DE4021517B4 - Formulierungen mit verlangsamter Freisetzung wasserlöslicher Peptide - Google Patents

Formulierungen mit verlangsamter Freisetzung wasserlöslicher Peptide Download PDF

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Publication number
DE4021517B4
DE4021517B4 DE4021517A DE4021517A DE4021517B4 DE 4021517 B4 DE4021517 B4 DE 4021517B4 DE 4021517 A DE4021517 A DE 4021517A DE 4021517 A DE4021517 A DE 4021517A DE 4021517 B4 DE4021517 B4 DE 4021517B4
Authority
DE
Germany
Prior art keywords
formulation
cys
slow release
thr
glycolide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE4021517A
Other languages
German (de)
English (en)
Other versions
DE4021517A1 (de
Inventor
David Dr. Bodmer
Jones W. Fong
Thomas Dr. Kissel
Hawkins V. Maulding
Oskar Nagele
Jane E. Pearson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Novartis AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis AG filed Critical Novartis AG
Priority to DE4042752A priority Critical patent/DE4042752B4/de
Publication of DE4021517A1 publication Critical patent/DE4021517A1/de
Application granted granted Critical
Publication of DE4021517B4 publication Critical patent/DE4021517B4/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A61K38/095—Oxytocins; Vasopressins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/23—Calcitonins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/31—Somatostatins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Rheumatology (AREA)
  • Emergency Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Cosmetics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DE4021517A 1989-07-07 1990-07-06 Formulierungen mit verlangsamter Freisetzung wasserlöslicher Peptide Expired - Lifetime DE4021517B4 (de)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DE4042752A DE4042752B4 (de) 1989-07-07 1990-07-06 Verfahren zur Herstellung von Mikropartikeln, welche einen Wirkstoff in einem bioabbaubaren polymeren Träger enthalten

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US37702389A 1989-07-07 1989-07-07
US377023 1989-07-07
US41134789A 1989-09-22 1989-09-22
DE4042746 1990-07-06
DE4042752A DE4042752B4 (de) 1989-07-07 1990-07-06 Verfahren zur Herstellung von Mikropartikeln, welche einen Wirkstoff in einem bioabbaubaren polymeren Träger enthalten
DE4042753 1990-07-06
US411347 1999-10-01

Publications (2)

Publication Number Publication Date
DE4021517A1 DE4021517A1 (de) 1991-01-17
DE4021517B4 true DE4021517B4 (de) 2009-04-09

Family

ID=27007654

Family Applications (2)

Application Number Title Priority Date Filing Date
DE4021517A Expired - Lifetime DE4021517B4 (de) 1989-07-07 1990-07-06 Formulierungen mit verlangsamter Freisetzung wasserlöslicher Peptide
DE4042752A Expired - Lifetime DE4042752B4 (de) 1989-07-07 1990-07-06 Verfahren zur Herstellung von Mikropartikeln, welche einen Wirkstoff in einem bioabbaubaren polymeren Träger enthalten

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE4042752A Expired - Lifetime DE4042752B4 (de) 1989-07-07 1990-07-06 Verfahren zur Herstellung von Mikropartikeln, welche einen Wirkstoff in einem bioabbaubaren polymeren Träger enthalten

Country Status (27)

Country Link
JP (5) JPH0832624B2 (he)
KR (2) KR100303681B1 (he)
AT (1) AT406225B (he)
AU (2) AU641407B2 (he)
BE (1) BE1004486A3 (he)
CA (1) CA2020477C (he)
CH (1) CH685230A5 (he)
CY (1) CY1965A (he)
DE (2) DE4021517B4 (he)
DK (1) DK175849B1 (he)
FI (3) FI108611B (he)
FR (1) FR2649319A1 (he)
GB (2) GB2234896B (he)
GR (1) GR1001121B (he)
HK (2) HK97695A (he)
HU (2) HU221294B1 (he)
IE (2) IE64411B1 (he)
IL (3) IL131881A (he)
IT (1) IT1241460B (he)
LU (1) LU87764A1 (he)
MY (1) MY106722A (he)
NL (1) NL195027C (he)
NO (2) NO302928B1 (he)
NZ (1) NZ234384A (he)
PT (1) PT94628B (he)
SE (1) SE512992C2 (he)
SG (1) SG26416G (he)

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US6013853A (en) * 1992-02-14 2000-01-11 The University Of Texas System Continuous release polymeric implant carrier
US5876452A (en) * 1992-02-14 1999-03-02 Board Of Regents, University Of Texas System Biodegradable implant
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JP2944419B2 (ja) * 1993-05-10 1999-09-06 ノバルティス アクチエンゲゼルシャフト 持続性遊離組成物中の薬理学的活性成分の安定
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US6270795B1 (en) 1995-11-09 2001-08-07 Microbiological Research Authority Method of making microencapsulated DNA for vaccination and gene therapy
EP0862419B2 (en) 1995-11-09 2010-11-17 Microbiological Research Authority Microencapsulated dna for vaccination and gene therapy
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US5968895A (en) * 1996-12-11 1999-10-19 Praecis Pharmaceuticals, Inc. Pharmaceutical formulations for sustained drug delivery
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AR044852A1 (es) * 2003-06-24 2005-10-05 Novartis Ag Una composicion farmaceutica para la administracion parenteral que comprende un analogo de somatostatina
EP1660039B1 (en) * 2003-07-18 2016-09-28 Oakwood Laboratories L.L.C. Prevention of molecular weight reduction of the polymer, impurity formation and gelling in polymer compositions
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KR20130024987A (ko) * 2005-12-22 2013-03-08 노파르티스 아게 옥트레오티드 및 ２종 이상의 폴리락티드-코-글리콜리드 중합체를 포함하는 서방형 제제
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JP5791278B2 (ja) 2008-01-30 2015-10-07 ノバルティス アーゲー オクトレオチドおよび３種の線状ポリラクチド−コ−グリコリドポリマーを含む徐放性製剤
USRE49251E1 (en) 2010-01-04 2022-10-18 Mapi Pharma Ltd. Depot systems comprising glatiramer or pharmacologically acceptable salt thereof
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TW201605488A (zh) 2013-10-15 2016-02-16 大塚製藥股份有限公司 用以預防及／或治療多囊腎病之藥物
KR102464650B1 (ko) 2016-05-03 2022-11-10 엘에스일렉트릭(주) 배선용 차단기의 한류장치
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Title
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Also Published As

Publication number Publication date
NO903001D0 (no) 1990-07-05
DK162590A (da) 1991-01-08
FR2649319B1 (he) 1994-12-09
PT94628A (pt) 1991-03-20
NO983923D0 (no) 1998-08-26
NL195027B (nl) 2003-08-01
FI108611B (fi) 2002-02-28
SE512992C2 (sv) 2000-06-12
NL9001537A (nl) 1991-02-01
JPH07309897A (ja) 1995-11-28
HU903974D0 (en) 1990-11-28
JPH07285853A (ja) 1995-10-31
FI109543B (fi) 2002-08-30
JPH08198771A (ja) 1996-08-06
FI20000059A (fi) 2000-01-12
NO302928B1 (no) 1998-05-11
HUT54037A (en) 1991-01-28
CH685230A5 (de) 1995-05-15
GB2234896A (en) 1991-02-20
IL131881A (he) 2001-12-23
MY106722A (en) 1995-07-31
ATA144090A (de) 1999-08-15
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GB2265311A (en) 1993-09-29
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DK162590D0 (da) 1990-07-05
JP2931773B2 (ja) 1999-08-09
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AT406225B (de) 2000-03-27
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AU2332195A (en) 1995-09-07
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DK175849B1 (da) 2005-03-29
IE902435A1 (en) 1991-02-13
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CA2020477C (en) 2000-11-21
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FI109334B (fi) 2002-07-15
KR100442931B1 (ko) 2004-08-02
HU211602A9 (en) 1995-12-28
SE9002364D0 (sv) 1990-07-05
JP2001233897A (ja) 2001-08-28
FI20000060A (fi) 2000-01-12
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IL94983A0 (en) 1991-06-10
IT1241460B (it) 1994-01-17
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DE4021517A1 (de) 1991-01-17
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GR1001121B (el) 1993-04-28

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