DE60228997D1 - Zusammensetzungen und verfahren zur diagnose und behandlung eines tumors - Google Patents
Zusammensetzungen und verfahren zur diagnose und behandlung eines tumorsInfo
- Publication number
- DE60228997D1 DE60228997D1 DE60228997T DE60228997T DE60228997D1 DE 60228997 D1 DE60228997 D1 DE 60228997D1 DE 60228997 T DE60228997 T DE 60228997T DE 60228997 T DE60228997 T DE 60228997T DE 60228997 D1 DE60228997 D1 DE 60228997D1
- Authority
- DE
- Germany
- Prior art keywords
- polypeptides
- present
- methods
- tumor
- diagnosis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000000034 method Methods 0.000 title abstract 2
- 206010028980 Neoplasm Diseases 0.000 title 1
- 238000003745 diagnosis Methods 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 229920001184 polypeptide Polymers 0.000 abstract 7
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 7
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 7
- 150000007523 nucleic acids Chemical class 0.000 abstract 2
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 239000013598 vector Substances 0.000 abstract 1
Classifications
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- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4748—Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
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- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
- G01N33/6845—Methods of identifying protein-protein interactions in protein mixtures
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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- C—CHEMISTRY; METALLURGY
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2799/00—Uses of viruses
- C12N2799/02—Uses of viruses as vector
- C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
- C12N2799/026—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a baculovirus
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- C—CHEMISTRY; METALLURGY
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- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/136—Screening for pharmacological compounds
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/04—Endocrine or metabolic disorders
- G01N2800/042—Disorders of carbohydrate metabolism, e.g. diabetes, glucose metabolism
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/827—Proteins from mammals or birds
- Y10S530/828—Cancer
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/866—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof involving immunoglobulin or antibody fragment, e.g. fab', fab, fv, fc, heavy chain or light chain
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Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
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US10/028,072 US20030004311A1 (en) | 1997-06-18 | 2001-12-19 | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
US10/119,480 US20040087769A1 (en) | 1998-09-10 | 2002-04-09 | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
PCT/US2002/033050 WO2003053334A2 (en) | 2001-12-19 | 2002-10-16 | Compositions and methods for the diagnosis and treatment of tumor |
Publications (1)
Publication Number | Publication Date |
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DE60228997D1 true DE60228997D1 (de) | 2008-10-30 |
Family
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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DE60228997T Expired - Lifetime DE60228997D1 (de) | 2001-12-19 | 2002-10-16 | Zusammensetzungen und verfahren zur diagnose und behandlung eines tumors |
Country Status (5)
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US (468) | US20020137890A1 (de) |
KR (1) | KR20040074090A (de) |
AT (1) | ATE408419T1 (de) |
DE (1) | DE60228997D1 (de) |
ZA (1) | ZA200404849B (de) |
Families Citing this family (171)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6300487B1 (en) * | 1996-03-19 | 2001-10-09 | Cell Therapuetics, Inc. | Mammalian lysophosphatidic acid acyltransferase |
US20020137890A1 (en) * | 1997-03-31 | 2002-09-26 | Genentech, Inc. | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
US20060122373A1 (en) * | 1997-04-04 | 2006-06-08 | Millennium Pharmaceuticals, Inc. | Delta3, FTHMA-070, Tango85, Tango77, SPOIL,NEOKINE, Tango129 and integrin alpha subunit protein and nucleic acid molecules and uses thereof |
US20040141972A1 (en) | 1997-11-21 | 2004-07-22 | Genentech, Inc. | Compounds, compositions and methods for the treatment of diseases characterized by A-33 related antigens |
AU764441B2 (en) * | 1998-02-09 | 2003-08-21 | Genset S.A. | cDNAs encoding secreted proteins |
US20030175778A1 (en) * | 1998-06-05 | 2003-09-18 | Jian Ni | Interferon Receptor HKAEF92 |
US20030211578A1 (en) * | 1998-06-05 | 2003-11-13 | Jian Ni | Interferon receptor HKAEF92 |
US6699688B1 (en) * | 1998-09-16 | 2004-03-02 | The Research Foundation Of The State University Of New York | Human platelet F11 receptor |
WO2000018904A2 (en) * | 1998-09-30 | 2000-04-06 | Millennium Pharmaceuticals, Inc. | Secreted proteins and nucleic acids encoding them |
US7393823B1 (en) | 1999-01-20 | 2008-07-01 | Oregon Health And Science University | HER-2 binding antagonists |
US7396810B1 (en) * | 2000-08-14 | 2008-07-08 | Oregon Health Sciences University | Compositions and methods for treating cancer by modulating HER-2 and EGF receptors |
US7625859B1 (en) * | 2000-02-16 | 2009-12-01 | Oregon Health & Science University | HER-2 binding antagonists |
US7144996B1 (en) * | 1999-03-05 | 2006-12-05 | Genentech, Inc. | Nucleic acid encoding human suppressor of fused |
WO2000061610A2 (en) * | 1999-04-12 | 2000-10-19 | Agensys, Inc. | Prostate-restricted gene 30p3c8 expressed in prostate cancer |
US6468543B1 (en) | 1999-05-03 | 2002-10-22 | Zymogenetics, Inc. | Methods for promoting growth of bone using ZVEGF4 |
US6630142B2 (en) | 1999-05-03 | 2003-10-07 | Zymogenetics, Inc. | Method of treating fibroproliferative disorders |
AUPQ206399A0 (en) * | 1999-08-06 | 1999-08-26 | Imr Worldwide Pty Ltd. | Network user measurement system and method |
US7842458B2 (en) | 1999-08-12 | 2010-11-30 | Agensys, Inc. | Nucleic acids and corresponding proteins entitled 58P1D12 useful in treatment and detection of cancer |
IL147902A0 (en) | 1999-08-12 | 2002-08-14 | Agensys Inc | C-type lectin transmembrane antigen expressed in human prostate cancer and uses thereof |
US20030228288A1 (en) | 1999-10-15 | 2003-12-11 | Scarborough Nelson L. | Volume maintaining osteoinductive/osteoconductive compositions |
ATE478952T1 (de) * | 1999-10-28 | 2010-09-15 | Agensys Inc | 36p6d5: ausgeschiedenes tumorprotein |
US6639041B2 (en) * | 1999-12-03 | 2003-10-28 | Dupont-Toray Co. Ltd. | Spandex having low set at low temperatures |
US20010044525A1 (en) * | 2000-01-05 | 2001-11-22 | Conklin Darrell C. | Novel FGF Homolog zFGF12 |
US20060160181A1 (en) * | 2000-02-15 | 2006-07-20 | Amgen Inc. | Fibroblast Growth Factor-23 molecules and uses thereof |
US20040081961A1 (en) * | 2001-05-04 | 2004-04-29 | Delegeane Angelo M | Proteases |
CA2407746A1 (en) * | 2000-05-04 | 2001-11-08 | Incyte Genomics, Inc. | Proteases |
MXPA02012717A (es) * | 2000-06-21 | 2003-09-22 | Amgen Inc | Polipeptidos estromaticos-1 del colon, epiteliales, secretados, acidos nucleicos que los codifican y sus usos. |
US9387094B2 (en) | 2000-07-19 | 2016-07-12 | Warsaw Orthopedic, Inc. | Osteoimplant and method of making same |
US8044259B2 (en) | 2000-08-03 | 2011-10-25 | The Regents Of The University Of Michigan | Determining the capability of a test compound to affect solid tumor stem cells |
US6984522B2 (en) | 2000-08-03 | 2006-01-10 | Regents Of The University Of Michigan | Isolation and use of solid tumor stem cells |
EP1191097A1 (de) * | 2000-09-21 | 2002-03-27 | Leids Universitair Medisch Centrum | Induktion von "exon-skipping" in eukaryotischen Zellen |
US7323193B2 (en) | 2001-12-14 | 2008-01-29 | Osteotech, Inc. | Method of making demineralized bone particles |
CA2443123A1 (en) * | 2001-04-10 | 2002-10-24 | Agensys, Inc. | Nuleic acids and corresponding proteins useful in the detection and treatment of various cancers |
US7927597B2 (en) | 2001-04-10 | 2011-04-19 | Agensys, Inc. | Methods to inhibit cell growth |
JP2005505351A (ja) | 2001-10-12 | 2005-02-24 | オステオテック インコーポレーテッド | 改善された骨移植片 |
US20050123925A1 (en) | 2002-11-15 | 2005-06-09 | Genentech, Inc. | Compositions and methods for the diagnosis and treatment of tumor |
ATE384783T1 (de) * | 2001-10-19 | 2008-02-15 | Zymogenetics Inc | Dimerisierter wachstumsfaktor sowie materialien und verfahren zu seiner herstellung |
US7030018B2 (en) | 2002-02-04 | 2006-04-18 | Kla-Tencor Technologies Corp. | Methods and systems for monitoring a parameter of a measurement device during polishing, damage to a specimen during polishing, or a characteristic of a polishing pad or tool |
US7241593B2 (en) * | 2002-02-11 | 2007-07-10 | Zymogenetics, Inc. | Materials and methods for preparing dimeric growth factors |
US6993539B2 (en) | 2002-03-19 | 2006-01-31 | Network Appliance, Inc. | System and method for determining changes in two snapshots and for transmitting changes to destination snapshot |
EP1541677A4 (de) | 2002-07-10 | 2007-06-27 | Takeda Pharmaceutical | Neue proteine und verwendung davon |
US7126148B2 (en) * | 2002-07-17 | 2006-10-24 | The Johns Hopkins University | Neutron detection based on boron activated liquid scintillation |
DE10232329A1 (de) * | 2002-07-17 | 2004-02-05 | Daimlerchrysler Ag | Kraftwagenkarosserie mit einer Strebenanordnung |
AU2003279084A1 (en) * | 2002-09-25 | 2004-04-19 | Genentech, Inc. | Novel compositions and methods for the treatment of psoriasis |
US6890175B2 (en) * | 2002-12-18 | 2005-05-10 | Ultradent Products, Inc. | Cooling system for hand-held curing light |
JP2004267015A (ja) * | 2003-03-05 | 2004-09-30 | National Institute Of Advanced Industrial & Technology | 核酸及び該核酸を用いた癌化検定方法 |
RS54160B1 (sr) | 2003-03-19 | 2015-12-31 | Biogen Idec Ma Inc. | Protein koji se vezuje za nogo receptor |
WO2004083432A1 (en) | 2003-03-21 | 2004-09-30 | Academisch Ziekenhuis Leiden | Modulation of exon recognition in pre-mrna by interfering with the secondary rna structure |
CA2528086C (en) * | 2003-06-11 | 2013-01-08 | Osteotech, Inc. | Osteoimplants and methods for their manufacture |
JP4054727B2 (ja) * | 2003-07-14 | 2008-03-05 | 株式会社リコー | 出力バッファ回路及び出力バッファ回路を使用したインタフェース回路 |
US20070178458A1 (en) * | 2003-09-05 | 2007-08-02 | O'brien Philippa | Methods of diagnosis and prognosis of ovarian cancer II |
EP1560025A3 (de) * | 2003-10-03 | 2011-09-07 | F. Hoffmann-La Roche AG | Marker spezifisch für Diabetes |
EP1694864A2 (de) * | 2003-11-20 | 2006-08-30 | Genentech, Inc. | Zusammensetzungen und verfahren für die tumor-diagnose und behandlung |
WO2005075511A1 (en) * | 2004-01-29 | 2005-08-18 | Genentech, Inc. | Variants of the extracellular domain of bcma and uses thereof |
ATE549352T1 (de) * | 2004-02-20 | 2012-03-15 | Develogen Ag | Verwendung sekretierter proteinprodukte zur prävention und behandlung von erkrankungen der bauchspeicheldrüse und/oder adipositas und/oder des metabolischen syndroms |
DE102004010203B4 (de) * | 2004-03-02 | 2007-05-10 | Siemens Ag | Verfahren, Vorrichtung und Computerprogramm zur Erstellung einer Projektierung für ein Bediengerät einer Automatisierungskomponente |
WO2005089799A1 (ja) * | 2004-03-24 | 2005-09-29 | Oncotherapy Science, Inc. | Fam3dに対する抗体のエフェクター機能による細胞障害方法 |
US20050214303A1 (en) * | 2004-03-24 | 2005-09-29 | Oncotherapy Science, Inc. | Methods for damaging cells using effector functions of anti FAM3D antibodies |
US7659915B2 (en) * | 2004-04-02 | 2010-02-09 | K-Nfb Reading Technology, Inc. | Portable reading device with mode processing |
CA2563445C (en) | 2004-04-14 | 2016-07-19 | Genentech, Inc. | Compositions and methods for modulating vascular development |
US20080038730A1 (en) * | 2004-05-10 | 2008-02-14 | Heinz Von Der Kammer | Diagnostic and Therapeutic Use of Kcnj6 for Alzheimer's Disease |
EP1751188A1 (de) * | 2004-06-04 | 2007-02-14 | Applied Research Systems ARS Holding N.V. | Eine spleissvariante von unc5h2 |
KR101239542B1 (ko) | 2004-06-24 | 2013-03-07 | 바이오겐 아이덱 엠에이 인코포레이티드 | 탈수초화를 수반하는 병의 치료 |
WO2006005459A2 (en) * | 2004-07-15 | 2006-01-19 | Bayer Healthcare Ag | Diagnostics and therapeutics for diseases associated with thyrotropin-releasing hormone degrading ectoenzyme (trhde) |
KR101254815B1 (ko) * | 2004-07-20 | 2013-09-03 | 제넨테크, 인크. | 안지오포이에틴-유사 4 단백질의 저해제, 배합물, 그의용도 |
CN101080419B (zh) * | 2004-07-20 | 2014-07-02 | 健泰科生物技术公司 | 利用血管生成素样4蛋白的组合物和方法 |
US8604185B2 (en) | 2004-07-20 | 2013-12-10 | Genentech, Inc. | Inhibitors of angiopoietin-like 4 protein, combinations, and their use |
EP2311953A1 (de) * | 2004-08-04 | 2011-04-20 | Riken | Knochen-/Gelenkerkrankungsempfänglichkeitsgen und Verwendung davon |
EP1778284B1 (de) * | 2004-08-16 | 2012-04-25 | Agensys, Inc. | Nukleinsäuren und entsprechende proteine 58p1d12 zum nachweis von krebs |
EP1807106A2 (de) * | 2004-10-05 | 2007-07-18 | Oregon Health and Science University | Zusammensetzungen und verfahren zur behandlung von erkrankungen |
US7938307B2 (en) * | 2004-10-18 | 2011-05-10 | Tyco Healthcare Group Lp | Support structures and methods of using the same |
US20060155862A1 (en) * | 2005-01-06 | 2006-07-13 | Hari Kathi | Data traffic load balancing based on application layer messages |
WO2006076712A2 (en) * | 2005-01-14 | 2006-07-20 | Osteotech, Inc. | Expandable osteoimplant |
CA2593351A1 (en) * | 2005-01-27 | 2006-08-03 | Genentech, Inc. | Compositions and methods for the diagnosis and treatment of tumor |
EP1882712B1 (de) | 2005-04-22 | 2010-04-21 | Mitsubishi Chemical Corporation | Aus biomasseressourcen gewonnener polyester und herstellungsverfahren dafür |
EP1885872A4 (de) * | 2005-04-25 | 2009-03-25 | Univ Yamanashi | Zusammensetzungen und verfahren zur behandlung von mit clec-2-signaltransduktion assoziierten hämostasestörungen |
RS53058B (en) | 2005-07-08 | 2014-04-30 | Biogen Idec Ma Inc. | SP35 ANTIBODIES AND THEIR APPLICATIONS |
EP1922410A2 (de) * | 2005-08-15 | 2008-05-21 | Genentech, Inc. | Genunterbrechungen, zusammensetzungen und verfahren in verbindung damit |
ZA200800969B (en) * | 2005-08-16 | 2009-08-26 | Genentech Inc | Apoptosis sensitivity to APO2L/TRAIL by testing for GalNac-T14 expression in cells/tissues |
JP2007063225A (ja) | 2005-09-01 | 2007-03-15 | Takeda Chem Ind Ltd | イミダゾピリジン化合物 |
DE602006015985D1 (de) | 2005-09-30 | 2010-09-16 | Philadelphia Health & Educatio | Antigene gegen das leberstadium von plasmodium |
ES2547421T3 (es) | 2005-10-31 | 2015-10-06 | Oncomed Pharmaceuticals, Inc. | Composiciones y métodos para diagnosticar y tratar el cáncer |
US7723477B2 (en) | 2005-10-31 | 2010-05-25 | Oncomed Pharmaceuticals, Inc. | Compositions and methods for inhibiting Wnt-dependent solid tumor cell growth |
WO2007056671A1 (en) * | 2005-11-02 | 2007-05-18 | Osteotech, Inc. | Hemostatic bone graft |
US7293487B2 (en) * | 2005-11-15 | 2007-11-13 | 3M Innovative Properties Company | Cutting tool having variable and independent movement in an x-direction and a z-direction into and laterally along a work piece for making microstructures |
JP2009515997A (ja) * | 2005-11-18 | 2009-04-16 | タケダ サン ディエゴ インコーポレイテッド | グルコキナーゼ活性剤 |
WO2007084487A2 (en) * | 2006-01-13 | 2007-07-26 | Wayne State University | Pericytes for use as stem cells |
JP5302012B2 (ja) | 2006-03-08 | 2013-10-02 | タケダ カリフォルニア インコーポレイテッド | グルコキナーゼ活性剤 |
WO2007123391A1 (en) * | 2006-04-20 | 2007-11-01 | Academisch Ziekenhuis Leiden | Therapeutic intervention in a genetic disease in an individual by modifying expression of an aberrantly expressed gene. |
EP1857548A1 (de) * | 2006-05-19 | 2007-11-21 | Academisch Ziekenhuis Leiden | Mittel und Verfahren zur Induktion von Exon-skipping |
WO2007143434A2 (en) | 2006-05-31 | 2007-12-13 | Takeda San Diego, Inc. | Indazole and isoindole derivatives as glucokinase activating agents |
CA2660523C (en) | 2006-08-11 | 2019-03-19 | Prosensa Technologies B.V. | Methods and means for treating dna repeat instability associated genetic disorders |
EA018260B1 (ru) * | 2006-09-29 | 2013-06-28 | Онкомед Фармасьютикалз, Инк. | Антитела к дельта-подобному лиганду 4 человека и их применение |
US7875747B2 (en) * | 2006-10-10 | 2011-01-25 | Afton Chemical Corporation | Branched succinimide dispersant compounds and methods of making the compounds |
CA2666498A1 (en) * | 2006-10-20 | 2008-10-23 | Schrader Electronics Ltd. | Method for detecting and correcting data errors in an rf data link |
CA2663523A1 (en) * | 2006-11-14 | 2008-10-23 | Genentech, Inc. | Novel gene disruptions, compositions and methods relating thereto |
US8163779B2 (en) | 2006-12-20 | 2012-04-24 | Takeda San Diego, Inc. | Glucokinase activators |
US7980000B2 (en) | 2006-12-29 | 2011-07-19 | Applied Materials, Inc. | Vapor dryer having hydrophilic end effector |
US8128926B2 (en) | 2007-01-09 | 2012-03-06 | Biogen Idec Ma Inc. | Sp35 antibodies and uses thereof |
EP2106439B1 (de) | 2007-01-24 | 2014-11-12 | The Regents of the University of Michigan | Zusammensetzungen und verfahren zur behandlung und diagnostizierung von pankreaskrebs |
EP1961849A1 (de) * | 2007-02-22 | 2008-08-27 | ALBIS Spa | Vorverfestigte Spinnvliesbahn, Verbundvlies mit vorverfestigter Spinnvliesbahn, Verfahren und kontinuierliches System zur Herstellung dieses Verbundstoffes |
GB0704396D0 (en) * | 2007-03-07 | 2007-04-11 | Royal Bank Of Scotland Plc The | Cash dispensing methods and systems |
US8173645B2 (en) | 2007-03-21 | 2012-05-08 | Takeda San Diego, Inc. | Glucokinase activators |
US20080240081A1 (en) * | 2007-03-30 | 2008-10-02 | Texas Instruments Incorporated | Method, system and apparatus for providing rules-based restriction of incoming calls |
US7705085B2 (en) * | 2007-04-06 | 2010-04-27 | 3M Innovative Properties Company | Fluoroelastomer composition for cold shrink articles |
EP2167135A2 (de) * | 2007-07-12 | 2010-03-31 | Prosensa Technologies B.V. | Moleküle für targeting von verbindungen auf verschiedene ausgewählte organe, gewebe oder tumorzellen |
CA2693048C (en) * | 2007-07-12 | 2016-10-18 | Prosensa Technologies B.V. | Molecules for targeting compounds to various selected organs or tissues |
US8103302B2 (en) * | 2007-09-11 | 2012-01-24 | Telefonaktiebolaget Lm Ericsson (Publ) | Power-aware link adaptation with variable bandwidth allocation |
WO2009046123A2 (en) * | 2007-10-02 | 2009-04-09 | Genentech, Inc. | Nlrr-1 antagonists and uses thereof |
US20110020786A1 (en) * | 2007-10-08 | 2011-01-27 | Baylor College Of Medicine | Peptide dendrimers: affinity reagents for binding noroviruses |
CN101980603A (zh) * | 2007-10-11 | 2011-02-23 | 比奥根艾迪克Ma公司 | LINGO-1和TrkB拮抗剂的用途 |
HUE028662T2 (en) | 2007-10-26 | 2016-12-28 | Academisch Ziekenhuis Leiden | Preparations and methods for controlling muscle disorders |
USRE48468E1 (en) | 2007-10-26 | 2021-03-16 | Biomarin Technologies B.V. | Means and methods for counteracting muscle disorders |
AU2008325107B2 (en) * | 2007-11-08 | 2015-04-23 | Biogen Ma Inc. | Use of LINGO-4 antagonists in the treatment of conditions involving demyelination |
WO2009099326A1 (en) * | 2008-02-08 | 2009-08-13 | Prosensa Holding Bv | Methods and means for treating dna repeat instability associated genetic disorders |
EP2119783A1 (de) | 2008-05-14 | 2009-11-18 | Prosensa Technologies B.V. | Verfahren für effizientes Exon (44)-Skipping bei Duchenne-Muskeldystrophie und entsprechende Mittel |
DK2982695T3 (da) * | 2008-07-09 | 2019-05-13 | Biogen Ma Inc | Sammensætninger, der omfatter antistoffer mod lingo eller fragmenter deraf |
US20100047166A1 (en) * | 2008-08-20 | 2010-02-25 | Kanner Steven B | Antibodies and related molecules that bind to 58p1d12 proteins |
EP2326669A2 (de) * | 2008-09-04 | 2011-06-01 | Oxford Biotherapeutics Ltd. | Pta072-protein |
NZ592338A (en) | 2008-09-26 | 2012-11-30 | Oncomed Pharm Inc | Frizzled-binding agents and uses thereof |
AU2009308191A1 (en) | 2008-10-24 | 2010-04-29 | Warsaw Orthopedic, Inc. | Compositions and methods for promoting bone formation |
JP2010225758A (ja) * | 2009-03-23 | 2010-10-07 | Fuji Xerox Co Ltd | 有機半導体トランジスタ |
WO2010123369A1 (en) | 2009-04-24 | 2010-10-28 | Prosensa Technologies B.V. | Oligonucleotide comprising an inosine for treating dmd |
PE20120902A1 (es) | 2009-05-08 | 2012-08-08 | Genentech Inc | Anticuerpos anti-egfl7 humanizados |
JP2012526563A (ja) * | 2009-05-15 | 2012-11-01 | インサイト ジェネティクス インコーポレイテッド | 癌を診断および治療するためのalkの融合に関する方法および組成物 |
KR101640633B1 (ko) | 2009-08-28 | 2016-07-18 | 솔레니스 테크놀러지스 케이맨, 엘.피. | 안정적인 산 변성된 대두/우레아 접착제 및 그의 제조 방법 |
ES2567030T3 (es) | 2009-09-03 | 2016-04-19 | Cancer Research Technology Limited | Inhibidores de CLEC14A |
US20110086806A1 (en) * | 2009-10-09 | 2011-04-14 | Anaphore, Inc. | Polypeptides that Bind IL-23R |
JP5965318B2 (ja) | 2009-10-16 | 2016-08-03 | オンコメッド ファーマシューティカルズ インコーポレイテッド | Dll4アンタゴニストおよび降圧剤の治療的併用およびそれらによる治療の方法 |
EP2494351B1 (de) | 2009-10-26 | 2016-06-08 | Externautics S.p.A. | Kolon- und rektaltumormarker sowie verfahren zu ihrer verwendung |
EP3345920A1 (de) | 2009-10-26 | 2018-07-11 | Externautics S.p.A. | Brustkrebsmarker und verfahren zur verwendung davon |
EP2493916B1 (de) | 2009-10-26 | 2016-06-08 | Externautics S.p.A. | Marker für lungentumore und deren verwendung |
US9134323B2 (en) | 2009-12-01 | 2015-09-15 | The Rockefeller University | Antibody that specifically binds to an epitope in the tureet region of a human Kir channel |
EP2506875A4 (de) * | 2009-12-01 | 2013-11-27 | Oncomed Pharm Inc | Verfahren zur behandlung von tumoren mit k-ras-mutationen |
GB0922085D0 (en) * | 2009-12-17 | 2010-02-03 | Cambridge Entpr Ltd | Cancer diagnosis and treatment |
WO2011078672A1 (en) | 2009-12-24 | 2011-06-30 | Prosensa Technologies B.V. | Molecule for treating an inflammatory disorder |
TWI535445B (zh) | 2010-01-12 | 2016-06-01 | 安可美德藥物股份有限公司 | Wnt拮抗劑及治療和篩選方法 |
AU2011235904B2 (en) | 2010-04-01 | 2015-10-08 | Oncomed Pharmaceuticals, Inc. | Frizzled-binding agents and uses thereof |
MX2012011688A (es) * | 2010-04-09 | 2012-11-23 | Amgen Inc | Proteinas btnl9, acidos nucleicos y anticuerpos y usos de los mismos. |
US9139629B2 (en) | 2010-06-05 | 2015-09-22 | The Uab Research Foundation | Methods for treatment of nephrotic syndrome and related conditions |
US20110301103A1 (en) | 2010-06-05 | 2011-12-08 | Chugh Sumant S | Methods of Treatment |
US8551479B2 (en) | 2010-09-10 | 2013-10-08 | Oncomed Pharmaceuticals, Inc. | Methods for treating melanoma |
CN102569428B (zh) * | 2010-12-21 | 2015-06-03 | 上海华虹宏力半导体制造有限公司 | 纵向电压控制变容器及其制备方法 |
HRP20230078T1 (hr) | 2011-09-23 | 2023-05-12 | Mereo Biopharma 5, Inc. | Sredstva za vezivanje vegf/dll4 i njihova uporaba |
WO2013059426A1 (en) * | 2011-10-21 | 2013-04-25 | The Regents Of The University Of California | Human endogenous retrovirus peptides, antibodies to the peptides, and methods of use thereof |
US9443007B2 (en) | 2011-11-02 | 2016-09-13 | Salesforce.Com, Inc. | Tools and techniques for extracting knowledge from unstructured data retrieved from personal data sources |
ITUD20110196A1 (it) * | 2011-12-02 | 2013-06-03 | Asoltech S R L | Composizione a base di ubidecarenone |
CA2862628C (en) | 2012-01-27 | 2021-08-24 | Prosensa Technologies B.V. | Rna modulating oligonucleotides with improved characteristics for the treatment of duchenne and becker muscular dystrophy |
NZ702178A (en) | 2012-05-14 | 2017-01-27 | Biogen Ma Inc | Lingo-2 antagonists for treatment of conditions involving motor neurons |
US20140035949A1 (en) * | 2012-08-03 | 2014-02-06 | Tempo Ai, Inc. | Method and apparatus for enhancing a calendar view on a device |
US9266959B2 (en) | 2012-10-23 | 2016-02-23 | Oncomed Pharmaceuticals, Inc. | Methods of treating neuroendocrine tumors using frizzled-binding agents |
CA2889638A1 (en) | 2012-10-31 | 2014-05-08 | Oncomed Pharmaceuticals, Inc. | Methods and monitoring of treatment with a dll4 antagonist |
US9359444B2 (en) | 2013-02-04 | 2016-06-07 | Oncomed Pharmaceuticals Inc. | Methods and monitoring of treatment with a Wnt pathway inhibitor |
US9168300B2 (en) | 2013-03-14 | 2015-10-27 | Oncomed Pharmaceuticals, Inc. | MET-binding agents and uses thereof |
EP2970484B2 (de) | 2013-03-15 | 2022-09-21 | Amgen Inc. | Heterodimere bispezifische antikörper |
EP3733710A1 (de) | 2013-09-25 | 2020-11-04 | Amgen, Inc | Heterodimeriche v-c-fc-v-c-antikörper |
US10367649B2 (en) | 2013-11-13 | 2019-07-30 | Salesforce.Com, Inc. | Smart scheduling and reporting for teams |
WO2016046778A2 (en) | 2014-09-25 | 2016-03-31 | Amgen Inc | Protease-activatable bispecific proteins |
US20160176962A1 (en) | 2014-10-31 | 2016-06-23 | Oncomed Pharmaceuticals, Inc. | Combination Therapy For Treatment Of Disease |
AU2016205197B2 (en) | 2015-01-08 | 2021-10-21 | Biogen Ma Inc. | LINGO-1 antagonists and uses for treatment of demyelinating disorders |
PL3347376T3 (pl) | 2015-09-07 | 2021-12-06 | Heiko LICKERT | Nowy receptor IGFR-podobny i jego zastosowania |
ES2968074T3 (es) | 2015-09-23 | 2024-05-07 | Mereo Biopharma 5 Inc | Anticuerpo bi-específico anti-VEGF/DLL4 para su uso en el tratamiento del cáncer de ovario resistente al platino |
US20180061660A1 (en) * | 2016-08-26 | 2018-03-01 | Infineon Technologies Ag | Barrier Layer Formation Using Thermal Processing |
WO2018075621A1 (en) * | 2016-10-19 | 2018-04-26 | Vanderbilt University | Human orthopoxvirus antibodies and methods of use therefor |
US11634486B2 (en) | 2016-12-23 | 2023-04-25 | Bluefin Biomedicine, Inc. | Anti-SEZ6L2 antibodies and antibody drug conjugates |
US20180196053A1 (en) * | 2017-01-10 | 2018-07-12 | Chang Gung Memorial Hospital, Linkou | Methods and kits for detecting cancer |
US11043305B1 (en) * | 2018-02-02 | 2021-06-22 | Immuneering Corporation | Systems and methods for rapid gene set enrichment analysis |
AU2019369498A1 (en) * | 2018-10-31 | 2021-05-20 | Delinia, Inc. | Multivalent regulatory T cell modulators |
MX2021015045A (es) | 2019-06-07 | 2022-03-17 | Amgen Inc | Construcciones de unión biespecíficas. |
US20230203198A1 (en) | 2020-06-04 | 2023-06-29 | Amgen Inc. | Bispecific binding constructs |
CN116783217A (zh) | 2020-12-03 | 2023-09-19 | 安进公司 | 具有多个结合结构域的免疫球蛋白构建体 |
Family Cites Families (363)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US553637A (en) * | 1896-01-28 | bagnall | ||
US2929866A (en) * | 1953-10-30 | 1960-03-22 | Westinghouse Electric Corp | Television pickup tube |
GB937358A (en) * | 1961-11-13 | 1963-09-18 | Marconi Wireless Telegraph Co | Improvements in or relating to television scanning systems |
JPS4844279B1 (de) * | 1965-05-08 | 1973-12-24 | ||
US3515800A (en) * | 1966-05-10 | 1970-06-02 | Victor Company Of Japan | Television camera for selectively picking up scenes in color or monochromatically |
US3654090A (en) * | 1968-09-24 | 1972-04-04 | Organon | Method for the determination of antigens and antibodies |
US3783190A (en) * | 1971-04-08 | 1974-01-01 | Gte Sylvania Inc | Aperture correction circuit for low light level television camera |
JPS5110986B2 (de) * | 1972-10-05 | 1976-04-08 | ||
GB1415827A (en) * | 1973-03-31 | 1975-11-26 | Schumacher Klimsch Co E | Photomechanical reproduction |
US4256833A (en) * | 1979-01-08 | 1981-03-17 | Majid Ali | Enzyme immunoassay for allergic disorders |
JPS57108866A (en) * | 1980-12-26 | 1982-07-07 | Fuji Xerox Co Ltd | Dichromatic copying machine |
US4554101A (en) * | 1981-01-09 | 1985-11-19 | New York Blood Center, Inc. | Identification and preparation of epitopes on antigens and allergens on the basis of hydrophilicity |
US4433346A (en) * | 1982-03-31 | 1984-02-21 | Xerox Corporation | Raster input scanner |
US4491865A (en) * | 1982-09-29 | 1985-01-01 | Welch Allyn, Inc. | Image sensor assembly |
US4516153A (en) * | 1983-03-30 | 1985-05-07 | Rca Corporation | Composite video signal processing apparatus providing amplitude equalization |
US4816567A (en) * | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
DE3429548A1 (de) * | 1983-08-24 | 1985-05-15 | Kabushiki Kaisha Toshiba, Kawasaki, Kanagawa | Farbsteuereinheit fuer ein bilderzeugungsgeraet |
KR850004274A (ko) * | 1983-12-13 | 1985-07-11 | 원본미기재 | 에리트로포이에틴의 제조방법 |
US4608606A (en) * | 1984-03-15 | 1986-08-26 | Rca Corporation | CCD floating-element output stages providing low reset noise with single sampling |
US4658956A (en) * | 1984-05-30 | 1987-04-21 | El Planning System Ltd. | Portable case for a small size audio-visual sensory apparatus |
JPS612957A (ja) * | 1984-06-18 | 1986-01-08 | Toyota Motor Corp | 無段変速機付き動力伝達装置の油圧制御装置 |
JPS6147919A (ja) * | 1984-08-15 | 1986-03-08 | Olympus Optical Co Ltd | 内視鏡用撮像光学系 |
JPS6142513U (ja) * | 1984-08-23 | 1986-03-19 | 富士写真光機株式会社 | 内視鏡 |
US4599116A (en) * | 1984-11-08 | 1986-07-08 | Parker Chemical Company | Alkaline cleaning process |
US4879224A (en) * | 1985-01-10 | 1989-11-07 | Biogen, Inc. | DNA sequences, recombinant DNA molecules and processes for producing human phospholipase inhibitor polypeptides |
WO1987001246A1 (en) * | 1985-08-13 | 1987-02-26 | Robert Joseph Mears | Fibre-optic lasers and amplifiers |
JPH0522897Y2 (de) * | 1985-08-16 | 1993-06-11 | ||
JP2679014B2 (ja) * | 1986-03-19 | 1997-11-19 | オリンパス光学工業株式会社 | 電子内視鏡装置 |
JPS6365840A (ja) * | 1986-04-04 | 1988-03-24 | オリンパス光学工業株式会社 | 内視鏡 |
US4735501A (en) * | 1986-04-21 | 1988-04-05 | Identechs Corporation | Method and apparatus for fluid propelled borescopes |
JPH0664243B2 (ja) * | 1986-04-30 | 1994-08-22 | オリンパス光学工業株式会社 | 内視鏡 |
DE3715417A1 (de) * | 1986-05-13 | 1987-11-19 | Olympus Optical Co | Halbleiter-bilderzeugungsvorrichtung, sowie hiermit ausgestattetes endoskop |
JPS635722A (ja) * | 1986-06-25 | 1988-01-11 | オリンパス光学工業株式会社 | 内視鏡 |
JP2812940B2 (ja) * | 1986-09-01 | 1998-10-22 | オリンパス光学工業株式会社 | 内視鏡 |
US4946778A (en) * | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
US5013652A (en) * | 1986-10-14 | 1991-05-07 | Genex Corporation | Composite yeast vectors |
US4733937A (en) * | 1986-10-17 | 1988-03-29 | Welch Allyn, Inc. | Illuminating system for endoscope or borescope |
US4758891A (en) * | 1986-10-20 | 1988-07-19 | North American Philips Consumer Electronics Corp. | Method and apparatus for improving the rise and fall time of a video signal |
US4895431A (en) * | 1986-11-13 | 1990-01-23 | Olympus Optical Co., Ltd. | Method of processing endoscopic images |
US5011912A (en) * | 1986-12-19 | 1991-04-30 | Immunex Corporation | Hybridoma and monoclonal antibody for use in an immunoaffinity purification system |
US4727859A (en) * | 1986-12-29 | 1988-03-01 | Welch Allyn, Inc. | Right angle detachable prism assembly for borescope |
US4918521A (en) * | 1987-01-20 | 1990-04-17 | Olympus Optical Co., Ltd. | Solid state imaging apparatus |
JPS63316476A (ja) * | 1987-06-18 | 1988-12-23 | Seiko Instr & Electronics Ltd | 半導体装置およびその製造方法 |
US4796607A (en) * | 1987-07-28 | 1989-01-10 | Welch Allyn, Inc. | Endoscope steering section |
US4794912A (en) * | 1987-08-17 | 1989-01-03 | Welch Allyn, Inc. | Borescope or endoscope with fluid dynamic muscle |
US4786609A (en) * | 1987-10-05 | 1988-11-22 | North American Philips Corporation, Signetics Division | Method of fabricating field-effect transistor utilizing improved gate sidewall spacers |
US5021888A (en) * | 1987-12-18 | 1991-06-04 | Kabushiki Kaisha Toshiba | Miniaturized solid state imaging device |
JP2594627B2 (ja) * | 1988-02-26 | 1997-03-26 | オリンパス光学工業株式会社 | 電子内視鏡装置 |
US5583103A (en) * | 1988-06-28 | 1996-12-10 | La Jolla Cancer Research Foundation | Inhibition of transforming growth factor beta activity |
US5654270A (en) * | 1988-06-28 | 1997-08-05 | La Jolla Cancer Research Foundation | Use of fibromodulin to prevent or reduce dermal scarring |
US4862253A (en) * | 1988-07-20 | 1989-08-29 | Welch Allyn, Inc. | Apparatus for converting a video processor |
US5089473A (en) * | 1988-08-29 | 1992-02-18 | Monsanto Company | Somatotropin variants and their use |
US4909600A (en) * | 1988-10-28 | 1990-03-20 | Welch Allyn, Inc. | Light chopper assembly |
US5530101A (en) * | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
US5968778A (en) * | 1989-01-12 | 1999-10-19 | Jurgen Hoppe | PDGF-AB, preparation process and pharmaceuticals containing them |
JP2751320B2 (ja) * | 1989-02-21 | 1998-05-18 | 日本電気株式会社 | エミッタホロワ回路 |
US5116964A (en) * | 1989-02-23 | 1992-05-26 | Genentech, Inc. | Hybrid immunoglobulins |
US4993405A (en) * | 1989-05-15 | 1991-02-19 | Olympus Optical Co., Ltd. | Imaging apparatus |
US5014515A (en) * | 1989-05-30 | 1991-05-14 | Welch Allyn, Inc. | Hydraulic muscle pump |
US4913369A (en) * | 1989-06-02 | 1990-04-03 | Welch Allyn, Inc. | Reel for borescope insertion tube |
JPH0323832A (ja) * | 1989-06-22 | 1991-01-31 | Toshiba Corp | 電子内視鏡装置 |
US5194596A (en) * | 1989-07-27 | 1993-03-16 | California Biotechnology Inc. | Production of vascular endothelial cell growth factor |
US5395760A (en) * | 1989-09-05 | 1995-03-07 | Immunex Corporation | DNA encoding tumor necrosis factor-α and -β receptors |
US4941454A (en) * | 1989-10-05 | 1990-07-17 | Welch Allyn, Inc. | Servo actuated steering mechanism for borescope or endoscope |
US4941456A (en) * | 1989-10-05 | 1990-07-17 | Welch Allyn, Inc. | Portable color imager borescope |
FR2654258A1 (fr) * | 1989-11-03 | 1991-05-10 | Philips Nv | Procede pour fabriquer un dispositif a transistor mis ayant une electrode de grille en forme de "t" inverse. |
JP2579372B2 (ja) * | 1989-12-04 | 1997-02-05 | 日本テキサス・インスツルメンツ株式会社 | 低消費電力撮像装置 |
US4971655A (en) * | 1989-12-26 | 1990-11-20 | Micron Technology, Inc. | Protection of a refractory metal silicide during high-temperature processing using a dual-layer cap of silicon dioxide and silicon nitride |
WO1991010727A1 (en) | 1990-01-22 | 1991-07-25 | La Jolla Cancer Research Foundation | Inhibitors of cell regulatory factors |
US5014600A (en) * | 1990-02-06 | 1991-05-14 | Welch Allyn, Inc. | Bistep terminator for hydraulic or pneumatic muscle |
US4998182A (en) * | 1990-02-08 | 1991-03-05 | Welch Allyn, Inc. | Connector for optical sensor |
US4981810A (en) * | 1990-02-16 | 1991-01-01 | Micron Technology, Inc. | Process for creating field effect transistors having reduced-slope, staircase-profile sidewall spacers |
US5536638A (en) * | 1990-04-18 | 1996-07-16 | N.V. Innogenetics S.A. | Hybridization probes derived from the spacer region between the 16S and 23S rRNA genes for the detection of Neisseria gonorrhoeae |
US5126283A (en) * | 1990-05-21 | 1992-06-30 | Motorola, Inc. | Process for the selective encapsulation of an electrically conductive structure in a semiconductor device |
US5019121A (en) * | 1990-05-25 | 1991-05-28 | Welch Allyn, Inc. | Helical fluid-actuated torsional motor |
US4989581A (en) * | 1990-06-01 | 1991-02-05 | Welch Allyn, Inc. | Torsional strain relief for borescope |
US5018506A (en) * | 1990-06-18 | 1991-05-28 | Welch Allyn, Inc. | Fluid controlled biased bending neck |
US5203319A (en) * | 1990-06-18 | 1993-04-20 | Welch Allyn, Inc. | Fluid controlled biased bending neck |
JPH0456341A (ja) * | 1990-06-26 | 1992-02-24 | Matsushita Electric Ind Co Ltd | 半導体集積回路のレイアウト方法 |
US5306655A (en) * | 1990-07-24 | 1994-04-26 | Matsushita Electric Industrial Co., Ltd. | Structure and method of manufacture for MOS field effect transistor having lightly doped drain and source diffusion regions |
US5114636A (en) * | 1990-07-31 | 1992-05-19 | Welch Allyn, Inc. | Process for reducing the internal cross section of elastomeric tubing |
US5018436A (en) * | 1990-07-31 | 1991-05-28 | Welch Allyn, Inc. | Folded bladder for fluid dynamic muscle |
JP3216650B2 (ja) * | 1990-08-27 | 2001-10-09 | オリンパス光学工業株式会社 | 固体撮像装置 |
JPH0817235B2 (ja) * | 1990-08-29 | 1996-02-21 | 株式会社東芝 | オフセットゲート構造トランジスタおよびその製造方法 |
US5418566A (en) * | 1990-09-10 | 1995-05-23 | Kabushiki Kaisha Toshiba | Compact imaging apparatus for electronic endoscope with improved optical characteristics |
DE4037837A1 (de) * | 1990-11-28 | 1992-06-04 | Behringwerke Ag | Zellfreie rezeptorbindungsteste, ihre herstellung und verwendung |
WO1992010518A1 (en) | 1990-12-07 | 1992-06-25 | Yale University | Purified slit protein and sequence elements thereof |
EP0490535B1 (de) * | 1990-12-07 | 1996-08-21 | AT&T Corp. | Feldeffekttransistor mit inverser T-förmiger Silizid-Torelektrode |
US5291151A (en) * | 1991-01-19 | 1994-03-01 | Canon Kabushiki Kaisha | Sensor amplifier |
US5994088A (en) * | 1991-03-08 | 1999-11-30 | Board Of Trustees Of The University Of Illinois | Methods and reagents for preparing and using immunological agents specific for P-glycoprotein |
JP3078085B2 (ja) * | 1991-03-26 | 2000-08-21 | オリンパス光学工業株式会社 | 画像処理装置および画像処理方法 |
JPH0595900A (ja) * | 1991-04-11 | 1993-04-20 | Olympus Optical Co Ltd | 内視鏡画像処理装置 |
US5417210A (en) * | 1992-05-27 | 1995-05-23 | International Business Machines Corporation | System and method for augmentation of endoscopic surgery |
KR940006702B1 (ko) * | 1991-06-14 | 1994-07-25 | 금성일렉트론 주식회사 | 모스패트의 제조방법 |
US5191879A (en) * | 1991-07-24 | 1993-03-09 | Welch Allyn, Inc. | Variable focus camera for borescope or endoscope |
KR960000225B1 (ko) * | 1991-08-26 | 1996-01-03 | 가부시키가이샤 한도오따이 에네루기 겐큐쇼 | 절연게이트형 반도체장치의 제작방법 |
US5314834A (en) * | 1991-08-26 | 1994-05-24 | Motorola, Inc. | Field effect transistor having a gate dielectric with variable thickness |
US5445940A (en) * | 1991-08-28 | 1995-08-29 | Brigham & Women's Hospital | Methods and compositions for detecting and treating a subset of human patients having an autoimmune disease |
US5202758A (en) * | 1991-09-16 | 1993-04-13 | Welch Allyn, Inc. | Fluorescent penetrant measurement borescope |
US5565332A (en) * | 1991-09-23 | 1996-10-15 | Medical Research Council | Production of chimeric antibodies - a combinatorial approach |
JP3067347B2 (ja) * | 1991-10-30 | 2000-07-17 | 株式会社島津製作所 | ゲル状ビーズの選別装置 |
US5187759A (en) * | 1991-11-07 | 1993-02-16 | At&T Bell Laboratories | High gain multi-mode optical amplifier |
US5932211A (en) * | 1991-11-12 | 1999-08-03 | Women's And Children's Hospital | Glycosylation variants of iduronate 2-sulfatase |
US5817310A (en) * | 1991-12-02 | 1998-10-06 | Cor Therapeutics, Inc. | Inhibitory immunoglobulin polypeptides to human PDGF beta receptor |
US5614943A (en) * | 1991-12-19 | 1997-03-25 | Olympus Optical Co., Ltd. | Dissimilar endoscopes usable with a common control unit |
US5278642A (en) * | 1992-02-26 | 1994-01-11 | Welch Allyn, Inc. | Color imaging system |
US5441883A (en) * | 1992-03-03 | 1995-08-15 | State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education On Behalf Of The Oregon Health Sciences University | A3 adenosine receptor, DNA, and uses |
GB2264948B (en) * | 1992-03-13 | 1996-10-16 | Merck & Co Inc | Human adenosine receptors |
US5569662A (en) | 1992-03-23 | 1996-10-29 | Pfizer Inc. | Quinuclidine derivatives as substance P antagonists |
DE4211547C2 (de) * | 1992-04-06 | 1994-08-11 | Henke Sass Wolf Gmbh | Schutzabdeckung für das distale Ende von Endoskopen |
US5306951A (en) * | 1992-05-14 | 1994-04-26 | Micron Technology, Inc. | Sidewall silicidation for improved reliability and conductivity |
US5762959A (en) * | 1992-05-29 | 1998-06-09 | Vivorx, Inc. | Microencapsulation of cells |
US5429821A (en) * | 1992-05-29 | 1995-07-04 | The Regents Of The University Of California | Non-fibrogenic high mannuronate alginate coated transplants, processes for their manufacture, and methods for their use |
AU681855B2 (en) | 1992-06-22 | 1997-09-11 | Matritech, Inc. | Novel malignant cell type markers of the interior nuclear matrix |
US5874082A (en) * | 1992-07-09 | 1999-02-23 | Chiron Corporation | Humanized anti-CD40 monoclonal antibodies and fragments capable of blocking B cell proliferation |
GB9214857D0 (en) * | 1992-07-13 | 1992-08-26 | Medical Res Council | Human nucleic acid fragments and their use |
US5275152A (en) * | 1992-07-27 | 1994-01-04 | Welch Allyn, Inc. | Insertion tube terminator |
DE69332485T2 (de) * | 1992-08-11 | 2003-11-13 | Harvard College | Immunmodulierende peptide |
US5480805A (en) * | 1992-08-12 | 1996-01-02 | Amoco Corporation | Composition for modulating sterols in yeast |
US5322807A (en) * | 1992-08-19 | 1994-06-21 | At&T Bell Laboratories | Method of making thin film transistors including recrystallization and high pressure oxidation |
JP3472587B2 (ja) * | 1992-08-28 | 2003-12-02 | アベンティス ファーマ株式会社 | 骨関連カルボキシペプチダーゼ様タンパク質およびその製造法 |
JPH06121678A (ja) * | 1992-08-28 | 1994-05-06 | Hoechst Japan Ltd | 骨関連サルファターゼ様タンパク質およびその製造法 |
US5262352A (en) * | 1992-08-31 | 1993-11-16 | Motorola, Inc. | Method for forming an interconnection structure for conductive layers |
EP0672131B1 (de) * | 1992-10-30 | 2003-12-17 | The General Hospital Corporation | Ein neues zellzyklus kontrollprotein |
KR970011744B1 (ko) * | 1992-11-04 | 1997-07-15 | 마쯔시다덴기산교 가부시기가이샤 | 상보형 반도체장치 및 그 제조방법 |
KR950011983B1 (ko) * | 1992-11-23 | 1995-10-13 | 삼성전자주식회사 | 반도체 장치의 제조방법 |
US5371026A (en) * | 1992-11-30 | 1994-12-06 | Motorola Inc. | Method for fabricating paired MOS transistors having a current-gain differential |
US5314070A (en) * | 1992-12-16 | 1994-05-24 | Welch Allyn, Inc. | Case for flexible borescope and endoscope insertion tubes |
JP3220538B2 (ja) * | 1992-12-24 | 2001-10-22 | オリンパス光学工業株式会社 | 立体視内視鏡及び立体視内視鏡装置 |
US5798224A (en) * | 1992-12-29 | 1998-08-25 | Doheny Eye Institute | Nucleic acids encoding protocadherin |
JPH06214354A (ja) * | 1993-01-14 | 1994-08-05 | Fuji Photo Film Co Ltd | ハロゲン化銀カラー写真感光材料及びその処理方法 |
US5293836A (en) * | 1993-01-15 | 1994-03-15 | Ziggity Systems, Inc. | Water retaining trigger pin |
US5386344A (en) * | 1993-01-26 | 1995-01-31 | International Business Machines Corporation | Flex circuit card elastomeric cable connector assembly |
US5633675A (en) * | 1993-02-16 | 1997-05-27 | Welch Allyn, Inc, | Shadow probe |
US5674182A (en) * | 1993-02-26 | 1997-10-07 | Olympus Optical Co., Ltd. | Endoscope system including endoscope and protection cover |
USD358471S (en) * | 1993-03-11 | 1995-05-16 | Welch Allyn, Inc. | Combined control handle and viewing screen for an endoscope |
US5334556A (en) * | 1993-03-23 | 1994-08-02 | Texas Instruments Incorporated | Method for improving gate oxide integrity using low temperature oxidation during source/drain anneal |
US5738985A (en) * | 1993-04-02 | 1998-04-14 | Ribogene, Inc. | Method for selective inactivation of viral replication |
US5536637A (en) * | 1993-04-07 | 1996-07-16 | Genetics Institute, Inc. | Method of screening for cDNA encoding novel secreted mammalian proteins in yeast |
US5323899A (en) * | 1993-06-01 | 1994-06-28 | Welch Allyn, Inc. | Case for video probe |
US5435296A (en) * | 1993-06-11 | 1995-07-25 | Welch Allyn, Inc. | Endoscope having crimped and soldered cable terminator |
US5382533A (en) * | 1993-06-18 | 1995-01-17 | Micron Semiconductor, Inc. | Method of manufacturing small geometry MOS field-effect transistors having improved barrier layer to hot electron injection |
GB9315011D0 (en) * | 1993-07-20 | 1993-09-01 | British Telecomm | Dispersion compensation |
US5439483A (en) * | 1993-10-21 | 1995-08-08 | Ventritex, Inc. | Method of quantifying cardiac fibrillation using wavelet transform |
US6983051B1 (en) * | 1993-11-18 | 2006-01-03 | Digimarc Corporation | Methods for audio watermarking and decoding |
US5439846A (en) * | 1993-12-17 | 1995-08-08 | Sgs-Thomson Microelectronics, Inc. | Self-aligned method for forming contact with zero offset to gate |
US5556767A (en) | 1993-12-22 | 1996-09-17 | Human Genome Sciences, Inc. | Polynucleotide encoding macrophage inflammatory protein γ |
US5552329A (en) * | 1994-01-05 | 1996-09-03 | Lg Semicon Co., Ltd. | Method of making metal oxide semiconductor transistors |
US5519003A (en) * | 1994-02-01 | 1996-05-21 | Board Of Trustees Of The Leland Stanford Junior University | WD-40-derived peptides and uses thereof |
JP3423761B2 (ja) * | 1994-03-02 | 2003-07-07 | 東北パイオニア株式会社 | 光波長変換装置 |
US5712111A (en) * | 1994-04-15 | 1998-01-27 | Merck & Co., Inc. | DNA encoding bradykinin B1 receptor |
TW387560U (en) * | 1994-05-13 | 2000-04-11 | Prec Optics Coroporation | Viewing scope with image intensification |
KR0141195B1 (ko) * | 1994-06-08 | 1998-07-15 | 김광호 | 저저항 게이트전극을 갖는 반도체소자의 제조방법 |
US5622701A (en) * | 1994-06-14 | 1997-04-22 | Protein Design Labs, Inc. | Cross-reacting monoclonal antibodies specific for E- and P-selectin |
JPH0829701A (ja) * | 1994-07-18 | 1996-02-02 | Olympus Optical Co Ltd | 立体視内視鏡システム |
US5853975A (en) * | 1994-08-23 | 1998-12-29 | Millennium Pharmaceuticals, Inc. | Methods for identifying compositions for the treatment of body weight disorders, including obesity |
US6068867A (en) * | 1994-11-02 | 2000-05-30 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Protective coatings for food and agricultural products |
US6221839B1 (en) * | 1994-11-14 | 2001-04-24 | Helsinki University Licensing Ltd. Oy | FIt4 ligand and methods of use |
US5888774A (en) * | 1994-12-19 | 1999-03-30 | Cangene Corporation | Recombinant DNA molecules and expression vectors for erythropoietin |
JPH08243078A (ja) * | 1995-03-07 | 1996-09-24 | Fuji Photo Optical Co Ltd | 電子内視鏡の撮像素子組付け体 |
US5730129A (en) * | 1995-04-03 | 1998-03-24 | General Electric Company | Imaging of interventional devices in a non-stationary subject |
GB9506954D0 (en) * | 1995-04-04 | 1995-05-24 | Street Graham S B | Method and apparatus for image enhancement |
US6008325A (en) * | 1995-04-19 | 1999-12-28 | Orion Diagnostica | Antibody to aminoterminal propeptide of type 1 procollagen |
US5972609A (en) * | 1995-04-24 | 1999-10-26 | Medical Research Council | Utrophin gene promotor |
CA2221798A1 (en) * | 1995-06-06 | 1996-12-12 | Human Genome Sciences, Inc. | Colon specific genes and proteins |
US5684126A (en) * | 1995-06-06 | 1997-11-04 | The Johns Hopkins University School Of Medicine | Ebnerin: a secreted von Ebner's gland protein associated with taste buds |
US5627848A (en) * | 1995-09-05 | 1997-05-06 | Imra America, Inc. | Apparatus for producing femtosecond and picosecond pulses from modelocked fiber lasers cladding pumped with broad area diode laser arrays |
US6060879A (en) * | 1995-09-07 | 2000-05-09 | Core Engineering Inc. | Current magnitude sensing circuit |
ATE290077T1 (de) * | 1995-09-29 | 2005-03-15 | Univ Siena | Regulierte gene und ihre verwendungen |
KR0169376B1 (ko) * | 1995-10-10 | 1999-03-20 | 김광호 | 멀티미디어 대응 가능한 씨씨디 카메라 시스템 |
JPH09124697A (ja) * | 1995-11-01 | 1997-05-13 | Toagosei Co Ltd | ペプチド及びモノクローナル抗体 |
KR970049406A (ko) * | 1995-12-15 | 1997-07-29 | 김광호 | 그래픽 오버레이속도 향상기능을 갖는 화상처리장치 |
US6613544B1 (en) * | 1995-12-22 | 2003-09-02 | Amgen Inc. | Osteoprotegerin |
US6586570B1 (en) * | 1996-01-11 | 2003-07-01 | Corixa Corporation | Compositions and methods for the treatment and diagnosis of breast cancer |
US5867305A (en) * | 1996-01-19 | 1999-02-02 | Sdl, Inc. | Optical amplifier with high energy levels systems providing high peak powers |
US6300487B1 (en) * | 1996-03-19 | 2001-10-09 | Cell Therapuetics, Inc. | Mammalian lysophosphatidic acid acyltransferase |
CA2248136A1 (en) * | 1996-03-21 | 1997-09-25 | Human Genome Sciences, Inc. | Human endometrial specific steroid-binding factor i, ii and iii |
US6004780A (en) * | 1996-03-26 | 1999-12-21 | Human Genome Sciences, Inc. | Growth factor HTTER36 |
US5874254A (en) * | 1996-03-29 | 1999-02-23 | Director-General Of Agency Of Industrial Science And Technology | FGF-5 analogous protein, and pharmaceutical composition containing the same |
US5861248A (en) * | 1996-03-29 | 1999-01-19 | Urocor, Inc. | Biomarkers for detection of prostate cancer |
ATE294863T1 (de) * | 1996-07-15 | 2005-05-15 | Chugai Pharmaceutical Co Ltd | Neuartige vegf-ähnliche faktoren |
US5857963A (en) * | 1996-07-17 | 1999-01-12 | Welch Allyn, Inc. | Tab imager assembly for use in an endoscope |
US5734418A (en) * | 1996-07-17 | 1998-03-31 | Welch Allyn, Inc. | Endoscope with tab imager package |
US5754313A (en) * | 1996-07-17 | 1998-05-19 | Welch Allyn, Inc. | Imager assembly |
US6111090A (en) * | 1996-08-16 | 2000-08-29 | Schering Corporation | Mammalian cell surface antigens; related reagents |
US6586210B1 (en) * | 1996-08-23 | 2003-07-01 | Human Genome Sciences, Inc. | Polynucleotides encoding T1 receptor like ligand II |
JP2001517075A (ja) * | 1996-08-23 | 2001-10-02 | ルードヴィッヒ・インスティテュート・フォア・キャンサー・リサーチ | 組換え血管内皮細胞増殖因子d(vegf―d) |
US6329197B2 (en) * | 1996-10-09 | 2001-12-11 | Synaptic Pharmaceutical Corporation | DNA encoding galanin GALR3 receptors and uses thereof |
KR100497423B1 (ko) * | 1996-10-25 | 2005-07-07 | 지.디. 썰 엘엘씨 | 다기능 키메라 조혈 수용체 아고니스트 |
US6632923B1 (en) * | 1996-11-27 | 2003-10-14 | Boston Heart Foundation, Inc. | Low density lipoprotein binding proteins and their use in diagnosing and treating atherosclerosis |
US6084461A (en) * | 1996-11-29 | 2000-07-04 | Varian Medical Systems, Inc. | Charge sensitive amplifier with high common mode signal rejection |
AU5902398A (en) * | 1996-12-31 | 1998-07-31 | Human Genome Sciences, Inc. | Cortistatin polypeptides |
WO1998031818A2 (en) * | 1997-01-21 | 1998-07-23 | Human Genome Sciences, Inc. | Tace-like and matrilysin-like polypeptides |
US5840532A (en) * | 1997-01-21 | 1998-11-24 | Board Of Regents, The University Of Texas System | Neuronal bHLH-PAS domain proteins |
US5965397A (en) * | 1997-01-31 | 1999-10-12 | Genetics Institute, Inc. | Secreted proteins and polynucleotides encoding them |
US6130325A (en) * | 1997-02-14 | 2000-10-10 | Incyte Pharmaceuticals, Inc. | Human P24 vesicle proteins |
US5939271A (en) * | 1997-02-19 | 1999-08-17 | The Regents Of The University Of California | Netrin receptor |
JPH10295388A (ja) | 1997-02-28 | 1998-11-10 | Japan Tobacco Inc | 哺乳動物由来生理活性タンパク |
WO1998039448A2 (en) | 1997-03-07 | 1998-09-11 | Human Genome Sciences, Inc. | 186 human secreted proteins |
EP0972029A1 (de) * | 1997-03-07 | 2000-01-19 | Human Genome Sciences, Inc. | 70 humane sekretierte proteine |
WO2000011014A1 (en) * | 1998-08-25 | 2000-03-02 | Human Genome Sciences, Inc. | 49 human secreted proteins |
US20030065139A1 (en) * | 1998-03-19 | 2003-04-03 | Craig A. Rosen | Secreted protein hmmbd35 |
US7053190B2 (en) * | 1997-03-07 | 2006-05-30 | Human Genome Sciences, Inc. | Secreted protein HRGDF73 |
WO2000006698A1 (en) * | 1998-07-30 | 2000-02-10 | Human Genome Sciences, Inc. | 98 human secreted proteins |
US6420526B1 (en) * | 1997-03-07 | 2002-07-16 | Human Genome Sciences, Inc. | 186 human secreted proteins |
WO1998042738A1 (en) * | 1997-03-21 | 1998-10-01 | Human Genome Sciences, Inc. | 87 human secreted proteins |
WO1998056804A1 (en) | 1997-06-13 | 1998-12-17 | Human Genome Sciences, Inc. | 86 human secreted proteins |
WO2002068628A1 (en) * | 2001-02-23 | 2002-09-06 | Human Genome Sciences, Inc. | 70 human secreted proteins |
US5856139A (en) * | 1997-03-11 | 1999-01-05 | Incyte Pharmaceuticals, Inc. | Proline-rich acidic protein |
US5989909A (en) * | 1997-09-26 | 1999-11-23 | Millennium Biotherapeutics, Inc. | Huchordin and uses thereof |
US20030004311A1 (en) * | 1997-06-18 | 2003-01-02 | Genentech, Inc. | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
US5925521A (en) * | 1997-03-31 | 1999-07-20 | Incyte Pharmaceuticals, Inc. | Human serine carboxypeptidase |
US20020137890A1 (en) * | 1997-03-31 | 2002-09-26 | Genentech, Inc. | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
US6088612A (en) * | 1997-04-04 | 2000-07-11 | Medtech Research Corporation | Method and apparatus for reflective glare removal in digital photography useful in cervical cancer detection |
US5877803A (en) * | 1997-04-07 | 1999-03-02 | Tritech Mircoelectronics International, Ltd. | 3-D image detector |
US20030162956A1 (en) * | 1997-04-07 | 2003-08-28 | Human Genome Sciences, Inc. | Leukocyte regulatory factors 1 and 2 |
US20010039335A1 (en) * | 1997-04-10 | 2001-11-08 | Kenneth Jacobs | Secreted proteins and polynucleotides encoding them |
JP2001515361A (ja) * | 1997-05-06 | 2001-09-18 | ザイモジェネティクス,インコーポレイティド | 新規な腫瘍抗原 |
PL193575B1 (pl) * | 1997-05-15 | 2007-02-28 | Chugai Pharmaceutical Co Ltd | Zastosowanie przeciwciała przeciwko białku pokrewnemu z hormonem przytarczyc (PTHrP) |
US5922567A (en) * | 1997-06-03 | 1999-07-13 | Incyte Pharmaceuticals, Inc. | Two new human DNAJ-like proteins |
US6525174B1 (en) * | 1997-06-06 | 2003-02-25 | Human Genome Sciences, Inc. | Precerebellin-like protein |
DE19726796A1 (de) * | 1997-06-24 | 1999-01-07 | Basf Ag | Propylenpolymerisate |
US5818630A (en) * | 1997-06-25 | 1998-10-06 | Imra America, Inc. | Single-mode amplifiers and compressors based on multi-mode fibers |
AU8389498A (en) * | 1997-07-11 | 1999-02-08 | Eli Lilly And Company | Combinatorial process for preparing fused substituted pyrimidine libraries |
ES2264207T3 (es) * | 1997-07-18 | 2006-12-16 | Zymogenetics, Inc. | Homonologos proteinicos especificos de adipocitos. |
US6060284A (en) * | 1997-07-25 | 2000-05-09 | Schering Corporation | DNA encoding interleukin-B30 |
DK1000146T3 (da) * | 1997-08-01 | 2007-01-08 | Serono Genetics Inst Sa | 5' EST'er for non-vævsspecifikke secernerede proteiner |
US6380370B1 (en) * | 1997-08-14 | 2002-04-30 | Genome Therapeutics Corporation | Nucleic acid and amino acid sequences relating to Staphylococcus epidermidis for diagnostics and therapeutics |
JP2002537756A (ja) | 1997-08-21 | 2002-11-05 | ジェネティックス・インスチチュート・インコーポレーテッド | 分泌蛋白 |
US5876963A (en) * | 1997-08-27 | 1999-03-02 | Mitchell; Peter | Human nucleotide pyrophosphohydrolase |
US6211904B1 (en) * | 1997-09-11 | 2001-04-03 | Edwin L. Adair | Surgical devices incorporating reduced area imaging devices |
ATE447583T1 (de) | 1997-09-17 | 2009-11-15 | Genentech Inc | Polypeptide und dafür kodierende nukleinsäure |
US6388064B1 (en) * | 1997-10-06 | 2002-05-14 | Zymogenetics, Inc. | Human 2-19 protein homologue, z219a |
AU1273499A (en) * | 1997-10-24 | 1999-05-17 | Human Genome Sciences, Inc. | 148 human secreted proteins |
US20030176681A1 (en) * | 1997-10-24 | 2003-09-18 | Ping Feng | 148 human secreted proteins |
US5932445A (en) * | 1997-11-07 | 1999-08-03 | Incyte Pharmaceuticals, Inc. | Signal peptide-containing proteins |
US6573068B1 (en) * | 1997-11-13 | 2003-06-03 | Genset, S. A. | Claudin-50 protein |
US6548633B1 (en) * | 1998-12-22 | 2003-04-15 | Genset, S.A. | Complementary DNA's encoding proteins with signal peptides |
US6025194A (en) * | 1997-11-19 | 2000-02-15 | Geron Corporation | Nucleic acid sequence of senescence asssociated gene |
US5972684A (en) * | 1997-11-25 | 1999-10-26 | Incyte Pharmaceuticals, Inc. | Carbonic anhydrase VIII |
US6194556B1 (en) * | 1997-12-11 | 2001-02-27 | Millennium Pharmaceuticals, Inc. | Angiotensin converting enzyme homolog and therapeutic and diagnostic uses therfor |
WO1999031241A1 (en) * | 1997-12-17 | 1999-06-24 | Immunex Corporation | Cell surface glycoproteins associated with human b cell lymphomas - ulbp, dna and polypeptides |
US6124095A (en) * | 1997-12-22 | 2000-09-26 | Incyte Pharmaceuticals, Inc. | Human nucleotide pyrophosphohydrolase-2 |
WO1999033963A1 (en) * | 1997-12-31 | 1999-07-08 | Chiron Corporation | Metastatic cancer regulated gene |
US6191809B1 (en) * | 1998-01-15 | 2001-02-20 | Vista Medical Technologies, Inc. | Method and apparatus for aligning stereo images |
US6607879B1 (en) * | 1998-02-09 | 2003-08-19 | Incyte Corporation | Compositions for the detection of blood cell and immunological response gene expression |
AU764441B2 (en) | 1998-02-09 | 2003-08-21 | Genset S.A. | cDNAs encoding secreted proteins |
JP2002504361A (ja) * | 1998-02-26 | 2002-02-12 | ヒューマン ジノーム サイエンシーズ, インコーポレイテッド | 36個のヒト分泌タンパク質 |
US6034975A (en) * | 1998-03-09 | 2000-03-07 | Imra America, Inc. | High power, passively modelocked fiber laser, and method of construction |
ES2312205T3 (es) | 1998-03-10 | 2009-02-16 | Genentech, Inc. | Nuevo polipeptido y acidos nucleicos que lo codifican. |
US6174687B1 (en) * | 1999-02-26 | 2001-01-16 | The Burnham Institute | Methods of identifying lung homing molecules using membrane dipeptidase |
US6245550B1 (en) * | 1998-03-20 | 2001-06-12 | Smithkline Beecham Corporation | Cytokine family member EF-7 |
US5945308A (en) * | 1998-04-03 | 1999-08-31 | Incyte Pharmaceuticals, Inc. | Human oxidized LDL receptor |
ATE474849T1 (de) * | 1998-04-14 | 2010-08-15 | Chugai Pharmaceutical Co Ltd | Neues cytokinartiges protein |
DE19817948A1 (de) * | 1998-04-17 | 1999-10-21 | Metagen Gesellschaft Fuer Genomforschung Mbh | Menschliche Nukleinsäuresequenzen aus Endometrium-Tumor |
US6573095B1 (en) * | 1998-04-29 | 2003-06-03 | Genesis Research & Development Corporation Limited | Polynucleotides isolated from skin cells |
US6150502A (en) * | 1998-04-29 | 2000-11-21 | Genesis Research & Development Corporation Limited | Polypeptides expressed in skin cells |
CA2328895A1 (en) | 1998-06-02 | 1999-12-09 | Genentech, Inc. | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
US6800473B1 (en) * | 1998-06-05 | 2004-10-05 | Daiichi Fine Chemical Co., Ltd. | Human cathepsin L2 protein, gene encoding said protein and use thereof |
US20020182677A1 (en) | 1998-08-03 | 2002-12-05 | Zymogenetics, Inc. | Pancreatic and ovarian polypeptide, zsig58 |
EP0978251B1 (de) * | 1998-08-07 | 2005-01-26 | Olympus Corporation | Autoklavierbares Endoskop |
US6168920B1 (en) * | 1998-08-10 | 2001-01-02 | Incyte Genomics, Inc. | Extracellular adhesive proteins |
EP1112285A1 (de) * | 1998-08-10 | 2001-07-04 | Genetics Institute, Inc. | Menschliche chordin-verwandte proteine und dafür kodierende polynukleotide |
US20030096951A1 (en) * | 1998-08-14 | 2003-05-22 | Kenneth Jacobs | Secreted proteins and polynucleotides encoding them |
EP1107978A1 (de) * | 1998-08-24 | 2001-06-20 | Alphagene, Inc. | Sekretierte proteine und polynukleotide die sie kodieren |
CA2339043A1 (en) | 1998-09-01 | 2000-03-09 | Genentech, Inc. | Further pro polypeptides and sequences thereof |
US7026448B2 (en) * | 1998-09-01 | 2006-04-11 | Genentech, Inc. | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
AU6142899A (en) | 1998-09-10 | 2000-03-27 | Incyte Pharmaceuticals, Inc. | Human transferase proteins |
US6808895B1 (en) * | 1999-10-06 | 2004-10-26 | Incyte Corporation | DNA encoding oxidoreductase and polypeptide encoded thereby |
US6174311B1 (en) * | 1998-10-28 | 2001-01-16 | Sdgi Holdings, Inc. | Interbody fusion grafts and instrumentation |
CA2348824A1 (en) * | 1998-10-28 | 2000-05-25 | Human Genome Sciences, Inc. | 12 human secreted proteins |
US6214582B1 (en) * | 1998-11-16 | 2001-04-10 | The Research Foundation Of State University Of Ny | Y2H35 a strong IKK binding protein |
US6472193B1 (en) * | 1998-11-19 | 2002-10-29 | Azwell Inc. | Recombinant lysophosphatidic acid phosphatase |
US6275512B1 (en) * | 1998-11-25 | 2001-08-14 | Imra America, Inc. | Mode-locked multimode fiber laser pulse source |
WO2001053455A2 (en) | 1999-12-23 | 2001-07-26 | Hyseq, Inc. | Novel nucleic acids and polypeptides |
AU1512900A (en) * | 1998-12-09 | 2000-06-26 | Shionogi & Co., Ltd. | Human secretory phospholipase a2 |
JP2003521229A (ja) | 1998-12-16 | 2003-07-15 | ジェネンテック・インコーポレーテッド | 分泌及び膜貫通ポリペプチドとそれをコードする核酸 |
US6278042B1 (en) * | 1998-12-16 | 2001-08-21 | E.I. Du Pont De Nemours And Company | Plant arsenic transporters |
US6184514B1 (en) * | 1998-12-18 | 2001-02-06 | Eastman Kodak Company | Plastic cover for image sensors |
ATE322909T1 (de) * | 1998-12-21 | 2006-04-15 | Ludwig Inst Cancer Res | Antikörper gegen verkürzten vegf-d und deren verwendungen |
US6172361B1 (en) * | 1998-12-29 | 2001-01-09 | Cirrus Logic, Inc. | Methods for mounting an imager to a support structure and circuitry and systems embodying the same |
WO2000042201A2 (en) * | 1999-01-11 | 2000-07-20 | Incyte Pharmaceuticals, Inc. | Human peptidases |
US20040132158A1 (en) * | 1999-01-11 | 2004-07-08 | Incyte Corporation | Human peptidases |
US6083152A (en) * | 1999-01-11 | 2000-07-04 | Welch Allyn, Inc. | Endoscopic insertion tube |
AU3208700A (en) | 1999-01-19 | 2000-08-07 | Human Genome Sciences, Inc. | 33 human secreted proteins |
WO2000043493A2 (en) * | 1999-01-22 | 2000-07-27 | Human Genome Sciences, Inc. | Metalloproteinase adam 22 |
US6492505B1 (en) * | 1999-02-01 | 2002-12-10 | Incyte Genomics, Inc. | Composition for detection of genes encoding membrane-associated proteins |
JP2002539826A (ja) | 1999-03-26 | 2002-11-26 | スミスクライン ビーチャム バイオロジカルズ ソシエテ アノニム | 新規化合物 |
US6331427B1 (en) * | 1999-03-26 | 2001-12-18 | Millennium Pharmaceuticals, Inc. | Protease homologs |
CA2383592A1 (en) | 1999-03-31 | 2000-10-05 | Curagen Corporation | 2384891 acids including open reading frames encoding polypeptides; orfx |
US6538732B1 (en) * | 1999-05-04 | 2003-03-25 | Everest Vit, Inc. | Inspection system and method |
CA2373231A1 (en) * | 1999-05-19 | 2000-11-23 | Incyte Genomics, Inc. | Extracellular signaling molecules |
JP2003503014A (ja) * | 1999-05-20 | 2003-01-28 | ヒューマン ジノーム サイエンシーズ, インコーポレイテッド | 7回膜貫通レセプター遺伝子 |
US6186834B1 (en) * | 1999-06-08 | 2001-02-13 | Avaya Technology Corp. | Enhanced communication connector assembly with crosstalk compensation |
US6960651B2 (en) * | 1999-06-29 | 2005-11-01 | Millennium Pharmaceuticals, Inc. | TANGO 332 polypeptides |
US6696279B1 (en) * | 1999-07-01 | 2004-02-24 | University Of Tennessee Research Foundation | Purified and isolated Mat II β subunit nucleic acids and polypeptides and therapeutic and screening methods using same |
EP1396543A3 (de) | 1999-07-08 | 2004-03-31 | Research Association for Biotechnology | Primer zur Synthese von vollständigen cDNA Klonen und ihre Verwendung |
US6951738B2 (en) * | 1999-07-16 | 2005-10-04 | Human Genome Sciences, Inc. | Human tumor necrosis factor receptors TR13 and TR14 |
WO2001007612A2 (en) * | 1999-07-21 | 2001-02-01 | Incyte Genomics, Inc. | Receptors and associated proteins |
US20050048623A1 (en) * | 1999-07-21 | 2005-03-03 | Incyte Corporation | Cell cycle and proliferation proteins |
EP1074617A3 (de) | 1999-07-29 | 2004-04-21 | Research Association for Biotechnology | Primers für Synthese von ganzen-Länge cDNS und deren Anwendung |
WO2001009318A1 (fr) * | 1999-07-29 | 2001-02-08 | Helix Research Institute | Genes associes au cancer du foie |
CA2311201A1 (en) * | 1999-08-05 | 2001-02-05 | Genset S.A. | Ests and encoded human proteins |
IL147902A0 (en) * | 1999-08-12 | 2002-08-14 | Agensys Inc | C-type lectin transmembrane antigen expressed in human prostate cancer and uses thereof |
CA2381985A1 (en) * | 1999-08-16 | 2001-02-22 | Universita'degli Studi Di Siena | Vegf-d and angiogenic use thereof |
US7090847B1 (en) * | 1999-09-09 | 2006-08-15 | Schering Corporation | Mammalian cytokines; related reagents and methods |
JP2003511012A (ja) * | 1999-09-24 | 2003-03-25 | ヒューマン ジノーム サイエンシーズ, インコーポレイテッド | 32個のヒト分泌タンパク質 |
CA2384713A1 (en) | 1999-09-29 | 2001-04-05 | Human Genome Sciences, Inc. | Colon and colon cancer associated polynucleotides and polypeptides |
AU7508100A (en) * | 1999-10-04 | 2001-05-10 | Jens Andersen | Human seizure related proteins |
AU7999300A (en) * | 1999-10-07 | 2001-05-10 | Zymogenetics Inc. | Novel human phosphodiesterase zcytor13 |
US6992170B2 (en) * | 1999-10-15 | 2006-01-31 | Curagen Corporation | Polypeptides and polynucleotides homologous to thymosin, ephrin a receptors, and fibromodulin |
AU1449001A (en) | 1999-11-05 | 2001-06-06 | Human Genome Sciences, Inc. | 28 human secreted proteins |
AUPQ434899A0 (en) * | 1999-11-26 | 1999-12-23 | University Of Queensland, The | Novel polynucleotide and polypeptide |
JP2004522404A (ja) | 1999-12-01 | 2004-07-29 | ジェネンテック・インコーポレーテッド | 分泌及び膜貫通ポリペプチドとそれをコードしている核酸 |
WO2001053312A1 (en) | 1999-12-23 | 2001-07-26 | Hyseq, Inc. | Novel nucleic acids and polypeptides |
US6569662B1 (en) * | 2000-01-21 | 2003-05-27 | Hyseq, Inc. | Nucleic acids and polypeptides |
GB0001898D0 (en) * | 2000-01-27 | 2000-03-22 | Smithkline Beecham Plc | Novel compounds |
EP1252298A2 (de) * | 2000-01-28 | 2002-10-30 | Incyte Genomics, Inc. | Phosphodiesterasen |
WO2001055317A2 (en) | 2000-01-31 | 2001-08-02 | Human Genome Sciences, Inc. | Nucleic acids, proteins, and antibodies |
CA2392428A1 (en) | 2000-01-31 | 2001-08-02 | Human Genome Sciences Inc. | Nucleic acids, proteins, and antibodies |
AU2001234944A1 (en) | 2000-02-03 | 2001-08-14 | Hyseq, Inc. | Novel nucleic acids and polypeptides |
EP1254236A2 (de) | 2000-02-11 | 2002-11-06 | Incyte Genomics, Inc. | Arzneimittelmetabolisierende enzyme |
JP2003523190A (ja) * | 2000-02-14 | 2003-08-05 | スミスクライン・ビーチャム・コーポレイション | 新規化合物 |
US20060160181A1 (en) * | 2000-02-15 | 2006-07-20 | Amgen Inc. | Fibroblast Growth Factor-23 molecules and uses thereof |
US20020068823A1 (en) * | 2000-03-24 | 2002-06-06 | Meyers Rachel A. | 33877 and 47179, novel human glycosyltransferase family members and uses thereof |
EP1261638A2 (de) * | 2000-03-08 | 2002-12-04 | Chiron Corporation | Humanes fgf-23 gen und genexpressionsprodukte |
US6800455B2 (en) * | 2000-03-31 | 2004-10-05 | Scios Inc. | Secreted factors |
AU2001266557A1 (en) | 2000-04-12 | 2001-10-23 | Human Genome Sciences, Inc. | Albumin fusion proteins |
US7264926B2 (en) * | 2000-04-18 | 2007-09-04 | Millennium Pharmaceuticals, Inc. | Nucleoside Phosphatase |
WO2001085942A2 (en) * | 2000-05-05 | 2001-11-15 | Incyte Genomics, Inc. | Cytoskeleton-associated proteins |
US7422743B2 (en) * | 2000-05-10 | 2008-09-09 | Schering Corporation | Mammalian receptor protein DCRS5;methods of treatment |
WO2001090304A2 (en) | 2000-05-19 | 2001-11-29 | Human Genome Sciences, Inc. | Nucleic acids, proteins, and antibodies |
WO2001090326A2 (en) * | 2000-05-22 | 2001-11-29 | Pharmacia & Upjohn Company | Novel matrix metalloproteinases |
US7190705B2 (en) * | 2000-05-23 | 2007-03-13 | Imra America. Inc. | Pulsed laser sources |
US6429127B1 (en) * | 2000-06-08 | 2002-08-06 | Micron Technology, Inc. | Methods for forming rough ruthenium-containing layers and structures/methods using same |
US6590470B1 (en) * | 2000-06-13 | 2003-07-08 | Welch Allyn, Inc. | Cable compensator circuit for CCD video probe |
EP1176200A3 (de) * | 2000-06-20 | 2005-01-12 | Switch Biotech Aktiengesellschaft | Verwendung von Polypeptiden oder diese kodierende Nukleinsäuren zur Diagnose oder Behandlung von Hauterkrankung oder Wundheilung sowie ihre Verwendung zur Indentifizierung von pharmakologisch aktiven Substanzen |
EP1383892A2 (de) | 2000-06-30 | 2004-01-28 | Incyte Genomics, Inc. | Humane extrazelluläre matrix- und zelladhäsions-polypeptide |
ATE461213T1 (de) * | 2000-07-19 | 2010-04-15 | Advanced Res & Tech Inst | Neuer fibroblastwachstumsfaktor (fgf23) und methoden zur verwendung |
US6812339B1 (en) * | 2000-09-08 | 2004-11-02 | Applera Corporation | Polymorphisms in known genes associated with human disease, methods of detection and uses thereof |
US6492281B1 (en) * | 2000-09-22 | 2002-12-10 | Advanced Micro Devices, Inc. | Method of fabricating conductor structures with metal comb bridging avoidance |
US20030143686A1 (en) * | 2000-09-29 | 2003-07-31 | Incyte Genomics, Inc. | Transferases |
US6531297B2 (en) * | 2000-10-20 | 2003-03-11 | Applera Corporation | Isolated human drug-metabolizing proteins, nucleic acid molecules encoding human drug-metabolizing proteins, and uses thereof |
US20030130485A1 (en) * | 2000-11-14 | 2003-07-10 | Meyers Rachel E. | Novel human genes and methods of use thereof |
EP1341804A4 (de) | 2000-11-17 | 2005-08-24 | Nuvelo Inc | Neue nukleinsäuren und polypeptide |
EP1397495A2 (de) | 2000-12-21 | 2004-03-17 | Millenium Pharmaceuticals, Inc. | 22347, eine menschliche sulfatase und deren verwendungen |
US20030148920A1 (en) | 2000-12-27 | 2003-08-07 | Steven Rosen | Sulfatases and methods of use thereof |
US7262797B2 (en) * | 2001-02-22 | 2007-08-28 | Ge Inspection Technologies Lp | Method and system for storing calibration data within image files |
US6536637B1 (en) | 2001-03-16 | 2003-03-25 | Mclaughlin Marty E. | Combination backpack and water container |
CA2442062A1 (en) * | 2001-03-30 | 2002-10-10 | Incyte Genomics, Inc. | Secreted proteins |
US7436435B2 (en) * | 2001-10-01 | 2008-10-14 | Minolta Co., Ltd. | Image taking device having image-blur compensator |
US6841087B2 (en) * | 2002-04-19 | 2005-01-11 | Korea Institute Of Science And Technology | Refrigerant composition comprising difluoromethane, 1,1,1-trifluoroethane and 1,1,1,2-tetrafluoroethane |
DE60328823D1 (de) * | 2002-10-30 | 2009-09-24 | Genentech Inc | Hemmung von il-17 produktion |
US20050129108A1 (en) * | 2003-01-29 | 2005-06-16 | Everest Vit, Inc. | Remote video inspection system |
WO2004071517A2 (en) * | 2003-02-06 | 2004-08-26 | Schering Corporation | Uses of il-23 related reagents |
ES2330220T3 (es) * | 2003-03-10 | 2009-12-07 | Schering Corporation | Usos de antagonistas de il-23; reactivos relacionados. |
US20050050707A1 (en) * | 2003-09-05 | 2005-03-10 | Scott Joshua Lynn | Tip tool |
EP1694864A2 (de) | 2003-11-20 | 2006-08-30 | Genentech, Inc. | Zusammensetzungen und verfahren für die tumor-diagnose und behandlung |
US20050162643A1 (en) * | 2004-01-22 | 2005-07-28 | Thomas Karpen | Automotive fuel tank inspection device |
EP1901768B1 (de) * | 2004-02-17 | 2011-11-16 | Schering Corporation | Verfahren zur modulation der il-23-aktivität; relevante reagenzien |
US20050287593A1 (en) * | 2004-05-03 | 2005-12-29 | Schering Corporation | Use of cytokine expression to predict skin inflammation; methods of treatment |
US20060050983A1 (en) * | 2004-09-08 | 2006-03-09 | Everest Vit, Inc. | Method and apparatus for enhancing the contrast and clarity of an image captured by a remote viewing device |
WO2006068987A2 (en) * | 2004-12-20 | 2006-06-29 | Schering Corporation | Uses of il-23 antagonists in the treatment of diabetes mellitus |
-
2001
- 2001-11-14 US US09/990,456 patent/US20020137890A1/en not_active Abandoned
-
2002
- 2002-04-11 US US10/121,046 patent/US20030194791A1/en not_active Abandoned
- 2002-04-11 US US10/121,045 patent/US20030073210A1/en not_active Abandoned
- 2002-04-11 US US10/121,051 patent/US20030092147A1/en not_active Abandoned
- 2002-04-11 US US10/121,040 patent/US20030082759A1/en not_active Abandoned
- 2002-04-11 US US10/121,041 patent/US20030077776A1/en not_active Abandoned
- 2002-04-11 US US10/121,042 patent/US20030096386A1/en not_active Abandoned
- 2002-04-11 US US10/121,047 patent/US20030077778A1/en not_active Abandoned
- 2002-04-11 US US10/121,059 patent/US20030190721A1/en not_active Abandoned
- 2002-04-11 US US10/121,044 patent/US20030190717A1/en not_active Abandoned
- 2002-04-12 US US10/121,054 patent/US20030199054A1/en not_active Abandoned
- 2002-04-12 US US10/121,055 patent/US20030190718A1/en not_active Abandoned
- 2002-04-12 US US10/121,062 patent/US20030077779A1/en not_active Abandoned
- 2002-04-12 US US10/121,056 patent/US20030082760A1/en not_active Abandoned
- 2002-04-12 US US10/121,057 patent/US20030190719A1/en not_active Abandoned
- 2002-04-12 US US10/121,048 patent/US20030199051A1/en not_active Abandoned
- 2002-04-12 US US10/121,050 patent/US20030054516A1/en not_active Abandoned
- 2002-04-12 US US10/121,063 patent/US20030199055A1/en not_active Abandoned
- 2002-04-12 US US10/121,053 patent/US20030199053A1/en not_active Abandoned
- 2002-04-12 US US10/121,043 patent/US7220831B2/en not_active Expired - Lifetime
- 2002-04-12 US US10/121,061 patent/US20030082761A1/en not_active Abandoned
- 2002-04-12 US US10/121,052 patent/US20030199052A1/en not_active Abandoned
- 2002-04-12 US US10/121,060 patent/US20030190722A1/en not_active Abandoned
- 2002-04-12 US US10/121,058 patent/US20030190720A1/en not_active Abandoned
- 2002-04-15 US US10/123,157 patent/US20030190725A1/en not_active Abandoned
- 2002-04-15 US US10/123,215 patent/US7291329B2/en not_active Expired - Lifetime
- 2002-04-15 US US10/123,322 patent/US7700736B2/en not_active Expired - Lifetime
- 2002-04-15 US US10/123,154 patent/US20030190724A1/en not_active Abandoned
- 2002-04-15 US US10/123,235 patent/US20030082762A1/en not_active Abandoned
- 2002-04-15 US US10/123,292 patent/US20030073211A1/en active Granted
- 2002-04-15 US US10/123,108 patent/US7635478B2/en not_active Expired - Fee Related
- 2002-04-15 US US10/123,213 patent/US20030199057A1/en active Granted
- 2002-04-15 US US10/123,214 patent/US7343721B2/en not_active Expired - Fee Related
- 2002-04-15 US US10/123,262 patent/US20030049816A1/en not_active Abandoned
- 2002-04-15 US US10/123,156 patent/US20030194792A1/en not_active Abandoned
- 2002-04-15 US US10/123,291 patent/US20030199058A1/en not_active Abandoned
- 2002-04-15 US US10/123,771 patent/US20030199060A1/en not_active Abandoned
- 2002-04-15 US US10/123,109 patent/US20030190723A1/en not_active Abandoned
- 2002-04-15 US US10/123,155 patent/US20030068794A1/en not_active Abandoned
- 2002-04-15 US US10/123,322 patent/US20030199059A1/en active Granted
- 2002-04-15 US US10/123,212 patent/US7276577B2/en not_active Expired - Lifetime
- 2002-04-15 US US10/123,236 patent/US20030068795A1/en not_active Abandoned
- 2002-04-15 US US10/123,261 patent/US20030068796A1/en not_active Abandoned
- 2002-04-16 US US10/123,904 patent/US20030022328A1/en not_active Abandoned
- 2002-04-16 US US10/123,911 patent/US7408032B2/en not_active Expired - Lifetime
- 2002-04-16 US US10/123,908 patent/US7335728B2/en not_active Expired - Lifetime
- 2002-04-16 US US10/123,910 patent/US7329404B2/en not_active Expired - Lifetime
- 2002-04-16 US US10/123,907 patent/US7084258B2/en not_active Expired - Fee Related
- 2002-04-16 US US10/123,903 patent/US20030073212A1/en not_active Abandoned
- 2002-04-16 US US10/123,902 patent/US20030077781A1/en not_active Abandoned
- 2002-04-16 US US10/123,909 patent/US7193049B2/en not_active Expired - Lifetime
- 2002-04-16 US US10/123,913 patent/US20030203462A1/en not_active Abandoned
- 2002-04-16 US US10/123,906 patent/US20030190726A1/en not_active Abandoned
- 2002-04-16 US US10/123,912 patent/US20030100087A1/en not_active Abandoned
- 2002-04-17 US US10/124,824 patent/US20030077659A1/en not_active Abandoned
- 2002-04-17 US US10/124,816 patent/US20030190728A1/en not_active Abandoned
- 2002-04-17 US US10/124,817 patent/US20030077786A1/en not_active Abandoned
- 2002-04-17 US US10/124,815 patent/US7342096B2/en not_active Expired - Lifetime
- 2002-04-17 US US10/124,813 patent/US7312307B2/en not_active Expired - Lifetime
- 2002-04-17 US US10/124,814 patent/US7105335B2/en not_active Expired - Lifetime
- 2002-04-17 US US10/124,821 patent/US20030199023A1/en not_active Abandoned
- 2002-04-17 US US10/125,795 patent/US7304131B2/en not_active Expired - Lifetime
- 2002-04-17 US US10/124,820 patent/US20030190729A1/en not_active Abandoned
- 2002-04-17 US US10/124,818 patent/US20030082763A1/en not_active Abandoned
- 2002-04-17 US US10/125,704 patent/US7357926B2/en not_active Expired - Lifetime
- 2002-04-17 US US10/124,822 patent/US7109305B2/en not_active Expired - Lifetime
- 2002-04-17 US US10/124,823 patent/US20030199062A1/en not_active Abandoned
- 2002-04-17 US US10/125,805 patent/US20030194794A1/en not_active Abandoned
- 2002-04-17 US US10/124,819 patent/US7285626B2/en not_active Expired - Lifetime
- 2002-04-19 US US10/125,932 patent/US7317079B2/en not_active Expired - Fee Related
- 2002-04-19 US US10/125,923 patent/US20030087348A1/en not_active Abandoned
- 2002-04-19 US US10/125,927 patent/US20030190731A1/en not_active Abandoned
- 2002-04-19 US US10/125,928 patent/US20030087349A1/en not_active Abandoned
- 2002-04-19 US US10/125,931 patent/US20030199063A1/en not_active Abandoned
- 2002-04-19 US US10/125,930 patent/US7291700B2/en not_active Expired - Lifetime
- 2002-04-19 US US10/125,926 patent/US20030082686A1/en not_active Abandoned
- 2002-04-19 US US10/125,924 patent/US7342097B2/en not_active Expired - Lifetime
- 2002-04-19 US US10/125,922 patent/US7309762B2/en not_active Expired - Lifetime
- 2002-04-19 US US10/125,921 patent/US7312313B2/en not_active Expired - Lifetime
- 2002-04-22 US US10/127,839 patent/US7449554B2/en not_active Expired - Lifetime
- 2002-04-22 US US10/127,842 patent/US20030082692A1/en not_active Abandoned
- 2002-04-22 US US10/127,840 patent/US20030153033A1/en not_active Abandoned
- 2002-04-22 US US10/127,852 patent/US20030203428A1/en not_active Abandoned
- 2002-04-22 US US10/127,850 patent/US20030082698A1/en not_active Abandoned
- 2002-04-22 US US10/127,825 patent/US20030077710A1/en not_active Abandoned
- 2002-04-22 US US10/127,826 patent/US7309763B2/en not_active Expired - Lifetime
- 2002-04-22 US US10/127,848 patent/US20030082696A1/en not_active Abandoned
- 2002-04-22 US US10/127,833 patent/US20030087358A1/en not_active Abandoned
- 2002-04-22 US US10/127,849 patent/US20030082697A1/en not_active Abandoned
- 2002-04-22 US US10/127,900 patent/US20030203429A1/en not_active Abandoned
- 2002-04-22 US US10/127,832 patent/US20030087357A1/en not_active Abandoned
- 2002-04-22 US US10/127,844 patent/US7566774B2/en not_active Expired - Lifetime
- 2002-04-22 US US10/127,831 patent/US20030082689A1/en not_active Abandoned
- 2002-04-22 US US10/127,829 patent/US20030077711A1/en not_active Abandoned
- 2002-04-22 US US10/127,834 patent/US20030087359A1/en not_active Abandoned
- 2002-04-22 US US10/127,830 patent/US7351793B2/en not_active Expired - Lifetime
- 2002-04-22 US US10/127,841 patent/US20030087361A1/en not_active Abandoned
- 2002-04-22 US US10/127,837 patent/US20030082690A1/en not_active Abandoned
- 2002-04-22 US US10/127,836 patent/US7432345B2/en not_active Expired - Lifetime
- 2002-04-22 US US10/127,835 patent/US20030077712A1/en not_active Abandoned
- 2002-04-22 US US10/127,824 patent/US20030087352A1/en not_active Abandoned
- 2002-04-22 US US10/127,828 patent/US20030087355A1/en not_active Abandoned
- 2002-04-22 US US10/127,821 patent/US20030087350A1/en not_active Abandoned
- 2002-04-22 US US10/127,901 patent/US7342098B2/en not_active Expired - Fee Related
- 2002-04-22 US US10/127,822 patent/US7371827B2/en not_active Expired - Lifetime
- 2002-04-22 US US10/127,846 patent/US20030082695A1/en not_active Abandoned
- 2002-04-22 US US10/127,843 patent/US20030082693A1/en not_active Abandoned
- 2002-04-22 US US10/127,845 patent/US20030082694A1/en not_active Abandoned
- 2002-04-22 US US10/127,851 patent/US7348414B2/en not_active Expired - Fee Related
- 2002-04-22 US US10/127,827 patent/US20030087354A1/en not_active Abandoned
- 2002-04-22 US US10/127,838 patent/US20030082691A1/en not_active Abandoned
- 2002-04-22 US US10/127,847 patent/US20030119103A1/en not_active Abandoned
- 2002-04-23 US US10/128,687 patent/US20030087363A1/en not_active Abandoned
- 2002-04-23 US US10/128,685 patent/US20030203430A1/en not_active Abandoned
- 2002-04-23 US US10/128,689 patent/US20030087365A1/en not_active Abandoned
- 2002-04-23 US US10/128,688 patent/US7323544B2/en not_active Expired - Fee Related
- 2002-04-23 US US10/128,694 patent/US7189813B2/en not_active Expired - Lifetime
- 2002-04-23 US US10/128,690 patent/US20030082702A1/en not_active Abandoned
- 2002-04-23 US US10/128,686 patent/US7345146B2/en not_active Expired - Fee Related
- 2002-04-23 US US10/128,691 patent/US7319135B2/en not_active Expired - Lifetime
- 2002-04-23 US US10/128,693 patent/US7355006B2/en not_active Expired - Lifetime
- 2002-04-23 US US10/128,692 patent/US7704496B2/en active Active
- 2002-04-23 US US10/128,684 patent/US20030082700A1/en not_active Abandoned
- 2002-04-24 US US10/131,818 patent/US7166703B2/en not_active Expired - Fee Related
- 2002-04-24 US US10/131,830 patent/US20030077720A1/en not_active Abandoned
- 2002-04-24 US US10/131,823 patent/US7304132B2/en not_active Expired - Lifetime
- 2002-04-24 US US10/131,825 patent/US7282566B2/en not_active Expired - Lifetime
- 2002-04-24 US US10/131,817 patent/US7291701B2/en not_active Expired - Lifetime
- 2002-04-24 US US10/131,836 patent/US7351794B2/en not_active Expired - Lifetime
- 2002-04-24 US US10/131,813 patent/US7279551B2/en not_active Expired - Lifetime
- 2002-04-24 US US10/131,824 patent/US7326413B2/en not_active Expired - Fee Related
- 2002-04-24 US US10/131,828 patent/US7309777B2/en not_active Expired - Lifetime
- 2002-04-24 US US10/131,821 patent/US20030092105A1/en not_active Abandoned
- 2002-04-24 US US10/131,837 patent/US7294495B2/en not_active Expired - Lifetime
- 2002-04-24 US US10/131,815 patent/US20030092103A1/en not_active Abandoned
- 2002-04-24 US US10/131,819 patent/US7273926B2/en not_active Expired - Lifetime
- 2002-04-24 US US10/131,816 patent/US7361337B2/en not_active Expired - Lifetime
- 2002-04-24 US US10/131,835 patent/US7294705B2/en not_active Expired - Lifetime
- 2002-04-24 US US10/131,820 patent/US7312314B2/en not_active Expired - Lifetime
- 2002-04-24 US US10/131,829 patent/US20030082705A1/en not_active Abandoned
- 2002-04-24 US US10/131,826 patent/US7202345B2/en not_active Expired - Lifetime
- 2002-04-24 US US10/131,833 patent/US7141652B1/en not_active Expired - Fee Related
- 2002-04-24 US US10/131,822 patent/US7189806B2/en not_active Expired - Lifetime
- 2002-05-03 US US10/137,872 patent/US20030077722A1/en not_active Abandoned
- 2002-05-03 US US10/137,864 patent/US7291715B2/en not_active Expired - Lifetime
- 2002-05-03 US US10/137,873 patent/US20060084138A1/en not_active Abandoned
- 2002-05-03 US US10/137,865 patent/US20030032155A1/en not_active Abandoned
- 2002-05-03 US US10/137,866 patent/US20030129689A1/en not_active Abandoned
- 2002-05-03 US US10/137,870 patent/US20030138883A1/en not_active Abandoned
- 2002-05-03 US US10/137,868 patent/US20030082764A1/en not_active Abandoned
- 2002-05-03 US US10/137,871 patent/US7323545B2/en not_active Expired - Lifetime
- 2002-05-03 US US10/137,869 patent/US7282558B2/en not_active Expired - Lifetime
- 2002-05-03 US US10/137,867 patent/US20030207349A1/en not_active Abandoned
- 2002-05-06 US US10/140,024 patent/US20040058424A1/en not_active Abandoned
- 2002-05-06 US US10/140,472 patent/US20030138888A1/en not_active Abandoned
- 2002-05-06 US US10/140,020 patent/US20030207415A1/en not_active Abandoned
- 2002-05-06 US US10/139,963 patent/US7288625B2/en not_active Expired - Lifetime
- 2002-05-06 US US10/140,019 patent/US20030148423A1/en not_active Abandoned
- 2002-05-06 US US10/140,471 patent/US7291702B2/en not_active Expired - Lifetime
- 2002-05-06 US US10/140,470 patent/US7521539B2/en not_active Expired - Lifetime
- 2002-05-06 US US10/140,470 patent/US20030022331A1/en active Granted
- 2002-05-06 US US10/140,023 patent/US20030207416A1/en not_active Abandoned
- 2002-05-06 US US10/140,018 patent/US20030138885A1/en not_active Abandoned
- 2002-05-06 US US10/140,474 patent/US20030032156A1/en not_active Abandoned
- 2002-05-06 US US10/139,980 patent/US7247710B2/en not_active Expired - Lifetime
- 2002-05-06 US US10/140,021 patent/US7279552B2/en not_active Expired - Lifetime
- 2002-05-06 US US10/140,274 patent/US20030143674A1/en not_active Abandoned
- 2002-05-06 US US10/140,473 patent/US20030207351A1/en not_active Abandoned
- 2002-05-06 US US10/140,022 patent/US7285627B2/en not_active Expired - Lifetime
- 2002-05-07 US US10/140,808 patent/US7425621B2/en not_active Expired - Lifetime
- 2002-05-07 US US10/140,806 patent/US7309764B2/en not_active Expired - Lifetime
- 2002-05-07 US US10/140,863 patent/US7288626B2/en not_active Expired - Lifetime
- 2002-05-07 US US10/140,921 patent/US7317080B2/en not_active Expired - Fee Related
- 2002-05-07 US US10/140,810 patent/US20030207353A1/en not_active Abandoned
- 2002-05-07 US US10/140,862 patent/US7285628B2/en not_active Expired - Lifetime
- 2002-05-07 US US10/140,928 patent/US20030068798A1/en not_active Abandoned
- 2002-05-07 US US10/140,805 patent/US20030207417A1/en not_active Abandoned
- 2002-05-07 US US10/140,807 patent/US7335745B2/en not_active Expired - Lifetime
- 2002-05-07 US US10/140,926 patent/US20030134356A1/en not_active Abandoned
- 2002-05-07 US US10/140,860 patent/US7307151B2/en not_active Expired - Lifetime
- 2002-05-07 US US10/140,927 patent/US7495082B2/en not_active Expired - Lifetime
- 2002-05-07 US US10/140,865 patent/US20030207420A1/en not_active Abandoned
- 2002-05-07 US US10/140,924 patent/US20030134355A1/en not_active Abandoned
- 2002-05-07 US US10/140,809 patent/US20030207418A1/en not_active Abandoned
- 2002-05-07 US US10/140,923 patent/US7282559B2/en not_active Expired - Lifetime
- 2002-05-07 US US10/140,861 patent/US20030148425A1/en not_active Abandoned
- 2002-05-07 US US10/140,925 patent/US20030073215A1/en not_active Abandoned
- 2002-05-07 US US10/140,922 patent/US7309765B2/en not_active Expired - Lifetime
- 2002-05-07 US US10/140,864 patent/US20030207419A1/en not_active Abandoned
- 2002-05-08 US US10/141,757 patent/US7314920B2/en not_active Expired - Fee Related
- 2002-05-08 US US10/141,754 patent/US7361732B2/en not_active Expired - Lifetime
- 2002-05-08 US US10/141,705 patent/US7396906B2/en not_active Expired - Lifetime
- 2002-05-08 US US10/141,755 patent/US7297764B2/en not_active Expired - Lifetime
- 2002-05-08 US US10/141,698 patent/US7282560B2/en not_active Expired - Lifetime
- 2002-05-08 US US10/141,700 patent/US7312308B2/en not_active Expired - Lifetime
- 2002-05-08 US US10/141,706 patent/US7425609B2/en not_active Expired - Lifetime
- 2002-05-08 US US10/141,699 patent/US7390887B2/en not_active Expired - Lifetime
- 2002-05-08 US US10/141,758 patent/US7301007B2/en not_active Expired - Lifetime
- 2002-05-08 US US10/141,760 patent/US7342104B2/en not_active Expired - Fee Related
- 2002-05-08 US US10/141,701 patent/US20030207421A1/en not_active Abandoned
- 2002-05-08 US US10/141,704 patent/US7396916B2/en not_active Expired - Lifetime
- 2002-05-08 US US10/141,759 patent/US7291716B2/en not_active Expired - Lifetime
- 2002-05-08 US US10/141,761 patent/US7335729B2/en not_active Expired - Fee Related
- 2002-05-08 US US10/141,756 patent/US7488586B2/en not_active Expired - Lifetime
- 2002-05-08 US US10/141,762 patent/US20030207362A1/en not_active Abandoned
- 2002-05-08 US US10/141,703 patent/US20030207357A1/en not_active Abandoned
- 2002-05-08 US US10/141,697 patent/US7417123B2/en not_active Expired - Lifetime
- 2002-05-08 US US10/141,753 patent/US7323550B2/en not_active Expired - Lifetime
- 2002-05-08 US US10/141,702 patent/US7294692B2/en not_active Expired - Lifetime
- 2002-05-09 US US10/143,034 patent/US7378502B2/en not_active Expired - Lifetime
- 2002-05-09 US US10/143,027 patent/US20030207366A1/en not_active Abandoned
- 2002-05-09 US US10/143,113 patent/US7329730B2/en not_active Expired - Lifetime
- 2002-05-09 US US10/142,888 patent/US20030157606A1/en not_active Abandoned
- 2002-05-09 US US10/142,427 patent/US7294702B2/en not_active Expired - Lifetime
- 2002-05-09 US US10/142,887 patent/US7291717B2/en not_active Expired - Lifetime
- 2002-05-09 US US10/142,761 patent/US7306795B2/en not_active Expired - Lifetime
- 2002-05-09 US US10/142,420 patent/US20030148434A1/en not_active Abandoned
- 2002-05-09 US US10/143,115 patent/US7309767B2/en not_active Expired - Lifetime
- 2002-05-09 US US10/142,417 patent/US7304133B2/en not_active Expired - Lifetime
- 2002-05-09 US US10/142,426 patent/US20040048333A1/en not_active Abandoned
- 2002-05-09 US US10/142,889 patent/US20030194765A1/en not_active Abandoned
- 2002-05-09 US US10/142,428 patent/US20030207363A1/en not_active Abandoned
- 2002-05-09 US US10/142,762 patent/US7288627B2/en not_active Expired - Lifetime
- 2002-05-09 US US10/142,421 patent/US7311909B2/en not_active Expired - Lifetime
- 2002-05-09 US US10/143,117 patent/US7318922B2/en not_active Expired - Lifetime
- 2002-05-09 US US10/142,422 patent/US7385030B2/en not_active Expired - Lifetime
- 2002-05-09 US US10/142,425 patent/US20030207424A1/en not_active Abandoned
- 2002-05-09 US US10/143,114 patent/US20030036180A1/en not_active Abandoned
- 2002-05-09 US US10/142,430 patent/US7309766B2/en not_active Expired - Lifetime
- 2002-05-09 US US10/143,118 patent/US7309768B2/en not_active Expired - Lifetime
- 2002-05-09 US US10/142,432 patent/US7390877B2/en not_active Expired - Lifetime
- 2002-05-09 US US10/143,035 patent/US7317081B2/en not_active Expired - Fee Related
- 2002-05-09 US US10/143,116 patent/US7390486B2/en not_active Expired - Lifetime
- 2002-05-10 US US10/142,423 patent/US20030049817A1/en not_active Abandoned
- 2002-05-10 US US10/143,033 patent/US20030134363A1/en not_active Abandoned
- 2002-05-10 US US10/142,429 patent/US20030207364A1/en not_active Abandoned
- 2002-05-10 US US10/142,431 patent/US7285629B2/en not_active Expired - Lifetime
- 2002-05-10 US US10/142,418 patent/US7297765B2/en not_active Expired - Lifetime
- 2002-05-10 US US10/142,766 patent/US7390883B2/en not_active Expired - Lifetime
- 2002-05-10 US US10/142,424 patent/US7297766B2/en not_active Expired - Lifetime
- 2002-05-10 US US10/143,032 patent/US7408033B2/en not_active Expired - Lifetime
- 2002-05-10 US US10/142,884 patent/US20030207365A1/en not_active Abandoned
- 2002-05-10 US US10/142,886 patent/US20030203432A1/en not_active Abandoned
- 2002-05-10 US US10/142,767 patent/US7294693B2/en not_active Expired - Lifetime
- 2002-05-10 US US10/142,763 patent/US7189807B2/en not_active Expired - Lifetime
- 2002-05-10 US US10/142,419 patent/US7153941B2/en not_active Expired - Lifetime
- 2002-05-10 US US10/142,885 patent/US7718173B2/en not_active Expired - Lifetime
- 2002-05-10 US US10/142,765 patent/US20030157603A1/en not_active Abandoned
- 2002-05-10 US US10/142,764 patent/US20030180865A1/en not_active Abandoned
- 2002-05-10 US US10/142,760 patent/US20030148437A1/en not_active Abandoned
- 2002-05-13 US US10/144,958 patent/US7479545B2/en not_active Expired - Lifetime
- 2002-05-13 US US10/144,992 patent/US20030157611A1/en not_active Abandoned
- 2002-05-13 US US10/145,015 patent/US7439325B2/en not_active Expired - Lifetime
- 2002-05-13 US US10/144,956 patent/US20030207368A1/en not_active Abandoned
- 2002-05-13 US US10/144,994 patent/US20030134364A1/en not_active Abandoned
- 2002-05-13 US US10/145,091 patent/US20030157614A1/en not_active Abandoned
- 2002-05-13 US US10/145,127 patent/US7355007B2/en not_active Expired - Lifetime
- 2002-05-13 US US10/144,957 patent/US20030157610A1/en not_active Abandoned
- 2002-05-13 US US10/144,993 patent/US20040038336A1/en not_active Abandoned
- 2002-05-13 US US10/145,090 patent/US20030157613A1/en not_active Abandoned
- 2002-05-14 US US10/145,751 patent/US20030166074A1/en not_active Abandoned
- 2002-05-14 US US10/145,746 patent/US20030134366A1/en not_active Abandoned
- 2002-05-14 US US10/145,827 patent/US7304140B2/en not_active Expired - Lifetime
- 2002-05-14 US US10/145,824 patent/US7411047B2/en not_active Expired - Lifetime
- 2002-05-14 US US10/145,755 patent/US7312312B2/en not_active Expired - Lifetime
- 2002-05-14 US US10/145,958 patent/US7408042B2/en not_active Expired - Lifetime
- 2002-05-14 US US10/145,633 patent/US20030138892A1/en not_active Abandoned
- 2002-05-14 US US10/145,823 patent/US20030134368A1/en not_active Abandoned
- 2002-05-14 US US10/145,874 patent/US20030194766A1/en not_active Abandoned
- 2002-05-14 US US10/145,821 patent/US20030148438A1/en not_active Abandoned
- 2002-05-14 US US10/145,961 patent/US20040235092A1/en not_active Abandoned
- 2002-05-14 US US10/145,634 patent/US20030170788A1/en not_active Abandoned
- 2002-05-14 US US10/145,630 patent/US7309778B2/en not_active Expired - Lifetime
- 2002-05-14 US US10/145,818 patent/US20030157622A1/en not_active Abandoned
- 2002-05-14 US US10/145,632 patent/US7385031B2/en not_active Expired - Lifetime
- 2002-05-14 US US10/145,878 patent/US7317088B2/en not_active Expired - Lifetime
- 2002-05-14 US US10/145,872 patent/US20030157624A1/en not_active Abandoned
- 2002-05-14 US US10/145,877 patent/US7411040B2/en not_active Expired - Lifetime
- 2002-05-14 US US10/145,629 patent/US7285644B2/en not_active Expired - Lifetime
- 2002-05-14 US US10/145,822 patent/US20030166075A1/en not_active Abandoned
- 2002-05-14 US US10/145,826 patent/US7375195B2/en not_active Expired - Lifetime
- 2002-05-14 US US10/145,628 patent/US7285636B2/en not_active Expired - Lifetime
- 2002-05-14 US US10/145,754 patent/US20030157620A1/en not_active Abandoned
- 2002-05-14 US US10/145,747 patent/US20030157618A1/en not_active Abandoned
- 2002-05-14 US US10/145,750 patent/US7417115B2/en not_active Expired - Lifetime
- 2002-05-14 US US10/145,962 patent/US7335746B2/en not_active Expired - Lifetime
- 2002-05-14 US US10/145,869 patent/US20030166078A1/en not_active Abandoned
- 2002-05-14 US US10/145,871 patent/US7396907B2/en not_active Expired - Lifetime
- 2002-05-14 US US10/145,959 patent/US7390878B2/en not_active Expired - Lifetime
- 2002-05-14 US US10/145,625 patent/US20030180868A1/en not_active Abandoned
- 2002-05-14 US US10/145,960 patent/US7317074B2/en not_active Expired - Lifetime
- 2002-05-14 US US10/145,820 patent/US20030157623A1/en not_active Abandoned
- 2002-05-14 US US10/145,748 patent/US7354998B2/en not_active Expired - Lifetime
- 2002-05-14 US US10/145,749 patent/US20030207371A1/en not_active Abandoned
- 2002-05-14 US US10/145,626 patent/US7429640B2/en not_active Expired - Lifetime
- 2002-05-14 US US10/145,631 patent/US7371824B2/en not_active Expired - Lifetime
- 2002-05-14 US US10/145,825 patent/US7335740B2/en not_active Expired - Lifetime
- 2002-05-14 US US10/145,752 patent/US7319136B2/en not_active Expired - Lifetime
- 2002-05-14 US US10/145,870 patent/US7294703B2/en not_active Expired - Lifetime
- 2002-05-15 US US10/146,725 patent/US20030134374A1/en not_active Abandoned
- 2002-05-15 US US10/146,791 patent/US20030082709A1/en not_active Abandoned
- 2002-05-15 US US10/146,795 patent/US20030134375A1/en not_active Abandoned
- 2002-05-15 US US10/146,793 patent/US20030166084A1/en not_active Abandoned
- 2002-05-15 US US10/146,790 patent/US20030166083A1/en not_active Abandoned
- 2002-05-15 US US10/146,792 patent/US20030207428A1/en not_active Abandoned
- 2002-05-15 US US10/146,726 patent/US20030129690A1/en not_active Abandoned
- 2002-05-15 US US10/146,787 patent/US20030166082A1/en not_active Abandoned
- 2002-05-15 US US10/146,728 patent/US20030203437A1/en not_active Abandoned
- 2002-05-15 US US10/146,730 patent/US20030207427A1/en not_active Abandoned
- 2002-05-15 US US10/146,729 patent/US20030082708A1/en not_active Abandoned
- 2002-05-15 US US10/146,788 patent/US20030129693A1/en not_active Abandoned
- 2002-05-15 US US10/146,724 patent/US20030134373A1/en not_active Abandoned
- 2002-05-15 US US10/146,731 patent/US20030129692A1/en not_active Abandoned
- 2002-05-16 US US10/147,512 patent/US7087428B2/en not_active Expired - Fee Related
- 2002-05-16 US US10/147,508 patent/US20030082711A1/en not_active Abandoned
- 2002-05-16 US US10/147,528 patent/US20030219885A1/en not_active Abandoned
- 2002-05-16 US US10/147,517 patent/US20030077726A1/en not_active Abandoned
- 2002-05-16 US US10/147,520 patent/US20030170789A1/en not_active Abandoned
- 2002-05-16 US US10/147,509 patent/US20030134380A1/en not_active Abandoned
- 2002-05-16 US US10/147,524 patent/US20030166093A1/en not_active Abandoned
- 2002-05-16 US US10/147,529 patent/US20030134383A1/en not_active Abandoned
- 2002-05-16 US US10/147,502 patent/US20030077724A1/en not_active Abandoned
- 2002-05-16 US US10/147,484 patent/US20030082710A1/en not_active Abandoned
- 2002-05-16 US US10/147,503 patent/US20030157628A1/en not_active Abandoned
- 2002-05-16 US US10/147,497 patent/US20030194767A1/en not_active Abandoned
- 2002-05-16 US US10/147,518 patent/US20040214269A1/en not_active Abandoned
- 2002-05-16 US US10/147,500 patent/US20030077723A1/en not_active Abandoned
- 2002-05-16 US US10/147,523 patent/US20030092113A1/en not_active Abandoned
- 2002-05-17 US US10/147,489 patent/US20030207376A1/en not_active Abandoned
- 2002-05-17 US US10/147,511 patent/US20030134382A1/en not_active Abandoned
- 2002-05-17 US US10/147,501 patent/US20030134377A1/en not_active Abandoned
- 2002-05-17 US US10/147,491 patent/US20030175865A1/en not_active Abandoned
- 2002-05-17 US US10/147,515 patent/US20030077725A1/en not_active Abandoned
- 2002-05-17 US US10/147,495 patent/US20030134376A1/en not_active Abandoned
- 2002-05-17 US US10/147,487 patent/US20030166088A1/en not_active Abandoned
- 2002-05-17 US US10/147,531 patent/US20040253667A1/en not_active Abandoned
- 2002-05-17 US US10/147,498 patent/US20030166091A1/en not_active Abandoned
- 2002-05-17 US US10/147,494 patent/US20030166090A1/en not_active Abandoned
- 2002-05-17 US US10/147,499 patent/US20030203439A1/en not_active Abandoned
- 2002-05-17 US US10/147,506 patent/US20030134379A1/en not_active Abandoned
- 2002-05-17 US US10/147,526 patent/US20030077727A1/en not_active Abandoned
- 2002-05-17 US US10/147,488 patent/US20040253666A1/en not_active Abandoned
- 2002-05-17 US US10/147,486 patent/US20030166087A1/en not_active Abandoned
- 2002-05-17 US US10/147,482 patent/US20030157627A1/en not_active Abandoned
- 2002-05-17 US US10/147,514 patent/US20030166092A1/en not_active Abandoned
- 2002-05-17 US US10/147,519 patent/US20030077791A1/en not_active Abandoned
- 2002-05-17 US US10/147,492 patent/US20030082765A1/en not_active Abandoned
- 2002-05-17 US US10/147,490 patent/US20030166089A1/en not_active Abandoned
- 2002-05-17 US US10/147,510 patent/US20030134381A1/en not_active Abandoned
- 2002-05-17 US US10/147,505 patent/US20030180875A1/en not_active Abandoned
- 2002-05-17 US US10/147,481 patent/US20030157626A1/en not_active Abandoned
- 2002-05-17 US US10/147,496 patent/US20030180874A1/en not_active Abandoned
- 2002-05-17 US US10/147,504 patent/US20030134378A1/en not_active Abandoned
- 2002-05-17 US US10/147,537 patent/US20030207379A1/en not_active Abandoned
- 2002-05-17 US US10/147,516 patent/US20030180876A1/en not_active Abandoned
- 2002-05-17 US US10/147,485 patent/US7098003B2/en not_active Expired - Fee Related
- 2002-05-17 US US10/147,536 patent/US20040077064A1/en not_active Abandoned
- 2002-05-17 US US10/147,480 patent/US20030166085A1/en not_active Abandoned
- 2002-05-17 US US10/147,535 patent/US20030207378A1/en not_active Abandoned
- 2002-05-17 US US10/147,527 patent/US20030077728A1/en not_active Abandoned
- 2002-05-17 US US10/147,513 patent/US7220568B2/en not_active Expired - Fee Related
- 2002-05-17 US US10/147,507 patent/US20030207377A1/en not_active Abandoned
- 2002-05-17 US US10/147,522 patent/US20030157629A1/en not_active Abandoned
- 2002-05-17 US US10/147,483 patent/US20030180873A1/en not_active Abandoned
- 2002-05-17 US US10/147,493 patent/US20040029217A1/en not_active Abandoned
- 2002-05-20 US US10/152,373 patent/US20030186367A1/en not_active Abandoned
- 2002-05-20 US US10/152,531 patent/US20030148439A1/en not_active Abandoned
- 2002-05-20 US US10/152,396 patent/US20030199027A1/en not_active Abandoned
- 2002-05-20 US US10/152,397 patent/US20030134384A1/en not_active Abandoned
- 2002-05-20 US US10/152,405 patent/US20030211571A1/en not_active Abandoned
- 2002-05-20 US US10/152,393 patent/US20030199026A1/en not_active Abandoned
- 2002-05-20 US US10/152,406 patent/US20030166096A1/en not_active Abandoned
- 2002-05-20 US US10/152,400 patent/US20030207383A1/en not_active Abandoned
- 2002-05-20 US US10/152,401 patent/US20030157630A1/en not_active Abandoned
- 2002-05-21 US US10/152,375 patent/US7160993B2/en not_active Expired - Lifetime
- 2002-05-21 US US10/152,399 patent/US20030194774A1/en not_active Abandoned
- 2002-05-21 US US10/152,395 patent/US7189534B2/en not_active Expired - Lifetime
- 2002-05-21 US US10/152,398 patent/US7074910B2/en not_active Expired - Fee Related
- 2002-05-21 US US10/152,379 patent/US20030166094A1/en not_active Abandoned
- 2002-05-21 US US10/152,374 patent/US20030194769A1/en not_active Abandoned
- 2002-05-21 US US10/152,371 patent/US20030194768A1/en not_active Abandoned
- 2002-05-21 US US10/152,382 patent/US20030175867A1/en not_active Abandoned
- 2002-05-21 US US10/152,394 patent/US20030166095A1/en not_active Abandoned
- 2002-05-21 US US10/152,389 patent/US20030175871A1/en not_active Abandoned
- 2002-05-21 US US10/152,386 patent/US20030194772A1/en not_active Abandoned
- 2002-05-21 US US10/152,387 patent/US20030175870A1/en not_active Abandoned
- 2002-05-21 US US10/152,377 patent/US20030194771A1/en not_active Abandoned
- 2002-05-21 US US10/152,372 patent/US20040126839A1/en not_active Abandoned
- 2002-05-21 US US10/152,391 patent/US20030194773A1/en not_active Abandoned
- 2002-05-21 US US10/152,376 patent/US20030207381A1/en not_active Abandoned
- 2002-05-21 US US10/152,403 patent/US20030175874A1/en not_active Abandoned
- 2002-05-21 US US10/152,380 patent/US20030129694A1/en not_active Abandoned
- 2002-05-21 US US10/152,378 patent/US20030175866A1/en not_active Abandoned
- 2002-05-21 US US10/152,381 patent/US20030207382A1/en not_active Abandoned
- 2002-05-21 US US10/152,383 patent/US20030175868A1/en not_active Abandoned
- 2002-05-21 US US10/152,392 patent/US20030175873A1/en not_active Abandoned
- 2002-05-21 US US10/152,384 patent/US20030175869A1/en not_active Abandoned
- 2002-05-21 US US10/152,390 patent/US20030175872A1/en not_active Abandoned
- 2002-05-21 US US10/152,385 patent/US20030199025A1/en not_active Abandoned
- 2002-05-21 US US10/152,370 patent/US20060084139A1/en not_active Abandoned
- 2002-05-22 US US10/153,586 patent/US20030134385A1/en not_active Abandoned
- 2002-05-22 US US10/153,756 patent/US20030175875A1/en not_active Abandoned
- 2002-05-22 US US10/153,585 patent/US20030207384A1/en not_active Abandoned
- 2002-05-22 US US10/153,840 patent/US20030199029A1/en not_active Abandoned
- 2002-05-22 US US10/153,552 patent/US20030199028A1/en not_active Abandoned
- 2002-05-22 US US10/153,934 patent/US20030129695A1/en not_active Abandoned
- 2002-05-28 US US10/156,845 patent/US20030199033A1/en not_active Abandoned
- 2002-05-28 US US10/156,841 patent/US20030199030A1/en not_active Abandoned
- 2002-05-28 US US10/156,848 patent/US20030194775A1/en not_active Abandoned
- 2002-05-28 US US10/156,844 patent/US20030199032A1/en not_active Abandoned
- 2002-05-28 US US10/156,842 patent/US20030199031A1/en not_active Abandoned
- 2002-05-28 US US10/156,847 patent/US20030166098A1/en not_active Abandoned
- 2002-05-29 US US10/157,782 patent/US20030077792A1/en not_active Abandoned
- 2002-05-29 US US10/158,462 patent/US20030158104A1/en not_active Abandoned
- 2002-05-29 US US10/157,784 patent/US20030175878A1/en not_active Abandoned
- 2002-05-29 US US10/157,800 patent/US20030207386A1/en not_active Abandoned
- 2002-05-29 US US10/157,794 patent/US20030194777A1/en not_active Abandoned
- 2002-05-29 US US10/157,801 patent/US20030207387A1/en not_active Abandoned
- 2002-05-29 US US10/157,783 patent/US20030157631A1/en not_active Abandoned
- 2002-05-29 US US10/158,491 patent/US20030175880A1/en not_active Abandoned
- 2002-05-29 US US10/157,797 patent/US20030175879A1/en not_active Abandoned
- 2002-05-29 US US10/157,798 patent/US20030203440A1/en not_active Abandoned
- 2002-05-29 US US10/157,779 patent/US20030175877A1/en not_active Abandoned
- 2002-05-29 US US10/157,781 patent/US20030170790A1/en not_active Abandoned
- 2002-05-29 US US10/157,799 patent/US20030166101A1/en not_active Abandoned
- 2002-05-29 US US10/157,796 patent/US20030194778A1/en not_active Abandoned
- 2002-05-29 US US10/157,778 patent/US20030166100A1/en not_active Abandoned
- 2002-05-29 US US10/157,802 patent/US20030207388A1/en not_active Abandoned
- 2002-05-29 US US10/157,780 patent/US20030207385A1/en not_active Abandoned
- 2002-05-29 US US10/157,785 patent/US20030194776A1/en not_active Abandoned
- 2002-05-29 US US10/157,786 patent/US20030208055A1/en not_active Abandoned
- 2002-05-30 US US10/158,782 patent/US20030082766A1/en not_active Abandoned
- 2002-05-30 US US10/160,500 patent/US20030194779A1/en not_active Abandoned
- 2002-05-30 US US10/158,786 patent/US20030134791A1/en not_active Abandoned
- 2002-05-30 US US10/160,498 patent/US20030073216A1/en not_active Abandoned
- 2002-05-30 US US10/160,503 patent/US20040033559A1/en not_active Abandoned
- 2002-05-30 US US10/158,784 patent/US20030207389A1/en not_active Abandoned
- 2002-05-30 US US10/160,504 patent/US20030166102A1/en not_active Abandoned
- 2002-05-30 US US10/158,788 patent/US20050074837A1/en not_active Abandoned
- 2002-05-30 US US10/158,787 patent/US20040039164A1/en not_active Abandoned
- 2002-05-30 US US10/158,789 patent/US20030207390A1/en not_active Abandoned
- 2002-05-30 US US10/158,792 patent/US20030157632A1/en not_active Abandoned
- 2002-05-30 US US10/158,790 patent/US20030180879A1/en not_active Abandoned
- 2002-05-30 US US10/158,783 patent/US20030138893A1/en not_active Abandoned
- 2002-05-30 US US10/158,785 patent/US20030092115A1/en not_active Abandoned
- 2002-05-30 US US10/158,791 patent/US20030207429A1/en not_active Abandoned
- 2002-08-28 US US10/230,417 patent/US7297768B2/en not_active Expired - Lifetime
- 2002-10-16 KR KR10-2004-7009417A patent/KR20040074090A/ko not_active Application Discontinuation
- 2002-10-16 DE DE60228997T patent/DE60228997D1/de not_active Expired - Lifetime
- 2002-10-16 AT AT02805508T patent/ATE408419T1/de not_active IP Right Cessation
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2004
- 2004-06-18 ZA ZA200404849A patent/ZA200404849B/en unknown
- 2004-08-31 US US10/931,886 patent/US20050019823A1/en not_active Abandoned
- 2004-09-29 US US10/955,952 patent/US20050153396A1/en not_active Abandoned
- 2004-10-12 US US10/964,241 patent/US20070026487A1/en not_active Abandoned
- 2004-10-22 US US10/973,115 patent/US20060040351A1/en not_active Abandoned
- 2004-12-21 US US11/020,604 patent/US20050153348A1/en not_active Abandoned
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2005
- 2005-01-14 US US11/036,869 patent/US20050170396A1/en not_active Abandoned
- 2005-01-21 US US11/040,809 patent/US20050118635A1/en not_active Abandoned
- 2005-02-11 US US11/056,802 patent/US20050136515A1/en not_active Abandoned
- 2005-02-11 US US11/057,268 patent/US20060084144A1/en not_active Abandoned
- 2005-02-14 US US11/057,966 patent/US20050187379A1/en not_active Abandoned
- 2005-02-16 US US11/060,652 patent/US20050136475A1/en not_active Abandoned
- 2005-02-16 US US11/060,240 patent/US20050164279A1/en not_active Abandoned
- 2005-04-19 US US11/110,520 patent/US20050202496A1/en not_active Abandoned
- 2005-04-27 US US11/117,757 patent/US20050214846A1/en not_active Abandoned
- 2005-11-30 US US11/290,153 patent/US7524497B2/en not_active Expired - Fee Related
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2006
- 2006-01-27 US US11/341,175 patent/US7468427B2/en not_active Expired - Fee Related
- 2006-09-29 US US11/537,235 patent/US7504484B2/en not_active Expired - Fee Related
- 2006-10-04 US US11/538,714 patent/US8106156B2/en not_active Expired - Fee Related
- 2006-10-27 US US11/553,810 patent/US20070264686A1/en not_active Abandoned
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2007
- 2007-10-30 US US11/929,190 patent/US20080050758A1/en not_active Abandoned
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2009
- 2009-02-02 US US12/364,329 patent/US20090142786A1/en not_active Abandoned
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