 Otefal Srl Procedimento per la produzione di polveri a granulometria controllata e prodotto in polvere cosi' ottenuto
AT401871B (de) * 1994-01-28 1996-12-27 Gebro Broschek Gmbh Verfahren zur herstellung von s(+)-ibuprofen- partikeln mit verbesserten fliesseigenschaften und deren verwendung zur arzneimittelherstellung
GB9413202D0 (en) * 1994-06-30 1994-08-24 Univ Bradford Method and apparatus for the formation of particles
WO1996029998A1 (en) * 1995-03-28 1996-10-03 Fidia Advanced Biopolymers S.R.L. Nanospheres comprising a biocompatible polysaccharide
SE9501384D0 (sv) * 1995-04-13 1995-04-13 Astra Ab Process for the preparation of respirable particles
US5803966A (en) * 1995-11-01 1998-09-08 Alcon Laboratories, Inc. Process for sizing prednisolone acetate using a supercritical fluid anti-solvent
US5728315A (en) * 1996-05-01 1998-03-17 Alliedsignal Inc. Azeotrope-like compositions of trifluoromethane, carbon dioxide, ethane and hexafluoroethane
FR2753639B1 (fr) † 1996-09-25 1998-12-11 Procede de preparation de microcapsules de matieres actives enrobees par un polymere et nouvelles microcapsules notamment obtenues selon le procede
AU5374398A (en) * 1996-12-17 1998-07-15 Cordant Technologies, Inc. Salting-out process of crystallizing 2,4,6,8,10,12-hexanitro-2,4,6,8,10,12-hexaazatetracyclo (5.5.0.05,903,11)-dodecane
SE9701956D0 (sv) 1997-05-23 1997-05-23 Astra Ab New composition of matter
US6221153B1 (en) * 1998-06-09 2001-04-24 Trevor Percival Castor Method for producing large crystals of complex molecules
SE9804003D0 (sv) * 1998-11-23 1998-11-23 Astra Ab A method of producing drug particles
GB9828721D0 (en) * 1998-12-24 1999-02-17 Glaxo Group Ltd Novel apparatus and process
SE9901667D0 (sv) 1999-05-07 1999-05-07 Astra Ab Method and device for forming particles
GB9915975D0 (en) 1999-07-07 1999-09-08 Bradford Particle Design Ltd Method for the formation of particles
US6884911B2 (en) * 2000-03-03 2005-04-26 Boehringer Ingelheim Pharmaceuticals, Inc. Material processing by repeated solvent expansion-contraction
CH694686A5 (it) 2000-03-04 2005-06-15 Eco2 Sa Prodotto di micronizzazione di sostanze farmaceutiche.
US6620351B2 (en) 2000-05-24 2003-09-16 Auburn University Method of forming nanoparticles and microparticles of controllable size using supercritical fluids with enhanced mass transfer
ES2170008B1 (es) * 2000-08-25 2003-05-01 Soc Es Carburos Metalicos Sa Procedimiento para la precipitacion de particulas solidas finamente divididas.
GB0027357D0 (en) 2000-11-09 2000-12-27 Bradford Particle Design Plc Particle formation methods and their products
AUPR197000A0 (en) * 2000-12-08 2001-01-11 Unisearch Limited Synthesis of small particles
US8067032B2 (en) 2000-12-22 2011-11-29 Baxter International Inc. Method for preparing submicron particles of antineoplastic agents
US9700866B2 (en) 2000-12-22 2017-07-11 Baxter International Inc. Surfactant systems for delivery of organic compounds
DE10105801B4 (de) 2001-02-07 2004-07-08 Henkel Kgaa Wasch- und Reinigungsmittel umfassend feine Mikropartikel mit Reinigungsmittelbestandteilen
JP2004534900A (ja) 2001-07-12 2004-11-18 イーストマン コダック カンパニー 圧縮流体配合物
GB0208742D0 (en) 2002-04-17 2002-05-29 Bradford Particle Design Ltd Particulate materials
GB0117696D0 (en) 2001-07-20 2001-09-12 Bradford Particle Design Plc Particle information
EP1429749A2 (de) 2001-09-26 2004-06-23 Baxter International Inc. Herstellung von nanopartikeln im submikrometerbereich durch dispersion und entzug des lösungsmittels oder der flüssigen phase
US20060003012A9 (en) 2001-09-26 2006-01-05 Sean Brynjelsen Preparation of submicron solid particle suspensions by sonication of multiphase systems
ES2318145T3 (es) * 2002-02-19 2009-05-01 Resolution Chemicals Limited Esterilizacion de esteroides por medio de disolventes.
DE10218107A1 (de) * 2002-04-23 2003-11-20 Jenapharm Gmbh Verfahren zum Herstellen von Kristallen von Steroiden, danach erhältliche Kristalle und deren Verwendung in pharmazeutischen Formulierungen
US9339459B2 (en) 2003-04-24 2016-05-17 Nektar Therapeutics Particulate materials
MY143936A (en) 2003-03-27 2011-07-29 Nycomed Gmbh Process for preparing crystalline ciclesonide with defined particle size
BRPI0409962A (pt) 2003-05-08 2006-04-25 Nektar Therapeutics Uk Ltd co-formulação particulada de uma substáncia ativa e um excipiente, composição farmacêutica ou nutricêutrica, produto farmacêutico ou nutricêutico, método para preparar uma co-formulação particulada de uma substáncia ativa e um excipiente, e, uso de uma substáncia ativa e um excipiente
US20060275219A1 (en) * 2003-06-10 2006-12-07 Taisho Pharmaceutical Co., Ltd. Radial spherical crystallization product, process for producing the same, and dry powder preparation containing the crystallization product
NZ545146A (en) 2006-02-07 2009-03-31 Ind Res Ltd Near-critical fluid fractionation process for extracting plant or animal material
CA2932389A1 (en) 2006-03-24 2007-10-04 Auxilium International Holdings, Inc. Stabilized compositions containing alkaline labile drugs
CA2676803A1 (en) * 2007-01-31 2008-08-07 Toyama Chemical Co., Ltd. Novel crystal of piperacillin sodium
PL2425820T3 (pl) 2007-02-11 2015-08-31 Map Pharmaceuticals Inc Sposób terapeutycznego stosowania dhe w celu umożliwienia szybkiego złagodzenia migreny przy jednoczesnym zminimalizowaniu profilu działań niepożądanych
EP2156823A1 (de) * 2008-08-14 2010-02-24 Pharmatex Italia Srl Verfahren zur Herstellung von sterilen pulverförmigen pharmazeutischen Zusammensetzungen in Form von Mikro- und Nanopartikeln
US8071656B2 (en) 2009-03-03 2011-12-06 Dynasep Llc Nylon extraction from commingled materials
WO2011015226A1 (en) * 2009-08-03 2011-02-10 Pharmatex Italia Srl Process for the preparation of sterile powdered pharmaceutical compounds in the form of micro and nanoparticles
CA2767773C (en) 2011-02-11 2015-11-24 Grain Processing Corporation Composition comprising a salt and a crystallization interrupter
CA2897670C (en) * 2013-01-07 2021-04-06 Aciex Therapeutics, Inc. Preparations of hydrophobic therapeutic agents, methods of manufacture and use thereof
US8778181B1 (en) * 2013-03-14 2014-07-15 Crititech, Inc. Equipment assembly for and method of processing particles
WO2022149937A2 (ko) * 2021-01-08 2022-07-14 서울대학교 산학협력단 골관절염 치료를 위한 건조된 세포 분비물 기반 치료제

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GB899667A (en) * 1960-04-19 1962-06-27 Glaxo Lab Ltd Crystalline griseofulvin
US4044126A (en) * 1972-04-20 1977-08-23 Allen & Hanburys Limited Steroidal aerosol compositions and process for the preparation thereof
MX3864E (es) * 1975-05-27 1981-08-26 Syntex Corp Un proceso para prepara el compuesto cristalino 6-fluiro-11b 21-dihiroxi-16 17-isopropilidendioxipregna-1 4-dien-3 20-diona
FR2608988B1 (fr) * 1986-12-31 1991-01-11 Centre Nat Rech Scient Procede de preparation de systemes colloidaux dispersibles d'une substance, sous forme de nanoparticules

Also Published As

Publication number Publication date
HK89396A (en) 1996-05-31
DK59091D0 (da) 1991-04-03
WO1990003782A2 (en) 1990-04-19
AU4219889A (en) 1990-05-01
EP0437451B1 (de) 1993-06-09
DK175208B1 (da) 2004-07-12
WO1990003782A3 (en) 1990-07-26
DE68907062D1 (de) 1993-07-15
KR0132576B1 (ko) 1998-04-17
DK59091A (da) 1991-04-03
HU895780D0 (en) 1991-07-29
JPH04500925A (ja) 1992-02-20
EP0437451A1 (de) 1991-07-24
AU624421B2 (en) 1992-06-11
HU209603B (en) 1994-09-28
KR900701253A (ko) 1990-12-01
JP2843857B2 (ja) 1999-01-06
HUT56265A (en) 1991-08-28
CA1338106C (en) 1996-03-05

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: PHARMACIA & UPJOHN CO., KALAMAZOO, MICH., US