ATE447583T1 - Polypeptide und dafür kodierende nukleinsäure - Google Patents

Polypeptide und dafür kodierende nukleinsäure

Info

Publication number
ATE447583T1
ATE447583T1 AT05024504T AT05024504T ATE447583T1 AT E447583 T1 ATE447583 T1 AT E447583T1 AT 05024504 T AT05024504 T AT 05024504T AT 05024504 T AT05024504 T AT 05024504T AT E447583 T1 ATE447583 T1 AT E447583T1
Authority
AT
Austria
Prior art keywords
polypeptides
present
nucleic acids
acids coding
coding therefor
Prior art date
Application number
AT05024504T
Other languages
English (en)
Inventor
William I Wood
Austin L Gurney
Audrey Goddard
Diane Pennica
Jian Chen
Jean Yuan
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Application granted granted Critical
Publication of ATE447583T1 publication Critical patent/ATE447583T1/de

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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/5758Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/30Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Zoology (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Dermatology (AREA)
AT05024504T 1997-09-17 1998-09-16 Polypeptide und dafür kodierende nukleinsäure ATE447583T1 (de)

Applications Claiming Priority (50)

Application Number Priority Date Filing Date Title
US5912297P 1997-09-17 1997-09-17
US5911997P 1997-09-17 1997-09-17
US5912197P 1997-09-17 1997-09-17
US5911597P 1997-09-17 1997-09-17
US5911797P 1997-09-17 1997-09-17
US5918497P 1997-09-17 1997-09-17
US5911397P 1997-09-17 1997-09-17
US5926397P 1997-09-18 1997-09-18
US5926697P 1997-09-18 1997-09-18
US6212597P 1997-10-15 1997-10-15
US6228797P 1997-10-17 1997-10-17
US6228597P 1997-10-17 1997-10-17
US6348697P 1997-10-21 1997-10-21
US6304597P 1997-10-24 1997-10-24
US6312797P 1997-10-24 1997-10-24
US6312197P 1997-10-24 1997-10-24
US6281697P 1997-10-24 1997-10-24
US6312097P 1997-10-24 1997-10-24
US6312897P 1997-10-24 1997-10-24
US6281497P 1997-10-24 1997-10-24
US6332797P 1997-10-27 1997-10-27
US6332997P 1997-10-27 1997-10-27
US6354497P 1997-10-28 1997-10-28
US6354197P 1997-10-28 1997-10-28
US6356497P 1997-10-28 1997-10-28
US6354297P 1997-10-28 1997-10-28
US6354997P 1997-10-28 1997-10-28
US6355097P 1997-10-28 1997-10-28
US6343597P 1997-10-29 1997-10-29
US6373497P 1997-10-29 1997-10-29
US6373597P 1997-10-29 1997-10-29
US6373897P 1997-10-29 1997-10-29
US6370497P 1997-10-29 1997-10-29
US6421597P 1997-10-29 1997-10-29
US6373297P 1997-10-29 1997-10-29
US6410397P 1997-10-31 1997-10-31
US6387097P 1997-10-31 1997-10-31
US6424897P 1997-11-03 1997-11-03
US6480997P 1997-11-07 1997-11-07
US6518697P 1997-11-12 1997-11-12
US6584697P 1997-11-17 1997-11-17
US6569397P 1997-11-18 1997-11-18
US6612097P 1997-11-21 1997-11-21
US6636497P 1997-11-21 1997-11-21
US6645397P 1997-11-24 1997-11-24
US6677297P 1997-11-24 1997-11-24
US6651197P 1997-11-24 1997-11-24
US6646697P 1997-11-24 1997-11-24
US6677097P 1997-11-24 1997-11-24
US6684097P 1997-11-25 1997-11-25

Publications (1)

Publication Number Publication Date
ATE447583T1 true ATE447583T1 (de) 2009-11-15

Family

ID=27586996

Family Applications (1)

Application Number Title Priority Date Filing Date
AT05024504T ATE447583T1 (de) 1997-09-17 1998-09-16 Polypeptide und dafür kodierende nukleinsäure

Country Status (9)

Country Link
US (1) US7208312B1 (de)
JP (6) JP2001516580A (de)
KR (1) KR100502596B1 (de)
AT (1) ATE447583T1 (de)
AU (1) AU741060C (de)
CA (1) CA2303834A1 (de)
IL (2) IL134968A0 (de)
NZ (1) NZ503343A (de)
WO (1) WO1999014328A2 (de)

Families Citing this family (121)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000021996A2 (en) * 1998-10-13 2000-04-20 Genentech, Inc. Methods and compositions for inhibiting neoplastic cell growth
WO2001004311A1 (en) * 1999-07-07 2001-01-18 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
WO2001019991A1 (en) * 1999-09-15 2001-03-22 Genentech, Inc. Compositions and methods for the treatment of immune related diseases
US5728546A (en) 1995-06-05 1998-03-17 Human Genome Sciences, Inc. Fibroblast growth factor 13
CA2272239A1 (en) 1996-11-27 1998-06-04 Human Genome Sciences, Inc. Fibroblast growth factor-13
US7026447B2 (en) 1997-10-09 2006-04-11 Human Genome Sciences, Inc. 53 human secreted proteins
EP0970209A1 (de) * 1997-03-28 2000-01-12 Genetics Institute, Inc. Sekretierte proteine und polynukleotide die für diese kodieren
US20020137890A1 (en) 1997-03-31 2002-09-26 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
US7057017B2 (en) 1997-04-16 2006-06-06 Millennium Pharmaceuticals, Inc. Human dickkopf-related protein and nucleic acid molecules and uses therefor
US7169906B2 (en) 1997-09-17 2007-01-30 Genentech, Inc. PRO211 polypeptides
US20030054400A1 (en) * 1997-09-17 2003-03-20 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
US20020192659A1 (en) * 1997-09-17 2002-12-19 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
US6974689B1 (en) 1997-09-18 2005-12-13 Genentech, Inc. Nucleic acid encoding PRO211 polypeptides
US20030032102A1 (en) 1997-09-18 2003-02-13 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
US7307152B2 (en) 1997-10-17 2007-12-11 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
EP1032668B1 (de) * 1997-11-25 2008-05-28 Genentech, Inc. Fibroblasten-wachstumsfaktor-19
US7446181B2 (en) 1998-01-15 2008-11-04 Millennium Pharmaceuticals, Inc. Antibodies that bind human Dickkopf-1 proteins
US6203979B1 (en) 1998-01-16 2001-03-20 Incyte Pharmaceuticals, Inc. Human protease molecules
US7045333B1 (en) 1998-01-16 2006-05-16 Incyte Corporation Human protease molecules
EP0939124A3 (de) * 1998-02-24 2001-03-21 Smithkline Beecham Plc MBGP1-Sequenzen
JP2002504377A (ja) * 1998-02-25 2002-02-12 スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー ヒトシステインプロテアーゼcprot03
US20020076753A1 (en) * 2000-03-31 2002-06-20 Glucksmann Maria Alexandra 31939, a novel human leucine-rich repeat family member and uses thereof
IL140938A0 (en) 1998-08-07 2002-02-10 Immunex Corp Molecules designated b7l-1
US6168920B1 (en) * 1998-08-10 2001-01-02 Incyte Genomics, Inc. Extracellular adhesive proteins
IL141426A0 (en) * 1998-09-10 2002-03-10 Genentech Inc Compositions and methods for the treatment of tumor
KR20010085792A (ko) * 1998-09-14 2001-09-07 제넨테크, 인크. 혈관형성 및 심혈관형성의 촉진 또는 억제
AU5922999A (en) * 1998-09-16 2000-04-03 Genentech Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
CA2343006A1 (en) * 1998-09-17 2000-03-23 Genentech, Inc. Compositions and methods for the treatment of immune related diseases
US6344541B1 (en) * 1998-09-25 2002-02-05 Amgen Inc. DKR polypeptides
US7030235B1 (en) * 1998-09-29 2006-04-18 The Brigham & Women's Hospital, Inc. Compositions to detect lesions associated with hearing loss in the cochlear gene, COCH5B2
JP2002525117A (ja) * 1998-09-30 2002-08-13 ミレニアム・フアーマシユーチカルズ・インコーポレーテツド Slgpタンパク質及び核酸分子並びにそれらの使用
US6808895B1 (en) 1999-10-06 2004-10-26 Incyte Corporation DNA encoding oxidoreductase and polypeptide encoded thereby
WO2000020604A2 (en) * 1998-10-06 2000-04-13 Incyte Pharmaceuticals, Inc. Oxidoreductase molecules
US6902892B1 (en) 1998-10-19 2005-06-07 Diadexus, Inc. Method of diagnosing, monitoring, staging, imaging and treating prostate cancer
WO2000031275A1 (en) * 1998-11-19 2000-06-02 Azwell Inc. Recombinant lysophosphatidic acid phosphatase
US20050053983A1 (en) 1998-11-20 2005-03-10 Fuso Pharmaceutical Industries, Ltd. Novel serine protease BSSP4
WO2000031277A1 (en) * 1998-11-20 2000-06-02 Fuso Pharmaceutical Industries, Ltd. Novel serine proteases bssp4
AU2588000A (en) * 1998-12-02 2000-06-19 Icos Corporation Novel adhesion molecule and methods of use
EP2075335A3 (de) * 1998-12-22 2009-09-30 Genentech, Inc. Verfahren und Zusammensetzungen zur Hemmung des neoplastischen Zellenwachstums
AU2375800A (en) * 1998-12-23 2000-07-31 Immunex Corporation Lectin s3939 dna and polypeptides
AU2376200A (en) * 1999-01-07 2000-07-24 Incyte Pharmaceuticals, Inc. Insulin-synthesis genes
US6174682B1 (en) 1999-03-08 2001-01-16 Millenium Pharmaceuticals, Inc. Thioredoxin family active site molecules and uses therefor
AU1749800A (en) * 1999-03-12 2000-10-04 Genentech Inc. Methods and compositions for inhibiting neoplastic cell growth
US6436642B1 (en) 1999-04-20 2002-08-20 Curagen Corporation Method of classifying a thyroid carcinoma using differential gene expression
US6485957B1 (en) * 1999-04-30 2002-11-26 Ortho-Mcneil Pharmaceutical, Inc. DNA encoding the human serine protease EOS
US7034132B2 (en) 2001-06-04 2006-04-25 Anderson David W Therapeutic polypeptides, nucleic acids encoding same, and methods of use
EP1978029A3 (de) * 1999-06-15 2008-10-15 Genentech, Inc. Sekretierte und Transmembran-Polypeptide sowie Nukleinsäuren zu deren Kodierung
ATE448246T1 (de) * 1999-06-15 2009-11-15 Genentech Inc Sekretierte und transmembran-polypeptide sowie nukleinsäuren zu deren kodierung
US6960651B2 (en) 1999-06-29 2005-11-01 Millennium Pharmaceuticals, Inc. TANGO 332 polypeptides
US7001766B2 (en) 1999-07-20 2006-02-21 Curagen Corporation Nucleic acid sequences encoding human angiopoietin-like polypeptides
AU2390700A (en) * 1999-07-20 2001-02-05 Genentech Inc. Polypeptidic compositions and methods for the treatment of tumors
US6426199B1 (en) * 1999-08-31 2002-07-30 Ortho-Mcneil Pharmaceutical, Inc. Dna
US6458564B1 (en) 1999-08-31 2002-10-01 Ortho-Mcneil Pharmaceutical, Inc. DNA encoding the human serine protease T
CN1560249A (zh) * 1999-09-08 2005-01-05 杰南技术公司 成纤维细胞生长因子-19(fgf-19)的核酸和多肽以及用于治疗肥胖的方法
AU7452300A (en) * 1999-10-01 2001-05-10 Kyowa Hakko Kogyo Co. Ltd. Shear stress-response dna
US6824780B1 (en) 1999-10-29 2004-11-30 Genentech, Inc. Anti-tumor antibody compositions and methods of use
US7115665B1 (en) 2000-11-16 2006-10-03 Onocozyme Pharma, Inc. Inhibitors of endo-exonuclease activity for treating cancer
EP1234877B1 (de) * 1999-11-19 2010-06-02 Kumon, Hiromi Die zellvermehrung hemmendes protein, polynukleotid, antisens-polynukleotid und zellvermehrungshemmer, krebsdiagnostik, krebsheilmittel und zusammensetzungen zur gentherapie
EP1672070A3 (de) * 1999-12-01 2006-10-04 Genentech, Inc. Sekretierte und transmembrane Polypeptide, sowie dafür codierende Nukleinsäuren
US20070087342A1 (en) * 2000-01-14 2007-04-19 Incyte Corporation Secreted proteins
US7122631B2 (en) 2000-02-22 2006-10-17 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
WO2001062785A2 (en) * 2000-02-24 2001-08-30 Oxford Glycosciences (Uk) Ltd. Protein and gene and their use for diagnosis and treatment of schizophrenia
AU3589101A (en) * 2000-02-24 2001-09-03 Oxford Glycosciences (Uk) Limited Dpi-6, a putative therapeutic target and biomarker in neuropsychiatric and neurological disorders
EP1918366A1 (de) 2000-02-26 2008-05-07 Artecel, Inc. Pluripotente Stammzellen aus Bindegewebszellen aus dem Fettgewebe und Verwendungen dafür
WO2001064882A2 (en) * 2000-02-29 2001-09-07 Millennium Pharmaceuticals, Inc. 1983, 52881, 2398, 45449, 50289, and 52872, g protein-coupled receptors and uses therefor
US6627423B2 (en) 2000-03-24 2003-09-30 Millennium Pharmaceuticals, Inc. 21481, a novel dehydrogenase molecule and uses therefor
US6511834B1 (en) 2000-03-24 2003-01-28 Millennium Pharmaceuticals, Inc. 32142,21481,25964,21686, novel human dehydrogenase molecules and uses therefor
WO2001075099A1 (en) * 2000-04-04 2001-10-11 National Cancer Centre Of Singapore Pte Ltd Nucleic acid molecule encoding a uterine estrogen agonist-inducible protein
EP1309686A2 (de) * 2000-06-30 2003-05-14 Millennium Pharmaceuticals, Inc. Slgp protein und dessen nukleinsäuren und verwendungen
DE10106835A1 (de) * 2001-02-14 2002-09-05 Basf Lynx Bioscience Ag Signaltransduktionsproteine 15B3, 15B3-1 und 15B3-2 und zugrundeliegende DNA-Sequenzen
JP4272512B2 (ja) 2001-06-27 2009-06-03 キャンサー・リサーチ・テクノロジー・リミテッド
WO2003025162A2 (en) * 2001-09-20 2003-03-27 Bayer Healthcare Ag Regulation of human prolyl 4-hydroxylase alpha subunit precursor
US20050089957A1 (en) * 2001-10-19 2005-04-28 Audrey Goddard Compositions and methods for the diagnosis and treatment of inflammatory bowel disorders
AU2003227179A1 (en) * 2002-02-08 2003-09-09 Amersham Biosciences K.K. Fused protein having glucuronyl transferase activity
EP1491628A4 (de) * 2002-03-29 2006-10-18 Nat Inst Of Advanced Ind Scien Neue galactosetransferasen, peptide davon und diese codierende nukleinsäure
MXPA04012243A (es) 2002-06-07 2005-02-25 Genentech Inc Composiciones y metodos para l diagnostico y tratamiento de tumores.
AU2003246085A1 (en) * 2002-06-28 2004-01-19 Takeda Chemical Industries, Ltd. Diagnostics/preventives/remedies for respiratory diseases
EP1541677A4 (de) 2002-07-10 2007-06-27 Takeda Pharmaceutical Neue proteine und verwendung davon
CA2511556A1 (en) * 2002-12-27 2004-07-29 Applied Research Systems Ars Holding N.V. Novel fibrillin-like polypeptides
WO2004085648A2 (en) 2003-03-19 2004-10-07 Biogen Idec Ma Inc. Nogo receptor binding protein
RU2005141341A (ru) * 2003-05-30 2006-06-10 Эйдженсис, Инк., Сша (Us) Полинуклеотид, родственный антигену стволовых клеток простаты (psca), и кодируемый им белок (пептид), гибридома и трансгенное животное для продуцирования антител, композиция для лечения, профилактики, диагностики и прогноза течения раковых заболеваний на их основе (варианты), способ определения их присутствия в исследуемом образце, способ генерации иммунного ответа, способ доставки цитотоксического или диагностического агента в клетку, способ ингибирования роста раковых клеток с их использованием
US7595379B2 (en) 2003-05-30 2009-09-29 Agensys, Inc. Antibodies and related molecules that bind to PSCA proteins
US7541442B2 (en) 2003-05-30 2009-06-02 Agensys, Inc. Antibodies and related molecules that bind to PSCA proteins
CA2550117A1 (en) 2003-12-16 2005-06-30 Genentech, Inc. Novel gene disruptions, compositions and methods relating thereto
ES2567634T3 (es) 2004-02-09 2016-04-25 Human Genome Sciences, Inc. Proteínas de fusión de albúmina
US20100031378A1 (en) 2008-08-04 2010-02-04 Edwards Joel A Novel gene disruptions, compositions and methods relating thereto
JP2007527712A (ja) * 2004-02-12 2007-10-04 レキシコン・ジェネティクス・インコーポレーテッド 新規な遺伝子破壊、これに関する組成物と方法
GB0406215D0 (en) 2004-03-19 2004-04-21 Procure Therapeutics Ltd Prostate stem cell
JP4566603B2 (ja) * 2004-03-31 2010-10-20 財団法人かずさディー・エヌ・エー研究所 細胞付着ポリペプチド
EP1744620A2 (de) * 2004-05-12 2007-01-24 Genentech, Inc. Neue gendisruptionen, zusammensetzungen und verfahren hierfür
PT1776136E (pt) 2004-06-24 2012-12-05 Biogen Idec Inc Tratamento de estados que envolvem desmielinização
MX2007001221A (es) 2004-08-04 2007-03-23 Amgen Inc Anticuerpos para proteina dickkopf-1 (dkk-1).
US7544659B2 (en) 2004-08-13 2009-06-09 Genentech, Inc. Promotion of axonal regeneration
US7947436B2 (en) 2004-12-13 2011-05-24 Alethia Biotherapeutics Inc. Polynucleotides and polypeptide sequences involved in the process of bone remodeling
SI1904104T1 (sl) 2005-07-08 2013-12-31 Biogen Idec Ma Inc. Protitelesa SP35 in njihova uporaba
US8128926B2 (en) 2007-01-09 2012-03-06 Biogen Idec Ma Inc. Sp35 antibodies and uses thereof
EP2285961A4 (de) * 2008-05-15 2012-10-17 Topigen Pharmaceuticals Inc Oligonukleotide zur behandlung von entzündungen und neoplastischer zellvermehrung
DK2982695T3 (da) 2008-07-09 2019-05-13 Biogen Ma Inc Sammensætninger, der omfatter antistoffer mod lingo eller fragmenter deraf
WO2010054096A1 (en) * 2008-11-07 2010-05-14 The Cleveland Clinic Foundation Method for detecting and purifying pancreatic beta cells
JP5773879B2 (ja) 2008-11-25 2015-09-02 バイオジェン・エムエイ・インコーポレイテッドBiogen MA Inc. 神経系の細胞の生存を促進するためのDR6およびp75のアンタゴニストの使用
WO2013006486A2 (en) 2011-07-01 2013-01-10 Ngm Biopharmaceuticals, Inc. Compositions, uses and methods for treatment of metabolic disorders and diseases
CN104470541A (zh) 2012-05-14 2015-03-25 比奥根艾迪克Ma公司 用于治疗涉及运动神经元的疾患的lingo-2拮抗剂
US9290557B2 (en) 2012-11-28 2016-03-22 Ngm Biopharmaceuticals, Inc. Compositions comprising variants and fusions of FGF19 polypeptides
HK1214832A1 (zh) 2012-11-28 2016-08-05 恩格姆生物制药公司 用於代謝病症和疾病治療的組合物和方法
US9273107B2 (en) 2012-12-27 2016-03-01 Ngm Biopharmaceuticals, Inc. Uses and methods for modulating bile acid homeostasis and treatment of bile acid disorders and diseases
MX383664B (es) 2012-12-27 2025-03-14 Ngm Biopharmaceuticals Inc Uso de un péptido para modular la homeostasis de los ácidos biliares o tratamiento de una enfermedad relacionada con los ácidos biliares.
WO2015065897A1 (en) 2013-10-28 2015-05-07 Ngm Biopharmaceuticals, Inc. Cancer models and associated methods
PT3097122T (pt) 2014-01-24 2020-07-21 Ngm Biopharmaceuticals Inc Anticorpos de ligação de domínio 2 de beta klotho e métodos de utilização dos mesmos
US10398758B2 (en) 2014-05-28 2019-09-03 Ngm Biopharmaceuticals, Inc. Compositions comprising variants of FGF19 polypeptides and uses thereof for the treatment of hyperglycemic conditions
WO2015195509A2 (en) 2014-06-16 2015-12-23 Ngm Biopharmaceuticals, Inc. Methods and uses for modulating bile acid homeostasis and treatment of bile acid disorders and diseases
US9616114B1 (en) 2014-09-18 2017-04-11 David Gordon Bermudes Modified bacteria having improved pharmacokinetics and tumor colonization enhancing antitumor activity
CN114129709A (zh) 2014-10-23 2022-03-04 恩格姆生物制药公司 包含肽变异体的药物组合物及其使用方法
US10434144B2 (en) 2014-11-07 2019-10-08 Ngm Biopharmaceuticals, Inc. Methods for treatment of bile acid-related disorders and prediction of clinical sensitivity to treatment of bile acid-related disorders
JP2018504400A (ja) 2015-01-08 2018-02-15 バイオジェン・エムエイ・インコーポレイテッドBiogen MA Inc. Lingo‐1拮抗薬及び脱髄障害の治療のための使用
US10676723B2 (en) 2015-05-11 2020-06-09 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
WO2017019957A2 (en) 2015-07-29 2017-02-02 Ngm Biopharmaceuticals, Inc. Binding proteins and methods of use thereof
JP6728352B2 (ja) 2015-11-09 2020-07-22 エヌジーエム バイオファーマシューティカルス,インコーポレーテッド 胆汁酸に関係した障害の治療方法
EP3503882A4 (de) 2016-08-26 2020-07-29 NGM Biopharmaceuticals, Inc. Verfahren zur behandlung von fibroblastenwachstumsfaktor-19-vermittelten karzinomen und tumoren
US11180535B1 (en) 2016-12-07 2021-11-23 David Gordon Bermudes Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria
US11129906B1 (en) 2016-12-07 2021-09-28 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
CN107271337B (zh) * 2017-04-24 2023-09-15 中国人民解放军军事医学科学院卫生装备研究所 一种人体肺泡气溶胶沉积测量实验系统

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030054400A1 (en) * 1997-09-17 2003-03-20 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same

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AU9317898A (en) 1999-04-05
CA2303834A1 (en) 1999-03-25
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IL134968A (en) 2007-05-15
AU741060C (en) 2002-09-19
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US7208312B1 (en) 2007-04-24
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