DE513200T1 - Verfahren und zusammensetzungen zur synthese von bch-189 und verwandten verbindungen. - Google Patents
Verfahren und zusammensetzungen zur synthese von bch-189 und verwandten verbindungen.Info
- Publication number
- DE513200T1 DE513200T1 DE0513200T DE91904454T DE513200T1 DE 513200 T1 DE513200 T1 DE 513200T1 DE 0513200 T DE0513200 T DE 0513200T DE 91904454 T DE91904454 T DE 91904454T DE 513200 T1 DE513200 T1 DE 513200T1
- Authority
- DE
- Germany
- Prior art keywords
- bch
- related compounds
- synthesising
- compositions
- analogues
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D327/00—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms
- C07D327/02—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms one oxygen atom and one sulfur atom
- C07D327/04—Five-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D411/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms
- C07D411/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D411/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/473,318 US5204466A (en) | 1990-02-01 | 1990-02-01 | Method and compositions for the synthesis of bch-189 and related compounds |
PCT/US1991/000685 WO1991011186A1 (en) | 1990-02-01 | 1991-01-31 | Method and compositions for the synthesis of bch-189 and related compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
DE513200T1 true DE513200T1 (de) | 1995-07-13 |
Family
ID=23879071
Family Applications (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE0513200T Pending DE513200T1 (de) | 1990-02-01 | 1991-01-31 | Verfahren und zusammensetzungen zur synthese von bch-189 und verwandten verbindungen. |
DE200412000015 Active DE122004000015I2 (de) | 1990-02-01 | 1991-01-31 | Verfahren und zusammensetzungen zur Synthese von BCH-189 und verwandten Verbindungen. |
DE69133556T Expired - Lifetime DE69133556T2 (de) | 1990-02-01 | 1991-01-31 | Verfahren und Zusammensetzungen für die Synthese von BCH-189 und verwandten Verbindungen |
DE69130166T Expired - Lifetime DE69130166T3 (de) | 1990-02-01 | 1991-01-31 | Verfahren und zusammensetzungen zur synthese von bch-189 und verwandten verbindungen |
Family Applications After (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE200412000015 Active DE122004000015I2 (de) | 1990-02-01 | 1991-01-31 | Verfahren und zusammensetzungen zur Synthese von BCH-189 und verwandten Verbindungen. |
DE69133556T Expired - Lifetime DE69133556T2 (de) | 1990-02-01 | 1991-01-31 | Verfahren und Zusammensetzungen für die Synthese von BCH-189 und verwandten Verbindungen |
DE69130166T Expired - Lifetime DE69130166T3 (de) | 1990-02-01 | 1991-01-31 | Verfahren und zusammensetzungen zur synthese von bch-189 und verwandten verbindungen |
Country Status (22)
Country | Link |
---|---|
US (8) | US5204466A (de) |
EP (3) | EP0513200B2 (de) |
JP (6) | JPH07618B2 (de) |
KR (2) | KR100188357B1 (de) |
AT (1) | ATE170750T1 (de) |
AU (6) | AU658136C (de) |
BG (1) | BG62236B1 (de) |
CA (3) | CA2678778A1 (de) |
DE (4) | DE513200T1 (de) |
DK (2) | DK0872237T3 (de) |
ES (2) | ES2279559T3 (de) |
FI (4) | FI114471B (de) |
GR (1) | GR950300024T1 (de) |
HK (1) | HK1014664A1 (de) |
HU (4) | HUT62566A (de) |
LU (1) | LU91073I2 (de) |
MC (1) | MC2233A1 (de) |
NL (1) | NL300148I2 (de) |
NO (6) | NO923014L (de) |
RO (1) | RO108564B1 (de) |
RU (1) | RU2125558C1 (de) |
WO (1) | WO1991011186A1 (de) |
Families Citing this family (150)
Publication number | Priority date | Publication date | Assignee | Title |
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US5466806A (en) * | 1989-02-08 | 1995-11-14 | Biochem Pharma Inc. | Processes for preparing substituted 1,3-oxathiolanes with antiviral properties |
US6903224B2 (en) | 1988-04-11 | 2005-06-07 | Biochem Pharma Inc. | Substituted 1,3-oxathiolanes |
US7119202B1 (en) * | 1989-02-08 | 2006-10-10 | Glaxo Wellcome Inc. | Substituted-1,3-oxathiolanes and substituted-1,3-dioxolanes with antiviral properties |
US6175008B1 (en) * | 1988-04-11 | 2001-01-16 | Biochem Pharma Inc. | Processes for preparing substituted 1,3-oxathiolanes with antiviral properties |
DK0674634T3 (da) * | 1989-02-08 | 2003-08-04 | Iaf Biochem Int | Fremgangsmåde til fremstilling af substituerede 1,3-oxathiolaner med antivirale egenskaber |
US6703396B1 (en) * | 1990-02-01 | 2004-03-09 | Emory University | Method of resolution and antiviral activity of 1,3-oxathiolane nuclesoside enantiomers |
US5914331A (en) * | 1990-02-01 | 1999-06-22 | Emory University | Antiviral activity and resolution of 2-hydroxymethyl-5-(5-fluorocytosin-1-yl)-1,3-oxathiolane |
US6346627B1 (en) * | 1990-02-01 | 2002-02-12 | Emory University | Intermediates in the synthesis of 1,3-oxathiolane nucleoside enantiomers |
US5204466A (en) * | 1990-02-01 | 1993-04-20 | Emory University | Method and compositions for the synthesis of bch-189 and related compounds |
US20090239887A1 (en) * | 1990-02-01 | 2009-09-24 | Emory University | Method of resolution and antiviral activity of 1,3-oxathiolane nucleoside enantiomers |
US5276151A (en) * | 1990-02-01 | 1994-01-04 | Emory University | Method of synthesis of 1,3-dioxolane nucleosides |
GB9009861D0 (en) * | 1990-05-02 | 1990-06-27 | Glaxo Group Ltd | Chemical compounds |
US5444063A (en) * | 1990-12-05 | 1995-08-22 | Emory University | Enantiomerically pure β-D-dioxolane nucleosides with selective anti-Hepatitis B virus activity |
US5925643A (en) * | 1990-12-05 | 1999-07-20 | Emory University | Enantiomerically pure β-D-dioxolane-nucleosides |
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US6812233B1 (en) * | 1991-03-06 | 2004-11-02 | Emory University | Therapeutic nucleosides |
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US5817667A (en) * | 1991-04-17 | 1998-10-06 | University Of Georgia Research Foudation | Compounds and methods for the treatment of cancer |
GB9109506D0 (en) * | 1991-05-02 | 1991-06-26 | Wellcome Found | Therapeutic nucleosides |
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US6391859B1 (en) | 1995-01-27 | 2002-05-21 | Emory University | [5-Carboxamido or 5-fluoro]-[2′,3′-unsaturated or 3′-modified]-pyrimidine nucleosides |
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US6689761B1 (en) | 1995-02-01 | 2004-02-10 | Merck & Co., Inc. | Combination therapy for HIV infection |
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