NL195027B - Process for preparing microparticles for slow release of water-soluble peptides and preparations thereof. - Google Patents

Process for preparing microparticles for slow release of water-soluble peptides and preparations thereof.

Info

Publication number
NL195027B
NL195027B NL9001537A NL9001537A NL195027B NL 195027 B NL195027 B NL 195027B NL 9001537 A NL9001537 A NL 9001537A NL 9001537 A NL9001537 A NL 9001537A NL 195027 B NL195027 B NL 195027B
Authority
NL
Netherlands
Prior art keywords
preparations
water
slow release
soluble peptides
preparing microparticles
Prior art date
Application number
NL9001537A
Other languages
Dutch (nl)
Other versions
NL9001537A (en
NL195027C (en
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of NL9001537A publication Critical patent/NL9001537A/en
Publication of NL195027B publication Critical patent/NL195027B/en
Priority to NL9900037A priority Critical patent/NL195092C/en
Priority to NL9900039A priority patent/NL195090C/en
Priority to NL9900038A priority patent/NL195089C/en
Application granted granted Critical
Publication of NL195027C publication Critical patent/NL195027C/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A61K38/095—Oxytocins; Vasopressins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/23—Calcitonins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/31—Somatostatins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
NL9001537A 1989-07-07 1990-07-05 Process for preparing microparticles for slow release of water-soluble peptides and preparations thereof. NL195027C (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
NL9900037A NL195092C (en) 1989-07-07 2003-08-19 Preparations of water-soluble peptides with a slow release.
NL9900039A NL195090C (en) 1989-07-07 2003-08-19 Preparations of water-soluble peptides with a slow release.
NL9900038A NL195089C (en) 1989-07-07 2003-08-19 Preparations of water-soluble peptides with a slow release.

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US37702389A 1989-07-07 1989-07-07
US37702389 1989-07-07
US41134789A 1989-09-22 1989-09-22
US41134789 1989-09-22

Publications (3)

Publication Number Publication Date
NL9001537A NL9001537A (en) 1991-02-01
NL195027B true NL195027B (en) 2003-08-01
NL195027C NL195027C (en) 2003-12-02

Family

ID=27007654

Family Applications (1)

Application Number Title Priority Date Filing Date
NL9001537A NL195027C (en) 1989-07-07 1990-07-05 Process for preparing microparticles for slow release of water-soluble peptides and preparations thereof.

Country Status (27)

Country Link
JP (5) JPH0832624B2 (en)
KR (2) KR100303681B1 (en)
AT (1) AT406225B (en)
AU (2) AU641407B2 (en)
BE (1) BE1004486A3 (en)
CA (1) CA2020477C (en)
CH (1) CH685230A5 (en)
CY (1) CY1965A (en)
DE (2) DE4021517B4 (en)
DK (1) DK175849B1 (en)
FI (3) FI108611B (en)
FR (1) FR2649319A1 (en)
GB (2) GB2234896B (en)
GR (1) GR1001121B (en)
HK (2) HK97695A (en)
HU (2) HU221294B1 (en)
IE (2) IE64216B1 (en)
IL (3) IL131881A (en)
IT (1) IT1241460B (en)
LU (1) LU87764A1 (en)
MY (1) MY106722A (en)
NL (1) NL195027C (en)
NO (2) NO302928B1 (en)
NZ (1) NZ234384A (en)
PT (1) PT94628B (en)
SE (1) SE512992C2 (en)
SG (1) SG26416G (en)

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US6013853A (en) * 1992-02-14 2000-01-11 The University Of Texas System Continuous release polymeric implant carrier
US5876452A (en) * 1992-02-14 1999-03-02 Board Of Regents, University Of Texas System Biodegradable implant
DE4218510A1 (en) * 1992-06-02 1993-12-09 Pharmatech Gmbh Process for the preparation of biodegradable polyesters
AU4198793A (en) † 1992-07-24 1994-01-27 Takeda Chemical Industries Ltd. Microparticle preparation and production thereof
JP2944419B2 (en) * 1993-05-10 1999-09-06 ノバルティス アクチエンゲゼルシャフト Stability of pharmacologically active ingredients in sustained release compositions
GB9310781D0 (en) * 1993-05-25 1993-07-14 Davis Stanley S Preparation of microparticles
US5603960A (en) * 1993-05-25 1997-02-18 O'hagan; Derek T. Preparation of microparticles and method of immunization
JP3645906B2 (en) 1993-11-19 2005-05-11 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ Microencapsulated 3-piperidinyl-substituted 1,2-benzisoxazoles and 1,2-benzisothiazoles
US6270795B1 (en) 1995-11-09 2001-08-07 Microbiological Research Authority Method of making microencapsulated DNA for vaccination and gene therapy
WO1997017063A1 (en) 1995-11-09 1997-05-15 Microbiological Research Authority Microencapsulated dna for vaccination and gene therapy
DE19545257A1 (en) 1995-11-24 1997-06-19 Schering Ag Process for the production of morphologically uniform microcapsules and microcapsules produced by this process
US5817343A (en) * 1996-05-14 1998-10-06 Alkermes, Inc. Method for fabricating polymer-based controlled-release devices
US5968895A (en) * 1996-12-11 1999-10-19 Praecis Pharmaceuticals, Inc. Pharmaceutical formulations for sustained drug delivery
US6126919A (en) 1997-02-07 2000-10-03 3M Innovative Properties Company Biocompatible compounds for pharmaceutical drug delivery systems
GB9810236D0 (en) * 1998-05-13 1998-07-08 Microbiological Res Authority Improvements relating to encapsulation of bioactive agents
US6632457B1 (en) * 1998-08-14 2003-10-14 Incept Llc Composite hydrogel drug delivery systems
US7107268B1 (en) 1998-11-12 2006-09-12 Printable Technologies, Inc. Centralized system and method for managing enterprise operations
US6226656B1 (en) 1998-11-12 2001-05-01 Sourcefinder, Inc. System and method for creating, generating and processing user-defined generic specs
US6204308B1 (en) 1999-03-01 2001-03-20 Novartis Ag Organic compounds
EP1044683A1 (en) 1999-04-15 2000-10-18 Debio Recherche Pharmaceutique S.A. One-step dispersion method for the microencapsulation of water soluble substances
US6461631B1 (en) * 1999-11-16 2002-10-08 Atrix Laboratories, Inc. Biodegradable polymer composition
KR100392501B1 (en) * 2000-06-28 2003-07-22 동국제약 주식회사 Preparation Method for Sustained Release Microparticles by Multiple Emulsion Method and Micropartic les Thereof
US6824822B2 (en) * 2001-08-31 2004-11-30 Alkermes Controlled Therapeutics Inc. Ii Residual solvent extraction method and microparticles produced thereby
US6899898B2 (en) 2000-12-21 2005-05-31 Nektar Therapeutics Induced phase transition method for the production of microparticles containing hydrophobic active agents
US20040097419A1 (en) * 2002-11-19 2004-05-20 Holger Petersen Organic compounds
AR044852A1 (en) * 2003-06-24 2005-10-05 Novartis Ag A PHARMACEUTICAL COMPOSITION FOR PARENTERAL ADMINISTRATION THAT INCLUDES A SOMATOSTATINE ANALOG
CA2533314C (en) * 2003-07-18 2013-07-09 Oakwood Laboratories, L.L.C. Prevention of molecular weight reduction of the polymer, impurity formation and gelling in polymer compositions
MY158342A (en) * 2003-11-14 2016-09-30 Novartis Ag Pharmaceutical composition
EP1719523A4 (en) * 2004-02-26 2009-07-15 Japan Science & Tech Agency Protein drug sustained-release microparticle preparation for injection and process for producing the same
DE102004053373A1 (en) * 2004-11-02 2006-05-04 Justus-Liebig-Universität Giessen Invention relating to nano / meso-fiber anisometric particles in the form of nano / meso-fiber tubes, cables and their curved or branched modifications
KR100741867B1 (en) * 2005-07-05 2007-07-24 전북대학교산학협력단 Preparation method of double-layered sphere using oil-in-water and solvent evaporation
KR101245919B1 (en) * 2005-12-22 2013-03-20 노파르티스 아게 Sustained release formulation comprising octreotide and two or more polylactide-co-glycolide polymers
KR100816065B1 (en) * 2006-11-27 2008-03-24 동국제약 주식회사 Preparation method of sustained-release microcapsules having good initial burst inhibiting property and the microcapsules thereby
AU2009209594A1 (en) 2008-01-30 2009-08-06 Novartis Ag Sustained release formulation comprising octreotide and three linear polylactide-co-glycolide polymers
USRE49251E1 (en) 2010-01-04 2022-10-18 Mapi Pharma Ltd. Depot systems comprising glatiramer or pharmacologically acceptable salt thereof
CN103298453A (en) * 2010-09-30 2013-09-11 赢创有限公司 Emulsion method for preparing low residual solvent microparticles
CN103370057A (en) * 2010-09-30 2013-10-23 赢创有限公司 Method for removing residual organic solvent from microparticles
TW201605488A (en) 2013-10-15 2016-02-16 大塚製藥股份有限公司 Drug for preventing and/or treating polycystic kidney disease
KR102464650B1 (en) 2016-05-03 2022-11-10 엘에스일렉트릭(주) Current limiting device of circuit breaker
EP3600553A4 (en) 2017-03-26 2020-09-02 Mapi Pharma Ltd. Glatiramer depot systems for treating progressive forms of multiple sclerosis

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Also Published As

Publication number Publication date
IL94983A (en) 1999-08-17
NL9001537A (en) 1991-02-01
SG26416G (en) 1995-09-01
SE9002364L (en) 1991-01-08
DK162590D0 (en) 1990-07-05
AU2332195A (en) 1995-09-07
IT1241460B (en) 1994-01-17
JPH07285853A (en) 1995-10-31
JPH0832624B2 (en) 1996-03-29
AU687553B2 (en) 1998-02-26
JP2931773B2 (en) 1999-08-09
NO983923D0 (en) 1998-08-26
IE64411B1 (en) 1995-08-09
JPH08198771A (en) 1996-08-06
NZ234384A (en) 1994-05-26
IE64216B1 (en) 1995-07-26
PT94628A (en) 1991-03-20
FI109334B (en) 2002-07-15
JP2001233897A (en) 2001-08-28
HU221294B1 (en) 2002-09-28
GB2265311B (en) 1994-02-09
HK97695A (en) 1995-06-23
KR910002430A (en) 1991-02-25
CY1965A (en) 1997-07-04
NO983923L (en) 1991-01-08
GB9306204D0 (en) 1993-05-19
SE9002364D0 (en) 1990-07-05
DE4042752B4 (en) 2009-05-07
MY106722A (en) 1995-07-31
AU5874690A (en) 1991-01-10
NL195027C (en) 2003-12-02
IT9048113A1 (en) 1992-01-05
IE902435A1 (en) 1991-02-13
GR1001121B (en) 1993-04-28
GB2265311A (en) 1993-09-29
HK197496A (en) 1996-11-08
AU641407B2 (en) 1993-09-23
NO320444B1 (en) 2005-12-05
PT94628B (en) 1997-06-30
IL94983A0 (en) 1991-06-10
BE1004486A3 (en) 1992-12-01
SE512992C2 (en) 2000-06-12
GB2234896B (en) 1994-01-19
CH685230A5 (en) 1995-05-15
GR900100513A (en) 1991-12-10
CA2020477A1 (en) 1991-01-08
HU211602A9 (en) 1995-12-28
FI20000059A (en) 2000-01-12
NO302928B1 (en) 1998-05-11
FI109543B (en) 2002-08-30
FR2649319B1 (en) 1994-12-09
JPH07309897A (en) 1995-11-28
CA2020477C (en) 2000-11-21
KR100303681B1 (en) 2002-05-16
DK175849B1 (en) 2005-03-29
GB2234896A (en) 1991-02-20
FR2649319A1 (en) 1991-01-11
LU87764A1 (en) 1992-03-11
AT406225B (en) 2000-03-27
FI108611B (en) 2002-02-28
FI903429A0 (en) 1990-07-06
IT9048113A0 (en) 1990-07-05
IL131881A (en) 2001-12-23
JPH0368511A (en) 1991-03-25
NO903001L (en) 1991-01-08
DE4021517A1 (en) 1991-01-17
HU903974D0 (en) 1990-11-28
DE4021517B4 (en) 2009-04-09
ATA144090A (en) 1999-08-15
HUT54037A (en) 1991-01-28
FI20000060A (en) 2000-01-12
KR100442931B1 (en) 2004-08-02
DK162590A (en) 1991-01-08
NO903001D0 (en) 1990-07-05
GB9014704D0 (en) 1990-08-22
IL131880A (en) 2001-12-23

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