CY1965A - Processes for the preparation of sustained release formulations of water soluble peptides - Google Patents

Processes for the preparation of sustained release formulations of water soluble peptides

Info

Publication number
CY1965A
CY1965A CY196597A CY196597A CY1965A CY 1965 A CY1965 A CY 1965A CY 196597 A CY196597 A CY 196597A CY 196597 A CY196597 A CY 196597A CY 1965 A CY1965 A CY 1965A
Authority
CY
Cyprus
Prior art keywords
processes
preparation
water soluble
sustained release
release formulations
Prior art date
Application number
CY196597A
Original Assignee
Sandoz Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz Ltd filed Critical Sandoz Ltd
Publication of CY1965A publication Critical patent/CY1965A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A61K38/095—Oxytocins; Vasopressins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/23—Calcitonins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/31—Somatostatins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
CY196597A 1989-07-07 1997-07-04 Processes for the preparation of sustained release formulations of water soluble peptides CY1965A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US37702389A 1989-07-07 1989-07-07
US41134789A 1989-09-22 1989-09-22

Publications (1)

Publication Number Publication Date
CY1965A true CY1965A (en) 1997-07-04

Family

ID=27007654

Family Applications (1)

Application Number Title Priority Date Filing Date
CY196597A CY1965A (en) 1989-07-07 1997-07-04 Processes for the preparation of sustained release formulations of water soluble peptides

Country Status (27)

Country Link
JP (5) JPH0832624B2 (en)
KR (2) KR100303681B1 (en)
AT (1) AT406225B (en)
AU (2) AU641407B2 (en)
BE (1) BE1004486A3 (en)
CA (1) CA2020477C (en)
CH (1) CH685230A5 (en)
CY (1) CY1965A (en)
DE (2) DE4021517B4 (en)
DK (1) DK175849B1 (en)
FI (3) FI108611B (en)
FR (1) FR2649319A1 (en)
GB (2) GB2234896B (en)
GR (1) GR1001121B (en)
HK (2) HK97695A (en)
HU (2) HU221294B1 (en)
IE (2) IE64216B1 (en)
IL (3) IL131880A (en)
IT (1) IT1241460B (en)
LU (1) LU87764A1 (en)
MY (1) MY106722A (en)
NL (1) NL195027C (en)
NO (2) NO302928B1 (en)
NZ (1) NZ234384A (en)
PT (1) PT94628B (en)
SE (1) SE512992C2 (en)
SG (1) SG26416G (en)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4990336A (en) * 1989-02-08 1991-02-05 Biosearch, Inc. Sustained release dosage form
YU48420B (en) * 1991-03-25 1998-07-10 Hoechst Aktiengesellschaft PROCEDURE FOR OBTAINING BIOLOGICAL DEGRADABLE MICROPARTICLES WITH LONG TERM ACTION
CH683149A5 (en) * 1991-07-22 1994-01-31 Debio Rech Pharma Sa Process for the preparation of microspheres of a biodegradable polymeric material.
US5876452A (en) * 1992-02-14 1999-03-02 Board Of Regents, University Of Texas System Biodegradable implant
US6013853A (en) * 1992-02-14 2000-01-11 The University Of Texas System Continuous release polymeric implant carrier
DE4218510A1 (en) * 1992-06-02 1993-12-09 Pharmatech Gmbh Process for the preparation of biodegradable polyesters
AU4198793A (en) † 1992-07-24 1994-01-27 Takeda Chemical Industries Ltd. Microparticle preparation and production thereof
EP0626170A3 (en) * 1993-05-10 1996-03-27 Sandoz Ltd Stabilisation of pharmacologically active compounds in sustained release compositions.
GB9310781D0 (en) * 1993-05-25 1993-07-14 Davis Stanley S Preparation of microparticles
US5603960A (en) * 1993-05-25 1997-02-18 O'hagan; Derek T. Preparation of microparticles and method of immunization
KR100354270B1 (en) 1993-11-19 2003-02-11 알커메스 컨트롤드 테라포이틱스 인코퍼레이티드 Ii Microencapsulated 3-piperidinyl-substituted 1,2-benzisoxazole and 1,2-benzisothiazole
US6270795B1 (en) 1995-11-09 2001-08-07 Microbiological Research Authority Method of making microencapsulated DNA for vaccination and gene therapy
AU717113B2 (en) 1995-11-09 2000-03-16 Health Protection Agency Microencapsulated DNA for vaccination and gene therapy
DE19545257A1 (en) 1995-11-24 1997-06-19 Schering Ag Process for the production of morphologically uniform microcapsules and microcapsules produced by this process
US5817343A (en) * 1996-05-14 1998-10-06 Alkermes, Inc. Method for fabricating polymer-based controlled-release devices
US5968895A (en) * 1996-12-11 1999-10-19 Praecis Pharmaceuticals, Inc. Pharmaceutical formulations for sustained drug delivery
US6126919A (en) 1997-02-07 2000-10-03 3M Innovative Properties Company Biocompatible compounds for pharmaceutical drug delivery systems
GB9810236D0 (en) 1998-05-13 1998-07-08 Microbiological Res Authority Improvements relating to encapsulation of bioactive agents
US6632457B1 (en) * 1998-08-14 2003-10-14 Incept Llc Composite hydrogel drug delivery systems
US7107268B1 (en) 1998-11-12 2006-09-12 Printable Technologies, Inc. Centralized system and method for managing enterprise operations
US6226656B1 (en) 1998-11-12 2001-05-01 Sourcefinder, Inc. System and method for creating, generating and processing user-defined generic specs
US6204308B1 (en) 1999-03-01 2001-03-20 Novartis Ag Organic compounds
EP1044683A1 (en) * 1999-04-15 2000-10-18 Debio Recherche Pharmaceutique S.A. One-step dispersion method for the microencapsulation of water soluble substances
US6461631B1 (en) * 1999-11-16 2002-10-08 Atrix Laboratories, Inc. Biodegradable polymer composition
KR100392501B1 (en) * 2000-06-28 2003-07-22 동국제약 주식회사 Preparation Method for Sustained Release Microparticles by Multiple Emulsion Method and Micropartic les Thereof
US6824822B2 (en) * 2001-08-31 2004-11-30 Alkermes Controlled Therapeutics Inc. Ii Residual solvent extraction method and microparticles produced thereby
ES2292634T3 (en) 2000-12-21 2008-03-16 Alrise Biosystems Gmbh Induced phase transition procedure for the production of microparticles containing active hydrophilic agents.
US20040097419A1 (en) * 2002-11-19 2004-05-20 Holger Petersen Organic compounds
AR044852A1 (en) * 2003-06-24 2005-10-05 Novartis Ag A PHARMACEUTICAL COMPOSITION FOR PARENTERAL ADMINISTRATION THAT INCLUDES A SOMATOSTATINE ANALOG
CA2533314C (en) * 2003-07-18 2013-07-09 Oakwood Laboratories, L.L.C. Prevention of molecular weight reduction of the polymer, impurity formation and gelling in polymer compositions
MY158342A (en) 2003-11-14 2016-09-30 Novartis Ag Pharmaceutical composition
EP1719523A4 (en) * 2004-02-26 2009-07-15 Japan Science & Tech Agency Protein drug sustained-release microparticle preparation for injection and process for producing the same
DE102004053373A1 (en) * 2004-11-02 2006-05-04 Justus-Liebig-Universität Giessen Invention relating to nano / meso-fiber anisometric particles in the form of nano / meso-fiber tubes, cables and their curved or branched modifications
KR100741867B1 (en) * 2005-07-05 2007-07-24 전북대학교산학협력단 Preparation method of double-layered sphere using oil-in-water and solvent evaporation
KR20140133968A (en) * 2005-12-22 2014-11-20 노파르티스 아게 Sustained release formulation comprising octreotide and two or more polylactide-co-glycolide polymers
KR100816065B1 (en) 2006-11-27 2008-03-24 동국제약 주식회사 Preparation method of sustained-release microcapsules having good initial burst inhibiting property and the microcapsules thereby
CN104127367A (en) 2008-01-30 2014-11-05 诺华股份有限公司 Sustained release formulation comprising octreotide and three linear polylactide-co-glycolide polymers
USRE49251E1 (en) 2010-01-04 2022-10-18 Mapi Pharma Ltd. Depot systems comprising glatiramer or pharmacologically acceptable salt thereof
CA2813302A1 (en) * 2010-09-30 2012-04-05 Evonik Corporation Emulsion method for preparing low residual solvent microparticles
CN103370057A (en) * 2010-09-30 2013-10-23 赢创有限公司 Method for removing residual organic solvent from microparticles
TW201605488A (en) 2013-10-15 2016-02-16 大塚製藥股份有限公司 Drug for preventing and/or treating polycystic kidney disease
KR102464650B1 (en) 2016-05-03 2022-11-10 엘에스일렉트릭(주) Current limiting device of circuit breaker
CA3050086A1 (en) 2017-03-26 2018-10-04 Mapi Pharma Ltd. Glatiramer depot systems for treating progressive forms of multiple sclerosis

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3773919A (en) * 1969-10-23 1973-11-20 Du Pont Polylactide-drug mixtures
CH644768A5 (en) * 1977-08-25 1984-08-31 Sandoz Ag METHOD FOR PRODUCING MICROBALLS.
US4622244A (en) * 1979-09-04 1986-11-11 The Washington University Process for preparation of microcapsules
US4293539A (en) * 1979-09-12 1981-10-06 Eli Lilly And Company Controlled release formulations and method of treatment
DE19375086I2 (en) * 1979-11-27 2003-01-09 Novartis Ag Polypeptides Process for their preparation pharmaceutical compositions containing these polypeptides and their use
US4389330A (en) * 1980-10-06 1983-06-21 Stolle Research And Development Corporation Microencapsulation process
PH19942A (en) * 1980-11-18 1986-08-14 Sintex Inc Microencapsulation of water soluble polypeptides
US4675189A (en) * 1980-11-18 1987-06-23 Syntex (U.S.A.) Inc. Microencapsulation of water soluble active polypeptides
IE52535B1 (en) * 1981-02-16 1987-12-09 Ici Plc Continuous release pharmaceutical compositions
DE3378250D1 (en) * 1982-04-22 1988-11-24 Ici Plc Continuous release formulations
CH656884A5 (en) * 1983-08-26 1986-07-31 Sandoz Ag POLYOLESTERS, THEIR PRODUCTION AND USE.
US4485101A (en) * 1983-10-11 1984-11-27 Administrators Of The Tulane Educational Fund Peptides
JPH0657658B2 (en) * 1985-04-11 1994-08-03 住友製薬株式会社 Sustained release formulation
JPS60100516A (en) * 1983-11-04 1985-06-04 Takeda Chem Ind Ltd Preparation of sustained release microcapsule
GB8331158D0 (en) * 1983-11-22 1983-12-29 British Telecomm Metal/semiconductor deposition
JPS60181029A (en) * 1984-02-29 1985-09-14 Toyo Jozo Co Ltd Preparation of sustained release preparation
CH660302A5 (en) * 1984-10-17 1987-04-15 Debiopharm Sa HETEROGENEOUS PHASE MICRO-ENCAPSULATION PROCESS OF WATER-SOLUBLE DRUG SUBSTANCES.
EP0190833B1 (en) * 1985-02-07 1991-03-27 Takeda Chemical Industries, Ltd. Method for producing microcapsule
US4725577A (en) * 1985-04-25 1988-02-16 Administrators Of The Tulane Educational Fund Biologically active lysine containing octapeptides
CH665558A5 (en) * 1985-10-09 1988-05-31 Debiopharm Sa Phase sepn. prodn. of microcapsules for water soluble pharmaceuticals - using fluoro-substd. aliphatic hydrocarbon as non-solvent in the hardening stage
JP2539789B2 (en) * 1986-03-06 1996-10-02 日本原子力研究所 Process for producing sustained-release drug complex composed of polylactone
GB2193891B (en) * 1986-08-18 1990-07-25 Sandoz Ltd Nasal pharmaceutical composition containing a somatostatin anologue.
JPH0725689B2 (en) * 1986-10-07 1995-03-22 中外製薬株式会社 Sustained-release preparation containing granulocyte colony-stimulating factor
GB2209937B (en) * 1987-09-21 1991-07-03 Depiopharm S A Water insoluble polypeptides
CH672887A5 (en) * 1987-10-14 1990-01-15 Debiopharm Sa
DE3738228A1 (en) * 1987-11-11 1989-05-24 Hoechst Ag METHOD FOR PRODUCING BIODEGRADABLE MICRO-CAPSULES OF WATER-SOLUBLE PEPTIDES AND PROTEINS AND MICRO-CAPSULES OBTAINED BY THIS PROCESS
JP2653255B2 (en) * 1990-02-13 1997-09-17 武田薬品工業株式会社 Long-term sustained release microcapsules

Also Published As

Publication number Publication date
DE4042752B4 (en) 2009-05-07
KR910002430A (en) 1991-02-25
FI903429A0 (en) 1990-07-06
NL195027B (en) 2003-08-01
HU211602A9 (en) 1995-12-28
GB9014704D0 (en) 1990-08-22
FI20000059A (en) 2000-01-12
NO320444B1 (en) 2005-12-05
SE512992C2 (en) 2000-06-12
GR1001121B (en) 1993-04-28
AU2332195A (en) 1995-09-07
JPH07309897A (en) 1995-11-28
DK162590A (en) 1991-01-08
CA2020477A1 (en) 1991-01-08
SE9002364D0 (en) 1990-07-05
MY106722A (en) 1995-07-31
HK97695A (en) 1995-06-23
IT9048113A1 (en) 1992-01-05
AU641407B2 (en) 1993-09-23
GB2265311A (en) 1993-09-29
CA2020477C (en) 2000-11-21
AU5874690A (en) 1991-01-10
HU221294B1 (en) 2002-09-28
IT9048113A0 (en) 1990-07-05
FI109543B (en) 2002-08-30
GB2265311B (en) 1994-02-09
GR900100513A (en) 1991-12-10
DK162590D0 (en) 1990-07-05
NL9001537A (en) 1991-02-01
DK175849B1 (en) 2005-03-29
IE902435A1 (en) 1991-02-13
JPH0368511A (en) 1991-03-25
AU687553B2 (en) 1998-02-26
SG26416G (en) 1995-09-01
FI20000060A (en) 2000-01-12
JPH08198771A (en) 1996-08-06
FR2649319A1 (en) 1991-01-11
IT1241460B (en) 1994-01-17
NO903001L (en) 1991-01-08
NO903001D0 (en) 1990-07-05
BE1004486A3 (en) 1992-12-01
GB9306204D0 (en) 1993-05-19
JPH0832624B2 (en) 1996-03-29
DE4021517B4 (en) 2009-04-09
HUT54037A (en) 1991-01-28
LU87764A1 (en) 1992-03-11
GB2234896A (en) 1991-02-20
JPH07285853A (en) 1995-10-31
CH685230A5 (en) 1995-05-15
FR2649319B1 (en) 1994-12-09
NO983923D0 (en) 1998-08-26
KR100303681B1 (en) 2002-05-16
AT406225B (en) 2000-03-27
FI108611B (en) 2002-02-28
IL94983A (en) 1999-08-17
NO302928B1 (en) 1998-05-11
HU903974D0 (en) 1990-11-28
DE4021517A1 (en) 1991-01-17
FI109334B (en) 2002-07-15
HK197496A (en) 1996-11-08
GB2234896B (en) 1994-01-19
IE64216B1 (en) 1995-07-26
ATA144090A (en) 1999-08-15
PT94628B (en) 1997-06-30
IL94983A0 (en) 1991-06-10
JP2931773B2 (en) 1999-08-09
NO983923L (en) 1991-01-08
NZ234384A (en) 1994-05-26
NL195027C (en) 2003-12-02
SE9002364L (en) 1991-01-08
IL131881A (en) 2001-12-23
IE64411B1 (en) 1995-08-09
IL131880A (en) 2001-12-23
PT94628A (en) 1991-03-20
KR100442931B1 (en) 2004-08-02
JP2001233897A (en) 2001-08-28

Similar Documents

Publication Publication Date Title
GB2234896B (en) Processes for the preparation of sustained release formulations of water soluble peptides
PH30995A (en) Sustained release formulations of water soluble peptides.
GB2230185B (en) Sustained release pharmaceutical compositions
IL87790A0 (en) Sustained release compositions containing water insoluble polypeptides
AU622526B2 (en) Sustained release pharmaceutical preparation
ZA915565B (en) Preparation process of sustained release compositions and the compositions thus obtained
EP0230654A3 (en) Sustained pulsewise release pharmaceutical preparation
IL89702A0 (en) Water soluble ibuprofen compositions,processes for the preparation thereof and pharmaceutical compositions containing the same
EP0420649A3 (en) Stabilized aqueous formulations of small peptides
IL98508A0 (en) Water insoluble microencapsular pharmaceutical compositions and methods for the preparation thereof
PH27350A (en) Process for the preparation of cefodizime sodium
GB2195893B (en) Sustained release pharmaceutical compositions
EP0416406A3 (en) Process for the preparation of alkylhalosilanes
HU906211D0 (en) Process for the preparation of anthelminthics
ZA905327B (en) Sustained release formulations of water soluble peptides
CY1844A (en) Sustained release formulations of water soluble peptides
IL131881A0 (en) Sustained release formulation comprising octreotide
GB8922061D0 (en) Controlled release formulations
HU895935D0 (en) Process for the preparation of water-soluble iode complex
IE890932L (en) Water soluble ibuprofen compositions
CA63032S (en) Bag for the preparation of ice-lollies
IE861214L (en) Compositions for the preparation of micro-particles for¹prolonged release
IE893777L (en) Sustained release diltiazen formulation
GB8624214D0 (en) Sustained release pharmaceutical compositions
IE871503L (en) Sustained release formulations